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| 1 | Detection of serum IgM and IgG for COVID-19 diagnosis显示文摘Dear Editor,Infection with the novel coronavirus(SARS-CoV-2,which is the virus responsible for the coronavirus disease 2019(COVID-19))was first reported in Wuhan,China on December 31,2019.The outbreak of COVID-19 remains ongoing and was linked to more than 80,000 infected patients and more than 3,000 deaths in China as of March 7,2020(Holshue et al.,2020). | Ling Zhong Junlan Chuan Bo Gong Ping Shuai Yu Zhou Yi Zhang Zhilin Jiang Dingding Zhang Xiaoqi Liu Shi Ma Yi Huang He Lin Qingwei Wang Lulin Huang Dan Jiang Fang Hao Juan Tang Chunqi Zheng Hua Yu Zhibin Wang Qi Jiang Tao Zeng Mei Luo Fanwei Zeng Fanxin Zeng Jianghai Liu Junxi Tian Yu Xu Tengxiang Long Kaiju Xu Xingxiang Yang Yuping Liu Yi Shi Li Jiang Zhenglin Yang | 2020 | Science China(Life Sciences)2020，63，5： | 8 |
| 2 | An Alternative Time Management Mechanism for Distributed Simulations 显示文摘 | Wentong Cai Stephen J Turner Bu-Sung Lee Junlan Zhou | 2005 | ACM Transactions on Modeling and Computer Simulation (TOMACS) (S1049-3301)2005，15，2： | 1 |
| 3 | Inhibition of aberrant Hif1αactivation delays intervertebral disc degeneration in adult mice显示文摘The intervertebral disc(IVD) is the largest avascular tissue. Hypoxia-inducible factors(HIFs) play essential roles in regulating cellular adaptation in the IVD under physiological conditions. Disc degeneration disease(DDD) is one of the leading causes of disability, and current therapies are ineffective. This study sought to explore the role of HIFs in DDD pathogenesis in mice. The findings of this study showed that among HIF family members, Hif1α was significantly upregulated in cartilaginous endplate(EP) and annulus fibrosus(AF) tissues from human DDD patients and two mouse models of DDD compared with controls. Conditional deletion of the E3 ubiquitin ligase Vhl in EP and AF tissues of adult mice resulted in upregulated Hif1α expression and age-dependent IVD degeneration. Aberrant Hif1α activation enhanced glycolytic metabolism and suppressed mitochondrial function. On the other hand, genetic ablation of the Hif1α gene delayed DDD pathogenesis in Vhl-deficient mice. Administration of 2-methoxyestradiol(2ME2), a selective Hif1α inhibitor, attenuated experimental IVD degeneration in mice. The findings of this study show that aberrant Hif1α activation in EP and AF tissues induces pathological changes in DDD, implying that inhibition of aberrant Hif1α activity is a potential therapeutic strategy for DDD. | Zuqiang Wang Hangang Chen Qiaoyan Tan Junlan Huang Siru Zhou Fengtao Luo Dali Zhang Jing Yang Can Li Bo Chen Xianding Sun Liang Kuang Wanling Jiang Zhenhong Ni Quan Wang Shuai Chen Xiaolan Du Di Chen Chuxia Deng Liangjun Yin Lin Chen Yangli Xie | 2022 | Bone Research2022，10，1： | 1 |
| 4 | B4显示文摘 | Sushant Jain Alok Kumar Subhasree Mandal Joon Ong Leon Poutievski Arjun Singh Subbaiah Venkata Jim Wanderer Junlan Zhou Min Zhu Jon Zolla Urs H?lzle Stephen Stuart Amin Vahdat | 2013 | ACM SIGCOMM Computer Communication Review2013，，： | 1 |
| 5 | China says no towards the second large- scale COVID- 19 outbreak: voices from the online public显示文摘With its fast and wide spread,coronavirus disease 2019(COVID-19)caused by a novel coronavirus broke out suddenly in Wuhan,China at the end of 2019.It posed a grave threat to human life and health,and brought massive challenges to global health.On 30 January 2020,the World Health Organiza-tion(WHO)declared the novel coronavirus constituted a‘public health emergency of international concern’.1 Due to its rapid trans-mission,it drew attention from more than 200 countries and areas worldwide. | Xiaona Zhou Junlan Liu Wei Wang Chunlei Jiang | 2021 | General Psychiatry2021，34，5： | 1 |
| 6 | Thickness effect on microstructural and mechanical properties of pulse-laser treated Ti/Ni multilayer thin films显示文摘Previous work showed that pulse-laser irradiation can strengthen metal multilayer thin films through intermetallic formation and the degree of strengthening is a function of laser pulse energy.In this work,the effect of individual layer thickness(λ)and total multilayer thickness(h)on the resulting microstructure and mechanical strength of laser-treated Ti/Ni multilayers was further investigated.Experiments were carried out on fourλ/hcombinations using individual layer thickness of 20 nm and 50 nm,and total multilayer thickness of 500 nm and1μm,respectively.Obvious intermetallic strengthening was observed in the 500 nm thick multilayers,especially with the 20 nm layer thickness,but not in the 1μm thick multilayers.Further,the multilayer surface morphology after laser treatment was observed to be dominated by competition between laser-induced optical interference and thermal melting,with the former leading to ripple or cross-hatched patterns and the latter leading to melted surfaces with pores and cracks. | Zhou Yang Melicent Stossel Junlan Wang | 2017 | 实验力学2017，32，5： | 0 |
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