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| 1 | Mouse miRNA-709 directly regulates miRNA-15a/16-1 biogenesis at the posttranscriptional level in the nucleus: evidence for a microRNA hierarchy system显示文摘MicroRNAs (miRNAs ) 是内长的 noncoding RNA (~ 22 nt ) 在细胞质在 post-transcriptional 水平调整目标基因表示。在房间原子核的要求功能的 argonaute 家庭蛋白质提示了我们假设那 miRNAs 的 miRNAs 和 miRNA 的存在的最近的发现可以也在房间原子核有规章的功能。在这研究,我们证明老鼠 miR-709 主要位于各种各样的房间类型的原子核并且它的原子本地化模式很快在 apoptotic 刺激之上变化。在房间原子核, miR-709 直接在 pri-miR-15a/16-1 上绑在一个 19-nt miR-709 识别元素并且阻止它处理成 pre-miR-15a/16-1,导致 miR-15a/16-1 成熟的抑制。而且,原子 miR-709 通过 miR-15a/16-1 小径参予房间 apoptosis 的规定。在摘要,现在的学习提供一 miRNA 能由直接在原子核指向他们的主要抄本控制另外的 miRNAs 的生物的续生说的第一条证据。 | Rui Tang Limin Li Dihan Zhu Dongxia Hou Ting Cao Hongwei Gu Jing Zhang Junyuan Chen Chen-Yu Zhang Ke Zen | 2012 | Cell Research2012，22，3： | 23 |
| 2 | Distinct characteristics and new prognostic scoring system for Chinese patients with Waldenstr(o)m macroglobulinemia显示文摘 | Yi Shuhua Cui Rui Li Zengjun An Gang Qi Junyuan Zou Dehui Zhang Peihong Chen Huishu Wang Jianxiang Chang Hong Qiu Lugui | 2014 | Chinese Medical Journal2014，，12： | 12 |
| 3 | Design and application of a small electrode experimental installation for resistivity measurement of mineral and solid insulating material显示文摘There has not been an effective method to measure the resistivity of small-size sample of mineral and solid insulating material until now.According to the Chinese National Standard(GB/T1410-2006) and features of digital high resistance meter,a small electrode experimental installation was developed;it can work with current high resistance meter;the sample decreases to 18 mm from standard size 100 mm in diameter and reduces by 30.86 times in area.A three-electrode system is supported and precisely positioned by two insulating bases whose diameter is 60 mm and height is 20 mm,which ensures accuracy of device structure and reliability of measuring results.The key technological parameters are as follows:diameter of high voltage electrode is 18mm;diameter of measuring electrode is 14.6 mm;internal diameter and external diameter of guard electrode are 16 and 18 mm,respectively;the gap between guard electrode and measuring electrode is set at 0.6 mm.These parameters are adequate for the measurement of flat specimen of mineral and solid insulating material whose diameter is 18 mm.According to the confirmatory experiment on the volume resistivity and surface resistivity,the measuring results are almost the same,using a small electrode experimental installation and a standard electrode. | WANG Ling LUO Ke LI ZiQiang GUAN SongYun GE Wei ZHANG JunYuan | 2011 | Science China(Technological Sciences)2011，54，4： | 8 |
| 4 | Optimization of Vehicle Side Curtain Airbag Module Based on Computer Aided Engineering显示文摘Compared with other kinds of airbags,curtain airbag(CAB) has more complex structures and larger coverage area. The product development process depends on many module tests,sled tests and full size vehicle tests. Computer aided engineering(CAE) technology can replace tests to a great extent,also save test costs and product development time. This paper introduces the way of setting up simulation models and application of static deployment tests and free motion headform(FMH) tests to verify simulation models. In the CAB simulation,uniform pressure airbag models and computational fluid dynamics(CFD) models are all used. The uniform pressure airbag models are not able to simulate the pressure difference among different parts inside the cushion during inflating process. CFD-based CAB models are used to help the curtain airbag optimization design. Based on effective CAE simulation,the optimization analyses related to diffuser tube parameters,inflator mass flow rate and cushion folding patterns are discussed and performed in different cases. The optimization result shows that the proposed techniques are helpful to the parametric optimization design of side curtain airbag module in curtain airbag development process. | ZHANG Junyuan LI Dongjun BI Ying YANG Donglin QIU Feng | 2009 | Chinese Journal of Mechanical Engineering2009，22，4： | 6 |
| 5 | Investigation on Measurement of Size and Concentration of Solid Phase Particles in Gas-Solid Two Phase Flow显示文摘Gas-solid two phase flow measurements have a wide range of applications in industrial production and scientific research. Based on optical principle and image processing, a measurement method of solid phase particle size and concentration of gas-solid two phase flow was presented, and an experimental system was built. By theoretical analysis and image processing algorithms, solid phase particle sizes and concentrations in gas-solid two phase flow were achieved. | WANG Yueming LYU Xiaoqi LI Wentao YAO Guodong BAI Junyuan BAO An | 2018 | Chinese Journal of Electronics2018，27，2： | 4 |
| 6 | Extended tacrolimus release via the combination of lipid-based solid dispersion and HPMC hydrogel matrix tablets显示文摘The objective of this study is to evaluate the feasibility of obtaining extended release of tacrolimus by a novel combination of lipid-based solid dispersion and matrix-type extended release tablet techniques. Tacrolimus solid dispersion was prepared using glycerylbehenate(Compritol~?ATO888) and Pluronic F127 as the carrier materials with hot-melt method, which was then blended with hydrogel matrix materials, such as HPMC and lactose, the powders were directly compressed into tablets. In vitro drug release tests were carried out to evaluate the performance of the solid dispersions and the tablets. The dissolution rate of tacrolimus was significantly improved by the lipid-based solid dispersion, and the incorporation of HPC into the solid dispersion obviously improved its stability after storage. Extended release tablets loaded with tacrolimus solid dispersion showed prolonged drug release patterns over 24 h, the release patterns of the tablets can be tailored by the compositions of the matrix materials, including the types and content of HPMCs. A modified processing method that directly mixed the melted solid dispersion with HPMC powders improved the uniformity of the solid dispersion inside the tablet matrix and release profile. The release data of the extended release tablet fitted well to the Korsmeyer–Peppas model with n value of 0.85, which suggested diffusion-and erosion-controlled release mechanism. The combination of lipid-based solid dispersion and HPMC hydrogel matrix may find wide applications in the extended release dosage forms of high potent, water-insoluble drugs. | Hui Xu Li Liu Xuehui Li Junyuan Ma Rui Liu Shaoning Wang | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，4： | 3 |
| 7 | KEY TECHNIQUES OF MULTI-BODY MODELING OF OCCUPANT RESTRAINT SYSTEM OF VEHICLE SIDE IMPACT显示文摘基于多身体动力学,汽车方面结构和占有人的模拟模型“ s 动态回答被建立,用占有人损害模拟软件 MADYMO3D.These,模型包括汽车身体结构,影响障碍,位子和哑巴。multi-bodyand 关节的定义和基于 FE,联合建模的关节的动力学性质,模型,安装被介绍。MADYMO 的凯尔文元素被介绍也显示出在 non-adjoiningrigid 身体之间的力量行动。然后,提及的方法的所有例子被给。由模拟和真实测试的比较,在为主要结构和哑巴的生物学力学性质的模拟和真实测试之间的合同曲线被获得。结果显示出模型的精确性和有效性。 | ZHANG Junyuan ZHANG Min DING Rufang QIU Shaobo ZHANG Yu LI Hongjian | 2006 | Chinese Journal of Mechanical Engineering2006，19，3： | 3 |
| 8 | Structure-activity relationship optimization for lassa virus fusion inhibitors targeting the transmembrane domain of GP2显示文摘Dear Editor,Lassa virus(LASV)belongs to the Mammarenavirus genus,Arenaviridae family.Arenaviruses are classified into two main groups-Old World(OW)and New World(NW)-based on virus genetics,serology,antigenic properties and geographical relationships.The OW LASV and Lujo virus(LUJV),as well as NW Jurn'n virus(JUNV),Machupo virus(MACV),Guanarito virus(GTOV),Sabia virus(SABV)and Chapare virus(CHAPV),are known to cause severe hemorrhagic fever and are listed as biosafety level 4(BSL-4)agents.The arenavirus glycoprotein complex(GPC)contains three subunits-the retained stable-signal peptide(SSP),the receptor-binding subunit GP1,and the membrane fusion subunit GP2(Lenz et al.,2001).Notably,the proximate external membrane region and TM of GP2,together with the ectodomain loop and TMs of SSP,form an SSP-GP2 interface,playing essential roles in regulating membrane fusion,and providing targets for distinct fusion inhibitors(Larson et al.,2008;Lee et al.,2008;York et al.,2008;York and Nunberg,2009;Thomas et al.,2011;Burgeson et al.,2013a;Shankar et al.,2016;Wang et al.,2016;Wang et al.,2018).Among these inhibitors,ST-161 is LASV specific(Burgeson et al.,2013a).In this study,we conducted structure-activity relationship(SAR)optimization of ST-161.As a result,21 derivatives with IC50 values<1 pmol/L are presented in Table S1.Hit compounds 21,29 and 57 exhibiting robust inhibition of the LASV pseudotype virus(LASVpv,VSV backbone enveloped by LASV GPC with single cycle infection)entry with IC50 values lower than 0.2 nmol/L(Figs.1A and S1),as well as hit compound 72 with an ester bond instead of acylhydrazone,were further investigated.To test whether the four hit compounds inhibit LASV entry by blocking the GPC-mediated membrane fusion,the inhibition effects of these compounds against LASV GPC mediated fusion were quantitatively determined by dual-luciferase assay(Thomas et al.,2011;Wang et al.,2018). | Guangshun Zhang Junyuan Cao Yan Cai Yang Liu Yanli Li Peilin Wang Xiaoying Jia Mengmeng Zhang Gengfu Xiao Yu Guo Wei Wang | 2019 | Protein & Cell2019，10，2： | 3 |
| 9 | Global dynamics of a heroin epidemic model with age structure and nonlinear incidence显示文摘 | Junyuan Yang Xiaoxia Li Fengqin Zhang | 2016 | International Journal of Biomathematics2016，9，3： | 2 |
| 10 | Precambrian sponges with cellular structures显示文摘 | Li Chiawei Chen Junyuan Hua Tzuen | 1998 | Science1998，279，： | 1 |
| 11 | Cardiac abnormalities in severe acute dichlorvos poisoning显示文摘 | Xinhua He Chunsheng Li Dongmei Wei Junyuan Wu Luhui Shen Tie Wang | 2011 | Critical Care Medicine2011，，8： | 1 |
| 12 | Precambrian sponges with cellular structures显示文摘 | Li Chiawei Chen Junyuan Hue Tze-En | 1998 | Scinece1998，279，： | 1 |
| 13 | Liver Function Derangement in Patients with Severe Fever and Thrombocytopenia Syndrome显示文摘Background and Aims:Patients with severe fever with thrombocytopenia syndrome(SFTS)commonly show liver function impairment.This study aimed to characterize the liver function indices in SFTS patients and investigate their association with mortality.Methods:Clinical information and laboratory results of 459 laboratory-confirmed SFTS patients,including 78 deceased and 381 surviving patients,were retrospectively analyzed.To explore the infectivity of SFTS caused by novel Bunyavirus(SFTSV)in hepatocytes,Huh7 human hepatoma cells were infected with various concentrations of SFTSV in vitro.Results:The proportion of SFTS patients developing liver injury during hospitalization was 73.2%(336/459);the hepatocellular injury was the predominant type.The median time to occurrence of liver injury from disease onset was 8 d.Liver injury in the deceased group occurred earlier than that in the surviving group.Alanine aminotransferase(ALT)level between 2–5 times upper limit of normal(ULN)at 4–6 d and between 5–15 ULN at 7–12 d of disease course were independent predictors of mortality.Alkaline phosphatase(ALP)>2 ULN at 7–9 d and elevated ALP at 10–12 days after disease onset were risk factors for death.ALT and aspartate transaminase(AST)levels were correlated with lymphocyte count and platelet-to-lymphocyte ratio(PLR).Total bilirubin(TB),ALT,AST levels showed positive correlation with viral load.In the in vitro experiment,SFTSV infected and replicated inside Huh7 cells.Conclusions:Liver injury is common in SFTS patients.ALT and ALP were independent predictors of SFTS-related mortality.Frequent monitoring and evaluation of liver function indices are needed for SFTS patients. | Sihong Lu Ling Xu Boyun Liang Hua Wang Tong Wang Tiandan Xiang Sumeng Li Lei Fan Junyuan Li Cheng Peng Xin Zheng | 2022 | Journal of Clinical and Translational Hepatology2022，10，5： | 1 |
| 14 | Antimony doped tin oxides and their composites with tin pyrophosphates as catalyst supports for oxygen evolution reaction in proton exchange membrane water electrolysis 显示文摘 | Xu Junyuan Li Qingfeng Martin Kalmar Hansen | 2012 | International Journal of Hydrogen Energy2012，37，18： | 1 |
| 15 | Plasma tailoring in WTe_(2)nanosheets for efficiently boosting hydrogen evolution reaction显示文摘2D transition metal dichalcogenides(TMDs)have been considered as promising non-precious electrocatalysts for the hydrogen evolution reaction(HER).However,their limited active sites and poor electric conductivity pose a significant hurdle to their HER performance,resulting in a large overpotential.Here,we report the defect engineering in ultrathin tungsten telluride(WTe_(2))nanosheets with semimetal nature to improve hydrogen evolution effectively.We find that the oxygen plasma etching imposes a cutting effect on WTe_(2)nanosheets,resulting in a large number of tungsten vacancies.Particularly,the sample after plasma treatment for 10 min shows a feather-like structure with an overpotential of 251m V at 10 m A/cm~2and a Tafel slope of 94 m V/dec,which is 4 times lower than the Tafel slope of pristine nanosheets.Further first-principles calculations shed light on the evolution of defect-rich WTe_(2)nanosheets and offer rational explanation to their superiority in efficient hydrogen evolution. | Xin Wang Jun Wang Bin Wei Nan Zhang Junyuan Xu Hongwei Miao Lifeng Liu Chenliang Su Ying Li Zhongchang Wang | 2021 | Journal of Materials Science & Technology2021，，19： | 1 |
| 16 | Experimental modal analysis of roller gap sensor structure on hot rolling mill显示文摘 | MA Weijin WANG Junyuan LI Fenfan | 2010 | Advanced Materials Research2010，97，： | 1 |
| 17 | A novel approach to synthesis of functional CPVC and CPE or graft copolymers-in situ chlorinating graft 显示文摘 | Jiruo Zhao Junyuan Li Ying Feng | 2007 | Polymers for Advanced Technologies2007，18，： | 1 |
| 18 | AKT activation promotes PTEN hamartoma tumor syndrome-associated cataract development显示文摘 | Sellitto Caterina Li Leping Gao Junyuan Robinson Michael L Lin Richard Z Mathias Richard T White Thomas W | 2013 | Journal of Clinical Investigation2013，，12： | 1 |
| 19 | Boosting acidic water oxidation performance by constructing arrays-like nanoporous Ir_(x)Ru_(1−x)O_(2) with abundant atomic steps显示文摘The fabrication of electrocatalysts with high activity and acid stability for acidic oxygen evolution reaction(OER)is an urgent need,yet extremely challenging.Here,we report the design and successful fabrication of a high performance self-supported cogwheel arrays-like nanoporous Ir_(x)Ru_(1−x)O_(2) catalyst with abundant atomic steps for acidic OER using a facile alloy-spinningelectrochemical activation method that allows large-scale fabrication.The obtained Ir_(x)Ru_(1−x)O_(2) catalysts merely need overpotentials of 211 and 295 mV to deliver catalytic current densities of 10 and 300 mA·cm^(−2) in 0.5 M H_(2)SO_(4),respectively,and can sustain constant OER electrolysis for at least 140 h at a high current density of 300 mA·cm^(−2).Further density functional theory(DFT)calculations uncover that such high intrinsic activities mainly originate from the largely exposed high-index atomic step planes,which markedly lower the limiting potential of the rate-determining step(RDS)of OER.These findings provide an insight into the exploration of high performance electrocatalysts,and open up an avenue for further developing the state-of-theart Ir and/or Ru-based catalysts for large-scale practical applications. | Junjie Li Zan Lian Qiang Li Zhongchang Wang Lifeng Liu Francis Leonard Deepak Yanping Liu Bo Li Junyuan Xu Zuxin Chen | 2022 | Nano Research2022，15，7： | 0 |
| 20 | Forming Mechanism and Morphology of CaSO4·H2O by SEM-EDS and ICP显示文摘To promote the development of 3D printing materials,gypsum powders used in 3D printing were analyzed in detailthrough SEM-EDS and ICP.The forming mechanism and morphology of CaSO_4·χH_2O powders were analyzed and confirmed.Furthermore,the printing mechanism of gypsum powders was analyzed and discussed.According to the results of SME-EDS analysis and ICP detection,the factors affecting the forming accuracy,strength,surface quality and reliability of CaSO_4·χH_2O crystalwere found in this paper.Adding a variety of additives to change the performance of calcium sulfate would be the further research. | 董磊 LUO Wei WANG Junyuan WANG Huajun LI Xing 王洪福 | 2016 | Journal of Wuhan University of Technology(Materials Science)2016，31，2： | 0 |
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