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| 1 | Interpola- tion of Continuous Micro Line Segment Trajectories Based on Look-ahead Algorithm in High-speed Maehi- ning显示文摘 | Ye Peiqing Shi Chuan Yang Kaiming | 2008 | International Journal of Advanced Manufac- turing Technology2008，37，： | 1 |
| 2 | Interpolation of Continuous Micro Line Segment Trajectories Based on Look-ahead Algorithm in High- speed Machining 显示文摘 | Ye Peiqing Shi Chuan Yang Kaiming | 2008 | International Journal of Advanced Manufacturing Technology2008，37，910： | 1 |
| 3 | Improvement of vitamin B12 fermentation by reducing the inhibitory metabolites by cell recycle system and a mixed culture显示文摘 | KEN-ICHIRO MIYANO KAIMING YE KAZUYUKI SHIMIZU | 2000 | Biochem Eng J2000，6，3： | 1 |
| 4 | Interpolation of continuous micro line segment trajectories based on look-ahead algorithm in high-speed machining显示文摘 | YE Peiqing SHI Chuan YANG Kaiming | 2008 | International Journal of Advanced Manufacturing Technology2008，37，910： | 1 |
| 5 | Interpolation,of,continuous,micro-line,segment trajectories based on look-ahead algorithm in high-speed machining显示文摘 | YE Peiqing SHI Chuan YANG Kaiming | 2008 | The International Journal of Advanced Manufacturing Technology2008，37，910： | 1 |
| 6 | Development of immunosensors using carbon nanotubes显示文摘 | JITHESH V VEETIL KAIMING YE | 2007 | Biotechnolngy Progress2007，23，3： | 1 |
| 7 | Hydrolysis hydrogen production mechanism of Mg10Ni10Ce alloy surface modified by SnO_(2) nanotubes in different aqueous systems显示文摘(Mg-10wt%Ni)-10wt%Ce(Mg10Ni10Ce)was ball-milled with SnO_(2)nanotubes and Mg10Ni10Ce-xSnO_(2)(x¼0,5,10 and 15 wt%)composites have been prepared.The phase compositions,microstructures,morphologies and hydrolysis H2 generation performance in different aqueous systems(distilled water,tap water and simulated seawater)have been investigated and the corresponding hydrolysis mechanism of Mg10Ni10Ce and Mg10Ni10CeeSnO_(2)has been proposed.Adding a small amount of SnO_(2)nanotubes can significantly enhance the hydrolysis reaction of Mg10Ni10Ce,especially the initial hydrolysis kinetics and the final H_(2) generation yield.Unfortunately,the Mg10Ni10Ce-xSnO_(2)hardly reacts with distilled water at room temperature.The hydrolysis reaction rate of Mg10Ni10Cee5SnO_(2)composite in tap water is still very slow with only 17.3%generation yield after 1 h at 303 K.Fortunately,in simulated seawater(3.5 wt%NaCl solution),the hydrolytic H2 generation behavior of the Mg10Ni10Cee5SnO_(2)composite has been greatly improved,which can release as high as 468.6 mL g^(-1 )H_(2) with about 60.9%generation yield within 30 s at 303 K.The Cl destroys the passivation layer on MgeNieCe alloy surface and the added SnO_(2)nanotubes accelerate the hydrolysis reaction rate and enhance the H2 generation yield.The Mg10Ni10Cee5SnO_(2)composite can rapidly generate a large amount of H2 in simulated seawater in a short time,which is expected to be applied on portable H2 generators in the future. | Xiaojiang Hou Lu Yang Kaiming Hou Hongchang Shi Lei Feng Guoquan Suo Xiaohui Ye Li Zhang Yanling Yang | 2021 | Green Energy & Environment2021，6，1： | 1 |
| 8 | Stereospecific Intramolecular S→Pt Transmethylation from 8-(Methylthio)quinoline to Coordinated PtMe2:Formation of syn-2 with Stacked Quinoline Rings显示文摘 | Ye S-F Kaim W Niemeyer M | 2005 | Organometa-llics2005，24，： | 1 |
| 9 | Complexes of the imine/thioether mixed-donor ligand 8-methylthio-quinoline with d6-configurated transition metal centers:synthesis,structures and comparison with complexes of 1-methyl-2-(methylthiomethyl)-1H-benzimidazole显示文摘 | Ye S-F Kaim W Albrecht M Lissner F | 2004 | Inorg Chim Acta2004，357，： | 1 |
| 10 | 3D tumor model biofabrication显示文摘Animal models have been extensively used in cancer pathology studies and drug discovery.These models,however,fail to reflect the complex human tumor microenvironment and do not allow for high-throughput drug screening in more human-like physiological conditions.Three-dimensional(3D)cancer models present an alternative to automated high-throughput cancer drug discovery and oncology.In this review,we highlight recent technology innovations in building 3D tumor models that simulate the complex human tumor microenvironment and responses of patients to treatment.We discussed various biofabrication technologies,including 3D bioprinting techniques developed for characterizing tumor progression,metastasis,and response to treatment. | Ming Li Xueer Song Sha Jin Kaiming Ye | 2021 | Bio-Design and Manufacturing2021，4，3： | 1 |
| 11 | Enhanced trimeric ACE2 exhibits potent prophylactic and therapeutic efficacy against the SARS-CoV-2 Delta and Omicron variants in vivo显示文摘Dear Editor,The outbreak of coronavirus disease 2019(COVID-19)has resulted in a severe global pandemic that has lasted for more than two years.1 Several vaccines were developed at an unprecedented speed to protect billions of people.2 Many monoclonal antibodies have also been discovered,several of which are in the clinical stages.3 However,limited vaccine availability and vaccine hesitancy compromise the impact of vaccines.The continuous evolution of SARS-CoV-2 has also resulted in many variants that can escape immunity,reducing the effects of vaccines and antibodies.4 With more than 30 mutations in the spike protein,the Omicron variant escapes the majority of existing antibodies and extensively evades vaccine-induced immunity.5,6 Thus,therapeutics that are broadly effective against current and future emerging SARS-CoV-2 variants are still highly desirable. | Mengjiao Li Zi-Wei Ye Kaiming Tang Liang Guo Wenwen Bi Yuyuan Zhang Yan-dong Tang Guoguang Rong Mohamad Sawan Xin Yin Ren Sun Shuofeng Yuan Bobo Dang | 2022 | Cell Research2022，32，6： | 1 |
| 12 | Interpolation of continuous micro line segment trajectories based on look-ahead algorithm in high-speed machining 显示文摘 | Ye Peiqing Shi Chuan Yang Kaiming | 2007 | The International Journal of Advanced Manufacturing Technology2007，37，910： | 1 |
| 13 | On the development of an intelligent control system for recombinant cell culture显示文摘 | Ye Kaiming Jin Sha Shimizu Kazuyuki | 1998 | International Journal of Intelligent Systems1998，13，6： | 1 |
| 14 | Interpolation of continuous micro line segment trajectories based on look-ahead algorithm in high-speed machining显示文摘 | YE Peiqing SHI Chuan YANG Kaiming | 2008 | The International Journal of Advanced Manufacturing Technology2008，37，910： | 1 |
| 15 | Targeting papain-like protease for broad-spectrum coronavirus inhibition显示文摘The emergence of SARS-CoV-2 variants of concern and repeated outbreaks of coronavirus epidemics in the past two decades emphasize the need for next-generation pan-coronaviral therapeutics.Drugging the multi-functional papain-like protease(PLpro)domain of the viral nsp3 holds promise.However,none of the known coronavirus PLpro inhibitors has been shown to be in vivo active.Herein,we screened a structurally diverse library of 50,080 compounds for potential coronavirus PLpro inhibitors and identified a noncovalent lead inhibitor F0213 that has broad-spectrum anti-coronaviral activity,including against the Sarbecoviruses(SARSCoV-1 and SARS-CoV-2),Merbecovirus(MERS-CoV),as well as the Alphacoronavirus(hCoV-229E and hCoVOC43).Importantly,F0213 confers protection in both SARS-CoV-2-infected hamsters and MERS-CoV-infected human DPP4-knockin mice.F0213 possesses a dual therapeutic functionality that suppresses coronavirus replication via blocking viral polyprotein cleavage,as well as promoting antiviral immunity by antagonizing the PLpro deubiquitinase activity.Despite the significant difference of substrate recognition,mode of inhibition studies suggest that F0213 is a competitive inhibitor against SARS2-PLpro via binding with the 157K amino acid residue,whereas an allosteric inhibitor of MERSPLpro interacting with its 271E position.Our proof-ofconcept findings demonstrated that PLpro is a valid target for the development of broad-spectrum anticoronavirus agents.The orally administered F0213 may serve as a promising lead compound for combating the ongoing COVID-19 pandemic and future coronavirus outbreaks. | Shuofeng Yuan Xiaopan Gao Kaiming Tang Jian-Piao Cai Menglong Hu Peng Luo Lei Wen Zi-Wei Ye Cuiting Luo Jessica Oi-Ling Tsang Chris Chun-Yiu Chan Yaoqiang Huang Jianli Cao Ronghui Liang Zhenzhi Qin Bo Qin Feifei Yin Hin Chu Dong-Yan Jin Ren Sun Jasper Fuk-Woo Chan Sheng Cui Kwok-Yung Yuen | 2022 | Protein & Cell2022，13，12： | 0 |
| 16 | H_2 generation kinetics/thermodynamics and hydrolysis mechanism of high-performance La-doped Mg-Ni alloys in Na Cl solution——A large-scale and quick strategy to get hydrogen显示文摘In this work,La-doped Mg-Ni multiphase alloys were prepared by resistance melting furnace(RMF)and then modified by high-energy ball milling(HEBM).The hydrolysis H_(2) generation kinetics/thermodynamics of prepared alloys in Na Cl solutions have been investigated with the help of nonlinear and linear fitting by Avrami-Erofeev and Arrhenius equations.Combining the microstructure information before and after hydrolysis and thermodynamics fitting results,the hydrolysis H_(2) generation mechanism based on nucleation&growth has been elaborated.The final H_(2) generation capacities of 0La,5La,10La and 15 La alloys are 677,653,641 and 770 m L·g^(-1)H_(2) in 240 min at291 K,respectively.While,the final H_(2) generation capacities of HEBM 0La,5La,10La and 15 La alloys are 632,824,611 and 653 m L·g^(-1)H_(2) in 20 min at 291 K,respectively.The as-cast 15La alloy and HEMB 5La alloy present the best H_(2) production rates and final H_(2) production capacities,especially the HEBM 5La can rapidly achieve high H_(2) generation capacity(670 and 824 m L·g^(-1)H_(2) )at low temperature(291 K)within short time(5 and 20 min).The difference between the H_(2) generation capacities is mainly originated from the initial nucleation rate of Mg(OH)_(2) and the subsequent processes affected by the microstructures and phase compositions of the hydrolysis alloys.Relative low initial nucleation rate and fully growth of Mg(OH)_(2) nucleus are the premise of high H_(2) generation capacity due to the hydrolysis H_(2) generation process consisted by the nucleation,growth and contacting of Mg(OH)_(2) nucleus.To utilization H_(2) by designing solid state H_(2) generators using optimized Mg-based alloys is expected to be a feasible H_(2) generation strategy at the moment. | Xiaojiang Hou Hongchang Shi Lu Yang Kaiming Hou Yi Wang Lei Feng Guoquan Suo Xiaohui Ye Li Zhang Yanling Yang | 2021 | Journal of Magnesium and Alloys2021，9，3： | 0 |
| 17 | RNA structure determination:From 2D to 3D显示文摘RNA molecules serve a wide range of functions that are closely linked to their structures.The basic structural units of RNA consist of single-and double-stranded regions.In order to carry out advanced functions such as catalysis and ligand binding,certain types of RNAs can adopt higher-order structures.The analysis of RNA structures has progressed alongside advancements in structural biology techniques,but it comes with its own set of challenges and corresponding solutions.In this review,we will discuss recent advances in RNA structure analysis techniques,including structural probing methods,X-ray crystallography,nuclear magnetic resonance,cryo-electron microscopy,and small-angle X-ray scattering.Often,a combination of multiple techniques is employed for the integrated analysis of RNA structures.We also survey important RNA structures that have been recently determined using various techniques. | Jie Deng Xianyang Fang Lin Huang Shanshan Li Lilei Xu Keqiong Ye Jinsong Zhang Kaiming Zhang Qiangfeng Cliff Zhang | 2023 | Fundamental Research2023，3，5： | 0 |
| 18 | Intranasal administration of a single dose of a candidate live attenuated vaccine derived from an NSP16-deficient SARS-CoV-2 strain confers sterilizing immunity in animals显示文摘Live attenuated vaccines might elicit mucosal and sterilizing immunity against SARS-CoV-2 that the existing mRNA,adenoviral vector and inactivated vaccines fail to induce.Here,we describe a candidate live attenuated vaccine strain of SARS-CoV-2 in which the NSP16 gene,which encodes 2′-O-methyltransferase,is catalytically disrupted by a point mutation.This virus,designated d16,was severely attenuated in hamsters and transgenic mice,causing only asymptomatic and nonpathogenic infection.A single dose of d16 administered intranasally resulted in sterilizing immunity in both the upper and lower respiratory tracts of hamsters,thus preventing viral spread in a contact-based transmission model.It also robustly stimulated humoral and cell-mediated immune responses,thus conferring full protection against lethal challenge with SARS-CoV-2 in a transgenic mouse model.The neutralizing antibodies elicited by d16 effectively cross-reacted with several SARS-CoV-2 variants.Secretory immunoglobulin A was detected in the blood and nasal wash of vaccinated mice.Our work provides proof-of-principle evidence for harnessing NSP16-deficient SARS-CoV-2 for the development of live attenuated vaccines and paves the way for further preclinical studies of d16 as a prototypic vaccine strain,to which new features might be introduced to improve safety,transmissibility,immunogenicity and efficacy. | Zi-Wei Ye Chon Phin Ong Kaiming Tang Yilan Fan Cuiting Luo Runhong Zhou Peng Luo Yun Cheng Victor Sebastien Gray Pui Wang Hin Chu Jasper Fuk-Woo Chan Kelvin Kai-Wang To Honglin Chen Zhiwei Chen Kwok-Yung Yuen Guang Sheng Ling Shuofeng Yuan Dong-Yan Jin | 2022 | Cellular & Molecular Immunology2022，19，5： | 0 |
| 19 | Adsorption of Au on β-SiC(111) Surfaces显示文摘The adsorption properties of Au on β-SiC(111)surfaces are studied using the charge self-consistent extended Hiickel theory.The intermixing between Au atom and β-SiC could happen only on the Si-terminated(111)surface.In the case of Si~terminated,there is a intrinsic surface state in the energy gap,and the Fermi energy is pinned at this surface state.But in the case of C-terminated,the surface state exists near the top of the valence band. | LU Wenchang YE Ling ZHANG Kaiming | 1992 | Chinese Physics Letters1992，9，2： | 0 |
| 20 | Determination of solubility of uranium in liquid sodium显示文摘An experimental technique has been developed which overcomes the two major problems common to liquid metal solubility measurements,namely,maintaining the integrity of the samples during transfer of the liquid sodium from container to whatever device is used for analysis and detecting solute at very low concentration in liquid sodium.The solubility of uranium in liquid sodium has been measured over the temperature range 150~400℃,by equilibration and sampling technique,the solubility of uranium is approximately 0.00001%. | YANG Tongzai XING Pifeng YE Shiyou LONG Kaiming FU Zhonghua HE Yuhui JIANG Tao | 2008 | Nuclear Science and Techniques2008，19，2： | 0 |
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