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| 1 | The ChinaMAP analytics of deep whole genome sequences in 10,588 individuals显示文摘Metabolic diseases are the most common and rapidly growing health issues worldwide.The massive population-based human genetics is crucial for the precise prevention and intervention of metabolic disorders.The China Metabolic Analytics Project(ChinaMAP)is based on cohort studies across diverse regions and ethnic groups with metabolic phenotypic data in China.Here,we describe the centralized analysis of the deep whole genome sequencing data and the genetic bases of metabolic traits in 10,588 individuals from the ChinaMAP.The frequency spectrum of variants,population structure,pathogenic variants and novel genomic characteristics were analyzed.The individual genetic evaluations of Mendelian diseases,nutrition and drug metabolism,and traits of blood glucose and BMI were integrated.Our study establishes a large-scale and deep resource for the genetics of East Asians and provides opportunities for novel genetic discoveries of metabolic characteristics and disorders. | Yanan Cao Lin Li Min Xu Zhimin Feng Xiaohui Sun Jieli Lu Yu Xu Peina Du Tiange Wang Ruying Hu Zhen Ye Lixin Shi Xulei Tang Li Yan Zhengnan Gao Gang Chen Yinfei Zhang Lulu Chen Guang Ning Yufang Bi Weiqing Wang The ChinaMAP Consortium | 2020 | Cell Research2020，30，9： | 20 |
| 2 | Plasma membrane proteome analysis of the early effect of alcohol on liver: implications for alcoholic liver disease显示文摘在人,酒精的在消费上能导致严肃的肝疾病。在肝疾病上检验酒精的早效果,老鼠被给足够的乙醇开发肝肝硬化。在纤维变性的发作前的老鼠在这个工作被学习。肝的血浆膜(下午) 被提取由两次蔗糖密度坡度 centrifugation。从对待乙醇的老鼠和控制的下午的 proteome 侧面为相对、绝对的 quantitation (iTRAQ ) 用二维的胶化电气泳动(2-DE ) 和等压的标签被分析技术。乙醇处理改变了 15 不同的肝蛋白质的数量:他们中的 10 个被 2-DE 检测并且 5 由 iTRAQ。角质素 8 被两个方法检测。这些差别的基因本体论分析检测了显示的蛋白质他们的那个大多数涉及象有约束力的活动那样的重要房间函数(包括离子, DNA, ATP 绑定,等等) ,房间结构,或酶活动。在这些之中, annexin A2,角质素 8,和角质素 18 进一步用西方的污点分析被验证, annexin A2 被 immunohistochemistry 验证。我们的结果建议酒精有潜力由在 PM 改变几相关蛋白质的表示层次影响房间结构,粘附和酶活动。就我们的知识而言,这是第一次在肝下午 proteome 上学习酒精的效果,它可能对理解导致白酒的肝疾病的可能的机制有用。 | Lijun Zhang Xiaofang Jia Yanling Feng Xia Peng Zhiyong Zhang Wenjiang Zhou Zhanqing Zhang Fang Ma Xiaohui Liu Ye Zheng Pengyuan Yang Zhenghong Yuan | 2011 | Acta Biochimica et Biophysica Sinica2011，43，1： | 8 |
| 3 | Online single particle analysis of chemical composition and mixing state of crop straw burning particles: from laboratory study to field measurement显示文摘新鲜稻草烧(SB ) 粒子被米饭的燃烧在实验室产生稻草和玉米稻草。化学作文和新鲜 SB 粒子的混合状态被一个喷雾器蒂米夫莱特·马斯分光计(ATOFMS ) 调查。基于团光谱模式, SB 粒子被聚类进四种主要类型:盐,器官的碳(OC ) ,元素的碳(EC ) ,和 EC 和 OC (EC-OC ) 的内部混合的粒子。另外,包含灰,多不的芳香的烃,重金属或烟碱的粒子也被观察。SB 粒子的物理、化学的变化立即与高度解决时间的数据在排放以后被分析。在变老的过程期间,平均粒子尺寸稳定地增加了。刚射出的有机化合物逐渐地在包含 OC 粒子被氧化到更多的氧化混合物。同时,重要排水量反应(2KCl + 那么 42 K 24+ 2Cl ) 因此被观察。为 SB 粒子的标记离子被优化并且适用在周围的空气识别 SB 粒子。ATOFMS 排序的周围的 SB 粒子的数字部分的变化与可溶的 K + 由联机离子层析测量了的水的同意很好,证明优化标记离子能是为在地大小的 SB 粒子的好 tracers。 | Juntao HUO Xiaohui LU Xinning WANG Hong CHEN Xingnan YE Song Gao Deborah S. Gross Jianmin CHEN Xin YANG | 2016 | Frontiers of Environmental Science & Engineering2016，10，2： | 4 |
| 4 | 雷公藤红素通过靶向核受体Nur77促进损伤线粒体自噬而抑制炎症反应显示文摘文章简介线粒体在细胞死亡、自噬、免疫和炎症中起着不可或缺的作用。前期研究发现,孤儿核受体Nur77通过靶向线粒体诱导细胞凋亡。本文报道了Nur77作为具有抗炎作用的雷公藤红素的直接靶点,介导雷公藤红素通过自噬清除损伤线粒体,抑制炎症反应而达到治疗炎症疾病包括肥胖症的功能。 | Mengjie Hu Qiang Luo Gulimiran Alitongbieke Shuyi Chong Chenting Xu Lei Xie Xiaohui Chen Duo Zhang Yuqi Zhou Zhaokai Wang Xiaohong Ye Lijun Cai Fang Zhang Huibin Chen Fuquan Jiang Hui Fang Shanjun Yang Jie Liu Maria T.Diaz-Meco Ying Su Hu Zhou Jorge Moscat Xiangzhi Lin 张晓坤 | 2018 | 科学新闻2018，0，4： | 3 |
| 5 | Effect of Curing Temperature on Intermediate Temperature Properties of Calcium Aluminate Cement Bonded Corundum Castables显示文摘In order to study the effect of the curing temperature on the intermediate temperature properties of calcium aluminate cement bonded corundum castables,the prepared castables were cured at 5,10,25,40 and 50℃,respectively,dried at 110℃ for 24 h and heat treated at 800 and 1100 ℃,respectively.Then the apparent porosity,the cold modulus of rupture and the cold crushing strength were measured.The phase composition of castable matrix specimens treated under the same conditions and the influence of the curing temperature on the intermediate temperature strength of the castables were also analyzed.The results show that with the increase of the curing temperature,the hydration degree of calcium aluminate cement increases,which promotes the uniform distribution of hydration products with AI203 after decomposition,thus enhancing the intermediate temperature strength of castables. | LI Ye LIU Kun DING Dafei WANG Qingfeng FU Xiaohui YE Guotian | 2021 | China's Refractories2021，30，3： | 3 |
| 6 | An Efficient Multi-area Networks-Merging Model for Power System Online Dynamic Modeling显示文摘To improve accuracy and efficiency in power systems dynamic modeling,the distributed online modeling approach is a good option.In this approach,the power system is divided into sub-grids,and the dynamic models of the sub-grids are built independently within the distributed modeling system.The subgrid models are subsequently merged,after which the dynamic model of the whole power system is finally constructed online.The merging of the networks plays an important role in the distributed online dynamic modeling of power systems.An efficient multi-area networks-merging model that can rapidly match the boundary power flow is proposed in this paper.The iterations of the boundary matching during network merging are eliminated due to the introduction of the merging model,and the dynamic models of the sub-grid can be directly“plugged in”with each other.The results of the calculations performed in a real power system demonstrate the accuracy of the integrated model under both steady and transient states. | Chuan Qin Ping Ju Feng Wu Yongkang Liu Xiaohui Ye Guoyang Wu | 2015 | CSEE Journal of Power and Energy Systems2015，1，4： | 2 |
| 7 | RanBPM is an acetylcholinesterase-interacting protein that translocates into the nucleus during apoptosis显示文摘Acetylcholinesterase (疼痛) 表示可以在各种各样的房间类型在 apoptosis 期间被导致。这里,我们使用了疼痛的 C 终端屏蔽人的胎儿的大脑图书馆并且发现它在组织微导管的中心(RanBPM ) 与跑绑定蛋白质交往了。这个相互作用被 coimmunoprecipitation 分析进一步证实。在 HEK293T 房间, RanBPM 和疼痛不同类地在 cisplatin 未经治疗的细胞质的摘录并且在对待 cisplatin 的细胞质或原子的摘录被表示。我们用词法方法执行的以前的研究在 apoptosis 期间从细胞质显示出那疼痛 translocates 到原子核。一起拿,这些结果建议 RanBPM 是在 apoptosis 期间是从进原子核的细胞质的 translocated 的交往疼痛的蛋白质,类似于在疼痛的情况下观察的 translocation。 | Xiaowen Gong Weiyuan Ye Haibo Zhou Xiaohui Ren Zhigang Li Weiyin Zhou Jun Wu Yicheng Gong Qi Ouyang Xiaolin Zhao Xuejun Zhang | 2009 | Acta Biochimica et Biophysica Sinica2009，41，11： | 2 |
| 8 | New insights into the significance of the BCR repertoire in B-1 cell development and function显示文摘As an important player of innate immunity,B-1 cells have been characterized by natural antibody production and rapid immune response.Based on their expression or lack of CD5,B-1 cells are further separated into B-1a and B-1b subsets.1 Although extensive studies have demonstrated a pivotal role of conventional B cells in adaptive immunity,there is increasing evidence indicating the close associations of B-1a cells with self-reactivity,autoimmunity,infection,and even leukemia.2–4 Here,we describe recent advances that lead to a clearer understanding of B-1 cell development with a focus on new insights into the significance of the B-cell receptor(BCR)repertoire in B-1a cell biology and discuss the potential strategies for specific targeting of B-1a cells under pathological settings. | Xiaohui Wang Cong Ye Xiang Lin Kongyang Ma Fan Xiao Lingli Dong Liwei Lu | 2019 | Cellular & Molecular Immunology2019，16，9： | 2 |
| 9 | Adsorptive removal of chloramphenicol from wastewater by NaOH modified bamboo charcoal显示文摘 | Ye Fan Bin Wang Songhu Yuan Xiaohui Wu Jing Chen Linling Wang | 2010 | Bioresource Technology2010，，19： | 2 |
| 10 | Full-spectrum responsive photocatalytic activity via non-noble metal Bi decorated mulberry-like BiVO_(4)显示文摘Due to its appropriate bandgap(~2.4 e V)and efficient light absorption,bismuth vanadate(Bi VO_(4))shows promising photocatalysis activity.However,the charge carrier recombination and poor electron transmission often induce poor photocatalytic performance.Herein,we report a new method to in-situ synthesize non-noble metal Bi decorated mulberry-like Bi VO_(4)by a two-step calcination process.Comprehensive characterizations reveal that non-noble metal Bi nanoparticles grown in-situ on Bi VO_(4)result in the red-shift of the absorbance edge,greatly extending the light absorption from the ultraviolet into the near-infrared region.The surface plasmon resonance excitation of Bi nanoparticles and synergetic effects between Bi and Bi VO_(4)effectively improve the photocatalytic efficiency and promote the separation of photoinduced electron-hole pairs in mulberry-like Bi VO_(4).Density functional theory(DFT)calculation results further verify that the electrons are transferred from Bi to Bi VO_(4)and the formation of·OH radical in Bi/Bi VO_(4)is attributed to the lower simulated free energy,which supports our experimental outcomes.This work provides a novel strategy to enhance light absorption and promote efficient solar utilization of photocatalysts for practical applications. | Yaxin Bi Yanling Yang Xiao-Lei Shi Lei Feng Xiaojiang Hou Xiaohui Ye Li Zhang Guoquan Suo Siyu Lu Zhi-Gang Chen | 2021 | Journal of Materials Science & Technology2021，，24： | 2 |
| 11 | Developing hierarchical CdS/NiO hollow heterogeneous architectures for boosting photocatalytic hydrogen generation显示文摘The hierarchical binary CdS/NiO hollow heterogeneous architectures(HHAs)with p–n heterojunction are constructed by a facile microwave-assisted wet chemical process for high-efficient photocatalytic hydrogen evolution reaction(HER)from water.The as-designed CdS/NiO HHAs are composed of hexagonal n-type CdS nanoparticles with a size in the range of 20–40 nm attaching to cubic p-type NiO hollow microspheres(HMSs)which are aggregates of porous nanoplates with a thickness of about 20 nm.The photocatalytic water splitting over CdS/NiO HHAs is significantly increased under simulated solar irradiation,among which the most active sample of CdS/NiO-3(the mass ratio of CdS to NiO is 1:3)exhibits the fastest photocatalytic HER rate of 1.77 mmol∙g^(−1)∙h^(−1),being 16.2 times than that of pure CdS.The boosted photocatalytic HER could be attributed to the synergistic effect on the proportional p–n heterojunction with special hierarchical hollow and porous morphology,an enhancement of visible light absorption,and an improvement of photoinduced charge separation as well as the photo-stability given by the composite heterojunction.This work shows a viable strategy to design the heterojunction with special morphology for the efficient hydrogen generation by water splitting utilizing solar energy. | Chonghai Deng Fan Ye Tao Wang Xiaohui Ling Lulu Peng Hong Yu Kangzhe Ding Hanmei Hu Qiang Dong Huirong Le Yongsheng Han | 2022 | Nano Research2022，15，3： | 2 |
| 12 | Upregulation of GLT25D1 in Hepatic Stellate Cells Promotes Liver Fibrosis via the TGF-β1/SMAD3 Pathway In Vivo and In vitro显示文摘Background and Aims:Collagenβ(1-O)galactosyltransferase 25 domain 1(GLT25D1)is associated with collagen production and glycosylation,and its knockout in mice results in embryonic death.However,its role in liver fibrosis remains elusive,particularly in hepatic stellate cells(HSCs),the primary collagen-producing cells associated with liver fibrogenesis.Herein,we aimed to elucidate the role of GLT25D1 in HSCs.Methods:Bile duct ligation(BDL)-induced mouse liver fibrosis models,primary mouse HSCs(mHSCs),and transforming growth factor beta 1(TGF-β1)-stimulated LX-2 human hepatic stellate cells were used in in vivo and in vitro studies.Stable LX-2 cell lines with either GLT25D1 overexpression or knockdown were established using lentiviral transfection.RNA-seq was performed to investigate the genomic differences.HPLCMS/MS were used to identify glycosylation sites.Scanning electronic microscopy(SEM)and second-harmonic generation/two-photon excited fluorescence(SHG/TPEF)were used to image collagen fibril morphology.Results:GLT25D1 expression was upregulated in nonparenchymal cells in human cirrhotic liver tissues.Meanwhile,its knockdown attenuated collagen deposition in BDL-induced mouse liver fibrosis and inhibited mHSC activation.GLT25D1 was overexpressed in activated versus quiescence LX-2 cells and regulated in vitro LX-2 cell activation,including proliferation,contraction,and migration.GLT25D1 also significantly increased liver fibrogenic gene and protein expression.GLT25D1 upregulation promoted HSC activation and enhanced collagen expression through the TGF-β1/SMAD signaling pathway.Mass spectrometry showed that GLT25D1 regulated the glycosylation of collagen in HSCs,affecting the diameter of collagen fibers.Conclusions:Collectively,the upregulation of GLT25D1 in HSCs promoted the progression of liver fibrosis by affecting HSCs activation and collagen stability. | Shiwei Wang Lingling He Fan Xiao Meixin Gao Herui Wei Junru Yang Yang Shu Fuyang Zhang Xiaohui Ye Ping Li Xiaohua Hao Xingang Zhou Hongshan Wei | 2023 | Journal of Clinical and Translational Hepatology2023，11，1： | 1 |
| 13 | Human four-and-a-half LIM family members suppress tumor cell growth through a TGF-[beta]-like signaling pathway显示文摘 | Ding Lihua Wang Zhaoyun Yan Jinghua Yang Xiao Liu Aijun Qiu Weiyi Zhu Jianhua Han Juqiang Zhang Hao Lin Jing Cheng Long Qin Xi Niu Chang Yuan Bin Wang Xiaohui Zhu Cui Zhou Yan Li Jiezhi Song Haifeng Huang Cuifen Ye Qinong | 2009 | Journal of Clinical Investigation2009，，2： | 1 |
| 14 | Construction of SnS2/SnO2 heterostructures with enhanced potassium storage performance显示文摘Increasing attention has been focused on potassium ion batteries(KIBs) as promising energy-sto rage system(ESS) owing to the abundance and low-cost of potassium resources.Here,SnS2/SnO2 hete rostructures were successfully fixed onto stainless steel mesh(SnS2/SnO2/SSM) through a facile two-step hydrothermal method and used as anodes for KIBs.Due to the advantages of SnS2/SnO2 heterostructures and good conductivity of SSM substrate,the SnS2/SnO2/SSM anodes display enhanced electrochemical performance.The SnS2/SnO2/SSM anodes deliver specific capacity of 394 mA h g^-1 at 50 mA g^-1 over 100 cycles,better than SnO2/SSM.Even at 500 mA g^-1 after 250 cycles,high capacity of 155 mA h g^-1 can still be obtained. | Guoquan Suo Dan Li Lei Feng Xiaojiang Hou Xiaohui Ye Li Zhang Qiyao Yu Yanling Yang Wei(Alex)Wang | 2020 | Journal of Materials Science & Technology2020，52，20： | 1 |
| 15 | Analysis of a consensus fragment in ERIC-PCR fingerprinting of Enterobacter sakazakii显示文摘 | Yingwang Ye Qingping Wu Lin Yao Xiaohui Dong Kui Wu Jumei Zhang | 2009 | International Journal of Food Microbiology2009，，2： | 1 |
| 16 | LIONS:an AWGRbased low-latency optical switch for high performance computing and data centers显示文摘 | Yin Yawei Proietti R Ye Xiaohui | 2012 | IEEE Journal of Selected Topics in Quantum Electronics2012，19，36： | 1 |
| 17 | Fast Crystallization of Poly (ethylene terephthalate) 显示文摘 | Mingxin Ye Xiaohui Wang | 1996 | Journal of Thermal Analy- sis1996，46，： | 1 |
| 18 | Detection of hepatitis B virus DNA in paraffin-embedded intrahepatic and extrahepatic cholangiocarcinoma tissue in the northern Chinese population显示文摘 | Yiqi Wu Tianzhen Wang Shengqian Ye Ran Zhao Xiaohui Bai Yingying Wu Kenji Abe Xiaoming Jin | 2012 | Human Pathology2012，，1： | 1 |
| 19 | Multiple chromatographic fingerprinting and its application to the quality control of herbal medicines 显示文摘 | Fan Xiaohui Cheng Yiyu Ye Zhengliang | 2006 | Anal Chim Acta2006，555，2： | 1 |
| 20 | Direct Conversion of Glucose to 5-Hydroxymethylfurfural over Zirconium Phosphate Catalyst in a Biphasic System显示文摘Efficient and selective production of 5-hydroxymethylfurfural(HMF) from glucose was achieved in the presence of zirconium phosphate(ZrPO) catalyst in a biphasic system.With the use of this catalyst,a high HMF yield of 56.8% was obtained from glucose in a water-tetrahydrofuran(THF) biphasic system.Characterization results showed that such catalyst had weak to strong acid sites and contained both Lewis and Br?nsted acid sites.The results of comparative experiments over some other solid acid catalysts demonstrated that the Lewis acid sites on the ZrPO catalyst played a crucial role in the isomerization of glucose to fructose and the Br?nsted ones were active in the dehydration of generated fructose to HMF.Moreover,less levulinic acid(LA) and formic acid(FA)(0.5%) were detected in the reaction solution,indicating that this ZrPO catalyst exhibited high selectivity towards the formation of HMF.Furthermore,the ZrPO catalyst was very stable and could maintain its activity after being used for six times. | Zhao Hong Ye Xinxin Yan Rui Liu Xiaohui Guo Yong Wang Yanqin | 2018 | China Petroleum Processing & Petrochemical Technology2018，20，2： | 1 |
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