|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 全球生态系统服务与自然资本的价值估算显示文摘编者按:地球上的生态系统是一种复杂的生命支持系统,生态系统对人类的贡献,在生态学研究中经常用“社会效益和经济效益”来表述,是可以用经济价值来估算的。然而,由于其复杂性和不确定性,对这两个效益如何进行估价,一直是困扰生态学家和经济学家的重要问题。Cos... | Robert Costanza Ralph d'Arge Rudolf de Groot Stephen Farber Monica Grasso Bruce Hannon Karin Limburg Shahid Naeem Robert V.O'neill Jose Paruelo Robert G.Raskin Paul Sutton Marjan van den Belt 陶大立(译) | 1999 | 生态学杂志1999，18，2： | 38 |
| 2 | The value of the world’s ecosystem services and natural capital显示文摘 | Robert Costanza Ralph d’Arge Rudolf de Groot Stephen Farber Monica Grasso Bruce Hannon Karin Limburg Shahid Naeem Robert V. O’Neill Jose Paruelo Robert G. Raskin Paul Sutton Marjan van den Belt | 1998 | Ecological Economics1998，，1： | 4 |
| 3 | Molecular phenotypes of human parvovirus B19 in patients with myocarditis显示文摘AIM:To investigate molecular phenotypes of myocardial B19V-infection to determine the role of B19V in myocarditis and dilated cardiomyopathy(DCM).METHODS:Endomyocardial biopsies(EMBs) from 498 B19V-positive patients with myocarditis and DCMwere analyzed using molecular methods and functional experiments.EMBs were obtained from the University Hospitals of Greifswald and Tuebingen and additionally from 36 German cardiology centers.Control tissues were obtained at autopsy from 34 victims of accidents,crime or suicide.Identification of mononuclear cell infiltrates in EMBs was performed using immunohistological staining.Anti-B19V-IgM and anti-B19V-IgG were analyzed by enzyme-linked immunosorbent assay(ELISA).B19V viral loads were determined using in-house quantitative real-time polymerase chain reaction(PCR).For B19V-genotyping a new B19V-genotype-specific restriction fragment length polymorphism(RFLP)-PCR was established.B19V-genotyping was verified by direct DNAsequencing and sequences were aligned using BLAST and BioEdit software.B19V P6-promoter and HHV6-U94-transactivator constructs were generated for cell culture experiments.Transfection experiments were conducted using human endothelial cells 1.Luciferase reporter assays were performed to determine B19Vreplication activity.Statistical analysis and graphical representation were calculated using SPSS and Prism5 software.RESULTS:The prevalence of B19V was significantly more likely to be associated with inflammatory cardiomyopathy(iCMP) compared to uninflamed DCM(59.6% vs 35.3%)(P < 0.0001).The detection of B19V-mRNA replication intermediates proved that replication of B19V was present.RFLP-PCR assays showed that B19V-genotype 1(57.4%) and B19V-genotype 2(36.7%) were the most prevalent viral genotypes.B19V-genotype 2 was observed more frequently in EMBs with iCMP(65.0%) compared to DCM(35%)(P = 0.049).Although there was no significant difference in gender-specific B19V-loads,women were more frequently infected with B19V-genotype 2(44.6%) than men(36.0%)(P = 0.0448).Coinfection with B19V and other cardiotropic viruses was found in 19.2% of tissuesamples and was associated with higher B19V viral load compared to B19V-monoinfected tissue(P = 0.0012).The most frequent coinfecting virus was human herpes virus 6(HHV6,16.5%).B19V-coinfection with HHV6 showed higher B19V-loads compared to B19V-monoinfected EMBs(P = 0.0033),suggesting that HHV6 had transactivated B19V.In vitro experiments confirmed a 2.4-fold increased B19V P6-promoter activity by the HHV6 U94-transactivator.CONCLUSION:The finding of significantly increased B19V loads in patients with histologically proven cardiac inflammation suggests a crucial role of B19V-genotypes and reactivation of B19V-infection by HHV6-coinfection in B19V-associated iCMP.Our findings suggest that B19V-infection of the human heart can be a causative event for the development of an endothelial cell-mediated inflammatory disease and that this is related to both viral load and genotype. | C-Thomas Bock Anja Düchting Friederike Utta Eva Brunner Bui Tien Sy Karin Klingel Florian Lang Meinrad Gawaz Stephan B Felix Reinhard Kandolf | 2014 | World Journal of Cardiology2014，6，4： | 3 |
| 4 | Dual-color deep-tissue three-photon microscopy with a multiband infrared laser显示文摘Multiphoton microscopy combined with genetically encoded fluorescent indicators is a central tool in biology.Threephoton(3P)microscopy with excitation in the short-wavelength infrared(SWIR)water transparency bands at 1.3 and 1.7μm opens up new opportunities for deep-tissue imaging.However,novel strategies are needed to enable in-depth multicolor fluorescence imaging and fully develop such an imaging approach.Here,we report on a novel multiband SWIR source that simultaneously emits ultrashort pulses at 1.3 and 1.7μm that has characteristics optimized for 3P microscopy:sub-70 fs duration,1.25 MHz repetition rate,and μJ-range pulse energy.In turn,we achieve simultaneous 3P excitation of green fluorescent protein(GFP)and red fluorescent proteins(mRFP,mCherry,tdTomato)along with third-harmonic generation.We demonstrate in-depth dual-color 3P imaging in a fixed mouse brain,chick embryo spinal cord,and live adult zebrafish brain,with an improved signal-to-background ratio compared to multicolor twophoton imaging.This development opens the way towards multiparametric imaging deep within scattering tissues. | Khmaies Guesmi Lamiae Abdeladim Samuel Tozer Pierre Mahou Takuma Kumamoto Karolis Jurkus Philippe Rigaud Karine Loulier Nicolas Dray Patrick Georges Marc Hanna Jean Livet Willy Supatto Emmanuel Beaurepaire Frédéric Druon | 2018 | Light(Science & Applications)2018，7，1： | 3 |
| 5 | Emergence of novel strains of avian infectious bronchitis virus in Sweden显示文摘 | Shahid Hussain Abro Lena H.M. Renstr?m Karin Ullman Mats Isaksson Siamak Zohari Désirée S. Jansson Sándor Belák Claudia Baule | 2011 | Veterinary Microbiology (-)2011，，2： | 2 |
| 6 | The value of the world’s ecosystem services and natural capital显示文摘 | Robert Costanza Ralph d'Arge Rudolf de Groot Stephen Farber Monica Grasso Bruce Hannon Karin Limburg Shahid Naeem Robert V. O'Neill Jose Paruelo Robert G. Raskin Paul Sutton Marjan van den Belt | 1998 | Ecological Economics1998，，1： | 2 |
| 7 | Regulated expression of Arabidopsis Shaker K+ channel genes involved in K+ uptake and distribution in the plant显示文摘 | Guillaume Pilot Frédéric Gaymard Karine Mouline Isabelle Chérel Hervé Sentenac | 2003 | Plant Molecular Biology2003，，5： | 1 |
| 8 | Systemic inflammation in chronic obstructive pulmonary disease 显示文摘 | Emiel F M Karin H G Mieke A D | 2007 | Proc Am Thorac Soc2007，4，8： | 1 |
| 9 | Sequence analysis and lipid modification of the cysteine-rich envelope protein of Chlamydia psittaci 6BC 显示文摘 | Karin D Everett E Thomas P H | 1991 | Journal of Bacteriology1991，173，： | 1 |
| 10 | Cloning and sequence analysis of the major outer menbrane protein gene of Chlamydia psittaci 6BC 显示文摘 | Karin D E E Andersen A Marianne P | 1991 | Infect and Immun1991，59，： | 1 |
| 11 | An Ecological-Economic Modelling Procedure to Design Compensation Payments for the Efficient Spatio-Temporal Allocation of Species Protection Measures显示文摘 | KARIN J MARTIN D FRANK W | 2002 | Ecological Economics2002，41，1： | 1 |
| 12 | A spare parts model with cold-standby redundancy on system level 显示文摘 | Karin S S D Nicole P E Ana I B | 2011 | Computers : Operations Research2011，38，7： | 1 |
| 13 | The role of enterovirus replicationin the development of acute and chronic heart muscle disease in differentimmunocompetent mouse strains显示文摘 | Karin K Reinhar D Kandol F | 1993 | Scand J Infect Dis1993，，： | 1 |
| 14 | Impaired neural networks for approximate calculation in dyscalculic children: a functional MRI study显示文摘 | Karin K Thomas L Thomas D | 2006 | Behav Brain Funct2006，2，1： | 1 |
| 15 | Sequential chemotherapy and radiotherapy inadvanced head and neck cancer显示文摘 | Stell PM karin D Mathe J | 1983 | Clin Radiol1983，34，： | 1 |
| 16 | Comparison of different depletion strategies for improved resolution in proteonfic analysis of human serum samples显示文摘 | Karin B Tasso M Pia D | 2004 | Proteomics2004，4，： | 1 |
| 17 | Speeiation, oxi- dation state, and reactivity of particulate manganese in marine sediments显示文摘 | Anschutz P Karine D Franck D | 2005 | Chemical Geology2005，218，34： | 1 |
| 18 | A software tool for designing cost-effective compensation payments for conservation measures 显示文摘 | Karin U Martin D Frank W | 2007 | Environmental Modelling & Software2007，11，： | 1 |
| 19 | The constructivist programme in the sociology of science:retreats or advances? 显示文摘 | Knorr - Cetina Karin D | 1982 | Social Studies of Science1982，12，2： | 1 |
| 20 | An ecological - economic modelling procedure to design compensation payments for the efficient spario - temporal allocation of species protection measures 显示文摘 | Karin J Martin D Frank W | 2002 | Ecological Economics2002，41，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员