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| 1 | Intracellular and extracellular TGF-β signaling in cancer: some recent topics显示文摘 | Kohei Miyazono Yoko Katsuno Daizo Koinuma Shogo Ehata Masato Morikawa | 2018 | Frontiers of Medicine2018，12，4： | 16 |
| 2 | Asymmetric dimethylarginine, a biomarker of cardiovascular complications in diabetes mellitus显示文摘Cardiovascular(CV) complications are an essential causal element of prospect in diabetes mellitus(DM), with carotid atherosclerosis being a common risk factor for prospective crisis of coronary artery diseases and/or cerebral infarction in DM subjects. From another point of view, asymmetric dimethylarginine(ADMA) has been established as an inhibitor of endogenous nitric oxide synthesis and the relationship between ADMA and arteriosclerosis has been reported. In our study with 87 type 2 DM(T2DM) patients, we have examined whether ADMA and other CV risk factors are the useful predictors of DMCV complications. After the measurement of the respective CV risk factors, we have followed the enrolled T2 DM patients for 5 years. We have finally analyzed 77 patients. DMCV complications developed in 15 cases newly within 5 years, and 4 cases recurred. The concentrations of ADMA in plasma were markedly more elevated in 19 DM patients with CV complications than in 58 DM patients without CV complications. Urinary albumin(U-Alb), mean intimal-medial thickness(IMT) and ankle brachial index(ABI) were also higher in patients with CV complications. Multiple regression analyses showed that U-Alb had an influence on the high level of ADMA(standardized β = 6.59, P = 0.00014) independently of age, systolic BP, fibrinogen, mean IMT, plaque score, and ABI. The review indicates what is presently known regarding plasma ADMA that might be a new and meaningful biomarker of CV complications in DM subjects. | Hiroyuki Konya Masayuki Miuchi Kahori Satani Satoshi Matsutani Yuzo Yano Taku Tsunoda Takashi Ikawa Toshihiro Matsuo Fumihiro Ochi Yoshiki Kusunoki Masaru Tokuda Tomoyuki Katsuno Tomoya Hamaguchi Jun-ichiro Miyagawa Mitsuyoshi Namba | 2015 | World Journal of Experimental Medicine2015，5，2： | 16 |
| 3 | Two-week treatment with proton pump inhibitor is sufficient for healing post endoscopic submucosal dissection ulcers显示文摘AIM:To investigate the optimum period of treatment for post endoscopic submucosal dissection(ESD)ulcers.METHODS:Patients who underwent ESD for gastric cancer were randomized to two groups and treated with esomeprazole 20 mg per day for 4 wk(4W group)or 2 wk(2W group).At 4 wk after ESD,we measured the size of the artificial ulcers by endoscopy and determined the ulcer healing rate,compared with the size of the ESD specimens.This randomized controlled trial study was approved by our ethics committee and registered in the UMIN Clinical Trial Registry.RESULTS:A total of 60 consecutive patients were included in the study.All patients received rebamipide 300 mg per day for 4 wk.One patient in 2W group who showed bleeding within two weeks and received endoscopic treatment was excluded from further analysis.The numbers of patients with ulcers in the healing/scar stage in the 2W and 4W groups at 4 wk after ESD were 20/6 and 28/5,respectively,with no significant difference.The ulcer healing rate in the 2W and 4W groups were 96.1%[95%confidence interval(CI):94.6%-97.55]vs 94.8%(95%CI:92.6%-97.1%),respectively,with no statistical difference(UMIN000006951).CONCLUSION:Two-wk treatment with a proton pump inhibitor is as effective as four-week treatment for healing post ESD ulcers. | Makoto Arai Tomoaki Matsumura Kenichiro Okimoto Arata Oyamada Keiko Saito Shoko Minemura Daisuke Maruoka Takeshi Tanaka Tomoo Nakagawa Tatsuro Katsuno Osamu Yokosuka | 2014 | World Journal of Gastroenterology2014，20，43： | 6 |
| 4 | Hepatocyte growth factor, a biomarker of macroangiopathy in diabetes mellitus显示文摘Atherosclerotic involvements are an essential causal element of prospect in diabetes mellitus(DM), with carotid atherosclerosis(CA) being a common risk-factor for prospective crisis of coronary artery diseases(CAD) and/or cerebral infarction(CI) in DM subjects. From another point of view, several reports have supplied augmenting proof that hepatocyte growth factor(HGF) has a physiopathological part in DM involvements. HGF has been a mesenchymal-derived polyphenic factor which modulates development, motion, and morphosis of diverse cells, and has been regarded as a humor intermediator of epithelial-mesenchymal interplays. The serum concentrations of HGF have been elevated in subjects with CAD and CI, especially during the acute phase of both disturbances. In our study with 89 type 2 DM patients, the association between serum concentrationsof HGF and risk-factors for macrovascular complicationsinclusive of CA were examined. The average of serumHGF levels in the subjects was more elevated than thereference interval. The serum HGF concentrations associated positively with both intimal-media thickness(IMT)(r = 0.24, P = 0.0248) and plaque score(r = 0.27, P =0.0126), indicating a relationship between the elevatedHGF concentrations and advancement of CA involvements. Multivariate statistical analysis accentuated thatserum concentrations of HGF would be associated inde-pendently with IMT(standardized = 0.28, P = 0.0499).The review indicates what is presently known regardingserum HGF might be a new and meaningful biomarkerof macroangiopathy in DM subjects. | Hiroyuki Konya Masayuki Miuchi Kahori Satani Satoshi Matsutani Taku Tsunoda Yuzo Yano Tomoyuki Katsuno Tomoya Hamaguchi Jun-Ichiro Miyagawa Mitsuyoshi Namba | 2014 | World Journal of Diabetes2014，5，5： | 5 |
| 5 | 在有阴暗胃肠的流血的病人的囊内视镜检查法的计算图象修正的功效显示文摘 AIM:To investigate whether flexible spectral color enhancement(FICE) improves diagnostic yields of capsule endoscopy(CE) for obscure gastro-intestinal bleeding(OGIB).METHODS:The study subjects consisted of 81 patients.Using FICE,there were three different sets with different wavelengths.Using randomly selected sets of FICE,images of CE were evaluated again by two individuals who were not shown the conventional CE reports and findings.The difference between FICE and conventional imaging was examined.RESULTS:The overall diagnostic yields in FICE sets 1,2,3 and conventional imaging(48.1%) were 51.9%,40.7%,51.9% and 48.1%,respectively,which showed no statistical difference compared to conventional imaging.The total numbers of detected lesions per examination in FICE imaging and conventional imaging were 2.5 ± 2.1 and 1.8 ± 1.7,respectively,which showed a significant difference(P = 0.01).CONCLUSION:The diagnostic yield for OGIB is not improved by FICE.However,FICE can detect significantly more small bowel lesions compared to conventional imaging. | Tomoaki Matsumura Makoto Arai Toru Sato Tomoo Nakagawa Daisuke Maruoka Masaru Tsuboi Sachio Hata Eiji Arai Tatsuro Katsuno Fumio Imazeki Osamu Yokosuka | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，9： | 4 |
| 6 | TGF-β signaling and epithelial–mesenchymal transition in cancer progression显示文摘 | Yoko Katsuno Samy Lamouille Rik Derynck | 2013 | Current Opinion in Oncology2013，，1： | 3 |
| 7 | Laparoscopic Appendectomy for Complicated Appendicitis: A Comparison with Open Appendectomy显示文摘 | Goutaro Katsuno Kunihiko Nagakari Seiichiro Yoshikawa Kazuyoshi Sugiyama Masaki Fukunaga | 2009 | World Journal of Surgery2009，，2： | 3 |
| 8 | Autonomic network configuration for networkable digital appliances显示文摘 | KATSUNO Y AIHARA T RES I | 2005 | IEEE Transactions on Consumer Electronics2005，51，2： | 1 |
| 9 | Phamacological induction of heat-shock proteins alleviates polyglutamine-mediated motor neuron disease显示文摘 | Katsuno M Sang C Adachi H | 2005 | Proc Natl Acad Sci USA2005，102，16： | 1 |
| 10 | Sergliflozin etabonate, a selective SGLT2 inhibitor, improves glyeemic control in streptozotocin-induced diabetic rats and Zucker fatty rats显示文摘 | Fujimori Y Katsuno K Ojima K | 2009 | Eur J Pharmaco12009，609，13： | 1 |
| 11 | Pathogenesis and molecular targeted therapy of spinal and bulbar muscular atrophy (SBMA) 显示文摘 | Banno H Katsuno M Suzuki K | 2012 | Cell Tissue Res2012，349，1： | 1 |
| 12 | Pathogenesis and therapy of spinal and bulbar muscular atrophy (SBMA) 显示文摘 | Katsuno M Tanaka F Adachi H | 2012 | Preg Neurobiol2012，99，3： | 1 |
| 13 | Deficiency of zonula occludens-1 causes embryonic lethal phenotype associated with defected yolk sac angiogenesis and apoptosis of embryonic cells显示文摘 | Katsuno T Umeda K Matsui T | 2008 | Mol Biol Cell2008，19，6： | 1 |
| 14 | Phase 2 trim of leuprorelin in patients with spinal and bulbar 显示文摘 | Banno H Katsuno M Suzuki K | 2009 | Ann Neurol2009，65，： | 1 |
| 15 | Revision of the Structure of a New Coumarin Isolated from Artemisia carviforia Wall显示文摘 | Takashi Harayama Keiko Katsuno | 2001 | Special issue2001，54，1： | 1 |
| 16 | Leuprorelin rescues polyglutamine-dependent phenotypes in a transgenic mouse model of spinal and bulbar muscular atrophy 显示文摘 | Katsuno M Adachi H Doyu M | 2003 | Nat Med2003，9，6： | 1 |
| 17 | Trends in hazardous trace metal concentrations in aerosols collected in Beijing,China from 2001 to 2006显示文摘 | Okuda T Katsuno M Naoi D | 2008 | Chemosphere2008，72，6： | 1 |
| 18 | TGF-fi signaling and epithelial- mesenchymal transition in cancer progression 显示文摘 | Katsuno Y Lamouille S Derynck R | 2013 | Curr Opin Oncol~2013，25，1： | 1 |
| 19 | Immediate re- sponse to light of rat pineal melatonin rhythm: analysis by in vivo microdialysis 显示文摘 | Kanematsu N Honma S Katsuno Y | 1994 | American Journal of Physiology1994，266，62： | 1 |
| 20 | Structural properties of subgrainboundaries in bulk SiC crystals 显示文摘 | Katsuno M Ohtani N Aigo T | 2000 | Journal of Crystal Growth2000，216，： | 1 |
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