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| 1 | Tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer显示文摘Metastasis,the development of secondary malignant growths at a distance from a primary tumor,is the cause of death for 90%of cancer patients,but little is known about how metastatic cancer cells adapt to and colonize new tissue environments.Here,using clinical samples,patient-derived xenograft(PDX)samples,PDX cells,and primary/metastatic cell lines,we discovered that liver metastatic colorectal cancer(CRC)cells lose their colon-specific gene transcription program yet gain a liver-specific gene transcription program.We showed that this transcription reprogramming is driven by a reshaped epigenetic landscape of both typical enhancers and super-enhancers.Further,we identified that the liver-specific transcription factors FOXA2 and HNF1A can bind to the gained enhancers and activate the liver-specific gene transcription,thereby driving CRC liver metastasis.Importantly,similar transcription reprogramming can be observed in multiple cancer types.Our data suggest that reprogrammed tissue-specific transcription promotes metastasis and should be targeted therapeutically. | Shuaishuai Teng Yang Eric Li Ming Yang Rui Qi Yiming Huang Qianyu Wang Yanmei Zhang Shanwen Chen Shasha Li Kequan Lin Yang Cao Qunsheng Ji Qingyang Gu Yujing Cheng Zai Chang Wei Guo Pengyuan Wang Ivan Garcia-Bassets Zhi John Lu Dong Wang | 2020 | Cell Research2020，30，1： | 11 |
| 2 | Apple leaf disease identification using genetic algorithm and correlation based feature selection method显示文摘Apple leaf disease is one of the main factors to constrain the apple production and quality.It takes a long time to detect the diseases by using the traditional diagnostic approach,thus farmers often miss the best time to prevent and treat the diseases.Apple leaf disease recognition based on leaf image is an essential research topic in the field of computer vision,where the key task is to find an effective way to represent the diseased leaf images.In this research,based on image processing techniques and pattern recognition methods,an apple leaf disease recognition method was proposed.A color transformation structure for the input RGB(Red,Green and Blue)image was designed firstly and then RGB model was converted to HSI(Hue,Saturation and Intensity),YUV and gray models.The background was removed based on a specific threshold value,and then the disease spot image was segmented with region growing algorithm(RGA).Thirty-eight classifying features of color,texture and shape were extracted from each spot image.To reduce the dimensionality of the feature space and improve the accuracy of the apple leaf disease identification,the most valuable features were selected by combining genetic algorithm(GA)and correlation based feature selection(CFS).Finally,the diseases were recognized by SVM classifier.In the proposed method,the selected feature subset was globally optimum.The experimental results of more than 90%correct identification rate on the apple diseased leaf image database which contains 90 disease images for there kinds of apple leaf diseases,powdery mildew,mosaic and rust,demonstrate that the proposed method is feasible and effective. | Zhang Chuanlei Zhang Shanwen Yang Jucheng Shi Yancui Chen Jia | 2017 | International Journal of Agricultural and Biological Engineering2017，10，2： | 7 |
| 3 | Control of facies/potential on hydrocarbon accumulation:a geological model for lacustrine rift basins显示文摘烃累积的形成和分发被 stratigraphic 外形和液体潜力联合控制,它能在烃累积上控制外形 / 潜力被缩短。外形和潜力肉眼可见地控制烃累积的时间空间分发并且烃累积用显微镜的含石油的特征。构造外形和沉积外形控制时间空间分发。岩相和 petrophysical 外形控制含石油的特征。在在中国的湖的裂缝盆的有利外形和高孔和渗透控制烃累积。液体潜力被要求的工作代表,它对严肃,压力,界面的精力和动能包括工作。烃移植和累积被多重驱动力的联合行动控制,并且被累积在低潜力的区域描绘。在结构的高度,低 geopotential 精力由快活控制引起了背斜的水库。lithological 油水池的形成被毛状的力量引起的低界面的精力控制。低压缩精力由过压和指责的活动控制引起了差错块水库的形成。盆边缘的低 geopotential 精力由快活控制 stratigraphic 水库引起了。很多油水库的统计在裂缝盆显示出那有利外形和低潜在的控制烃累积,在超过 85% 发现的烃累积在有有利外形和低潜力的陷井是分布式的的地方。案例研究证明由近来源有利的外形低的潜在的累积模型的申请的有利区域的预言在 Dongying 消沉与 Shahejie 形成的第三个成员的中间的节的超过 90% 发现的油水池分发相关很好, Bohai 海湾盆。 | Chen Dongxia Pang Xiongqi Zhang Shanwen Wang Yongshi Zhang Jun | 2008 | Petroleum Science2008，5，3： | 4 |
| 4 | Multi-platform omics analysis reveals molecular signature for COVID-19 pathogenesis,prognosis and drug target discovery显示文摘Disease progression prediction and therapeutic drug target discovery for Coronavirus disease 2019(COVID-19)are particularly important,as there is still no effective strategy for severe COVID-19 patient treatment.Herein,we performed multi-platform omics analysis of serial plasma and urine samples collected from patients during the course of COVID-19.Integrative analyses of these omics data revealed several potential therapeutic targets,such as ANXA1 and CLEC3B.Molecular changes in plasma indicated dysregulation of macrophage and suppression of T cell functions in severe patients compared to those in non-severe patients.Further,we chose 25 important molecular signatures as potential biomarkers for the prediction of disease severity.The prediction power was validated using corresponding urine samples and plasma samples from new COVID-19 patient cohort,with AUC reached to 0.904 and 0.988,respectively.In conclusion,our omics data proposed not only potential therapeutic targets,but also biomarkers for understanding the pathogenesis of severe COVID-19. | Yuming Li Guixue Hou Haibo Zhou Yanqun Wang Hein Min Tun Airu Zhu Jingxian Zhao Fei Xiao Shanwen Lin Dongdong Liu Dunrong Zhou Lang Mai Lu Zhang Zhaoyong Zhang Lijun Kuang Jiao Guan Qiushi Chen Liyan Wen Yanjun Zhang Jianfen Zhuo Fang Li Zhen Zhuang Zhao Chen Ling Luo Donglan Liu Chunke Chen Mian Gan Nanshan Zhong Jincun Zhao Yan Ren Yonghao Xu | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 1 |
| 5 | Effect of recombinant adenovirus-P53 combined with radiotherapy on long-term prognosis of advanced nasopharyngeal carcinoma 显示文摘 | Pan Jianji Zhang Shanwen Chen Chuanbeng | 2009 | J Clin Oncol2009，27，： | 1 |
| 6 | Effects of interlayer coupling on the excitons and electronic structures of WS_(2)/hBN/MoS_(2) van der Waals heterostructures显示文摘Inserting hexagonal boron nitride(hBN)as barrier layers into bilayer transition metal dichalcogenides heterointerface has been proved an efficient method to improve two dimensional tunneling optoelectronic device performance.Nevertheless,the physical picture of interlayer coupling effect during incorporation of monolayer(1L-)hBN is not explicit yet.In this article,spectroscopic ellipsometry was used to experimentally obtain the broadband excitonic and critical point properties of WS_(2)/MoS_(2)and WS_(2)/hBN/MoS_(2)van der Waals heterostructures.We find that 1L-hBN can only slightly block the interlayer electron transfer from WS_(2)layer to MoS_(2)layer.Moreover,insertion of 1L-hBN weakens the interlayer coupling effect by releasing quantum confinement and reducing efficient dielectric screening.Consequently,the exciton binding energies in WS_(2)/hBN/MoS_(2)heterostructures blueshift comparing to those in WS_(2)/MoS_(2)heterostructures.In this exciton binding energies tuning process,the reducing dielectric screening effect plays a leading role.In the meantime,the quasi-particle(QP)bandgap remains unchanged before and after 1L-hBN insertion,which is attributed to released quantum confinement and decreased dielectric screening effects canceling each other.Unchanged QP bandgap as along with blueshift exciton binding energies lead to the redshift exciton transition energies in WS_(2)/hBN/MoS_(2)heterostructures. | Xudan Zhu Junbo He Rongjun Zhang Chunxiao Cong Yuxiang Zheng Hao Zhang Songyou Wang Haibin Zhao Meiping Zhu Shanwen Zhang Shaojuan Li Liangyao Chen | 2022 | Nano Research2022，15，3： | 1 |
| 7 | Key materials and future perspective for aqueous rechargeable lithium-ion batteries显示文摘Aqueous rechargeable lithium-ion battery(ARLiB)is of specific importance due to the low-cost,environmentalfriendly properties.Recently,its energy denisty and cyclic life have been significantly enhanced,demonstarting the potential for real applications.The improvement on key materials of ARLiB,ranging from cathode,anode and electrolyte,can finally ameliorate coresponding performance of full cell.Hereon,the cathode materials of ARLiBs are summerized as spinel oxides,layered oxides,olivine polyanion compounds olivine and Prussian blue analogues,while anode materials are classified into vanadium-based,polyanion,titanium-based and organic ones.Meanwhile,the strategies for better aqueous electrolytes are discussed from the aspects of salt concentration,solvent and interface.In the last part,issues challenging the commercialization of ARLiBs are provided as well as the suggestions for future research and development. | Shigang Chen Soe Ring Jeong Shanwen Tao | 2022 | Materials Reports(Energy)2022，2，2： | 1 |
| 8 | Endovascular Stenting for Treatment of Nutcracker Syndrome: Report of 61 Cases With Long-Term Followup显示文摘 | Shanwen Chen Hongkun Zhang Heng Shi Lu Tian Wei Jin Ming Li | 2011 | The Journal of Urology2011，，2： | 1 |
| 9 | The environmental adaptability and reproductive properties of invasive green alga Codium fragile from the Nan'ao Island,South China Sea显示文摘It has been widely recognized that biological invasion has become one of the greatest threats to the ecosystem.Codium fragile is an invasive species which exhibits a variety of attributes like parthenogenesis,winter fragment,and vegetative reproduction;and therefore,it has become a successful invader,colonizing most subtropical regions.In China’s southeast coastal aquaculture waters,the green algal bloom caused by C.fragile will probably become a serious problem.In order to understand more details about the species,an experiment focused on its reproductive characteristics was conducted using culture established from a sample collected in the aquaculture raft of the Nan’ao Island in the South China Sea.The results showed that there were two types of gametes resembling aplanospores and zoospores respectively,both of which were able to germinate.During the gametes liberation,a long mucilage tube was formed out of the mouth of the gametangium assisting dispersal of gametes away from the parent plant.This tube was adapted not only to its surrounding flowing water environment but also to its parent plant’s outer gelatinous structure.In general,the optimum temperature for gametes release and germination was 15-20℃ and 15℃,respectively,which corresponded to the local offshore marine water.The plant was observed to produce vegetative buds under favourable reproductive conditions which were called propagules.They were capable of developing into filamentous thalli.The results will provide some scientific evidences for revealing the biological mechanism of bloom and control strategies of invasive green algae. | Lanping Ding Xulei Wang Bingxin Huang Weizhou Chen Shanwen Chen | 2022 | Acta Oceanologica Sinica2022，41，3： | 0 |
| 10 | Supraclinoid internal carotid artery blister-like aneurysms:hypothesized pathogenesis and microsurgical clipping outcomes显示文摘Background:Blister-like aneurysms(BLAs)on the supraclinoid segment of the internal carotid artery(ICA)are an enigma of cerebrovascular disease.Neither has a definite pathogenesis been so far identified,nor have uniform treatment guidelines been established for them.Our aim was to develop a hypothesis regarding the evolution of BLAs according to their macroscopic morphologies and to evaluate the efficacy of microsurgical clipping.Methods:The clinical data and morphological features of 15 consecutive patients with 16 BLAs on the supraclinoid ICA were retrospectively reviewed.The treatment strategies were analyzed,and functional outcomes were evaluated using the modified Rankin scale(mRS).Favorable outcomes were defined as a mRS score of 0-2.Results:Morphologically,aneurysm growth with expansion of the aneurysm neck before the surgical procedure occurred in two ruptured and one unruptured aneurysm.Daughter bleb formation was observed in two ruptured and five unruptured aneurysms.A varied degree of parent artery sclerosis was observed in nine patients.Thirteen patients were treated with direct surgical clipping,one patient was treated with clipping and wrapping,and the remaining patient was treated with an encircling clipping graft.Favorable and unfavorable outcomes were observed in 13 and two cases,respectively.Follow-up angiograms revealed 4 cases of stenosis with respective degree of mild,30%,50%,and 80%without any neurological dysfunction.Conclusions:We suggest a hypothesis that BLAs on the supraclinoid ICA may share different evolving mechanisms between ruptured and unruptured lesions.A majority of them can be reliably and safely obliterated by direct clipping technique,except for the aneurysms accompanied with severely atherosclerotic parent walls. | Shanwen Chen Xin Chen Bo Ning Yong Cao Shuo Wang | 2022 | Chinese Neurosurgical Journal2022，8，1： | 0 |
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