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| 1 | Application of ozone therapy in interventional medicine显示文摘Ozone therapy has been gradually accepted by doctors in various fields because it has been safe, convenient, and inexpensive since the twentieth century. It has been used in the treatment of various diseases with satisfactory results, especially in the application of interventional surgery. For lumbar disc herniation, knee osteoarthritis,tissue ischemia-reperfusion after revascularization, stroke, and cancer, ozone therapy can improve the efficacy of interventional surgery and reduce postoperative acute and chronic complications. Prospects of ozone therapy in interventional therapy and the underlying mechanisms of efficacy need further exploration. | Kenan Hao Shuiying Tang Huaning Xie Xinmin Li Xiaofeng He | 2019 | Journal of Interventional Medicine2019，2，1： | 5 |
| 2 | Clinical management and survival outcomes of patients withdifferent molecular subtypes of diffuse gliomas in China(2011–2017):a multicenter retrospective study from CGGA显示文摘Objective:We aimed to summarize the clinicopathological characteristics and prognostic features of various molecular subtypes of diffuse gliomas(DGs)in the Chinese population.Methods:In total,1,418 patients diagnosed with DG between 2011 and 2017 were classified into 5 molecular subtypes according to the 2016 WHO classification of central nervous system tumors.The IDH mutation status was determined by immunohistochemistry and/or DNA sequencing,and 1p/19q codeletion was detected with fluorescence in situ hybridization.The median clinical follow-up time was 1,076 days.T-tests and chi-square tests were used to compare clinicopathological characteristics.Kaplan‒Meier and Cox regression methods were used to evaluate prognostic factors.Results:Our cohort included 15.5%lower-grade gliomas,IDH-mutant and 1p/19q-codeleted(LGG-IDHm-1p/19q);18.1%lowergrade gliomas,IDH-mutant(LGG-IDHm);13.1%lower-grade gliomas,IDH-wildtype(LGG-IDHwt);36.1%glioblastoma,IDHwildtype(GBM-IDHwt);and 17.2%glioblastoma,IDH-mutant(GBM-IDHm).Approximately 63.3%of the enrolled primary gliomas,and the median overall survival times for LGG-IDHm,LGG-IDHwt,GBM-IDHwt,and GBM-IDHm subtypes were 75.97,34.47,11.57,and 15.17 months,respectively.The 5-year survival rate of LGG-IDHm-1p/19q was 76.54%.We observed a significant association between high resection rate and favorable survival outcomes across all subtypes of primary tumors.We also observed a significant role of chemotherapy in prolonging overall survival for GBM-IDHwt and GBM-IDHm,and in prolonging post-relapse survival for the 2 recurrent GBM subtypes.Conclusions:By controlling for molecular subtypes,we found that resection rate and chemotherapy were 2 prognostic factors associated with survival outcomes in a Chinese cohort with DG. | Kenan Zhang Xing Liu Guanzhang Li Xin Chang Shouwei Li Jing Chen Zheng Zhao Jiguang Wang Tao Jiang Ruichao Chai | 2022 | Cancer Biology & Medicine2022，19，10： | 4 |
| 3 | Predictive value of MGMT promoter methylation on the survival of TMZ treated IDH-mutant glioblastoma显示文摘Objective:O6 methylguanine-DNA methyltransferase(MGMT)promoter methylation is a biomarker widely used to predict the sensitivity of IDH-wildtype glioblastoma to temozolomide therapy.Given that the IDH status has critical effects on the survival and epigenetic features of glioblastoma,we aimed to assess the role of MGMT promoter methylation in IDH-mutant glioblastoma.Methods:This study included 187 IDH-mutant glioblastomas and used 173 IDH-wildtype glioblastomas for comparison.KaplanMeier curves and multivariate Cox regression were used to study the predictive effects.Results:Compared with IDH-wildtype glioblastomas,IDH-mutant glioblastomas showed significantly higher(P<0.0001)MGMT promoter methylation.We demonstrated that MGMT promoter methylation status,as determined by a high cutoff value(≥30%)in pyrosequencing,could be used to significantly stratify the survival of 50 IDH-mutant glioblastomas receiving temozolomide therapy(cohort A);this result was validated in another cohort of 25 IDH-mutant glioblastomas(cohort B).The median progression-free survival and median overall survival in cohort A were 9.33 and 13.76 months for unmethylated cases,and 18.37 and 41.61 months for methylated cases,and in cohort B were 6.97 and 9.10 months for unmethylated cases,and 23.40 and 26.40 months for methylated cases.In addition,we confirmed that the MGMT promoter methylation was significantly(P=0.0001)correlated with longer OS in IDH-mutant patients with GBM,independently of age,gender distribution,tumor type(primary or recurrent/secondary),and the extent of resection.Conclusions:MGMT promoter methylation has predictive value in IDH-mutant glioblastoma,but its cutoff value should be higher than that for IDH-wildtype glioblastoma. | Ruichao Chai Guanzhang Li Yuqing Liu Kenan Zhang Zheng Zhao Fan Wu Yuzhou Chang Bo Pang Jingjun Li Yangfang Li Tao Jiang Yongzhi Wang | 2021 | Cancer Biology & Medicine2021，18，1： | 2 |
| 4 | A Parallel Actuated Pantograph Leg for High-speed Locomotion显示文摘高速度的跑是在结构的设计和控制上要求严格的限制的 legged 机器人的地里的最重要的话题之一。为了解决高加速,高精力消费,高步频率和地面的问题,在高速度的运动期间影响,这份报纸论述一条平行激活的缩放仪腿与一近似 decoupled 配置。在轻重量,高负担能力,高机械的效率和结构的稳定性的明白表示的腿特征。在控制点和脚之间的力量和位置的类似特征被分析。使动态表演担心,被腿惯性的全面评估小心地优化并且集中在最大的脚轨道以内的关键设计参数, K 1 和 K 2, 。合并装载转换摆钟(SLIP ) 模型和活跃力量也是的虚拟春天的控制策略建议测试设计。没有机械弹簧,策略能实现高度灵活的阻抗,它实质地简化设计并且在高速度的跑期间满足可变僵硬要求。结构的合理性和控制法律的有效性被模拟和实验验证。 | Wei Guo Changrong Cai Mantian Li Fusheng Zha Pengfei Wang Kenan Wang | 2017 | Journal of Bionic Engineering2017，14，2： | 2 |
| 5 | 'The Syndrome of Reliance on Confessions in China Mainland Will Be Hard to Abolish' (大陆“口供依赖症”难除)显示文摘 | Li Kenan | 2014 | 凤凰周刊2014，3，： | 1 |
| 6 | An Old Story Retold: Loss of G1 Control Defines A Distinct Genomic Subtype of Esophageal Squamous Cell Carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC) has a high mortality rate. To determine the molecular basis of ESCC development, this study sought to identify characteristic genome-wide alterations in ESCC, including exonic mutations and structural alterations. The clinical implications of these genetic alterations were also analyzed. Exome sequencing and verification were performed for nine pairs of ESCC and the matched blood samples, followed by validation with additional samples using Sanger sequencing. Whole-genome SNP arrays were employed to detect copy number alteration(CNA) and loss of heterozygosity(LOH) in 55 cases, including the nine ESCC samples subjected to exome sequencing. A total of 108 non-synonymous somatic mutations(NSSMs) in102 genes were verified in nine patients. The chromatin modification process was found to be enriched in our gene ontology(GO) analysis. Tumor genomes with TP53 mutations were significantly more unstable than those without TP53 mutations. In terms of the landscape of genomic alterations, deletion of 9p21.3 covering CDKN2A/2B(30.9%), amplification of 11q13.3 covering CCND1(30.9%), and TP53 point mutation(50.9%) occurred in two-thirds of the cases. These results suggest that the deregulation of the G1 phase during the cell cycle is a key event in ESCC.Furthermore, six minimal common regions were found to be significantly altered in ESCC samples and three of them, 9p21.3, 7p11.2, and 3p12.1, were associated with lymph node metastasis. With the high correlation of TP53 mutation and genomic instability in ESCC, the amplification of CCND1, the deletion of CDKN2A/2B, and the somatic mutation of TP53 appear to play pivotal roles via G1 deregulation and therefore helps to classify this cancer into different genomic subtypes.These findings provide clinical significance that could be useful in future molecular diagnoses and therapeutic targeting. | Qiyan Wang Jian Bai Amir Abliz Ying Liu Kenan Gong Jingjing Li Wenjie Shi Yaqi Pan Fangfang Liu Shujuan Lai Haijun Yang Changdong Lu Lixin Zhang Wei Chen Ruiping Xu Hong Cai Yang Ke Changqing Zeng | 2015 | Genomics, Proteomics & Bioinformatics2015，13，4： | 1 |
| 7 | Crossover from 2D metal to 3D Dirac semimetal in metallic PtTe2 films with local Rashba effect显示文摘PtTe2 and PtSe2 with trigonal structure have attracted extensive research interests since the discovery of type-II Dirac fermions in the bulk crystals. The evolution of the electronic structure from bulk 3D topological semimetal to 2D atomic thin films is an important scientific question. While a transition from 3D type-II Dirac semimetal in the bulk to 2D semiconductor in monolayer(ML) film has been reported for PtSe2, so far the evolution of electronic structure of atomically thin PtTe2 films still remains unexplored.Here we report a systematic angle-resolved photoemission spectroscopy(ARPES) study of the electronic structure of high quality PtTe2 films grown by molecular beam epitaxy with thickness from 2 ML to 6 ML.ARPES measurements show that PtTe2 films still remain metallic even down to 2 ML thickness, which is in sharp contrast to the semiconducting property of few layer PtSe2 films. Moreover, a transition from 2D metal to 3D type-II Dirac semimetal occurs at film thickness of 4–6 ML. In addition, Spin-ARPES measurements reveal helical spin textures induced by local Rashba effect in the bulk PtTe2 crystal, suggesting that similar hidden spin is also expected in few monolayer PtTe2 films. Our work reveals the transition from2D metal to 3D topological semimetal and provides new opportunities for investigating metallic 2D films with local Rashba effect. | Ke Deng Mingzhe Yan Chu-Ping Yu Jiaheng Li Xue Zhou Kenan Zhang Yuxin Zhao Koji Miyamoto Taichi Okuda Wenhui Duan Yang Wu Xiaoyan Zhong Shuyun Zhou | 2019 | Science Bulletin2019，64，15： | 1 |
| 8 | Pressure-induced Lifshitz transition in the type Ⅱ Dirac semimetal PtTe_2显示文摘Numerous exotic properties have been discovered in Dirac Semimetals(DSMs) and Weyl Semimetals(WSMs). In a given DSM/WSM, the Dirac/Weyl nodes usually coexist with other bulk states, making their respective contribution elusive. In this work, we distinguish the role of bulk states from the tilted Dirac nodes on the transport properties in DSMs. Specifically, we applied pressure to a type-II DSM material, PtTe2, and studied its pressure modified electronic and lattice structure systematically by using in situ transport measurements and X-ray diffraction(XRD). A pressure-induced transition at about 20 GPa is revealed in the transport properties, while the layered lattice structure is robust against pressure as illustrated in XRD measurement results.Density functional theory(DFT) calculations suggest that this is originated from the Lifshitz transition in the bulk states. Our findings provide evidence to identify the bulk states' influence on transport from the topologically-protected DSM states in the DSM material. | FengLiang Liu JiaHeng Li KeNan Zhang Shang Peng HuaQing Huang MingZhe Yan NaNa Li Qian Zhang SongHao Guo XuJie Lü Peng Cai LiFeng Yin ShuYun Zhou WenHui Duan Jian Shen WenGe Yang | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，4： | 1 |
| 9 | Promoted biodegradation and microbiological effects of petroleum hydrocarbons by Impatiens balsamina L. with strong endurance显示文摘 | Zhang Cai Qixing Zhou Shengwei Peng Kenan Li | 2010 | Journal of Hazardous Materials2010，，1： | 1 |
| 10 | Promoted biodegradation and microbiological effects of petroleum hydrocarbons by Impatiens balsamina L. with strong endurance显示文摘 | Zhang Cai Qixing Zhou Shengwei Peng Kenan Li | 2010 | Journal of Hazardous Materials2010，，1： | 1 |
| 11 | Growth of large scale PtTe,PtTe_(2) and PtSe_(2) films on a wide range of substrates显示文摘1T phase of transition metal dichalcogenides(TMDCs)formed by group 10 transition metals(e.g.Pt,Pd)have attracted increasing interests due to their novel properties and potential device applications.Synthesis of large scale thin films with controlled phase is critical especially considering that these materials have relatively strong interlayer interaction and are difficult to exfoliate.Here we report the growth of centimeter-scale PtTe,1T-PtTe2 and 1T-PtSe2 films via direct deposition of Pt metals followed by tellurization or selenization.We find that by controlling the Te flux,a hitherto-unexplored PtTe phase can also be obtained,which can be further tuned into PtTe2 by high temperature annealing under Te flux.These films with different thickness can be grown on a wide range of substrates,including NaCl which can be further dissolved to obtain free-standing PtTe2 or PtSe2 films.Moreover,a systematic thickness dependent resistivity and Hall conductivity measurements show that distinguished from the semiconducting PtSe2 with hole carriers,PtTe2 and PtTe films are metallic.Our work opens new opportunities for investigating the physical properties and potential applications of group 10 TMDC films and the new monochalcogenide PtTe film. | Kenan Zhang Meng Wang Xue Zhou Yuan Wang Shengchun Shen Ke Deng Huining Peng Jiaheng Li Xubo Lai Liuwan Zhang Yang Wu Wenhui Duan Pu Yu Shuyun Zhou | 2021 | Nano Research2021，14，6： | 1 |
| 12 | A Universal Atomic Substitution Conversion Strategy Towards Synthesis of Large‑Size Ultrathin Nonlayered Two‑Dimensional Materials显示文摘Nonlayered two-dimensional(2D)materials have attracted increasing attention,due to novel physical properties,unique surface structure,and high compatibility with microfabrication technique.However,owing to the inherent strong covalent bonds,the direct synthesis of 2D planar structure from nonlayered materials,especially for the realization of large-size ultrathin 2D nonlayered materials,is still a huge challenge.Here,a general atomic substitution conversion strategy is proposed to synthesize large-size,ultrathin nonlayered 2D materials.Taking nonlayered CdS as a typical example,large-size ultrathin nonlayered CdS single-crystalline flakes are successfully achieved via a facile low-temperature chemical sulfurization method,where pre-grown layered CdI2 flakes are employed as the precursor via a simple hot plate assisted vertical vapor deposition method.The size and thickness of CdS flakes can be controlled by the CdI2 precursor.The growth mechanism is ascribed to the chemical substitution reaction from I to S atoms between CdI2 and CdS,which has been evidenced by experiments and theoretical calculations.The atomic substitution conversion strategy demonstrates that the existing 2D layered materials can serve as the precursor for difficult-to-synthesize nonlayered 2D materials,providing a bridge between layered and nonlayered materials,meanwhile realizing the fabrication of large-size ultrathin nonlayered 2D materials. | Mei Zhao Sijie Yang Kenan Zhang Lijie Zhang Ping Chen Sanjun Yang Yang Zhao Xiang Ding Xiaotao Zu Yuan Li Yinghe Zhao Liang Qiao Tianyou Zhai | 2021 | Nano-Micro Letters2021，13，11： | 1 |
| 13 | Single-chain antibodies against DNA aptamers for use as adapter molecules on DNA tile arrays in nanoscale materials organization显示文摘 | Li H Y LaBean T H Kenan D J | | 0，，18： | 1 |
| 14 | Erratum to Clinical management and survival outcomes of patients with different molecular subtypes of diffuse gliomas in China(2011-2017):a multicenter retrospective study from CGGA显示文摘In the published version of Figure 21,an error appeared in Figure 2C on page 1468.In Figure 2C,the Kaplan-Meier estimation of the overall survival of patients with recurrent DG classified according to molecular subtypes was mistakenly covered by the curves of patients with primary DGs during the figure layout process,while the number statistic under the figure is correct.Figure 2C has been updated to correct this mistake.The error does not affect the conclusions of this article.We apologize for the error and for any confusion that it might have caused. | Kenan Zhang Xing Liu Guanzhang Li Xin Chang Shouwei Li Jing Chen Zheng Zhao Jiguang Wang Tao Jiang Ruichao Chai | 2023 | Cancer Biology & Medicine2023，20，7： | 0 |
| 15 | Manipulating optical vortices using integrated photonics显示文摘光旋涡(OV ) 与方位角地改变从极化旋转或从在量,水平对应于光子纺纱或轨道的尖 momenta 的波浪向量的尖设计产生的阶段术语指圆柱的光模式的一个班。OV 在光学和 photonics 的许多区域吸引了研究人员的注意,作为他们从光通讯的潜在的应用范围,光操作,成像,察觉到,到量信息。在最近的年里,综合 photonics 有成为操作 OV 的一个有效方法。在这份报纸,理论框架和为 OV 的操作的综合 photonics 的试验性的进步被考察。 | Ning ZHANG Kenan CICEK Jiangbo ZHU Shimao LI Huanlu LI Marc SOREL Xinlun CAI Siyuan YU | 2016 | Frontiers of Optoelectronics2016，9，2： | 0 |
| 16 | An effector-reporter system to study cellular signal transduction in strawberry fruit (Fragaria ananassa)显示文摘An effector-reporter system is a powerful tool used to study cellular signal transduction,but this technique has been traditionally used in protoplasts.A similar system to study cellular signal transduction in fruits has not yet been established.In this study,we aimed to establish an effector–reporter system for strawberry fruit,a model nonclimacteric fruit.We first investigated the characteristics of transient gene expression in strawberry fruits and found marked variation in gene expression levels among individual fruits,and this variation has complicated the establishment of a technical system.To overcome this difficulty,we investigated a sampling strategy based on a statistical analysis of the activity pattern of four different reporters(GUS,GFP,FLuc,and RLuc)among individual fruits and combinations of pairs of reporters(GUS/GFP and RLuc/FLuc).Based on an optimized sampling strategy,we finally established a step-by step protocol for the effector/reporter assay.Using FaMYB10 and FaWRKY71 as the effectors and GUS driven by the FaCHS promoter as the reporter,we demonstrated that this effector/reporter system was practical and reliable.This effector/reporter technique will contribute to an in-depth exploration of the signaling mechanism for the regulation of strawberry fruit ripening. | Baozhen Zeng Tianyu Li Wei Wang Zhengrong Dai Jie Li Zhiyuan Xi Kenan Jia Yu Xing Bingbing Li Jiaqi Yan Wensuo Jia | 2021 | Horticulture Research2021，8，1： | 0 |
| 17 | Ediacaran Macrofossils in Shunyang Valley,Sixi,Three Gorges District,Hubei Province,China显示文摘Previously undescribed Ediacaran macrofossils are documented in and close to a quarry southwest of Zigui in Shunyang Valley,near Sixi Village,Yangtze Three Gorges region,Hubei Province,China.Discoidal impressions,vendotaenids,and a new branching form occur in bedded carbonates through the entire 235 m thickness of the Dengying Formation.The quarry and nearby outcrops in the stream valley have significant potential for further discoveries of Ediacaran macrofossils. | Roger Mason Yuejie Li Kenan Cao Yu Long Zhen-Bing She | 2017 | Journal of Earth Science2017，28，4： | 0 |
| 18 | Cooperative control of perpendicular magnetic anisotropy via crystal structure and orientation in freestanding SrRuO_(3)membranes显示文摘Flexible magnetic materials with robust and controllable perpendicular magnetic anisotropy(PMA)are highly desirable for developing flexible high-performance spintronic devices.However,it is still challenge to fabricate PMA films on polymers directly.Here,we report a facile method for synthesizing single-crystal freestanding SrRuO_(3) membranes with controlled crystal structure and orientation using water-soluble Ca_(3-x)Sr_(x)Al_(2)O_(3)6 sacrificial layers.Through cooperative effect of crystal structure and orientation,flexible membranes reveal highly tunable magnetic anisotropy from in-plane to out-of-plane with a remarkable PMA energy of 7×10^(6) erg·cm^(−3).First-principle calculations reveal that the underlying mechanism of PMA modulation is intimately correlated with structure-controlled Ru 4d-orbital occupation,as well as spin-orbital matrix element differences,dependent on the crystal orientation.In addition,even after 10,000 bending cycles,the PMA keeps stable,indicating a robust magnetism reliability in the prepared films.This work provides a feasible approach to prepare the flexible oxide films with strong and controllable PMA. | Zengxing Lu Yongjie Yang Lijie Wen Jiatai Feng Bin Lao Xuan Zheng Sheng Li Kenan Zhao Bingshan Cao Zeliang Ren Dongsheng Song Haifeng Du Yuanyuan Guo Zhicheng Zhong Xianfeng Hao Zhiming Wang Run-Wei Li | 2022 | npj Flexible Electronics2022，6，1： | 0 |
| 19 | Steganalysis of Low Embedding Rate CNV-QIM in Speech显示文摘To address the difficulty of detecting low embedding rate and high-concealment CNV-QIM(complementary neighbor vertices-quantization index modulation)steganography in low bit-rate speech codec,the code-word correlation model based on a BiLSTM(bi-directional long short-term memory)neural network is built to obtain the correlation features of the LPC codewords in speech codec in this paper.Then,softmax is used to classify and effectively detect low embedding rate CNV-QIM steganography in VoIP streams.The experimental results show that for speech steganography of short samples with low embedding rate,the BiLSTM method in this paper has a superior detection accuracy than state-of-the-art methods of the RNN-SM(recurrent neural network-steganalysis model)and SS-QCCN(simplest strong quantization codeword correlation network).At an embedding rate of 20%and a duration of 3 s,the detection accuracy of BiLSTM method reaches 75.7%,which is higher than that of RNNSM by 11.7%.Furthermore,the average testing time of samples(100%embedding)is 0.3 s,which shows that the method can realize real-time steganography detection of VoIP streams. | Wanxia Yang Miaoqi Li Beibei Zhou Yan Liu Kenan Liu Zhiyu Hu | 2021 | Computer Modeling in Engineering & Sciences2021，，8： | 0 |
| 20 | Measuring County Resilience After the 2008 Wenchuan Earthquake显示文摘The catastrophic earthquake that struck Sichuan Province,China,in 2008 caused serious damage to Wenchuan County and surrounding areas in southwestern China.In recent years,great attention has been paid to the resilience of the affected area.This study applied the resilience inference measurement(RIM) model to quantify and validate the community resilience of 105 counties in the impacted area.The RIM model uses cluster analysis to classify counties into four resilience levels according to the exposure,damage,and recovery conditions.The model then applies discriminant analysis to quantify the influence of socioeconomic characteristics on the county's resilience.Analysis results show that counties located at the epicenter had the lowest resilience,but counties immediately adjacent to the epicenter had the highest resilience capacities.Counties that were farther away from the epicenter returned to normal resiliency quickly.Socioeconomic variables—including sex ratio,per capita GDP,percent of ethnic minority,and medical facilities—were identified as the most influential characteristics influencing resilience.This study provides useful information to improve county resilience to earthquakes and support decision making for sustainable development. | Xiaolu Li Nina Lam Yi Qiang Kenan Li Lirong Yin Shan Liu Wenfeng Zheng | 2016 | International Journal of Disaster Risk Science2016，7，4： | 0 |
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