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| 1 | Dynamic Field Division of Hydrocarbon Migration,Accumulation and Hydrocarbon Enrichment Rules in Sedimentary Basins显示文摘Hydrocarbon distribution rules in the deep and shallow parts of sedimentary basins are considerably different, particularly in the following four aspects. First, the critical porosity for hydrocarbon migration is much lower in the deep parts of basins: at a depth of 7000 m, hydrocarbons can accumulate only in rocks with porosity less than 5%. However, in the shallow parts of basins (i.e., depths of around 1000 m), hydrocarbon can accumulate in rocks only when porosity is over 20%. Second, hydrocarbon reservoirs tend to exhibit negative pressures after hydrocarbon accumulation at depth, with a pressure coefficient less than 0.7. However, hydrocarbon reservoirs at shallow depths tend to exhibit high pressure after hydrocarbon accumulation. Third, deep reservoirs tend to exhibit characteristics of oil (-gas)-water inversion, indicating that the oil (gas) accumulated under the water. However, the oil (gas) tends to accumulate over water in shallow reservoirs. Fourth, continuous unconventional tight hydrocarbon reservoirs are distributed widely in deep reservoirs, where the buoyancy force is not the primary dynamic force and the caprock is not involved during the process of hydrocarbon accumulation. Conversely, the majority of hydrocarbons in shallow regions accumulate in traps with complex structures. The results of this study indicate that two dynamic boundary conditions are primarily responsible for the above phenomena: a lower limit to the buoyancy force and the lower limit of hydrocarbon accumulation overall, corresponding to about 10%-12% porosity and irreducible water saturation of 100%, respectively. These two dynamic boundary conditions were used to divide sedimentary basins into three different dynamic fields of hydrocarbon accumulation: the free fluid dynamic field, limit fluid dynamic field, and restrain fluid dynamic field. The free fluid dynamic field is located between the surface and the lower limit of the buoyancy force, such that hydrocarbons in this field migrate and accumulate under the influence of, for example, the buoyancy force, pressure, hydrodynamic force, and capillary force. The hydrocarbon reservoirs formed are characterized as 'four high,' indicating that they accumulate in high structures, are sealed in high locations, migrate into areas of high porosity, and are stored in reservoirs at high pressure. The basic features of distribution and accumulation in this case include hydrocarbon migration as a result of the buoyancy force and formation of a reservoir by a caprock. The limit fluid dynamic field is located between the lower limit of the buoyancy force and the lower limit of hydrocarbon accumulation overall; the hydrocarbon migrates and accumulates as a result of, for example, the molecular expansion force and the capillary force. The hydrocarbon reservoirs formed are characterized as 'four low,' indicating that hydrocarbons accumulate in low structures, migrate into areas of low porosity, and accumulate in reservoirs with low pressure, and that oil(-gas)-water inversion occurs at low locations. Continuous hydrocarbon accumulation over a large area is a basic feature of this field. The restrain fluid dynamic field is located under the bottom of hydrocarbon accumulation, such that the entire pore space is filled with water. Hydrocarbons migrate as a result of the molecular diffusion force only. This field lacks many of the basic conditions required for formation of hydrocarbon reservoirs: there is no effective porosity, movable fluid, or hydrocarbon accumulation, and potential for hydrocarbon exploration is low. Many conventional hydrocarbon resources have been discovered and exploited in the free fluid dynamic field of shallow reservoirs, where exploration potential was previously considered to be low. Continuous unconventional tight hydrocarbon resources have been discovered in the limit fluid dynamic field of deep reservoirs; the exploration potential of this setting is thought to be tremendous, indicating that future exploration should be focused primarily in this direction. | PANG Xiongqi LIU Keyu MA Zhongzhen JIANG Zhenxue XIANG Caifu HUO Zhipeng PANG Hong CHEN Junqing | 2012 | Acta Geologica Sinica(English Edition)2012，86，6： | 13 |
| 2 | A unified model for the formation and distribution of both conventional and unconventional hydrocarbon reservoirs显示文摘The discovery and large-scale exploration of unconventional oil/gas resources since 1980s have been considered as the most important advancement in the history of petroleum geology;that has not only changed the balance of supply and demand in the global energy market,but also improved our understanding of the formation mechanisms and distribution characteristics of oil/gas reservoirs.However,what is the difference of conventional and unconventional resources and why they always related to each other in petroliferous basins is not clear.As the differences and correlations between unconventional and conventional resources are complex challenging issues and very critical for resources assessment and hydrocarbon exploration,this paper focused on studying the relationship of formations and distributions among different oil/gas reservoirs.Drilling results of 12,237 exploratory wells in 6 representative petroliferous basins of China and distribution characteristics for 52,926 oil/gas accumulations over the world were applied to clarify the formation conditions and genetic relations of different oil/gas reservoirs in a petroliferous basin,and then to establish a unified model to address the differences and correlations of conventional and unconventional reservoirs.In this model,conventional reservoirs formed in free hydrocarbon dynamic field with high porosity and permeability located above the boundary of hydrocarbon buoyancy-driven accumulation depth limit.Unconventional tight reservoirs formed in confined hydrocarbon dynamic field with low porosity and permeability located between hydrocarbon buoyancy-driven accumulation depth limit and hydrocarbon accumulation depth limit.Shale oil/gas reservoirs formed in the bound hydrocarbon dynamic field with low porosity and ultra-low permeability within the source rock layers.More than 75%of proved reserves around the world are discovered in the free hydrocarbon dynamic field,which is estimated to contain only 10%of originally generated hydrocarbons.Most of undiscovered resources distributed in the confined hydrocarbon dynamic field and the bound hydrocarbon dynamic field,which contains 90%of original generated hydrocarbons,implying a reasonable and promising area for future hydrocarbon explorations.The buried depths of hydrocarbon dynamic fields become shallow with the increase of heat flow,and the remaining oil/gas resources mainly exist in the deep area of“cold basin”with low geothermal gradient.Lithology changing in the hydrocarbon dynamic field causes local anomalies in the oil/gas dynamic mechanism,leading to the local formation of unconventional hydrocarbon reservoirs in the free hydrocarbon dynamic field or the occurrence of oil/gas enrichment sweet points with high porosity and permeability in the confined hydrocarbon dynamic field.The tectonic movements destroy the medium conditions and oil/gas components,which leads to the transformation of conventional oil/gas reservoirs formed in free hydrocarbon dynamic field to unconventional ones or unconventional ones formed in confined and bound hydrocarbon dynamic fields to conventional ones. | Xiongqi Pang Chengzao Jia Junqing Chen Maowen Li Wenyang Wang Qinhong Hu Yingchun Guo Zhangxin Chen Junwen Peng Keyu Liu Keliu Wu | 2021 | Geoscience Frontiers2021，12，2： | 8 |
| 3 | Research and development of drug delivery systems based on drug transporter and nano-formulation显示文摘In recent years,the continuous occurrence of multi-drug resistance in the clinic has made people pay more attention to the transporter.Changes in the expression and activity of transporters can cause corresponding changes in drug pharmacokinetics and pharmacodynamics.The drug-drug interactions(DDI)caused by transporters can seriously affect drug effectiveness and toxicity.In the development of pharmaceutical preparations,people have increasingly concerned about the effects and regulation of transporters in drug effects.To improve the targeting and physicochemical properties of drugs,the development of targeted agents is very rapid.Among them,novel nano-formulations are the best.With the continuous innovation and development of nano-formulation,its application has become more and more extensive.Nano-formulation has exerted certain advantages in the drug development based on transporters,and is also involved in the combination of targeted transporters.This review focuses on the application of novel nano-agents targeting transporters and the introduction of drug-transporter-based nano-formulations. | Yi Peng Lu Chen Sheng Ye Yu Kang Junqing Liu Su Zeng Lushan Yu | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，2： | 8 |
| 4 | Design and field tests of a deck-extension bridge with small box girder显示文摘A jointless bridge could fundamentally eliminate vulnerable deck joints, thereby meeting the need for sustainable development of bridges, especially for an expressway with highspeed traffic. In this paper, one jointless bridge(deck-extension bridge) with a small box girder in an expressway was chosen as a case study to examine the structural design,construction and field test. The field tests of the bridge indicated that the designed and constructed structures can satisfy the requirement for service performance of the deckextension bridge. Some key technologies, such as the position of longitudinal reinforcements in the superstructure-approach slab connections and the arrangement of the sliding material layers, were introduced. The longitudinal thermal movement of the superstructure in the deck-extension bridge with a small box girder could be predicted accurately by using the average temperature of the cross section of a small box girder. The finite element model, built by using the MIDAS program, was used to analyze the temperature distribution on the cross section of a small box girder, the accuracy of which could be verified by comparing with the measured values. The maximum longitudinal thermal movement of the superstructure in deck-extension bridges with a small box girder under historically extreme temperature conditions was predicted. | Junqing Xue Bruno Briseghella Jianhui Lin Fuyun Huang Baochun Chen | 2018 | Journal of Traffic and Transportation Engineering(English Edition)2018，5，6： | 7 |
| 5 | Comparison of the Surface and Underground Natural Gas Occurrences in the Tazhong Uplift of the Tarim Basin显示文摘体积由探索的井的生产率揭示了的油,气体和水不反映实际地下的状况。在地质的条件下面,溶解天然气的某个数量在油或水被存储。在 Tazhong 基于探索的井的生产测试数据 Tarim 盆高举,这篇论文详细在在表面和地下的天然气之间的出现和分发 featrues 讨论差别;在不同温度,压力和中等条件下面根据天然气的可溶性介绍表面气体出现的恢复给实际地下的地质的条件;并且分类天然气进三个状态,即 oversaturated,浸透并且 undersaturated,根据它的相对内容地下。通过在表面和天然气的地下的出现的差别的比较分析,它讨论烃水库形成机制和分发规则,从而在学习区域为潜在的天然气水库分发的预言作为新方法和技术提供指导。 | TIAN Jun CHEN Junqing JIAO Jiao PANG Xiongqi | 2010 | Acta Geologica Sinica(English Edition)2010，84，5： | 6 |
| 6 | Climate background of the evolution from Paleolithic to Neolithic cultural transition during the last deglaciation in the middle reaches of the Yellow River显示文摘Shizitan in Jixian County, Shanxi Province, is a site of transitional period from Paleolithic to Neolithic. The dating and the sporopollen analysis show that the middle reaches of the Yellow River where the site is located had been maintaining a steppe environment during 35.1-9.4 kaBP, in which, 35.1-17 kaBP belonged to the last glacial. With cold and dry climate, this period featured a desert steppe environment. In the late of this period, the area had a cold and half-humid steppe environment. The 17.0-11.9 kaBP belonged to the early- and mid-period of the last deglaciation. Mild and half-arid steppe alternates with mild and half-arid steppe, with a small amount of deciduous broadleaf species. During the period of 11.9-10.5 kaBP, cold and dry glacial climate appeared once more, featuring a desert steppe environment. During 10.5-9.4 kaBP, it is mild and half-arid, and later transited toward warm and half-humid. The early phase of this period featured a steppe environment and the later transited into a | Zhengkai Xia Ge Chen Gongwang Zheng Fuyou Chen Junqing Han | 2002 | Chinese Science Bulletin2002，47，1： | 6 |
| 7 | In vitro testicular organogenesis from human fetal gonads produces fertilization-competent spermatids显示文摘Unlike most organs that mature during the fetal period,the male reproductive system reaches maturity only at puberty with the commencement of spermatogenesis.Robust modelling of human testicular organogenesis in vitro would facilitate research into mechanisms of and factors affecting human spermatogenic failure and male fertility preservation in prepubertal tumor patients.Here,we report successful recapitulation of human testicular organogenesis in vitro from fetal gonadal ridge.Our model displayed the formation of mature seminiferous epithelium and self-renewing spermatogonia.Remarkably,in vitro-derived haploid spermatids have undergone meiotic recombination,and showed increased genetic diversity as indicated by genetic analysis.Moreover,these spermatids were able to fertilize oocytes and support subsequent blastocyst formation.The in vitro testicular organogenesis system described here will play an important role in elucidating the regulation of human testis development and maintaining male fertility in prepubertal cancer patients. | Yan Yuan Laihua Li Qing Cheng Feiyang Diao Qiao Zeng Xiaoyu Yang Yibo Wu Hao Zhang Mingqian Huang Junqing Chen Quan Zhou Yunfei Zhu Rong Hua Jianyu Tian Xin Wang Zuomin Zhou Jie Hao Jinjin Yu Dong Hua Jiayin Liu Xuejiang Guo Qi Zhou Jiahao Sha | 2020 | Cell Research2020，30，3： | 6 |
| 8 | Effect of calycosin on left ventricular ejection fraction and angiogenesis in rat models with myocardial infarction显示文摘OBJECTIVE:To evaluated the effect of calycosin on left ventricular ejection fraction and angiogenesis.METHODS:Adult male Sprague-Dawley rats were randomly assigned into calycosin-treated groups(0.5,1,2,and 4 mg/kg qd),a dimethyl sulfoxide(DMSO),or a sham-operated control group.The myocardial ischaemia(Ml) model was intraperitoneally administered calycosin for 28 days.The survival rates and left ventricular ejection fractions(LVEF)were compared between groups.The expression levels of vascular endothelial growth factor(VEGF)and cluster of differentiation 31(CD31) in ischaemic myocardium were also measured and compared.RESULTS:The construction of MI model resulted in a LVEF reduction of 50% compared with the sham-control.After 28 days,the LVEF value was 10% higher when calycosin(4 mg/kg) was administered compared with the DMSO group.The expression of VEGF and CD31 showed a dose-dependent manner when calycosin was administrated.The calycosin-treated(4 mg/kg) group displayed a twofold increase in VEGF expression at both the mRNA and protein levels compared with the DMSO group.In addition,CD31 expression in the microvascular increased 1.5-fold in the 4 mg/kg calycosin-treated group.CONCLUSION:Calycosin improved left ventricular ejection fraction in the MI rat models,induced VEGF expression in the ischaemic myocardium,increased CD31 expression and promoted angiogenesis. | Gao Junqing Chen Tao Jin Huigen Liu Zongjun Zhao Deqiang | 2015 | Journal of Traditional Chinese Medicine2015，35，2： | 6 |
| 9 | Metal-organic frameworks nanoswitch:Toward photo-controllable endo/lysosomal rupture and release for enhanced cancer RNA interference显示文摘Endo/lysosomal escape and gene release are two critical bottlenecks in gene delivery.Herein,a novel photo-controllable metal-organic frameworks(MOFs)nanoswitch is rationally designed for enhancing small interfering RNA(siRNA)delivery.One single laser triggers the“off-to-on”switching of MOFs nanocomplexes,inducing significant siRNA release accompanied by rapid MOFs dissociation into protonatable 2-methylimidazalo and osmotic rupturing Zn2+ions,which cooperatively contribute to remarkable endo/lysosomal rupture(∼90%).The simultaneous endo/lysosomal rupture and release enable a high spatio-temporal control on RNA interference for effective cancer therapy.Notably,the“off-to-on”switching also activates fluorescence recovery for real-time monitoring siRNA delivery.The nanoswitch could easily be extended to deliver other therapeutic agents(e.g.,DNA,protein,anticancer drug)for overcoming endo/lysosomal entrapment. | Gan Lin Yang Zhang Long Zhang Junqing Wang Ye Tian Wen Cai Shangui Tang Chengchao Chu JiaJing Zhou Peng Mi Xiaoyuan Chen Gang Liu | 2020 | Nano Research2020，13，1： | 5 |
| 10 | Key factors controlling hydrocarbon accumulations in Ordovician carbonate reservoirs in the Tazhong area, Tarim basin, western China显示文摘 | Hong Pang Junqing Chen Xiongqi Pang Luofu Liu Keyu Liu Caifu Xiang | 2013 | Marine and Petroleum Geology2013，，： | 4 |
| 11 | Quick Evaluation of Present-Day Low-Total Organic Carbon Carbonate Source Rocks from Rock-Eval Data: Middle–Upper Ordovician in the Tabei Uplift, Tarim Basin显示文摘Previous studies have postulated the contribution of present-day low-total organic carbon(TOC) marine carbonate source rocks to oil accumulations in the Tabei Uplift, Tarim Basin, China. However, not all present-day low-TOC carbonates have generated and expelled hydrocarbons; therefore, to distinguish the source rocks that have already expelled sufficient hydrocarbons from those not expelled hydrocarbons, is crucial in source rock evaluation and resource assessment in the Tabei Uplift. Mass balance can be used to identify modern low-TOC carbonates resulting from hydrocarbon expulsion. However, the process is quite complicated, requiring many parameters and coefficients and thus also a massive data source. In this paper, we provide a quick and cost effective method for identifying carbonate source rock with present-day low TOC, using widely available Rock-Eval data. First, we identify present-day low-TOC carbonate source rocks in typical wells according to the mass balance approach. Second, we build an optimal model to evaluate source rocks from the analysis of the rocks' characteristics and their influencing factors, reported as positive or negative values of a dimensionless index of Rock-Eval data(IR). Positive IR corresponds to those samples which have expelled hydrocarbons. The optimal model optimizes complicated calculations and simulation processes; thus it could be widely applicable and competitive in the evaluation of present-day low TOC carbonates. By applying the model to the Rock-Eval dataset of the Tabei Uplift, we identify present-day low-TOC carbonate source rocks and primarily evaluate the contribution equivalent of 11.87×10~9 t oil. | CHEN Junqing PANG Xiongqi YANG Haljun PANG Hong PANG Bo | 2018 | Acta Geologica Sinica(English Edition)2018，92，4： | 4 |
| 12 | Distributed Flow Shop Scheduling with Sequence-Dependent Setup Times Using an Improved Iterated Greedy Algorithm显示文摘To meet the multi-cooperation production demand of enterprises,the distributed permutation flow shop scheduling problem(DPFSP)has become the frontier research in the field of manufacturing systems.In this paper,we investigate the DPFSP by minimizing a makespan criterion under the constraint of sequence-dependent setup times.To solve DPFSPs,significant developments of some metaheuristic algorithms are necessary.In this context,a simple and effective improved iterated greedy(NIG)algorithm is proposed to minimize makespan in DPFSPs.According to the features of DPFSPs,a two-stage local search based on single job swapping and job block swapping within the key factory is designed in the proposed algorithm.We compare the proposed algorithm with state-of-the-art algorithms,including the iterative greedy algorithm(2019),iterative greedy proposed by Ruiz and Pan(2019),discrete differential evolution algorithm(2018),discrete artificial bee colony(2018),and artificial chemical reaction optimization(2017).Simulation results show that NIG outperforms the compared algorithms. | Xue Han Yuyan Han Qingda Chen Junqing Li Hongyan Sang Yiping Liu Quanke Pan Yusuke Nojima | 2021 | Complex System Modeling and Simulation2021，1，3： | 4 |
| 13 | A fault warning for inter-turn short circuit of excitation winding of synchronous generator based on GRU-CNN显示文摘Synchronous generators are important components of power systems and are necessary to maintain its normal and stable operation.To perform the fault diagnosis of mild inter-turn short circuit in the excitation winding of a synchronous generator,a gate recurrent unit-convolutional neural network(GRU-CNN)model whose structural parameters were determined by improved particle swarm optimization(IPSO)is proposed.The outputs of the model are the excitation current and reactive power.The total offset distance,which is the fusion of the offset distance of the excitation current and offset distance of the reactive power,was selected as the fault judgment criterion.The fusion weights of the excitation current and reactive power were determined using the anti-entropy weighting method.The fault-warning threshold and fault-warning ratio were set according to the normal total offset distance,and the fault warning time was set according to the actual situation.The fault-warning time and fault-warning ratio were used to avoid misdiagnosis.The proposed method was verified experimentally. | Junqing Li Jing Liu Yating Chen | 2022 | Global Energy Interconnection2022，5，2： | 3 |
| 14 | Effective synthesis to control the growth of polyaniline nanofibers by interfacial polymerization显示文摘 | Ruiqi Li Zheng Chen Junqing Li Chunhong Zhang Qing Guo | 2013 | Synthetic Metals2013，，： | 3 |
| 15 | Surface disorder engineering in ZnCdS for cocatalyst free visible light driven hydrogen production显示文摘Metal chalcogenide solid solution,especially ZnCdS,has been intensively investigated in photocatalytic H_(2) generation due to their cost-effective synthetic procedure and adjustable band structures.In this work,we report on the defect engineering of ZnCdS with surface disorder layer by simple room temperature Li-ethylenediamine(Li-EDA)treatment.Experimental results confirm the formation of unusual Zn and S dual vacancies,where rich S vacancies(Vs)served as electron trapping sites,meanwhile Zn vacancies(Vzn)served as hole trapping sites.The refined structure significantly facilitates the photo charge carrier transfer and improves photocatalytic properties of ZnCdS.The disordered ZnCdS shows a highest photocatalytic H_(2) production rate of 33.6 mmol·g^(-1)·h^(-1) under visible light with superior photocatalytic stabilities,which is 7.3 times higher than pristine ZnCdS and 7 times of Pt(1 wt.%)loaded ZnCdS. | Enna Ha Shuhong Ruan Danyang Li Yuanmin Zhu Yanping Chen Jiangyuan Qiu Zhaohui Chen Tingting Xu Jingyun Su Luyang Wang Junqing Hu | 2022 | Nano Research2022，15，2： | 3 |
| 16 | Rational Operation for Primary Gastric Carcinoma with Liver Metastasis显示文摘OBJECTIVE To investigate the prognosis of advanced gastric carcinoma patients with liver metastasis,and provide a foundation for rational opera- tions. METHODS The operations and prognosis of 102 primary gastric carci- noma patients with liver metastasis were studied retrospectively. RESULTS In gastric carcinoma patients with H1 metastasis who under- went a resection operation,the 6-month,1-and 2-year post-operative sur- vival rates were 61%,42%and 7%.There was a statistically significant dif- ference in survival between resected and non-resected patients(P=0.000) In gastric carcinoma cases with H2 metastasis,resection operations resulted in 54%,16%and 8%respective survival rates,with no significant difference compared to patients not receiving a resection(P=0.132).Gastric carcinoma patients with H3 metastasis who received a resection operation showed 25%,13%and 0%respective survivals with no significantly better prognosis compared to the non-resected cases(P=0.135).There was no statistical y significant difference in survival between the cases with or without peritoneal metastasis(P=0.152). CONCLUSION A resection operation provides a better prognosis for gas- tric carcinoma patients with H1 metastasis independent of peritoneal metas- tasis,but resection has no benefit for gastric carcinoma cases with H2 or H3 metastasis.Peritoneal metastases are not the significant influencing factor for the prognosis of gastric cancer with liver metastasis. | Caigang Liu Ping Lu Jinsong Gu Junqing Chen | 2007 | Chinese Journal of Clinical Oncology2007，4，2： | 3 |
| 17 | Simulation and analysis of the carrying capacity for road networks using a grid-based approach显示文摘The number of vehicles that a road network can carry is limited.When the limit is exceeded,the network system is not able to function effectively.In this paper,an updated cellular automaton model for grid networks with all-way stop-controlled intersections is proposed to simulate the network level critical density and carrying capacity under different conditions,which essentially indicates the limit number of vehicles that the network can handle before going into gridlock.In the proposed model,two update rules,including lane-changing and the longitudinal location update,are adopted to describe the vehicle’s movements on road segments according to the driving condition on the road and the vehicle’s direction in the downstream intersection.The vehicle’s movements in intersection areas are prioritized based on vehicle’s position,so as to prevent collisions within the intersection area.The simulation results show that an increase in network size is able to expand the carrying capacity of a road network,whereas the expansion rate is lower than the change rate in the network size.The carrying capacity is also associated with the structure of road network.The carrying capacity is inversely proportional to the number of intersections,and proportional to the length of the road in the network.Also,optimizing the origin-destination(O-D)distribution can increase the carrying capacity of an urban road network. | Junqing Shi Linwu Chen Fengxiang Qiao Lei Yu Qing Li Guilian Fan | 2020 | Journal of Traffic and Transportation Engineering(English Edition)2020，7，4： | 3 |
| 18 | Comprehensive test stand for high-intensity cyclotron development显示文摘A comprehensive test stand for high-intensity cyclotron development,a 10 MeV 430 μA cyclotron,has been successfully constructed at China Institute of Atomic Energy (CIAE) for the experimental verification of the viability of a 100 MeV high-intensity cyclotron (CYCIAE-100) being constructed at CIAE.The verification includes the overall design technology,detail design and engineering technology for the crucial parts of the machine,e.g.main magnet and beam diagnostics.It will also pave the way for future enhancement of the beam intensity.The test stand consists of a H-ion source,axial injection system,central region,main magnet and coil,RF resonator,stripping extraction,and auxiliary systems,which include the RF power amplifier,high voltage and DC power supplies,electric apparatus,beam diagnostics,control,vacuum,water cooling,pneumatic system,and safety interlock.This paper presents the work regarding the design and sub-system development of the test sand,and the results of the beam commissioning of the machine. | ZHANG TianJue LI ZhenGuo CHU ChengJie XING JianSheng GUAN FengPing ZHONG JunQing JI Bin GE Tao YIN ZhiGuo HOU ShiGang PAN GaoFeng YAO HongJuan LU YinLong WANG ZhenHui WU LongCheng LIN Jun JIA XianLu WEI SuMin WEN LiPeng WANG Feng XIA Le CAI HongRu XIE HuaiDong CHEN RongFan ZHANG Yan ZHANG SuPing LIU GengShou ZOU Jian AN ShiZhong YANG JianJun BI YuanJie YANG Fang | 2011 | Chinese Science Bulletin2011，56，3： | 3 |
| 19 | RGD-FasL Induces Apoptosis of Pituitary Adenoma Cells显示文摘This study was to investigate the cytotoxic effects on pituitary adenoma cell lines GH3/MMQ/AtT20 induced by RGD-FasL and the underlying mechanism. Fas/DcR3 mRNAs were detected by RT-PCR and their surface expressions were measured by flow cytometry. Cytotoxicity exerted by RGD-FasL on tumor cells was measured with MTT assay and the induced apoptosis was determined by agarose gel electrophoresis. The cell cycle and apoptosis was assessed by flow cytometry with PI staining. The expressions of caspase8/9/3,Bcl-2,RANKL and JNK2 were detected by Western blotting. Approximately 13.7% of GH3 cells,25.5% of MMQ cells,22.2% of AtT20 cells express Fas,while 23.9% of GH3 cells,24.1% of MMQ cells,4.6% of AtT20 cells express DcR3. The cytotoxic effects of FasL/RGD-FasL on tumor cells were all taken in a dose-dependent manner. Cell lines MMQ/AtT20 showed the same sensitivity to RGD-FasL as to FasL,while cell line GH3 was less sensitive to RGD-FasL. The cell cycle analysis indicated that RGD-FasL could inhibit cells in G0/G1 phase and G2/M phase. In MMQ and AtT20 cells treated with RGD-FasL,the AI was not significantly different from that treated with FasL,while in GH3 cells treated with RGD-FasL,the AI was lower than that treated with FasL. The expressions of caspase-8/9/3,RANKL and JNK2 were increased while that of Bcl-2 was decreased after treatment with RGD-FasL,suggesting that RGD-FasL induces apoptosis through caspase activation. We concluded that RGD-FasL could possibly be considered as a novel therapeutical candidate for the treatment of pituitary adenomas. | Lukui Chen Guohong Zhuang Wenzhu Li Yunsheng Liu Junqing Zhang Xinhua Tian | 2008 | Cellular & Molecular Immunology2008，5，1： | 2 |
| 20 | PEG-mediated solvothermal synthesis of NaYF 4 :Yb/Er superstructures with efficient upconversion luminescence显示文摘 | Zhigang Chen Qiwei Tian Yuelin Song Jianmao Yang Junqing Hu | 2010 | Journal of Alloys and Compounds2010，，2： | 2 |
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