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| 1 | BYSL contributes to tumor growth by cooperating with the mTORC2 complex in gliomas显示文摘Objective:BYSL,which encodes the Bystin protein in humans,is upregulated in reactive astrocytes following brain damage and/or inflammation.We aimed to determine the role and mechanism of BYSL in glioma cell growth and survival.Methods:BYSL expression in glioma tissues was measured by quantitative real-time PCR,Western blot,and immunohistochemistry.In vitro assays were performed to assess the role of BYSL in cell proliferation and apoptosis.Protein interactions and co-localization were determined by co-immunoprecipitation and double immunofluorescence.The expression and activity of the AKT/m TOR signaling molecules were determined by Western blot analysis,and the role of BYSL in glioma growth was confirmed in an orthotopic xenograft model.Results:The BYSL m RNA and protein levels were elevated in glioma tissues.Silencing BYSL inhibited glioma cell proliferation,impeded cell cycle progression,and induced apoptosis,whereas overexpressing BYSL protein led to the opposite effects.We identified a complex consisting of BYSL,RIOK2,and m TOR,and observed co-localization and positive correlations between BYSL and RIOK2 in glioma cells and tissues.Overexpressing BYSL or RIOK2 increased the expression and activity of AKT/m TOR signaling molecules,whereas downregulation of BYSL or RIOK2 decreased the activity of AKT/m TOR signaling molecules.Silencing BYSL or RIOK2 decreased the growth of the tumors and prolonged the lifespan of the animals in an orthotopic xenograft model.Conclusions:High expression of BYSL in gliomas promoted tumor cell growth and survival both in vitro and in vivo.These effects could be attributed to the association of BYSL with RIOK2 and m TOR,and the subsequent activation of AKT signaling. | Shangfeng Gao Zhuang Sha Junbo Zhou Yihao Wu Yunnong Song Cheng Li Xuejiao Liu Tong Zhang Rutong Yu | 2021 | Cancer Biology & Medicine2021，18，1： | 3 |
| 2 | Highly stableβ‑ketoenamine‑based covalent organic frameworks(COFs):synthesis and optoelectrical applications显示文摘Covalent organic frameworks(COFs)are one class of porous materials with permanent porosity and regular channels,and have a covalent bond structure.Due to their interesting characteristics,COFs have exhibited diverse potential applications in many felds.However,some applications require the frameworks to possess high structural stability,excellent crystallinity,and suitable pore size.COFs based onβ-ketoenamine and imines are prepared through the irreversible enol-to-keto tautomerization.These materials have high crystallinity and exhibit high stability in boiling water,with strong resistance to acids and bases,resulting in various possible applications.In this review,we frst summarize the preparation methods for COFs based onβ-ketoenamine,in the form of powders,flms and foams.Then,the efects of diferent synthetic methods on the crystallinity and pore structure of COFs based onβ-ketoenamine are analyzed and compared.The relationship between structures and diferent applications including fuorescence sensors,energy storage,photocatalysis,electrocatalysis,batteries and proton conduction are carefully summarized.Finally,the potential applications,large-scale industrial preparation and challenges in the future are presented. | Yaqin Li Maosong Liu Jinjun Wu Junbo Li Xianglin Yu Qichun Zhang | 2022 | Frontiers of Optoelectronics2022，15，3： | 2 |
| 3 | Polymerization Kinetics and Stabilization Mechanism of the Monodisperse PMMA Microspheres显示文摘The effects of the concentration of monomer, crosslinking agent, initiator, stabilizer, and the polarity of medium on the polymerization kinetics were investigated. The results show that the rate of polymerization (Rp) and conversion increased with the increase of monomer concentration from 8% to 15% (total mass); the water content in dispersion medium and the initiator 2, 2′ -azobis (isobutyronitrile) (AIBN) concentration increased as well. Rp and conversion decreases with the increase of PVP when it is low, while it increases when it is high. Moreover, PVP plays an important role in microsphere stabilization. The stabilization mechanism was investigated primarily, which involves both adsorbing mechanism and graft mechanism. Within a certain range of crosslinking degree, Rp and conversion increased with the increase of the crosslinker concentration. The effect can be ignored when crosslinker concentration is above 0.3 % (total mass), and the reason was that the monomer can hardly be diffused into the microsphere phase with a certain degree of crosslinking. | YU Xianglin YE Chunjie LI Junbo CHENG Dongbing WANG Jun CHEN Rong | 2011 | Wuhan University Journal of Natural Sciences2011，16，4： | 2 |
| 4 | Effects of reverse voltage and subzero startup on the membrane electrode assembly of a PEMFC显示文摘 | Hongwei Wang Junbo Hou Hongmei Yu Shucheng Sun | 2007 | Journal of Power Sources2007，，1： | 1 |
| 5 | REMOVAL OF ORGANIC POLLUTANTS USING TITANIUM DIOXIDE MEDIATED PHOTOCATALYTIC OXIDATION显示文摘A simple and effective method of removing polluted organics in water isreported here.Titanium dioxide is a catalyst in photo-oxidation of monocrotophos.Themechanism of photocatalytic oxidation and the kinetics of the reaction were studied.This same principle also leads to the construction of instrument of PTR-FIA analysisfor monitoring organic phosphorus and phosphate in water. | Manping ZHANG Zongfeng XIA Shinan XIE Peipei LI Junbo BAO Juying WANG Daiwen KANG (Department of Marine Chemistry,Ocean University of Qingdao,Qingdao.266003) Yujun WANG Nianhong CHEN Lidong YU (Institute of Oceanography,Academia Sinica,Oingdao,266003) G.K-C LOW (CSIRO Division of Feul Technology,Lucas Heights Research laboratories,PMB 7,M nai,2234 NSW,Australia) | 1990 | Chinese Chemical Letters1990，1，3： | 1 |
| 6 | The determinant of entrepreneurship in China显示文摘 | Junbo Yu and Roger R Stough | 2005 | International Journal of Enterprise Management and Development2005，6，： | 1 |
| 7 | Continuous spinning of a single-walled carbon nanotube-nylon com- posite fiber显示文摘 | Gao Junbo Mikhail E I Yu Aiping | 2005 | Journal of The American Chemical Soci- ety2005，127，11： | 1 |
| 8 | Development of CAPP based on intergrated PDM显示文摘 | MAO Junbo YU Tao FANG Minglun | 1999 | 19 (7): 35 -- 39 (in Chinese)1999，19，7： | 1 |
| 9 | Coenzyme Q10 Inhibits the Aging of Mesenchymal Stem Cells Induced by D-Galactose through Akt/mTOR Signaling显示文摘 | Dayong Zhang Bingxi Yan Shanshan Yu Chong Zhang Baoming Wang Yayan Wang Junbo Wang Zhanggen Yuan Lihuang Zhang Jianping Pan Sidhartha D. Ray | 2015 | Oxidative Medicine and Cellular Longevity2015，，： | 1 |
| 10 | Co‑packaged optics(CPO):status,challenges,and solutions显示文摘Due to the rise of 5G,IoT,AI,and high-performance computing applications,datacenter trafc has grown at a compound annual growth rate of nearly 30%.Furthermore,nearly three-fourths of the datacenter trafc resides within datacenters.The conventional pluggable optics increases at a much slower rate than that of datacenter trafc.The gap between application requirements and the capability of conventional pluggable optics keeps increasing,a trend that is unsustainable.Copackaged optics(CPO)is a disruptive approach to increasing the interconnecting bandwidth density and energy efciency by dramatically shortening the electrical link length through advanced packaging and co-optimization of electronics and photonics.CPO is widely regarded as a promising solution for future datacenter interconnections,and silicon platform is the most promising platform for large-scale integration.Leading international companies(e.g.,Intel,Broadcom and IBM)have heavily investigated in CPO technology,an inter-disciplinary research feld that involves photonic devices,integrated circuits design,packaging,photonic device modeling,electronic-photonic co-simulation,applications,and standardization.This review aims to provide the readers a comprehensive overview of the state-of-the-art progress of CPO in silicon platform,identify the key challenges,and point out the potential solutions,hoping to encourage collaboration between diferent research felds to accelerate the development of CPO technology. | Min Tan Jiang Xu Siyang Liu Junbo Feng Hua Zhang Chaonan Yao Shixi Chen Hangyu Guo Gengshi Han Zhanhao Wen Bao Chen Yu He Xuqiang Zheng Da Ming Yaowen Tu Qiang Fu Nan Qi Dan Li Li Geng Song Wen Fenghe Yang Huimin He Fengman Liu Haiyun Xue Yuhang Wang Ciyuan Qiu Guangcan Mi Yanbo Li Tianhai Chang Mingche Lai Luo Zhang Qinfen Hao Mengyuan Qin | 2023 | Frontiers of Optoelectronics2023，16，1： | 1 |
| 11 | Largescale fabrication of aligned single-walled carbon nanotube array and hierarchical single-walled carbon nanotube assembly显示文摘 | GAO Junbo YU Aiping MIKHAILI E I | | 0，，51： | 1 |
| 12 | Cilostazol improves long-term outcomes after coronary stent implantation显示文摘 | Yaling Han Shouli Wang Yi Li Quanmin Jing Yingyan Ma Jie Deng Guitang Yang Haibo Yu Junbo Ge | 2005 | American Heart Journal2005，，3： | 1 |
| 13 | 结直肠癌中NF-κB表达的研究(英文)显示文摘Objective: The aim of the study was to explore the protein level of NF-κB change in carcinoma and different grades of tumor cells differentiation tissue in colorectal cancer patients. Methods: This was a comparative study between normal and carcinoma tissues and in different grades of tumor cells differentiation tissue in colorectal cancer patients. Ex-pression of NF-κΒ were assessed by immunohistochemical method using rabbit polyclonal antibodies against human p65 NF-κΒ proteins. Results: There was none or very little expression of NF-κB in non-neoplastic colon epithelial cells, while the expression of it's protein was significantly increased (P < 0.01) in adjacent cancerous cells. Moreover, there was a significant increase in the mean expression of NF-κB-p65 between poorly differentiated malignant epithelial cell and well-differentiated cells (P < 0.05). Conclusion: NF-κB-p65 may play an essential role in colorectal carcinogenesis and may be valuable for diagnosis, evaluating malignancy extent and prognosis. | Jin Li Xiaonian Cao Yu Deng Junbo Hu Jing Wang | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，7： | 1 |
| 14 | Urotensin II inhibited the proliferation of cardiac side population cells in mice during pressure overload by JNK ‐ LRP 6 signalling显示文摘 | Zhidan Chen Jiahong Xu Yong Ye Yang Li Hui Gong Guoping Zhang Jian Wu Jianguo jia Ming Liu Ying Chen Chunjie Yang Yu Tang Yichun Zhu Junbo Ge Yunzeng Zou | 2014 | J. Cell. Mol. Med2014，，5： | 1 |
| 15 | Postoperative sequential chemotherapy and radiotherapy for locally advanced gastric cancer显示文摘Objective The aim of the study was to evaluate the role of postoperative sequential chemotherapy and radiotherapy in patients with locally advanced gastric cancer.Methods From January 2003 to December 2010, 146 gastric cancer patients at our institution(Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China) received postoperative sequential chemotherapy and radiotherapy after radical surgery. Radiotherapy was administered as a dose of 4500 cGy in 25 fractions. For patients with positive margins, the dose was raised to 5040 cGy in 28 fractions. Three cycles of m FOLFOX or PF(cisplatin, 5-fluorouracil) chemotherapy regimen were applied before and after radiotherapy. Three-and 5-year survival rates were analyzed; any adverse effects with respect to hematology, hepatic and renal function, or the gastrointestinal tract that occurred during the treatment were evaluated.Results This cohort consisted of non-metastatic patients: 104 men and 42 women with a median age of 51.0 years. The full course of sequential chemotherapy and radiotherapy(4500–5040 cGy) was completed by 129 patients(88.4%). Seventeen regional relapses(9.8%) and 46 distant relapses(23.8%) were recorded. Fifty patients(34.2%) died during follow-up. The 3-and 5-year overall survival rates(OS) were 60% and 54%, and disease-free survival rates(DFS) were 53% and 47%, respectively. There were no significant differences in survival rate with respect to age, sex, histopathology, N stage, site of the tumor, or margin status. Multivariate analysis showed that only the depth of tumor invasion(T stage) was an independent prognostic factor for OS(P = 0.009) and DFS(P = 0.006). The rates of grades 3 and 4 neutropenia and vomiting were 9.6% and 3.4%, respectively, during the treatment.Conclusion Postoperative sequential chemotherapy with an m FOLFOX or PF regimen and radiotherapy were found to be an effective means of treating advanced gastric cancer patients with T3–T4 disease. The adverse effects of this treatment were tolerable. | Qiang Fu Shiying Yu Guoqing Hu Yuan Chen Junbo Hu Lihong Zhang Hong Qiu Xianglin Yuan | 2018 | Oncology and Translational Medicine2018，4，3： | 1 |
| 16 | Ownership, R&D and Productivity Change: Assessing the Catch-up in China' s High-tech Industries显示文摘 | Yu Junbo and Nijkamp P | 2009 | Studies in Regional Science2009，39，1： | 1 |
| 17 | A new generation method for spatial-temporal correlated MIMO Nakagami fading channel显示文摘 | ZHU Qiuming YU Xiangbin WANG Junbo XU Dazhuan CHEN Xiaomin | | 0，，2012： | 1 |
| 18 | Design spherical particles of potassium peroxymonosulfate compound salt with high stability and good powder properties via an agglomeration-dissolution mechanism显示文摘With the outbreak of COVID-19,disinfection protection has become a necessary measure to prevent infection.As a new type of disinfectant,potassium peroxymonosulfate compound salt(PMS)has the advantages of good bactericidal effect,non-toxicity,high safety and stability.However,the current PMS products with irregular particle shapes lead to poor flowability,high hygroscopicity,poor stability of reactive oxygen species(ROS)and serious caking problems.In this work,an agglomeration-dissolution mechanism was designed to prepare spherical PMS particles with large size(>300μm)and high sphericity(up to 90%),effectively addressing the above problems.Shaping(dissolution and abrasion)is the key to improving sphericity,which is mainly controlled by the design of the heating mode,residence time and stirring rate.Compared with the irregular PMS particles,the large spherical particles present better flowability(angle of repose decreased by 35.80%,Carr's index decreased by 64.29%,Hausner's ratio decreased by 19.14%),lower hygroscopicity(decreased by 38.0%),lower caking ratio(decreased by 84.50%),and higher stability(the monthly loss of ROS was reduced by 61.68%).The agglomeration-dissolution mechanism demonstrates the crystallization,agglomeration,dissolution and abrasion process of inorganic salt crystals,providing an opportunity to prepare high-end inorganic crystal materials with high-quality morphologies. | Shanshan Feng Changyou Yu Shilin Guo Jinbo Ouyang Fei Yin Xiaodong Zhang Yongjian Zhang Mingyang Chen Dandan Han Junbo Gong Jingkang Wang | 2023 | Particuology2023，，9： | 0 |
| 19 | γ-H2AX细胞周期相关性的分析(英文)显示文摘Objective:To analyze and discuss cell cycle's correlation of γ-H2AX,so as to accumulate the data for the further studies of γ-H2AX.Methods:MOLT-4 cells,and peripheral blood lymphocytes(PBLs),with or without 48 h stimulation of phytohemagglutinin(PHA),were irradiated by ultraviolet rays(UV rays).Fluorescence-labeled γ-H2AX antibody was used to detect γ-H2AX foci at the DNA double-strand breaks(DSBs) in chromatin,DNA damage was analyzed by flow cytometry,cell cycle and cell apoptosis were detected by sub-G1 peak method,the expression of γ-H2AX was detected by Western blot.Results:With the progression of time,sub-G1 peak emerged apparently in the DNA histograms,and the cells of apoptosis increased gradually;with the progression of time,the increase of γ-H2AX emerged and firstly raised,then decreased;PBLs with 48 h stimulation of PHA entered apparently cell cycle,cells of S and G2/M phase emerged,and PBLs without stimulation of PHA did not enter cell cycle;Western blot showed the increase of the expression of γ-H2AX,and the increase also firstly raised,then decreased.Conclusion:γ-H2AX expressed in the cells of stationary phase and proliferative phase,and with the progression of time,the increase of γ-H2AX firstly raised,and then decreased. | Yangping Yue Zhenchuang Zhu Dongdong Yu Yu Deng Dan Huang Xiaolan Li Wei Xiao Deding Tao Junbo Hu Jianping Gong | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，10： | 0 |
| 20 | Studies of CTLA4Ig in acute rejection of pancreas transplantation in rats显示文摘Objective: To investigate the protective effect of CTLA4Ig in rejection of pancreaticoduodenal transplantation model of rat. Methods: Pancreaticoduodenal transplantion models were established from the donor F344 rats to the Lewis recipients. The models were divided into 2 groups: Group A and B with 12 rats in each group.2 days after transplantation, reciepients in group A were treated with i.p. injection of sailine, and those in group B CTLA4I were injected(200g). On day 1,4,7,10 after transplantation, the grafts were harvested for histopathological examination. On day 4 after transplantation, the CD4+CD25+ T cells in the grafts were detected by Flow Cytometry. Results: Compared with group A: the degree of the rejection of grafts in group B was lower. The number of CD4+CD25+ T cells of graft was (7.91 ± 1.26)% in group A and (13.81 ± 1.71)% in group B, which had significant difference(P < 0.01). Conclusion: CTLA4Ig could inhibit T cell costimulatory pathway, prevent acute rejection, which might be mediated by increasing the number of CD4+CD25+ regulatory T cells. | Junbo Yu Zekuan Xu Shuguang Han Yi Miao | 2006 | Journal of Nanjing Medical University2006，20，5： | 0 |
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