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| 1 | IL-10-producing regulatory B cells restrain the T follicular helper cell response in primary Sjögren’s syndrome显示文摘Increased numbers of T follicular helper(Tfh)cells have been implicated in the development of autoimmune diseases including primary Sjögren’s syndrome(pSS),but how the Tfh cell response is regulated during autoimmune pathogenesis remains largely unclear.Here,we first found negative correlations between IL-10^(+)regulatory B(Breg)cell numbers and Tfh cell responses and disease activity in patients with pSS and mice with experimental Sjögren’s syndrome(ESS).Moreover,we detected high expression of IL-10 receptor on Tfh cells and their precursors in both humans and mice.In culture,IL-10 suppressed human and murine Tfh cell differentiation by promoting STAT5 phosphorylation.By using an adoptive transfer approach and two-photon live imaging,we found significantly increased numbers of Tfh cells with enhanced T cell homing into B cell follicles in the draining cervical lymph nodes of RAG-2−/−mice transferred with IL-10-deficient B cells during ESS development compared with those of RAG-2−/−mice transferred with wild-type B cells.In ESS mice,CD19^(+)CD1d^(hi)CD5^(+)Breg cells with decreased IL-10 production exhibited severely impaired suppressive effects on T cell proliferation.Consistently,CD19^(+)CD24^(+)CD38^(hi) Breg cells from pSS patients showed significantly reduced IL-10 production with defective inhibitory function in the suppression of autologous Tfh cell expansion.Furthermore,the adoptive transfer of IL-10-producing Breg cells markedly suppressed the Tfh cell response and ameliorated ESS progression in ESS mice.Together,these findings demonstrate a critical role for IL-10-producing Breg cells in restraining the effector Tfh cell response during pSS development. | Xiang Lin Xiaohui Wang Fan Xiao Kongyang Ma Lixiong Liu Xiaoqi Wang Dong Xu Fei Wang Xiaofei Shi Dongzhou Liu Yan Zhao Liwei Lu | 2019 | Cellular & Molecular Immunology2019，16，12： | 13 |
| 2 | Geochemical characteristics of natural gas from mud volcanoes in the southern Junggar Basin显示文摘A number of mud volcanoes exist in the southern Junggar Basin. To date few systematic studies on natural gas geochemistry of mud volcanoes have been conducted in China. In June 1991 and August 2010, the authors investigated the mud volcanoes in the southern Junggar Basin twice, and the mud volcanism weakened gradually as seen from the variations such as the decrease of gas pressure and output, the downthrow and dry up of the mud pool. The volcanic intensity was significantly weaker than that in Taiwan. The natural gas from the mud volcanoes in the southern Junggar Basin has similar geochemical characteristics, indicating the same source or origin. The main component of the mud volcano gas is alkane gas with contents of 91.15%-97.49%, and the gas is high-quality commercial gas since methane dominates in the alkane. The 13C1 values are 49.1‰--40.6‰, which are in accordance with the peak 13C1 frequency of mud volcano gas around the world, and the alkane gas displays positive carbon isotopic series, i.e., 13C1< 13C2< 13C3, suggesting typical thermogenic origin. The helium in the mud volcano gas is typically crust-derived due to the low R/Ra values of 0.011-0.054. The mud volcano gas is coal-derived since the 13C2 values are all greater than 28‰, and C1/C1-4 and 13C1 values are in accordance with those of natural gas derived from the Lower-Middle Jurassic coal-measures. Therefore, alkane gas from mud volcanoes in the southern Junggar Basin is mainly sourced from the Lower-Middle Jurassic coal-measures. | DAI JinXing WU XiaoQi NI YunYan WANG ZeCheng ZHAO ChangYi WANG ZhaoYun LIU GuiXia | 2012 | Science China Earth Sciences2012，55，3： | 13 |
| 3 | CAS FGOALS-f3-L Model Datasets for CMIP6 Historical Atmospheric Model Intercomparison Project Simulation显示文摘The outputs of the Chinese Academy of Sciences(CAS) Flexible Global Ocean–Atmosphere–Land System(FGOALS-f3-L) model for the baseline experiment of the Atmospheric Model Intercomparison Project simulation in the Diagnostic,Evaluation and Characterization of Klima common experiments of phase 6 of the Coupled Model Intercomparison Project(CMIP6) are described in this paper. The CAS FGOALS-f3-L model, experiment settings, and outputs are all given. In total,there are three ensemble experiments over the period 1979–2014, which are performed with different initial states. The model outputs contain a total of 37 variables and include the required three-hourly mean, six-hourly transient, daily and monthly mean datasets. The baseline performances of the model are validated at different time scales. The preliminary evaluation suggests that the CAS FGOALS-f3-L model can capture the basic patterns of atmospheric circulation and precipitation well, including the propagation of the Madden–Julian Oscillation, activities of tropical cyclones, and the characterization of extreme precipitation. These datasets contribute to the benchmark of current model behaviors for the desired continuity of CMIP. | Bian HE Qing BAO Xiaocong WANG Linjiong ZHOU Xiaofei WU Yimin LIU Guoxiong WU Kangjun CHEN Sicheng HE Wenting HU Jiandong LI Jinxiao LI Guokui NIAN Lei WANG Jing YANG Minghua ZHANG Xiaoqi ZHANG | 2019 | Advances in Atmospheric Sciences2019，36，8： | 12 |
| 4 | Association of COVID-19 Vaccination and Clinical Severity of Patients Infected with Delta or Omicron Variants——China,May 21,2021-February 28,2022显示文摘Summary What is already known about this topic?Compared with the international mRNA and adenovirus-vectored coronavirus disease 2019(COVID-19)vaccines,there is less real-world research data about breakthrough cases in people vaccinated with China-made COVID-19 vaccines.Analyses of clinical outcomes of breakthrough cases will be an important supplement to the clinical trial efficacy and observational effectiveness data of China-made COVID-19 vaccines. | Mingshuang Li Qianqian Liu Dan Wu Lin Tang Xiaoqi Wang Tingting Yan Zhijie An Zundong Yin Geroge F.Gao Fuzhen Wang Hui Zheng | 2022 | China CDC weekly2022，4，14： | 10 |
| 5 | Geochemical Characteristics and Genetic Types of Natural Gas in the Xinchang Gas Field, Sichuan Basin, SW China显示文摘The molecular compositions and stable carbon and hydrogen isotopic compositions of natural gas from the Xinchang gas field in the Sichuan Basin were investigated to determine the genetic types. The natural gas is mainly composed of methane (88.99%–98.01%), and the dryness coefficient varies between 0.908 and 0.997. The gas generally displays positive alkane carbon and hydrogen isotopic series. The geochemical characteristics and gas-source correlation indicate that the gases stored in the 5^(th) member of the Upper Triassic Xujiahe Formation are coal-type gases which are derived from source rocks in the stratum itself. The gases reservoired in the 4^(th) member of the Xujiahe Formation and Jurassic strata in the Xinchang gas field are also coal-type gases that are derived from source rocks in the 3^(rd) and 4^(th) members of the Xujiahe Formation. The gases reservoired in the 2^(nd) member of the Upper Triassic Xujiahe Formation are mainly coal-type gases with small amounts of oil-type gas that is derived from source rocks in the stratum itself. This is accompanied by a small amount of contribution brought by source rocks in the Upper Triassic Ma'antang and Xiaotangzi formations. The gases reservoired in the 4^(th) member of the Middle Triassic Leikoupo Formation are oil-type gases and are believed to be derived from the secondary cracking of oil which is most likely to be generated from the Upper Permian source rocks. | WU Xiaoqi LIU Quanyou LIU Guangxiang WANG Ping LI Huaji MENG Qingqiang CHEN Yingbin ZENG Huasheng | 2017 | Acta Geologica Sinica(English Edition)2017，91，6： | 9 |
| 6 | The scientific connotation of oil and gas formations under deep fluids and organic-inorganic interaction显示文摘As a relatively stable craton block in the earth system, the petroliferous basin is influenced by the evolution of the earth system from the early development environment of source rocks, hydrocarbon formation, and reservoir dissolution to hydrocarbon accumulation or destruction. As a link between the internal and external factors of the basin, deep fluids run through the whole process of hydrocarbon formation and accumulation through organic-inorganic interaction. The nutrients carried by deep fluids promote the bloom of hydrocarbon-generating organisms and extra addition of carbon and hydrogen source, which are beneficial to the development of high-quality source rock and enhancement of the hydrocarbon generation potential. The energy carried by the deep fluid promotes the early maturation of the source rock and facilitates the hydrocarbon generation by activation and hydrogenation in high-mature hydrocarbon sources. The dissolution alteration of carbonate rocks and clastic reservoirs by CO_2-rich deep fluids improves the deep reservoir space, thus extending the oil and gas reservoir space into greater depth. The extraction of deeply retained crude oil by deep supercritical CO_2 and the displacement of CH_4 in shale have both improved the hydrocarbon fluidity in deep and tight reservoirs. Simultaneously, the energy and material carried by deep fluids(C, H, and catalytic substances) not only induce inorganic CH_4 formation by Fischer-Tropsch(F-T) synthesis and 'hydrothermal petroleum' generation from organic matter by thermal activity but also cause the hydrothermal alteration of crude oil from organic sources. Therefore, from the perspective of the interaction of the earth's sphere, deep fluids not only input a significant amount of exogenous C and H into sedimentary basins but also improve the reservoir space for oil and gas, as well as their enrichment and accumulation efficiencies. | Quanyou LIU Dongya ZHU Qingqiang MENG Jiayi LIU Xiaoqi WU Bing ZHOU Qi FU Zhijun JIN | 2019 | Science China Earth Sciences2019，62，3： | 8 |
| 7 | Detection of serum IgM and IgG for COVID-19 diagnosis显示文摘Dear Editor,Infection with the novel coronavirus(SARS-CoV-2,which is the virus responsible for the coronavirus disease 2019(COVID-19))was first reported in Wuhan,China on December 31,2019.The outbreak of COVID-19 remains ongoing and was linked to more than 80,000 infected patients and more than 3,000 deaths in China as of March 7,2020(Holshue et al.,2020). | Ling Zhong Junlan Chuan Bo Gong Ping Shuai Yu Zhou Yi Zhang Zhilin Jiang Dingding Zhang Xiaoqi Liu Shi Ma Yi Huang He Lin Qingwei Wang Lulin Huang Dan Jiang Fang Hao Juan Tang Chunqi Zheng Hua Yu Zhibin Wang Qi Jiang Tao Zeng Mei Luo Fanwei Zeng Fanxin Zeng Jianghai Liu Junxi Tian Yu Xu Tengxiang Long Kaiju Xu Xingxiang Yang Yuping Liu Yi Shi Li Jiang Zhenglin Yang | 2020 | Science China(Life Sciences)2020，63，5： | 8 |
| 8 | Centrosomal protein FOR20 is essential for S-phase progression by recruiting Plkl to centrosomes显示文摘中心体主要被安排微导管动力学并且便于 G1/S 和 G2/M 转变为有效房间周期前进要求。然而,在 S 阶段前进的中心体的角色大部分是未知的。这里,我们报导 FOR20 (20 kDa 的蠢人相关的蛋白质) 的那弄空,保存 centrosomal 蛋白质,禁止 S 阶段前进并且阻止 Plk1 指向(像马球的 kinase 1 ) 到中心体,在 FOR20 与 Plk1 交往的地方。Plk1 的脱离显著地也导致 S 阶段缺点,它被没能本地化到中心体的 Plk1,甚至 kinase 死了的异种,然而并非异种的宫外的表示颠倒。拴住中心体的 Plk1 的外长的表示,然而并非野类型的 Plk1,撤销 FOR20 导致弄空的 S 阶段独立于它的 kinase 活动背叛。因此,这些数据显示到由 FOR20 的中心体的 Plk1 的招募可以充当一个信号准许 S 阶段的有效前进。这代表一迄今在房间周期规定的中心体的 uncharacterized 角色。 | Minhong Shen Yuqi Cai YuehongYang Xiaoyi Yan Xiaoqi Liu Tianhua Zhou | 2013 | Cell Research2013，23，11： | 6 |
| 9 | Effects of redox potential on soil cadmium solubility:Insight into microbial community显示文摘Understanding the role of microbes in the solubility of cadmium(Cd) is of fundamental importance for remediation of Cd toxicity. The present study aimed to identify the microbes that involved in regulating Cd solubility and to reveal possible mechanisms. Therefore,microbial communities were investigated through high-throughput sequencing approach, the molecular ecological network was constructed and metagenomes were predicted. Our results indicated that redox conditions affected both the solubility of soil Cd and the microbial communities. Anaerobic microbes, such as Anaerolineaceae, did not only play important roles in shaping the microbial community in soils, but might also be involved in regulating the Cd solubility. Two possible mechanisms that how Anaerolineaceae involved in Cd solubility are(1) Anaerolineaceae are important organic matter degraders under anoxic conditions and(2) Anaerolineaceae can co-exist with methane metabolism microbes, while methane metabolism promotes the precipitation of soluble Cd. Thus, application of Anaerolineaceae in bioremediation of soil Cadmium contamination is a potential approach. The study provided a novel insight into the role of microbial community in the regulation of Cd solubility under different redox conditions, and suggested a potential approach for the remediation of soil Cd contamination. | Delong Meng Juan Li Tianbo Liu Yongjun Liu Mingli Yan Jin Hu Xiaoqi Li Xueduan Liu Yili Liang Hongwei Liu Huaqun Yin | 2019 | Journal of Environmental Sciences2019，31，1： | 6 |
| 10 | Effects of blocking Le^Y oligosaccharide on cell surface to MMPs secreted by blastocysts and epithelial cells in mouse in vitro显示文摘In order to understand the role of Le+Y oligosaccharide antigen (Le+Y) during implantation, the relationship of Le+Y on the cell surface with matrix metalloproteinase (MMPs) secreted by blastocysts and monolayer epithelial cells during implantation in the mouse %in vitro% was studied by monoclonal antibody (mAb) AH-6, directed to Le+Y[Fuc α1-2 Gal β1-4 (Fuc α1-3) GlcNAc-], and gelatin zymography. The results showed that MMPs secretion was reduced after Le+Y on the cell surface of either epithelial cells or trophoblasts was blocked. It indicated that MMPs expression which played an important function during the process of implantation were regulated by Le+Y. Therefore, it was considered that Le+Y could regulate embryos invasion by some mechanism. | Xiaoqi Wang Yu Liu Enkui Duan Guoqing Zeng Zhengmei Zhu | 1998 | Chinese Science Bulletin1998，43，17： | 6 |
| 11 | Source apportionment of PM2.5 in Tangshan, China --Hybrid approaches for primary and secondary species apportionment显示文摘这篇论文的目的是在 Tangshan 的城市里为下午 2.5 的主要、第二等的种类的来源分配建议一条混合途径。基于受体的 PMF (积极矩阵因式分解) 与排放库存(EI ) 是综合的为主要种类的来源分配形成第一个混合方法。途径当时是的混合 CAMx-PSAT-CP (有扩展微粒来源分配技术化学药品侧面的全面空气质量模型) 求婚了并且为第二等的种类的来源分配使用了。为 Tangshan 识别的下午 2.5 来源包括了土壤灰尘,冶金工业,发电厂, coalfired 锅炉,车辆,水泥生产,和其它采购原料。PM 2.5 污染是一个地区性的问题,这被显示。在所有识别来源之中,冶金学工业是到开火煤的锅炉,车辆和土壤灰尘跟随的下午 2.5, 的最大的贡献来源。其它来源范畴特别地为第二等的种类的形成为下午 2.5, 起一个关键作用并且喷雾器,和这些另外的来源包括象农业活动那样的非指定的来源,生物资源燃烧,居住排出物,等等。来源分配结果能帮助本地当局做健全政策和规定更好保护公民免受本地人和地区性的下午 2.5 污染的伤害。学习也加亮在下午 2.5 来源的鉴定利用建议混合途径的力量。在这研究使用的技术为进一步的申请显示出可观的诺言到另外的区域以及到识别下午 2.5 的另外的来源范畴。 | Wei WEN Shuiyuan CHENG Lei LIU Gang WANG Xiaoqi WANG | 2016 | Frontiers of Environmental Science & Engineering2016，10，5： | 6 |
| 12 | Proteasome inhibition suppresses Th17 cell generation and ameliorates autoimmune development in experimental Sjögren’s syndrome显示文摘Immunoproteasome activation in immune cells is involved in the modulation of immune responses.Increasing evidence indicates that proteasome inhibitors show beneficial effects in treating autoimmune diseases,but it remains unclear whether proteasome inhibition is an effective approach for suppressing autoimmune development in Sjögren’s syndrome(SS).Our previous work has demonstrated a critical role for Th17 cells in the development of experimental SS(ESS)in mice.In this study,we detected high levels of low-molecular-weight protein 7(LMP7),a key subunit of the immunoproteasome,in Th17 cells from ESS mice.Moreover,treatment with bortezomib(BTZ),a proteasome inhibitor,markedly suppressed Th17 differentiation in both murine and human naive T cells in culture.Furthermore,ESS mice treated with BTZ displayed significantly higher saliva flow rates and a reduction in tissue destruction in the salivary glands compared with vehicle-treated ESS mice.Notably,BTZ-treated ESS mice showed markedly decreased Th17 cells,germinal center B cells and plasma cells in the peripheral lymphoid organs.In addition,adoptively transferred wild type naive CD4+T cells rapidly differentiated into Th17 cells and induced salivary dysfunction in IL-17-deficient mice immunized for ESS induction.However,BTZ treatment profoundly suppressed the donor T-cell-derived Th17 response and ameliorated the reduction in salivary secretion in IL-17-deficient recipient mice.Taken together,our findings demonstrate that proteasome inhibition can effectively ameliorate ESS by suppressing the Th17 response,which may contribute to the development of a novel therapeutic strategy for the treatment of SS. | Fan Xiao Xiang Lin Jie Tian Xiaohui Wang Qian Chen Ke Rui Jie Ma Shengjun Wang Qingwen Wang Xiaoqi Wang Dongzhou Liu Lingyun Sun Liwei Lu | 2017 | Cellular & Molecular Immunology2017，14，11： | 6 |
| 13 | Controlled growth and photoconductive properties of hexagonal SnS2 nanoflakes with mesa-shaped atomic steps显示文摘We demonstrated the controlled growth of two-dimensional (2D) hexagonal tin disulfide (SnS2) nanoflakes with stacked monolayer atomic steps. The morphology was similar to flat-topped and step-sided mesa plateaus or step pyramids. The SnS2 nanoflakes were grown on mica substrates via an atmospheric-pressure chemical vapor deposition process using tin monosulfide and sulfur powder as precursors. Atomic force microscopy (AFM), electron microscopy, and Raman characterizations were performed to investigate the structural features, and a sequential layer-wise epitaxial growth mechanism was revealed. In addition, systematic Raman characterizations were performed on individual SnS2 nanoflakes with a wide range of thicknesses (1-100 nm), indicating that the A1g peak intensity and Raman shifts were closely related to the thickness of the SnS2 nanoflakes. Moreover, photoconductive AFM was performed on the monolayer-stepped SnS2 nanoflakes, revealing that the flat surface and the edges of the SnS2 atomic steps had different electrical conductive properties and photoconductive behaviors. This is ascribed to the dangling bonds and defects at the atomic step edges, which caused a height difference of the Schottky barriers formed at the interfaces between the PtIr-coated AFM tip and the step edges or the flat surface of the SnS2 nanoflakes. The 2D SnS2 crystals with regular monolayer atomic steps and fast photoresponsivity are promising for novel applications in photodetectors and integrated optoelectronic circuits. | Yi Hu Tao Chen Xiaoqi Wang Lianbo Ma Renpeng Chen Hongfei Zhu Xin Yuan Changzeng Yan Guoyin Zhu Hongling Lv Jia Liang Zhong Jin Jie Liu | 2017 | Nano Research2017，10，4： | 5 |
| 14 | NIR-triggered thermo-responsive biodegradable hydrogel with combination of photothermal and thermodynamic therapy for hypoxic tumor显示文摘Hypoxia is a typical feature of solid tumors,which highly limits the application of the oxygen-dependent therapy.Also,the dense and hyperbaric tumor tissues impede the penetration of nanoparticles into the deep tumor.Thereby,we designed a novel localized injectable hydrogel combining the photothermal therapy(PTT)and the thermodynamic therapy(TDT),which is based on the generation of free radicals even in the absence of oxygen for hypoxic tumor therapy.In our study,gold nanorods(Au NRs)and 2,2-Azobis[2-(2-imidazalin-2-yl)propane]dihydrochlaride(AIPH)were incorporated into the hydrogel networks,which were formed by the copolymerization of hydrophobic N-isopropyl acrylamide(NIPAM)and hydrophilic glycidyl methacrylate modified hyaluronic acid(HAGMA)to fabricate an injectable and near-infrared(NIR)responsive hydrogel.The crosslinked in situ forming hydrogel could not only realize PTT upon the NIR laser irradiation,but also generate free radicals even in hypoxic condition.Meanwhile the shrink of hydrogels upon thermal could accelerate the generation of free radicals to further damage the tumors,achieving the controlled drug release on demand.The designed hydrogel with a sufficient loading capacity,excellent biocompatibility and negligible systemic toxicity could serve as a long-acting implant for NIR-triggered thermo-responsive free radical generation.The in vitro cytotoxicity result and the in vivo antitumor activity illustrated the excellent therapeutic effect of hydrogels even in the absence of oxygen.Therefore,this innovative oxygen-independent platform combining the antitumor effects of PTT and TDT would bring a new insight into hypoxic tumor therapy by the application of alkyl free radical. | Xiaoqi Sun Di Liu Xiaoyu Xu Yifeng Shen Yanjuan Huang Zishan Zeng Meng Xia Chunshun Zhao | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，6： | 5 |
| 15 | A static resistance model and the discontinuous pattern of hydrocarbon accumulation in tight oil reservoirs显示文摘In exploration for tight oil, the content and saturation of hydrocarbon in the tight reservoir is a key factor for evaluating the reserve. Therefore, it is necessary to study the geological history of hydrocarbon accumulation and the tight oil charging process. However, kinetic models used for petroleum development are not applicable for petroleum exploration. In this study, a static resistance model is proposed after analyzing resistances in ultra-slow flow in porous media. Using this model, the discontinuous pattern of oil charging is reproduced through incompressible Navier-Stokes equations, the phase field method and the finite element method. This study also explains macroscopic percolation behavior with microscopic flow mechanisms and discusses some issues in ultra-slow flow in a micro/nano pore-throat network. The resistance analysis reveals that capillary resistance and dissipation resistance are dominant factors in the mechanism of oil accumulation in tight reservoirs. Numerical simulations show that pressure thresholds exist and result in discontinuous oil charging. Generally, it is proven that the static model is more applicable than kinetic models in describing oil accumulation in tight reservoirs. | Sun Liang Zou Caineng Liu Xiaoli Zhu Rukai Wang Xiaoqi | 2014 | Petroleum Science2014，11，4： | 5 |
| 16 | Evolution Toward Artificial Intelligence of Things Under 6G Ubiquitous⁃X显示文摘With the evolution of cellular networks,6G is a promising technology to provide ubiquity of communications,computing,control,and consciousness(UC4)for“human⁃machine⁃thing⁃genie”and build a ubiquitous intelligent mobile society.Genie,which can act as the artificial intelligence assistance for 6G users,is the key enabler to realize the unprecedented transformation from mobile Internet to network of intelligence.While Internet of Things(IoT)is the digital nervous system,genie acts like the brain of the overall system.Supported by 6G,IoT will step into the Artificial Intelligence of Things(AIoT)era and the AIoT networks have the abilities of intelligent perception,intelligent analysis,and intelligent control.In this paper,the concept of Ubiquitous⁃X is introduced,which is considered as the fundamental architecture of 6G network,and the definition and architecture of AIoT under Ubiquitous⁃X is also presented.Several major technical challenges posed by the service requirements of novel AIoT applications are pinpointed,including massive and intelligent connectivity,efficient computing,security,privacy,authentication,high scalability and efficiency.Potential enabling technologies to support seamless service experiences across terminals to realize AIoT are introduced as well. | Ping Zhang Xiaodong Xu Xiaoqi Qin Yiming Liu Nan Ma Shujun Han | 2020 | Journal of Harbin Institute of Technology(New Series)2020，27，3： | 4 |
| 17 | Dynamic blood single-cell immune responses in patients with COVID-19显示文摘The 2019 coronavirus disease(COVID-19)outbreak caused by the SARS-CoV-2 virus is an ongoing global health emergency.However,the virus'pathogenesis remains unclear,and there is no cure for the disease.We investigated the dynamic changes of blood immune response in patients with COVID-19 at different stages by using 5'gene expression,T cell receptor(TCR),and B cell receptors(BCR)V(D)J transcriptome analysis at a single-cell resolution.We obtained single-cell mRNA sequencing(scRNA-seq)data of 341,420 peripheral blood mononuclear cells(PBMCs)and 185,430 donotypic T cells and 28,802 donotypic B cells from 25 samples of 16 patients with COVID-19 for dynamic studies.In addition,we used three control samples.We found expansion of dendritic cells(DCs),CD14+monocytes,and megakaryocytes progenitor cells(MP)/platelets and a reduction of naive CD4+T lymphocytes in patients with COVID-19,along with a significant decrease of CD8+T lymphocytes,and natural killer cells(NKs)in patients in critical condition.The type I interferon(IFN-I),mitogen-activated protein kinase(MAPK),and ferroptosis pathways were activated while the disease was active,and recovered gradually after patient conditions improved.Consistent with this finding,the mRNA level of IFN-I signal-induced gene IFI27 was significantly increased in patients with COVID-19 compared with that of the controls in a validation cohort that included 38 patients and 35 controls.The concentration of interferon-a(IFN-a)in the serum of patients with COVID-19 increased significantly compared with that of the controls in an additional cohort of 215 patients with COVID-19 and 106 controls,further suggesting the important role of the IFN-I pathway in the immune response of COVID-19.TCR and BCR sequences analyses indicated that patients with COVID-19 developed specific immune responses against SARS-CoV-2 antigens.Our study reveals a dynamic landscape of human blood immune responses to SARS-CoV-2 infection,providing clues for therapeutic potentials in treating COVID-19. | Lulin Huang Yi Shi Bo Gong Li Jiang Zhixin Zhang Xiaoqi Liu Jialiang Yang Yongquan He Zhilin Jiang Ling Zhong Juan Tang Chunfang You Qi Jiang Bo Long Tao Zeng Mei Luo Fanwei Zeng Fanxin Zeng Shuqiang Wang Xingxiang Yang Zhenglin Yang | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 4 |
| 18 | Near-infrared light-activated cancer cell targeting and drug delivery with aptamer-modified nanostructures显示文摘为肿瘤的高度精确的治疗的激活刺激的指向的交货系统在最近的年里收到了可观的注意。此处,我们揭示使用一个互补 DNA 序列到 hybridize 和结合到象金 nanorods 或围单人赛的碳 nanotubes (SWNT ) 那样的 photothermal 代理人上的面具 sgc8 aptamers 的光能被活化的指向癌症的策略。在暴露到之上在红外线附近(NIR ) 激光,局部性的 photothermal 在双 stranded DNA 的 dehybridization 加热那些 nano 代理人结果的表面并且 aptamer 顺序放允许指向的特定的癌症房间。作为一个模型系统利用装载 doxorubicin 的 SWNT,到 NIR 光激活的癌症房间的指向的药交货被完成。这个工作与有约束力的可控制的癌症房间表明 NIR 能被活化的指向肿瘤的交货系统的概念潜在地启用高度特定、有效的癌症治疗。 | Yu Yang Jingjing Liu Xiaoqi Sun Liangzhu Feng Wenwen Zhu Zhuang Liu Meiwan Chen | 2016 | Nano Research2016，0，1： | 4 |
| 19 | CAS FGOALS-f3-L Model Datasets for CMIP6 GMMIP Tier-1 and Tier-3 Experiments显示文摘The Chinese Academy of Sciences(CAS)Flexible Global Ocean Atmosphere Land System(FGOALS-f3-L)model datasets prepared for the sixth phase of the Coupled Model Intercomparison Project(CMIP6)Global Monsoons Model Intercomparison Project(GMMIP)Tier-1 and Tier-3 experiments are introduced in this paper,and the model descriptions,experimental design and model outputs are demonstrated.There are three simulations in Tier-1,with different initial states,and five simulations in Tier-3,with different topographies or surface thermal status.Specifically,Tier-3 contains four orographic perturbation experiments that remove the Tibetan Iranian Plateau,East African and Arabian Peninsula highlands,Sierra Madre,and Andes,and one thermal perturbation experiment that removes the surface sensible heating over the Tibetan Iranian Plateau and surrounding regions at altitudes above 500 m.These datasets will contribute to CMIP6’s value as a benchmark to evaluate the importance of long-term and short-term trends of the sea surface temperature in monsoon circulations and precipitation,and to a better understanding of the orographic impact on the global monsoon system over highlands. | Bian HE Yimin LIU Guoxiong WU Qing BAO Tianjun ZHOU Xiaofei WU Lei WANG Jiandong LI Xiaocong WANG Jinxiao LI Wenting HU Xiaoqi ZHANG Chen SHENG and Yiqiong TANG | 2020 | Advances in Atmospheric Sciences2020，37，1： | 4 |
| 20 | Epigenetic regulation of phosphodiesterase 4d in restrictive cardiomyopathy mice with cTnI mutations显示文摘Epigenetic regulations play an important role in disease development.In this study,we have investigated epigenetic regulations in restrictive cardiomyopathy mice with cTnI 193 His mutation.Our results demonstrated that phosphodiesterase(PDEs)4d was down-regulated in the heart of these mice.Further studies showed that the epigenetic modifications were associated with enhanced acetylation of histone 3 lysine 4 and lysines 9,whereas tri-methylation of histone 3 lysine 4,were decreased in histones near the PDE4d gene promoter regions.The binding levels of histone transmethylase SMYD1 and histone deacetylase HDAC1 were increased in the gene promoter regions in cTnI193 His transgenic hearts.Using immune-fluorescent labeling we found an evidence of cTnI existence in the nucleus of cardiomyocytes and Western blotting further confirmed that both wild type and mutated cTnI could be detected in the cell nucleus of the hearts.Furthermore,an interaction between cTnI and SMYD1,or cTnI and HDAC1 was observed.Overexpression of the mutated cTnI in cultured cardiomyocytes reduced the expression of PDE4d.Our data suggest that the decrease of PDE4d expression in RCM mice caused by cTnI mutations may be related to epigenetic regulation,i.e.,histone acetylation and methylation,and cTnI might be involved in this procedure via an interaction with HDAC1 and SMAD1 in the hearts. | Weian Zhao Xiaoqi Wu Zhiyuan Wang Bo Pan Lifei Liu Lingjuan Liu Xupei Huang Jie Tian | 2020 | Science China(Life Sciences)2020，63，4： | 4 |
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