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| 1 | Dengue virus infection:A review of advances in the emerging rapid detection methods显示文摘Dengue virus infections are increasing worldwide generally and in Asia,Central and South America and Africa,particularly.It poses a serious threat to the children population.The rapid and accurate diagnostic systems are essentially required due to lack of effective vaccine against dengue virus and the progressive spread of the dengue virus infection.The recent progress in developing micro-and nano-fabrication techniques has led to low cost and scale down the biomedical point-of-care devices.Starting from the conventional and modern available methods for the diagnosis of dengue infection,this review examines several emerging rapid and point-of-care diagnostic devices that hold significant potential for the progress in smart diagnosis tools.The given review revealed that an effective vaccine is required urgently against all the dengue virus serotypes.However,the rapid detection methods of dengue virus help in early treatment and significantly reduce the dengue virus outbreak. | MUBASHIR HUSSAIN ZEESHAN ALI BIN LIU JIANGUO DAI XIAOLONG LIU JUNCHEN ZHU YONGJUN TANG | 2022 | BIOCELL2022，46，1： | 0 |
| 2 | Themis suppresses the effector function of CD8^(+)T cells in acute viral infection显示文摘CD8^(+)T cells play a central role in antiviral immune responses.Upon infection,naive CD8^(+)T cells differentiate into effector cells to eliminate virus-infected cells,and some of these effector cells further differentiate into memory cells to provide long-term protection after infection is resolved.Although extensively investigated,the underlying mechanisms of CD+T-cell differentiation remain incompletely understood.Themis is a T-cell-specific protein that plays critical roles in T-cell development.Recent studies using Themis T-cell conditional knockout mice also demonstrated that Themis is required to promote mature CD8^(+)T-cell homeostasis,cytokine responsiveness,and antibacterial responses.In this study,we used LCMV Armstrong infection as a probe to explore the role of Themis in viral infection.We found that preexisting CD8^(+)T-cell homeostasis defects and cytokine hyporesponsiveness do not impair viral clearance in Themis T-cell conditional knockout mice.Further analyses showed that in the primary immune response,Themis deficiency promoted the differentiation of CD8^(+)effector cells and increased their TNF and IFNy production.Moreover,Themis deficiency impaired memory precursor cell(MPEC)differentiation but promoted short-lived effector cell(SLEC)differentiation.Themis deficiency also enhanced effector cytokine production in memory CD8^(+)T cells while impairing central memory CD8^(+)T-cell formation.Mechanistically,we found that Themis mediates PD-1 expression and its signaling in effector CD8^(+)T cells,which explains the elevated cytokine production in these cells when Themis is disrupted. | Jian Tang Xian Jia Jian Li Junchen Dong Jiayu Wang Wanyun Li Yuzhen Zhu Yanyan Hu Bowen Hou Chunjie Lin Yu Cong Tong Ren Changsheng Yan Hongying Yang Qian Lai Haiping Zheng Yuzhou Bao Namrata Gautam Hong-Rui Wang Bing Xu Xiao Lei Chen Qing Li Nicholas R.J.Gascoigne Guo Fu | 2023 | Cellular & Molecular Immunology2023，20，5： | 0 |
| 3 | Risk factors of major intraoperative blood loss at primary debulking surgery for ovarian cancer显示文摘Objective:The goal of this study was to find the risk factors for major intraoperative blood loss(MBL)of pr imary debulking surgery(PDS)for ovarian cancer.Methods:Patients wi th ovarian cancer who underwent PDS in our hospital,from 2010 to 2017,were enrolled.The association between risk factors and MBL was modeled with the use of logisde regr ession.Receiver operating characteristic(ROC)curve analysis was used to determine the predictive value of the logi stic regression model.Results:A total of 346 padients met the inclusion criteria.There were 150 patients with MBL.Tumor stage 3/4(P<0.001),American Society of Aneshesiologists(ASA)score 23(P=0.044),ascites volume≥500 ml(P=0.002),radical or ultra radical surgery(P=0.002),and diabetes(P=0.035)were independent risk factors for MBL in patients with ovarian cancer.The logistic regression combined model of these five factors is more reliable in the prediction of MBL with an area under the ROC curve of 0.729 than the tumor stage(ROC curve=0.645)and surgical complexity(ROC curve=0.568).Conclusion:In padients with ovarian cancer,five risk factors for major intraoperative bleeding were identified.Planned surgical procedures and preoperative risk factors can be used to predict perioperative blood requir ements. | Sha Dou Junchen Chen Yuanfen Wang Chongyuan Zhu Heng Cui Yi Li | 2022 | Gynecology and Obstetrics Clinical Medicine2022，2，1： | 0 |
| 4 | Purification and characterization of a salt-tolerant cellulase from the mangrove oyster, Crassostrea rivularis显示文摘有 pH 抵抗和高盐忍耐的宽范围的绗维素酶在红树属植物森林里从牡蛎 Crassostrea rivularis 生活的消化的腺被孤立。作为 CrCel 说出的 27 kDa 绗维素酶被净化由从在非减少的钠 dodecylsufate-polyacrylamide 胶化电气泳动以后的胶化的阴离子交换层析和抽取的 40.6 褶层。净化的绗维素酶的特定的活动是对 carboxymethyl 纤维素 CMC 的 23.4 U/mg。CrCel 的 N 终端氨基酸顺序决心是 NQKCQANSRV。CrCel 最好水解 -1,4-glucosidic 向木聚糖在纤维素材料和显示降级活动的非结晶的部分结合。K m 和 V 为 CMC 的 CrCel 的最大 价值决心是 2.1% 汵瑡潩 ? 景 ? 剄′獵湩 ? 浳污 ? 湩整晲牥湩 ? 乒 ? 楳乒 ? 灡牰慯档 ? 潢桴漠 ? 桴?散汬洠杩慲潴祲愠摮椠癮獡癩?桰湥瑯灹獥眠牥?楳湧晩捩湡汴?瑡整畮瑡摥眠敨?潣灭牡摥眠瑩?桴?潣瑮潲? | Tianchen An Zhu Dong Junchen Lv Yujun Liu Manchuriga Wang ShuangshuangWei Yanting Song Yingxia Zhang Shiming Deng | 2015 | Acta Biochimica et Biophysica Sinica2015，47，4： | 0 |
| 5 | In Situ Analysis of Tobacco Leaves Based on Microwave Plasma Torch Desorption Ionization Mass Spectrometry显示文摘Tobacco is an important economic crop worldwide.Tobacco leaves contain a large number of natural products.Therefore,the analysis of tobacco composition is crucial for the control of tobacco safety and quality assessment.Microwave plasma torch desorption ionization mass spectrometry(MPT-MS) is an emerging ambient mass spectrometry(AMS) technique that can be used for rapid real-time analysis of s amples without pretreatment.Our work focuses on the chemical composition analysis of tobacco using MPT-MS,and 14 compounds were detected in green flue-cured tobacco leaves,while 30 compounds were detected in cured flue-cured tobacco leaves,which confirms that curing can enhance the flavor of cigarettes.Furthermore,we successfully in situ identified characteristic fragment ions of α/β-CBD(α/β-cembranoids),an important aroma compound in tobacco by MPT-MS.The results demonstrate the capability of MPT-MS for in situ analysis of tobacco components and its potential for evaluating tobacco quality. | He Tang Yonggang Zhang Zhiguang Reng Junchen Zhu Yue Xie Xiaobin Zhang Hongru Feng Kailong Yuan Yuanjiang Pan | 2024 | Journal of Analysis and Testing2024，8，1： | 0 |
| 6 | Manipulating micro-electric field and coordination-saturated site configuration boosted activity and safety of frustrated single-atom Cu/O Lewis pair for acetylene hydrochlorination显示文摘Simultaneously boosting acetylene hydrochlorination activity and avoiding formation of explosive copper acetylide over Cu-based catalyst,which represented a promising alternative to Hg-based and noble metal catalysts,remained challenging.Herein,we fabricated a frustrated single-atom Cu/O Lewis pair catalyst(Cu/O-FLP)by coupling epoxide group(C-O-C)with atomdispersed Cu-cis-N_(2)C_(2)Cl center to address this challenge.The basic epoxy site modulated the electron-deficient state of Lewisacidic Cu center and paired with the Cu-cis-N_(2)C_(2)Cl moiety to preferentially break HCl into different electronegative Cu-Clδ-and C-O-H^(δ+)intermediates,which further induced both an extra localized electric field to polarize acetylene and a upshift of the dband center of catalyst,thereby promoting adsorption and enrichment of acetylene by enhancing the dipolar interaction between acetylene and active intermediates.Moreover,the generated Cu-Clδ-and C-O-H^(δ+)drastically reduced the energy barrier of ratelimiting step and made vinyl chloride easier to desorb from the Lewis-basic oxygen-atom site rather than traditional Lewis-acidic Cu center.These superiorities ensured a higher activity of Cu/O-FLP compared with its counterparts.Meanwhile,preferential dissociation of HCl endowed single-atom Cu with the coordination-saturated configuration,which impeded formation of explosive copper acetylide by avoiding the direct interaction between Cu and acetylene,ensuring the intrinsic safety during catalysis. | Junchen Peng Dandan Dong Zongyuan Wang Hong Yang Dongyang Qiao Qinqin Wang Wei Sun Minmin Liu Jiajun Wang Mingyuan Zhu Bin Dai Fei He Chaofeng Huang | 2023 | Nano Research2023，16，7： | 0 |
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