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| 1 | Gastroesophageal flap valve status distinguishes clinical phenotypes of large hiatal hernia显示文摘AIM: To investigate two distinct clinical phenotypes of reflux esophagitis and intra-hernial ulcer (Cameron lesions) in patients with large hiatal hernias. METHODS: A case series study was performed with 16 831 patients who underwent diagnostic esophagogastroduodenoscopy for 2 years at an academic referral center. A hiatus diameter ≥ 4 cm was defined as a large hernia. A sharp fold that surrounded the cardia was designated as an intact gastroesophageal flap valve (GEFV), and a loose fold or disappearance of the fold was classified as an impaired GEFV. We studied the associations between large hiatal hernias and the distinct clinical phenotypes (reflux esophagitis and Cameron lesions), and analyzed factors that distinguished the clinical phenotypes. RESULTS: Large hiatal hernias were found in 49 (0.3%) of 16 831 patients. Cameron lesions and reflux esopha-gitis were observed in 10% and 47% of these patients, and 0% and 8% of the patients without large hiatal hernias, which indicated significant associations between large hiatal hernias and these diseases. However, there was no coincidence of the two distinct disorders. Univariate analysis demonstrated significant associations between Cameron lesions and the clinico-endoscopic factors such as nonsteroidal anti-inflammatory drug (NSAID) intake (80% in Cameron lesion cases vs 18% in non-Cameron lesion cases, P=0.015) and intact GEFV (100% in Cameron lesion cases vs 18% in non-Cameron lesion cases, P=0.0007). In contrast, reflux esophagitis was linked with impaired GEFV (44% in reflux esophagitis cases vs 8% in non-reflux esophagitis cases, P = 0.01). Multivariate regression analysis confirmed these significant associations. CONCLUSION: GEFV status and NSAID intake distinguish clinical phenotypes of large hiatal hernias. Cameron lesions are associated with intact GEFV and NSAID intake. | Haruka Kaneyama Mitsuru Kaise Hiroshi Arakawa Yoshinori Arai Keisuke Kanazawa Hisao Tajiri | 2010 | World Journal of Gastroenterology2010，16，47： | 4 |
| 2 | Feasibility and safety of laparoscopic and endoscopic cooperative surgery for gastric submucosal tumors, including esophagogastric junction tumors显示文摘 | Shu Hoteya Shusuke Haruta Hisashi Shinohara Akihiro Yamada Tsukasa Furuhata Satoshi Yamashita Daisuke Kikuchi Toshifumi Mitani Osamu Ogawa Akira Matsui Toshiro Iizuka Harushi Udagawa Mitsuru Kaise | 2014 | Digestive Endoscopy2014，，4： | 4 |
| 3 | Influence of Helicobacter pylori status and eradication on the serum levels of trefoil factors and pepsinogen test: serum trefoil factor 3 is a stable biomarker显示文摘 | Mitsuru Kaise Jun Miwa Ai Fujimoto Jun Tashiro Daisuke Tagami Hiromi Sano Yasukazu Ohmoto | 2013 | Gastric Cancer2013，，3： | 3 |
| 4 | Diagnostic algorithm of magnifying endoscopy with narrow band imaging for superficial non‐ampullary duodenal epithelial tumors显示文摘 | Daisuke Kikuchi Shu Hoteya Toshiro Iizuka Ryusuke Kimura Mitsuru Kaise | 2014 | Digestive Endoscopy2014，，： | 3 |
| 5 | Equal Entitlement versus Tenure Security under a Regime of Collective Property Rights: Peasants′ Preference for Institutions in Post-reform Chinese Agriculture显示文摘 | James Kaising Kung | 1995 | Journal of Comparative Economics1995，，1： | 2 |
| 6 | Usefulness of Magnifying Endoscopy with Narrow-Band Imaging for Determining Tumor Invasion Depth in Early Gastric Cancer显示文摘 | Daisuke Kikuchi Toshiro Iizuka Shu Hoteya Akihiro Yamada Tsukasa Furuhata Satoshi Yamashita Kaoru Domon Masanori Nakamura Akira Matsui Toshifumi Mitani Osamu Ogawa Sumio Watanabe Mitsuru Kaise Guido Schumacher | 2013 | Gastroenterology Research and Practice2013，，： | 2 |
| 7 | Endoscopic submucosal dissection for nonampullary large superficial adenocarcinoma/adenoma of the duodenum: feasibility and long-term outcomes显示文摘 | Shu Hoteya Naohisa Yahagi Toshiro Iizuka Daisuke Kikuchi Toshifumi Mitani Akira Matsui Osamu Ogawa Satoshi Yamashita Tsukasa Furuhata Akihiro Yamada Ryusuke Kimura Kosuke Nomura Yasutaka Kuribayashi Mitsuru Kaise | 2013 | EIO2013，，01： | 2 |
| 8 | Magnifying Endoscopy Combined with Narrow Band Imaging System for Early Gastric Cancer: Correlation of Vascular Pattern with Histopathology (including video)显示文摘 | T. Nakayoshi H. Tajiri K. Matsuda M. Kaise M. Ikegami H. Sasaki | 2004 | Endoscopy2004，，12： | 2 |
| 9 | Delayed bleeding after endoscopic submucosal dissection for non‐ampullary superficial duodenal neoplasias might be prevented by prophylactic endoscopic closure: Analysis of risk factors显示文摘 | Shu Hoteya Mitsuru Kaise Toshiro Iizuka Osamu Ogawa Toshifumi Mitani Akira Matsui Daisuke Kikuchi Tsukasa Furuhata Satoshi Yamashita Akihiro Yamada Ryusuke Kimura Kousuke Nomura Yasutaka Kuribayashi Yoshifumi Miyata Naohisa Yahagi | 2015 | Digestive Endoscopy2015，，3： | 2 |
| 10 | Role of the gut in the development of injury-and shock induced SIRS and MODS: the gut-lymph hypothesis, a review显示文摘 | Deitch EA Xu D Kaise VL | 2006 | Front Biosci2006，11，： | 1 |
| 11 | Inorganic and methylated arsenic compounds induce cell death in murine macrophages via different mechanisms 显示文摘 | Sakurai T Kaise T Matsubara C | 1998 | Chem Res Toxicol1998，11，4： | 1 |
| 12 | Testosterone and friailty显示文摘 | Kaise FE Sih R | 1997 | Clin Geriatr Med1997，13，4： | 1 |
| 13 | Role of thyroid-stimulating blocking antibody in patients who developed hypothyroidism within one year after 131I treatment for Graves′ disease显示文摘 | Yoshida K Aizawa Y Kaise N | 1998 | Clin Endocrinol(Oxf)1998，48，1： | 1 |
| 14 | Modification of cyanate ester resin by soluble polyimides显示文摘 | Iijima Takao Kaise Tomohiro Tomoi Masao | 2003 | Journal of Applied Polymer Science2003，88，1： | 1 |
| 15 | Soluble P-selectin in the plasma of patients with connective tissue diseases显示文摘 | Kaise S Nishimaki T | 1994 | Int Arch Aller Immunol1994，105，： | 1 |
| 16 | A compara-tive study on acute toxicity of methyla rsonic acid, dimeth- ylarsinic acid and trimethylarsine oxide in mice显示文摘 | Kaise T Yamauchi H Horiguchi Y | 1989 | Appl Organomet Chem1989，，3： | 1 |
| 17 | Bacteremia and endotoxemia af- ter endoscopic submucosal dissection for gastric neoplasia: pilot study显示文摘 | Kato M Kaise M Obata T | 2012 | Gastric Cancer2012，15，1： | 1 |
| 18 | Pharmacological,pharmacokinetic and clinical properties of olopatadine hydrochloride,a new antiallergic drug显示文摘 | OHMORI K HAYASHI1 K KAISE T | 2002 | Jpn J Pharmacol2002，88，4： | 1 |
| 19 | Magnifying endoscopy with narrow-band imaging achieves superior accuracy in the differential diagnosis of superficial gastric lesions identified with white-light endoseopy:a prospective study显示文摘 | Kato M Kaise M Yonezawa J | 2010 | Gastrointest Endosc2010，72，3： | 1 |
| 20 | Environmental Attitude and Ecological Behavior显示文摘 | Kaise F G Wlfing S Fuhrer U | 1999 | Journal of Environmental Psychology1999，19，： | 1 |
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