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| 1 | Tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer显示文摘Metastasis,the development of secondary malignant growths at a distance from a primary tumor,is the cause of death for 90%of cancer patients,but little is known about how metastatic cancer cells adapt to and colonize new tissue environments.Here,using clinical samples,patient-derived xenograft(PDX)samples,PDX cells,and primary/metastatic cell lines,we discovered that liver metastatic colorectal cancer(CRC)cells lose their colon-specific gene transcription program yet gain a liver-specific gene transcription program.We showed that this transcription reprogramming is driven by a reshaped epigenetic landscape of both typical enhancers and super-enhancers.Further,we identified that the liver-specific transcription factors FOXA2 and HNF1A can bind to the gained enhancers and activate the liver-specific gene transcription,thereby driving CRC liver metastasis.Importantly,similar transcription reprogramming can be observed in multiple cancer types.Our data suggest that reprogrammed tissue-specific transcription promotes metastasis and should be targeted therapeutically. | Shuaishuai Teng Yang Eric Li Ming Yang Rui Qi Yiming Huang Qianyu Wang Yanmei Zhang Shanwen Chen Shasha Li Kequan Lin Yang Cao Qunsheng Ji Qingyang Gu Yujing Cheng Zai Chang Wei Guo Pengyuan Wang Ivan Garcia-Bassets Zhi John Lu Dong Wang | 2020 | Cell Research2020，30，1： | 11 |
| 2 | Diversity of arbuscular mycorrhizal fungal spore communities and its relations to plants under increased temperature and precipitation in a natural grassland显示文摘Arbuscular mycorrhizal fungi(AMF)form mutualisms with most plant species,and therefore,understanding how AMF communities will respond to climate change is essential for predictions of changes in plant communities.To evaluate the impact of global climate change on AMFs and plant-AMF interactions in a natural grassland in Inner Mongolia,both artificial warming and watering treatments were assigned to experimental plots.Our results indicate that(1)warming and precipitation significantly affected the relative spore abundance of abundant sporulating AMF species;(2)the relative abundance of weak sporulating AMF species and AMF diversity decreased under experimental warming;(3)evidence was found that the composition of the AMF community in a given year might be correlated with plant community composition in the following year;and(4)grasses and forbs showing different preferences to Claroideoglomus etunicatum or Ambispora gerdemannii dominated plots.Our results imply that climate change appears to induce changes in AMF assemblages with knock-on effects on grassland plant communities.AMF communities may play a much more important role than we have thought in the responses of ecosystem to global climate changes. | SUN XiuFeng SU YuanYing ZHANG Ying WU MingYu ZHANG Zhe PEI KeQuan SUN LiFu WAN ShiQiang LIANG Yu | 2013 | Chinese Science Bulletin2013，58，33： | 6 |
| 3 | Diversity of root-associated fungi of Vaccinium mandarinorum along a human disturbance gradient in subtropical forests,China显示文摘Aims Ericaceous plant species can host diverse fungi in their roots,including ericoid mycorrhizal fungi(ERMF),endophytes,pathogens and some species with unknown functions.However,how this diversity of fungi responds to different human disturbances is not well understood.Methods In this study,we examined the effects of different human disturbance on fungal diversity in hair roots of Vaccinium mandarinorum,an ericaceous plant.Fungal DNA was extracted from hair roots of V.mandarinorum and high-throughput sequencing was applied to detect the diversity of root-associated fungi along a human disturbance gradient in subtropical forests in Gutianshan National Nature Reserve(GNNR)in East China.The four forest types with different disturbance regime were:old growth forest(OGF),secondary forest with once cut(SEC I),secondary forest with twice cut(SEC II)and Cunninghamia lanceolata plantation(PLF).Important Findings The results showed that:(i)diverse fungal operational units(OTUs)were detected in hair roots of V.mandarinorum in the four types of forests,covering fungal phyla of Ascomycota,Basidiomycota,Chytridiomycota,Glomeromycota and Zygomycota;(ii)Community composition of root-associated fungi of V.mandarinorum in PLF was distinct from those in the other three forest types,and two types of secondary forests had similar fungal community composition;(iii)Different fungal families respond differently to human disturbances:fungal families with significant preference to OGF were ectomycorrhizal or saprophytic fungi while fungal families with higher relative abundance in PLF were plant pathogenic or saprophytic fungi;(iv)The first principal component(PC1)of plant community had a significant effect on composition of root-associated fungal community,while edaphic parameters showed no significant effect on fungal community composition in roots of V.mandarinorum.Our results help to better understand the responses of both ericaceous plants and their fungal partners to human disturbances and forest managements. | Yanhua Zhang Jian Ni Fangping Tang Lifen Jiang Tianrong Guo Kequan Pei Lifu Sun Yu Liang | 2017 | Journal of Plant Ecology2017，10，1： | 6 |
| 4 | METTL5 stabilizes c-Myc by facilitating USP5 translation to reprogram glucose metabolism and promote hepatocellular carcinoma progression显示文摘Background:Hepatocellular carcinoma(HCC)is one of the most prevalent cancers in the world,with a high likelihood of metastasis and a dismal prognosis.The reprogramming of glucosemetabolism is critical in the development ofHCC.TheWarburg effect has recently been confirmed to occur in a variety of cancers,including HCC.However,little is known about the molecular biological mechanisms underlying the Warburg effect in HCC cells.In this study,we sought to better understand how methyltransferase 5,N6-adenosine(METTL5)controls the development of HCC and theWarburg effect.Methods:In the current study,quantitative real-time polymerase chain reaction and Western blotting were used to detect the expression of METTL5 in HCC tissues and cell lines.Several different cell models and animal models were established to determine the role of METTL5 in glucose metabolism reprogramming and the underlying molecularmechanism of HCC.Glutathione-S-transferase pulldown,coimmunoprecipitation,RNA sequencing,non-targeted metabolomics,polysome profiling,and luciferase reporter assays were performed to investigate the molecular mechanisms of METTL5 in HCC cells.Results:We discovered that METTL5 drove glucose metabolic reprogramming to promote the proliferation and metastasis of HCC.Mechanistically,upregulation of METTL5 promoted c-Myc stability and thus activated its downstream glycolytic genes lactate dehydrogenase A(LDHA),enolase 1(ENO1),triosephosphate isomerase 1(TPI1),solute carrier family 2 member 1(SLC2A1),and pyruvate kinase M2(PKM2).The c-Box and ubiquitin binding domain(UBA)regions of ubiquitin specific peptidase 5(USP5)binded to c-Myc protein and inhibited K48-linked polyubiquitination of c-Myc.Further study revealed that METTL5 controled the USP5 translation process,which in turn regulated the ubiquitination of c-Myc.Furthermore,we identified cAMP responsive element binding protein 1(CREB1)/P300 as a critical transcriptional regulator ofMETTL5 that promoted the transcription of METTL5 in HCC.In patient-derived tumor xenograft(PDX)models,adenovirus-mediated knockout of METTL5 had a good antitumor effect and prolonged the survival of PDX-bearing mice.Conclusions:These findings point to a novel mechanism by which CREB1/P300-METTL5-USP5-c-Myc controls abnormal glucose metabolism and promotes tumor growth,suggesting that METTL5 is a potential therapeutic target and prognostic biomarker for HCC. | Peng Xia Hao Zhang Haofeng Lu Kequan Xu Xiang Jiang Yuke Jiang Xiangdong Gongye Zhang Chen Jie Liu Xi Chen Weijie Ma Zhonglin Zhang Yufeng Yuan | 2023 | Cancer Communications2023，43，3： | 3 |
| 5 | Optical Properties and Source Analysis of Aerosols over a Desert Area in Dunhuang,Northwest China显示文摘Aerosol observational data for 2012 obtained from Dunhuang Station of CARE-China(Campaign on Atmospheric Aerosol Research Network of China) were analyzed to achieve in-depth knowledge of aerosol optical properties over Dunhuang region. The results showed that the annual average aerosol optical depth(AOD) at 500 nm was 0.32 ± 0.06, and the ?ngstr?m exponent(α) was 0.73 ± 0.27. Aerosol optical properties revealed significant seasonal characteristics. Frequent sandstorms in MAM(March–April–May) resulted in the seasonal maximum AOD, 0.41 ± 0.04, and a relatively smaller αvalue, 0.44 ± 0.04. The tourism seasons, JJA(June–July–August) and SON(September–October–November) coincide with serious emissions of small anthropogenic aerosols. While in DJF(December–January–February), the composition of the atmosphere was a mixture of dust particles and polluted aerosols released by domestic heating; the average AOD and αwere 0.29 ± 0.02 and 0.66 ± 0.17, respectively. Different air masses exhibited different degrees of influence on the aerosol concentration over Dunhuang in different seasons. During MAM, ranges of AOD(0.11–1.18) and α(0.06–0.82) were the largest under the dust influence of northwest-short-distance air mass in the four trajectories. Urban aerosols transported by northwest-short-distance air mass accounted for a very large proportion in JJA and the mixed aerosols observed in SON were mainly conveyed by air masses from the west. In DJF, the similar ranges of AOD and α under the three air mass demonstrated the analogous diffusion effects on regional pollutants over Dunhuang. | Yongjing MA Jinyuan XIN Yining MA Lingbin KONG Kequan ZHANG Wenyu ZHANG Yuesi WANG Xiuqin WANG Yongfeng ZHU | 2017 | Advances in Atmospheric Sciences2017，34，8： | 2 |
| 6 | Combination of ARTP mutagenesis and color-mediated highthroughput screening to enhance 1-naphthol yield from microbial oxidation of naphthalene in aqueous system显示文摘Strain QCG of the aerobic bacteria Bacillus cereus is capable of producing l-naphthol from naphtha-lene,this strain was first isolated and characterized in this study.Strain QCG was mutagenized to enhance l-naphthol production,using atmospheric and room temperature plasma(ARTP)technology.Then,a microbial clone screening system was used to accelerate the operation.Meanwhile,a novel color-mediated high-throughput screening using 4-aminoantipyrine was performed to screen mutants.The optimal mutant strain QCG4 produced 19.58土0.34 mg·L-1-naphthol from naphthalene that was 47.32%higher than that of the original strain(13.29+0.28 mg·L-1).In addition,the optimal conditions for l-naphthol production via whole-cell catalysis of strain QCG4 were determined to be an OD600 of40,150 mg.L I naphthalene,and 7.5%dimethyl formamide as a co-solvent at pH 7.5 and 26℃ for 3 h,resulting in 41.18士0.12 mg·L-l-naphthol,i.e.,the mutant strain produces a 2.1-fold higher yield compared to the original strain. | Chenggang Qiu Alei Zhang Sha Tao Kang Li Kequan Chen Pingkai Ouyang | 2020 | Frontiers of Chemical Science and Engineering2020，14，5： | 2 |
| 7 | Chelating and radical scavenging activities of soy protein hydrolysates prepared from microbial proteases and their effect on meat lipid peroxidation显示文摘 | Lei Zhang Jianrong Li Kequan Zhou | 2009 | Bioresource Technology2009，，7： | 1 |
| 8 | Effective ablation therapy of adenomyosis with ultrasound-guided high-intensity focused ultrasound显示文摘 | Xin Zhang Kequan Li Bin Xie Min He Jia He Lian Zhang | 2013 | International Journal of Gynecology and Obstetrics2013，，： | 1 |
| 9 | In vitro binding of bile acids and triglycerides by selected chitosan preparations and their physico-chemical properties显示文摘 | Kequan Zhou Wenshui Xia Can Zhang Liangli (Lucy) Yu | 2005 | LWT - Food Science and Technology2005，，10： | 1 |
| 10 | Green catalytic engineering:A powerful tool for sustainable development in chemical industry显示文摘Catalysts play critical roles in modern chemical industry and more than 85% of all chemical processes involve the use of catalysts.The sustainable development of chemical industry calls for green catalytic engineering,which refers to the engineering design and development of environment-friendly,high-efficiency and cost-effective catalysts and catalytic processes for the Industrial manufacture of useful products and energy.It may be difficult to predict the future,but we are glad to identify the current trends that are likely to become ever more important,which is green catalytic engineering.To emphasize the latest advances in the exciting field,to explore efficient strategies for the future development,and to address challenges in chemical industry,we presents a Mini-Special Issue in Frontiers of Chemical Science and Engineering that highlights two featured research articles and three reviews on green catalytic engineering. | Kequan Chen Dangguo Cheng Chong Peng Dan Wang Jintao Zhang | 2018 | Frontiers of Chemical Science and Engineering2018，12，4： | 1 |
| 11 | Evaluating the Ozone Valley over the Tibetan Plateau in CMIP6 Models显示文摘Total column ozone(TCO)over the Tibetan Plateau(TP)is lower than that over other regions at the same latitude,particularly in summer.This feature is known as the“TP ozone valley”.This study evaluates long-term changes in TCO and the ozone valley over the TP from 1984 to 2100 using Coupled Model Intercomparison Project Phase 6(CMIP6).The TP ozone valley consists of two low centers,one is located in the upper troposphere and lower stratosphere(UTLS),and the other is in the middle and upper stratosphere.Overall,the CMIP6 models simulate the low ozone center in the UTLS well and capture the spatial characteristics and seasonal cycle of the TP ozone valley,with spatial correlation coefficients between the modeled TCO and the Multi Sensor Reanalysis version 2(MSR2)TCO observations greater than 0.8 for all CMIP6 models.Further analysis reveals that models which use fully coupled and online stratospheric chemistry schemes simulate the anticorrelation between the 150 hPa geopotential height and zonal anomaly of TCO over the TP better than models without interactive chemistry schemes.This suggests that coupled chemical-radiative-dynamical processes play a key role in the simulation of the TP ozone valley.Most CMIP6 models underestimate the low center in the middle and upper stratosphere when compared with the Microwave Limb Sounder(MLS)observations.However,the bias in the middle and upper stratospheric ozone simulations has a marginal effect on the simulation of the TP ozone valley.Most CMIP6 models predict the TP ozone valley in summer will deepen in the future. | Kequan ZHANG Jiakang DUAN Siyi ZHAO Jiankai ZHANG James KEEBLE Hongwen LIU | 2022 | Advances in Atmospheric Sciences2022，39，7： | 1 |
| 12 | High-intensity focused ultrasound (HIFU): effective and safe therapy for hepatocellular carcinoma adjacent to major hepatic veins显示文摘 | Lian Zhang Hui Zhu Chengbin Jin Kun Zhou Kequan Li Haibing Su Wenzhi Chen Jin Bai Zhibiao Wang | 2009 | European Radiology2009，，2： | 1 |
| 13 | Chelating and radical scavenging activities of soy protein hydrolysates prepared from microbial proteases and their effect on meat lipid peroxidation显示文摘 | ZHANG Lei LI Jianrong ZHOU Kequan | 2010 | Bioresource Technology2010，101，7： | 1 |
| 14 | In vitro binding of bile acids and triglycerides by selected chitosan preparations and their physico-chemical properties显示文摘 | ZHOU Kequan XIA Wenshui ZHANG Can | 2006 | LWT-Food Science and Technology2006，39，10： | 1 |
| 15 | Succinic acid production from enzymatic hydrolysate of sake lees using Actinobacillussuccinogenes 130Z 显示文摘 | Chen Kequan Zhang Han MiaoYelian etal | 2010 | Enzyme Microbial Technol2010，47，： | 1 |
| 16 | Chelating and radicalscavenging activities of soy protein hydrolysates prepared frommicrobial proteases and their effect on meat lipid peroxidation显示文摘 | ZHANG Lei LI Jianrong ZHOU Kequan | 2010 | Bioresource Technology2010，101，7： | 1 |
| 17 | Inhibitory effect of raspberries on starch digestive enzyme and their antioxidant properties and phenolic composition显示文摘 | Lei Zhang Jianrong Li Shelly Hogan Hyun Chung Gregory E. Welbaum Kequan Zhou | 2009 | Food Chemistry2009，，2： | 1 |
| 18 | A triboelectric nanogenerator based oncosmetic fixing powder for mechanicalenergy harvesting显示文摘In this work,we use commercial powder particulates(a cosmetic fixing powder)as triboelectric materials for constructing a triboelectric nanogenerator(CFP-TENG).Through finger pressing,the CFP-TENG generated approximate open-circuit voltage,short-circuit current,and maximum power density values of 1141 V,521μA,and 570.96μW/cm^(2),respectively.Thirty-seven commercial blue LEDs can be easily lit up by the CFP-TENG.Moreover,this TENG,which was designed as a novel palette structure for harvesting mechanical energy from bicycle motion,serves as a self-powered bicycle speed sensor.In addition,the cosmetic fixing powder can be used as an effective material to enhance the triboelectric property of skin.This study provides an effective method for developing a cost-effective TENG without the use of complex surface micro-/nano-texturing. | Kequan Xia Yue Chi Jiangming Fu Zhiyuan Zhu Hongze Zhang Chaolin Du Zhiwei Xu | 2019 | Microsystems & Nanoengineering2019，5，1： | 0 |
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