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| 1 | Multifunctional core/satellite polydopamine@Nd^3+- sensitized upconversion nanocomposite: A single 808 nm near-infrared light-triggered theranostic platform for in vivo imaging-guided photothermal therapy显示文摘重要变细并且过热,在水里由刺激乐队(980 nm ) 的吸收引起了,是主要障碍在在里面做 lanthanide 的 upconversion nanoparticles (UCNP ) 的 vivo 申请。因此,有 808 nm 刺激的适当地组织的 Nd 3+-doped UCNP 能是一种有希望的选择。此处,我们开发了 core-shell-shell 作为成像代理人组织了 Nd 3+-sensitized UCNP,并且装饰了他们到 polydopamine (PDA ) 的表面上构造新奇多功能的核心 / 卫星 nanotheranostic (PDA@UCNPs ) 为在 vivo 成像指导 photothermal 治疗使用单身者 808 nm 激光照耀。core-shell-shell 组织了设计启用的突出的 upconversion 光性质和强壮的 X 光检查变细,从而为优秀 upconversion luminescence/computed 断层摄影术使 nanocomposites 成为潜在的候选人双形式的成像。另外, PDA 核心不仅提供高 photothermal 变换效率和突出的 antitumor 效果,而且由于它的自然特征赋予站台以柔韧的 biocompatibility。因此,这多功能的 nanocomposite 能是在未来 oncotherapy 的有希望的 theranostic,与高治疗学的有效性但是低副作用。这研究将刺激在设计 bio-application-compatible 使多功能的 nanocomposites 感兴趣,特别为在 vivo 的癌症诊断和治疗。 | Xing Ding Jianhua Liu Dapeng Liu Junqi Li Fan Wang Leijiao Li Yinghui Wang Shuyan Song Hongjie Zhang | 2017 | Nano Research2017，10，10： | 16 |
| 2 | Type I IFN augments IL-27-dependent TRIM25 expression to inhibit HBV replication显示文摘Hepatitis B virus(HBV)can cause chronic hepatitis B,which may lead to cirrhosis and liver cancer.Type I interferon(IFN)is an approved drug for the treatment of chronic hepatitis B.However,the fundamental mechanisms of antiviral action by type I IFN and the downstream signaling pathway are unclear.TRIM25 is an IFN-stimulated gene(ISG)that has an important role in RIG-I ubiquitination and activation.Whether TRIM25 is induced in liver cells by type I IFN to mediate anti-HBV function remains unclear.Here we report that interleukin-27(IL-27)has a critical role in IFN-induced TRIM25 upregulation.TRIM25 induction requires both STAT1 and STAT3.In TRIM25 knockout HepG2 cells,type I IFN production was consistently attenuated and HBV replication was increased,whereas overexpression of TRIM25 in HepG2 cells resulted in elevated IFN production and reduced HBV replication.More interestingly,we found that TRIM25 expression was downregulated in HBV patients and the addition of serum samples from HBV patients could inhibit TRIM25 expression in HepG2 cells,suggesting that HBV might have involved a mechanism to inhibit antiviral ISG expression and induce IFN resistance.Collectively,our results demonstrate that type I IFN-induced TRIM25 is an important factor in inhibiting HBV replication,and the IFN-IL-27-TRIM25 axis may represent a new target for treating HBV infection. | Guangyun Tan Qingfei Xiao Hongxiao Song Feng Ma Fengchao Xu Di Peng Na Li Xiaosong Wang Junqi Niu Pujun Gao F Xiao-Feng Qin Genhong Cheng | 2018 | Cellular & Molecular Immunology2018，15，3： | 13 |
| 3 | Hepatitis C virus core protein triggers expansion and activation of CD4+CD25+ regulatory T cells in chronic hepatitis C patients显示文摘 | Naicui Zhai Xiumei Chi Tianyang Li Hongxiao Song Haijun Li Xia Jin Ian Nicholas Crispe Lishan Su Junqi Niu Zhengkun Tu | 2015 | Cellular & Molecular Immunology2015，12，6： | 10 |
| 4 | Microbial electro-fermentation for synthesis of chemicals and biofuels driven by bi-directional extracellular electron transfer显示文摘Electroactive bacteria could perform bi-directional extracellular electron transfer(EET)to exchange electrons and energy with extracellular environments,thus playing a central role in microbial electro-fermentation(EF)process.Unbalanced fermentation and microbial electrosynthesis are the main pathways to produce value-added chemicals and biofuels.However,the low efficiency of the bi-directional EET is a dominating bottleneck in these processes.In this review,we firstly demonstrate the main bi-directional EET mechanisms during EF,including the direct EET and the shuttle-mediated EET.Then,we review representative milestones and progresses in unbalanced fermentation via anode outward EET and microbial electrosynthesis via inward EET based on these two EET mechanisms in detail.Furthermore,we summarize the main synthetic biology strategies in improving the bi-directional EET and target products synthesis,thus to enhance the efficiencies in unbalanced fermentation and microbial electrosynthesis.Lastly,a perspective on the applications of microbial electro-fermentation is provided. | Ziying Gong Huan Yu Junqi Zhang Feng Li Hao Song | 2020 | Synthetic and Systems Biotechnology2020，5，4： | 4 |
| 5 | Solid ion transition route to 3D S-N-codoped hollow carbon nanosphere/graphene aerogel as a metal-free handheld nanocatalyst for organic reactions显示文摘新奇没有金属的体积 nanocatalyst, S-N-codoped 空碳 nanosphere/graphene aerogel (SNC-GA-1000 ) ,成功地用一条灵巧、干净的稳固的离子转变线路被制作了。在这个方法, ZnS 被用作难模板和 S 来源,当 polydopamine 充当一个减少的代理人和碳来源时。在高退火温度, Zn 金属被减少并且蒸发,离开仅仅自由的 S 蒸汽扩散进碳层。有趣地,同样获得的 SNC-GA-1000 比卸掉的赤裸的 S-N-codoped 碳 nanospheres 在器官的减小反应展出许多更高催化的活动。与 ZnS@polydopamine 核心壳 nanospheres (ZnS@PDA ) 装载的 graphene 氧化物表的热水的减小负担得起三维的体积 graphene aerogel。尽管 nanosized 催化剂展出高催化的活动,他们的随后的分离不总是是令人满意的,成为处理以后困难。这条途径完成在活动和可分性之间的一宗交易。更重要地,由于 3D,结构的自然,如此的体积和手持 nanocatalysts 能容易被分开并且再循环。 | Jing Pan Shuyan Song Junqi Li Fan Wang Xin Ge Shuang Yao Xiao Wang Hongjie Zhang | 2017 | Nano Research2017，10，10： | 3 |
| 6 | Systematic Full-Cycle Engineering Microbial Biofilms to Boost Electricity Production in Shewanella oneidensis显示文摘Electroactive biofilm plays a crucial rule in the electron transfer efficiency of microbial electrochemical systems(MES).However,the low ability to form biofilm and the low conductivity of the formed biofilm substantially limit the extracellular electron transfer rate of microbial cells to the electrode surfaces in MES. | Feng Li Rui Tang Baocai Zhang Chunxiao Qiao Huan Yu Qijing Liu Junqi Zhang Liang Shi Hao Song | 2023 | Research2023，，2： | 2 |
| 7 | Nitrate increases cisplatin chemosensitivity of oral squamous cell carcinoma via REDD1/AKT signaling pathway显示文摘Although cisplatin is one of the chemotherapeutics most frequently used in oral squamous cell carcinoma(OSCC)treatment,it exerts multiple side effects and poor chemosensitivity.Nitrate reportedly demonstrates several beneficial biological functions,and synthesized nitrates enhance the therapeutic efficacy of chemotherapy.However,the role of inorganic nitrate in cisplatin chemotherapy remains unclear.We therefore investigated the effect of inorganic nitrate exerted on cisplatin sensitivity in OSCC.We found that nitrate did not affect OSCC cell growth and apoptosis in OSCC cells and OSCC xenograft tumor animal studies.Cisplatin induced REDD1 expression and AKT activation in OSCC.However,nitrate could increase cisplatin chemosensitivity,reduce its REDD1 expression,and attenuate AKT signaling activation in OSCC cells.Dysregulation of high levels of REDD1,which could enhance AKT activation,was positively associated with poor prognosis in OSCC patients.Thus,reduced REDD1 expression and retarded AKT activation induced by inorganic nitrate might be a new potential approach to the sensitization of oral cancer to cisplatin treatment in the future. | Yuanyong Feng Xuedi Cao Bin Zhao Chunyan Song Baoxing Pang Liang Hu Chunmei Zhang Jinsong Wang Junqi He Songlin Wang | 2021 | Science China(Life Sciences)2021，64，11： | 2 |
| 8 | PBS3 Protects EDS1 from Proteasome-Mediated Degradation in Plant Immunity显示文摘Plant immunity is controlled by both positive regulators such as PBS3 and EDS1 and negative regulators such as NPR3 and NPR4.However,the relationships among these important immune regulators remain elusive.In this study,we found that PBS3 interacts with EDS1 in both the cytoplasm and the nucleus,and is required for EDS1 protein accumulation?NPR3 and NPR4,which function as salicylic acid receptors and adaptors of Cullin3-based E3 ligase,interact with and mediate the degradation of EDS1 via the 26S proteasome.We further discovered that PBS3 inhibits the polyubiquitination and subsequent degradation of EDS1 by reducing the association of EDS1 with the Cullin3 adaptors NPR3 and NPR4.Furthermore,we showed that PBS3 and EDS1 also contribute to PAMP-triggered immunity in addition to effector-triggered immunity.Collectively,our study reveals a novel mechanism by which plants fine-tune defense resporises by inhibiting the degradation of a positive player in plant immunity. | Ming Chang Jinping Zhao Huan Chen Guangyong Li Jian Chen Min Li Ian A.Palmer Junqi Song James R.Alfano Fengquan Liu Zheng Qing Fu | 2019 | Molecular Plant2019，12，5： | 2 |
| 9 | Effective phase separation of biomass pyrolysis oils by adding aqueous salt solutions 显示文摘 | SONG Qinhua NIE Junqi REN Mingguang | 2009 | Energy&Fuels2009，，23： | 1 |
| 10 | Coordinated regulation of plant immunity by poly(ADP-ribosyl)ation and K63-linked ubiquitination显示文摘Poly(ADP-ribosyl)ation(PARylation)is a posttranslational modification reversibly catalyzed by poly(ADP-ribose)polymerases(PARPs)and poly(ADP-ribose)glycohydrolases(PARGs)and plays a key role in multi-ple cellular processes.The molecular mechanisms by which PARylation regulates innate immunity remain largely unknown in eukaryotes.Here we show that Arabidopsis UBC13A and UBC13B,the major drivers of lysine 63(K63)-linked polyubiquitination,directly interact with PARPs/PARGs.Activation of pathogen-associated molecular pattern(PAMP)-triggered immunity promotes these interactions and enhances PARylation of UBC13.Both parp1 parp2 and ubc13a ubc13b mutants are compromised in immune responses with increased accumulation of total pathogenesis-related(PR)proteins but decreased accu-mulation of secreted PR proteins.Protein disulfide-isomerases(PDIs),essential components of endo-plasmic reticulum quality control(ERQC)that ensure proper folding and maturation of proteins destined for secretion,complex with PARPs/PARGs and are PARylated upon PAMP perception.Significantly,PARylation of UBC13 regulates K63-linked ubiquitination of PDIs,which may further promote their disulfide isomerase activities for correct protein folding and subsequent secretion.Taken together,these results indicate that plant immunity is coordinately regulated by PARylation and K63-linked ubiquitination. | Dongsheng Yao Marcus A.Arguez Ping He Andrew F.Bent Junqi Song | 2021 | Molecular Plant2021，14，12： | 1 |
| 11 | Engineering Shewanella carassii, a newly isolated exoelectrogen from activated sludge, to enhance methyl orange degradation and bioelectricity harvest显示文摘Electroactive microorganisms(EAMs)play important roles in biogeochemical redox processes and have been of great interest in the fields of energy recovery,waste treatment,and environmental remediation.However,the currently identified EAMs are difficult to be widely used in complex and diverse environments,due to the existence of poor electron transfer capability,weak environmental adaptability,and difficulty with engineering modifications,etc.Therefore,rapid and efficient screening of high performance EAMs from environments is an effective strategy to facilitate applications of microbial fuel cells(MFCs).In this study,to achieve efficient degradation of methyl orange(MO)by MFC and electricity harvest,a more efficient exoelectrogen Shewanella carassii-D5 that belongs to Shewanella spp.was first isolated from activated sludge by WO_(3) nanocluster probe technique.Physiological properties experiments confirmed that S.carassii-D5 is a Gram-negative strain with rounded colonies and smooth,slightly reddish surface,which could survive in media containing lactate at 30℃.Moreover,we found that S.carassii-D5 exhibited remarkable MO degradation ability,which could degrade 66%of MO within 72 h,1.7 times higher than that of Shewanella oneidensis MR-1.Electrochemical measurements showed that MFCs inoculated with S.carassii-D5 could generate a maximum power density of 704.6 mW/m^(2),which was 5.6 times higher than that of S.oneidensis MR-1.Further investigation of the extracellular electron transfer(EET)mechanism found that S.carassii-D5 strain had high level of c-type cytochromes and strong biofilm formation ability compared with S.oneidensis MR-1,thus facilitating direct EET.Therefore,to enhance indirect electron transfer and MO degradation capacity,a synthetic gene cluster ribADEHC encoding riboflavin synthesis pathway from Bacillus subtilis was heterologously expressed in S.carassii-D5,increasing riboflavin yield from 1.9 to 9.0 mg/g DCW with 1286.3 mW/m^(2) power density output in lactate fed-MFCs.Furthermore,results showed that the high EET rate endowed a faster degradation efficient of MO from 66%to 86%with a maximum power density of 192.3 mW/m^(2),which was 1.3 and 1.6 times higher than that of S.carassii-D5,respectively.Our research suggests that screening and engineering high-efficient EAMs from sludge is a feasible strategy in treating organic pollutants. | Chi Yang Junqi Zhang Baocai Zhang Dingyuan Liu Jichao Jia Feng Li Hao Song | 2022 | Synthetic and Systems Biotechnology2022，7，3： | 1 |
| 12 | O-Methy- lation of the Phenolic Bio-Oil with Dimethyl Carbonate in an Ionic Liquid Cl显示文摘 | Nie Junqi Chen Hongwei Song Qinhua | 2010 | Energy Fuels2010，24，10： | 1 |
| 13 | DNA repair pro- teins are directly involved in regulation of gene expression dur- ing plant immune response 显示文摘 | Song Junqi Durrant W E Wang Shui | 2011 | Cell Host & Microbe2011，9，2： | 1 |
| 14 | NLR immune receptor RB is differentially targeted by two homologous but functionally distinct effector proteins显示文摘Plant nucleotide-binding leucine-rich repeat(NLR)receptors mediate immune responses by directly or indirectly sensing pathogen-derived effectors.Despite significant advances in the understanding of NLR-mediated immunity,the mechanisms by which pathogens evolve to suppress NLR activation triggered by cognate effectors and gain virulence remain largely unknown.The agronomically important immune receptor RB recognizes the ubiquitous and highly conserved IPI-O RXLR family members(e.g.,IPI-O1)from Phytophthora infestans,and this process is suppressed by the rarely present and homologous effector IPIO4.Here,we report that self-association of RB via the coiled-coil(CC)domain is required for RB activation and is differentially affected by avirulence and virulence effectors.IPI-O1 moderately reduces the self-association of RB CC,potentially leading to changes in the conformation and equilibrium of RB,whereas IPIO4 dramatically impairs CC self-association to prevent RB activation.We also found that IPI-O1 associates with itself,whereas IPI-O4 does not.Notably,IPI-O4 interacts with IPI-O1 and disrupts its self-association,therefore probably blocking its avirulence function.Furthermore,IPI-O4 enhances the interaction between RB CC and IPI-O1,possibly sequestering RB and IPI-O1 and subsequently blocking their interactions with signaling components.Taken together,these findings considerably extend our understanding of the underlying mechanisms by which emerging virulent pathogens suppress the NLR-mediated recognition of cognate effectors. | Jinping Zhao Junqi Song | 2021 | Plant Communications2021，2，6： | 1 |
| 15 | The combination stretching function technique with simulated annealing algorithm for global optimization显示文摘 | He Junqi Dai Huiya Song Xueli | 2014 | Optimization Methods and Software2014，29，3： | 1 |
| 16 | Conductive proteins-based extracellular electron transfer of electroactive microorganisms显示文摘Electroactive microorganisms(EAMs)could utilize extracellular electron transfer(EET)pathways to exchange electrons and energy with their external surroundings.Conductive cytochrome proteins and nanowires play crucial roles in controlling electron transfer rate from cytosol to extracellular electrode.Many previous studies elucidated how the c-type cytochrome proteins and conductive nanowires are synthesized,assembled,and engineered to manipulate the EET rate,and quantified the kinetic processes of electron generation and EET.Here,we firstly overview the electron transfer pathways of EAMs and quantify the kinetic parameters that dictating intracellular electron production and EET.Secondly,we systematically review the structure,conductivity mechanisms,and engineering strategies to manipulate conductive cytochromes and nanowire in EAMs.Lastly,we outlook potential directions for future research in cytochromes and conductive nanowires for enhanced electron transfer.This article reviews the quantitative kinetics of intracellular electron production and EET,and the contribution of engineered c-type cytochromes and conductive nanowire in enhancing the EET rate,which lay the foundation for enhancing electron transfer capacity of EAMs. | Junqi Zhang Zixuan You Dingyuan Liu Rui Tang Chao Zhao Yingxiu Cao Feng Li Hao Song | 2023 | Quantitative Biology2023，11，4： | 0 |
| 17 | MAVS-loaded unanchored Lys63-linked polyubiquitin chains activate the RIG-I-MAVS signaling cascade显示文摘The adaptor molecule MAVS forms prion-like aggregates to govern the RIG-I-like receptor(RLR)signaling cascade.Lys63(K63)-linked polyubiquitination is critical for MAVS aggregation,yet the underlying mechanism and the corresponding E3 ligases and deubiquitinating enzymes(DUBs)remain elusive.Here,we found that the K63-linked polyubiquitin chains loaded on MAVS can be directly recognized by RIG-I to initiate RIG-I-mediated MAVS aggregation with the prerequisite of the CARDRIG-I-CARDMAVS interaction.Interestingly,many K63-linked polyubiquitin chains attach to MAVS via an unanchored linkage.We identified Ube2N as a major ubiquitin-conjugating enzyme for MAVS and revealed that Ube2N cooperates with the E3 ligase Riplet and TRIM31 to promote the unanchored K63-linked polyubiquitination of MAVS.In addition,we identified USP10 as a direct DUB that removes unanchored K63-linked polyubiquitin chains from MAVS.Consistently,USP10 attenuates RIG-I-mediated MAVS aggregation and the production of type I interferon.Mice with a deficiency in USP10 show more potent resistance to RNA virus infection.Our work proposes a previously unknown mechanism for the activation of the RLR signaling cascade triggered by MAVS-attached unanchored K63-linked polyubiquitin chains and establishes the DUB USP10 and the E2:E3 pair Ube2N-Riplet/TRIM31 as a specific regulatory system for the unanchored K63-linked ubiquitination and aggregation of MAVS upon viral infection. | Feng Liu Wanxin Zhuang Bin Song Yuan Yang Junqi Liu Yi Zheng Bingyu Liu Jie Zheng Wei Zhao Chengjiang Gao | 2023 | Cellular & Molecular Immunology2023，20，10： | 0 |
| 18 | Postoperative Radiotherapy and N2 Non-small Cell Lung Cancer Prognosis: A Retrospective Study Based on Surveillance, Epidemiology, and End Results Database显示文摘The purpose of this study is to clarify the significance of postoperative radiotherapy for N2 lung cancer.This study aimed to investigate the effect of postoperative radiotherapy on the survival and prognosis of patients with N2 lung cancer.Data from 12,000 patients with N2 lung cancer were extracted from the Surveillance,Epidemiology,and End Results database(2004-2012).Age at disease onset and 5-year survival rates were calculated.Survival curves were plotted using the Kaplan-Meier method.The univariate log-rank test was performed.Multivariate Cox regression were used to examine factors affecting survival.Patients’median age was 67 years(mean 66.46±10.03).The 5-year survival rate was 12.55%.Univariate analysis revealed age,sex,pathology,and treatment regimen as factors affecting prognosis.In multivariate analysis,when compared to postoperative chemotherapy,postoperative chemoradiotherapy was better associated with survival benefits(hazard ratio[HR]=0.85,95%confidence interval[CI]:0.813-0.898,P<0.001).Propensity score matching revealed that patients who had received postoperative chemoradiotherapy had a better prognosis than did patients who had received postoperative chemotherapy(HR=0.869,95%CI:0.817-0.925,P<0.001).Female patients and patients aged<65 years had a better prognosis than did their counterparts.Patients with adenocarcinoma had a better prognosis than did patients with squamous cell carcinoma.Moreover,prognosis worsened with increasing disease T stage.Patients who had received postoperative chemoradiotherapy had a better prognosis than did patients who had received postoperative chemotherapy.Postoperative radiotherapy was an independent prognostic factor in this patient group. | Yunbo Zhang Liping Zheng Junqi Liu Jinqiu Li Jianguang Zhang Jingjing Ma Yuxiu Song | 2021 | Journal of Oncology Research2021，3，2： | 0 |
| 19 | Expert consensus on irrigation and intracanal medication in root canal therapy显示文摘Chemical cleaning and disinfection are crucial steps for eliminating infection in root canal treatment. However, irrigant selection or irrigation procedures are far from clear. The vapor lock effect in the apical region has yet to be solved, impeding irrigation efficacy and resulting in residual infections and compromised treatment outcomes. | Xiaoying Zou Xin Zheng Yuhong Liang Chengfei Zhang Bing Fan Jingping Liang Junqi Ling Zhuan Bian Qing Yu Benxiang Hou Zhi Chen Xi Wei Lihong Qiu Wenxia Chen Wenxi He Xin Xu Liuyan Meng Chen Zhang Liming Chen Shuli Deng Yayan Lei Xiaoli Xie Xiaoyan Wang Jinhua Yu Jin Zhao Song Shen Xuedong Zhou Lin Yue | 2024 | International Journal of Oral Science2024，16，1： | 0 |
| 20 | BS_(0.5)BNT-based relaxor ferroelectric ceramic/glass-ceramic composites for energy storage显示文摘Relaxor ferroelectric ceramics have very high dielectric constant(e)but relatively low electrical breakdown strength(Eb),while glass-ceramics exhibit higher E,due to the more uniformly dispersed amorphous phases and submicrocrystals/nanocrystals inside.How to effectively combine the advantages of both relaxor ferroelectric ceramics and glass-ceramics is of great significance for the development of new dielectric materials with high energy storage performance.In this work,we firstly prepared BaO-SrO-Bi_(2)O_(3)-Na_(2)0-TiO_(2)-Al_(2)O_(3)-SiO_(2)(abbreviated as GS)glass powders,and then fabricated(Ba_(0.3)Sr_(0.7))_(0.5)(Bi_(0.5)Na_(0.5))_(0.5)TiO_(3)+x wt%GS ceramic composites(abbreviated as BSo.sBNT-xGS,x=0,2,6,10,14,16,and 18).Submicrocrystals/nanocrystals with a similar composition to BSo.sBNT were crystalized from the glass,ensuring the formation of uniform core-shell structure in BSo.sBNT-xGS relaxor ferroelectric ceramic/glass-ceramic composites.When the addition amount of GS was 14 wt%,the composite possessed both high&r(>3200 at 1 kHz)and high E,(~170 kV/cm)at room temperature,and their recoverable energy storage density and efficiency were Wrec=2.1 J/cm’and n=65.2%,respectively.The BSo.sBNT-14GS composite also had several attractive properties such as good temperature,frequency,cycle stability,and fast charge-discharge speed.This work provides insights into the relaxor ceramic/glass-ceramic composites for pulsed power capacitors and sheds light on the utilization of the hybrid systems. | Xuhai Shi Kai Li Zong-Yang Shen Junqi Liu Chaoqun Chen Xiaojun Zeng Bo Zhang Fusheng Song Wenqin Luo Zhumei Wang Yueming Li | 2023 | Journal of Advanced Ceramics2023，12，4： | 0 |
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