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| 1 | Reciprocal Screw Theory Based Singularity Analysis of a Novel 3-DOF Parallel Manipulator显示文摘Singularity analysis is an essential issue for the development and application of parallel manipulators.Most of the existing researches focus on the singularity of parallel manipulators are carried out based on the study of Jacobian matrices.A 3-DOF parallel manipulator with symmetrical structure is presented.The novel parallel manipulator employs only revolute joints and consists of four closed-loop subchains connecting to both base and platform via revolute joints.The closed-loop subchain in each chain-leg is a spherical 6R linkage.The motion characteristics of the output link in the spherical 6R linkage with symmetrical structure are analyzed based on the interrelationships between screw systems.The constraints that are exerted on the platform by each chain-leg are investigated applying the concept of generalized kinematic pair in terms of equivalent screw system.Considering the geometric characteristics of the parallel manipulator,the singularity criteria of the parallel manipulator corresponding to different configurations are revealed based on the dependency of screw system and line geometry.The existing conditions of certain configuration that a singularity must occur are determined.This paper presents a new way of singularity analysis based on disposition of constraint forces on the geometrically identified constraint plane and the proposed approach is capable of avoiding the complexity in solving the Jacobian matrices. | FANG Hairong FANG Yuefa ZHANG Ketao | 2012 | Chinese Journal of Mechanical Engineering2012，25，4： | 7 |
| 2 | Identification and Characterization of microRNA during Bemisia tabaci Infestations in Solanum lycopersicum and Solanum habrochaites显示文摘MicroRNAs(miRNAs) are a class of small non-coding RNAs that can regulate target gene expression during many plant growth and development processes. In recent years, several studies identified the miRNAs involved in fruit development, leaf development, and abiotic responses in tomato. However, little is known about the miRNAs that respond to insect attack. Here, miRNAs were identified by high-throughput sequencing at different stages after infections by the whitefly Bemisia tabaci in Solanum lycopersicum and Solanum habrochaites, which are susceptible and resistant to whitefly, respectively. A total of 44 known miRNA families were identified, and 33 were shared between the two species. Among these, 13 miRNA families were newly reported in tomato. After strict filtering, some novel miRNAs were also discovered. The global expression patterns of the miRNAs exhibited were different between the two species, reflecting their different responses and resistance levels to whitefly attack. Some of the predicted target genes of differentially expressed miRNAs may be involved in responding to, and defending against, diseases and insects. Thus, plant miRNAs are important in the responses to, and resistance against, insects and provide a useful resource for further investigations into the mechanism of miRNA-mediated plant–insect interactions. | WANG Ketao SU Xiaomei CUI Xia DU Yongchen ZHANG Shuaibin GAO Jianchang | 2018 | Horticultural Plant Journal2018，4，2： | 6 |
| 3 | Identification of Regulatory DNA Elements Using Genome-wide Mapping of DNase I Hypersensitive Sites during Tomato Fruit Development显示文摘开发并且西红柿水果成熟被 transcriptional 规定精确控制,它取决于规章的蛋白质的安排可接近性到倡导者和另外的 cis 规章的 DNA 元素。基因表示上的这可接近性和它的效果在定义发展进程起一个主要作用。为了理解规章的机制和词法、解剖的功能的元素 modulating,在水果开发期间变化,我们产生了 DNase 的染色体宽的高分辨率的地图我从西红柿栽培变种 “Moneymaker” 的水果纸巾的过分敏感的地点(DHS )在 20 点,天张贴开花期以及裂缝舞台。由越过水果发展阶段探索 DHS 的变化,我们指出了与发展特定的基因有关的最可能的过分敏感的地点。由在维生素酸 biosynthetic 小径在这些发展特定的基因或基因的 DHS 上检测有约束力的主题,我们揭示了贡献协调植物成熟的基因抄写的普通规章的元素并且专业化新陈代谢的小径。我们的结果贡献一更好涉及西红柿水果开发的基因的规章的动力学理解并且成熟。 | Zhengkun Qiu Ren Li Shuaibin Zhang Ketao Wang Meng Xu Jiayang Li Yongchen Du Hong YU Xia Cui | 2016 | Molecular Plant2016，9，8： | 6 |
| 4 | Endothelial cells modified by adenovirus vector containing nine copies hypoxia response elements and human vascular endothelial growth factor as the novel seed cells for bone tissue engineering显示文摘Vascularization 在为骨头织物工程的新治疗学的策略的发展期间是热点之一,它能减轻 hypoxic 情形并且阻止移植失败。脉管的 endothelial 生长因素(VEGF ) 基因 transfection 使用 recombinant 侵入人体气管粘膜的病菌(广告) 向量能有效地支持 angiogenesis,但是 VEGF 的不受管束的长期的连续表示带安全担心。这里,我们构造了包含 HRE 倡导者和 hVEGF165 基因的九个拷贝的 recombinant 广告向量,它保存了组织缺氧可诱导的 factor-1/hypoxia 反应元素(HIF-1/HRE ) 的氧敏感。在进人的脐的静脉 endothelial 房间(HUVEC ) 的 transfection 以后, hVEGF165 mRNA 和蛋白质层次响应组织缺氧是高得多的,作为分别地由 RT-PCR 和 ELISA 揭示了。而且, Ad-9HRE-hVEGF165 向量有效地在 hypoxic 条件下面支持了增长,移植和 HUVEC 的试管形成。因此,我们相信 Ad-9HRE-hVEGF165 向量能贡献 vascularization 的规定,哪个可以在骨头织物工程期间为 hVEGF165 的表达式的更好的控制提供一条新途径(吗?作者 2017。代表生物化学和房间生物学的研究所由牛津大学出版社出版了,为生物科学的上海研究所,中国科学院。版权所有。为权限,请发邮件:journals.permissions@oup.com。) | Xiaobin Song Liang Shi Lamei Chen Xinyu Liu Xun Qu Ketao Wang Fengcai Wei | 2017 | Acta Biochimica et Biophysica Sinica2017，49，11： | 5 |
| 5 | Entanglement in a two-spin (1/2,3/2) mixed-spin Heisenberg XX chain with an inhomogeneous external magnetic field显示文摘By using the concept of negativity, we investigate the thermal entanglement of a two-spin (1/2, 3/2) mixed-spin Heisenberg XX chain with an inhomogeneous external magnetic field. We obtain the analytical results of entanglement of this model. For the case of uniform magnetic field, we find that the critical temperature is higher than the results of the spin-1/2 chain and (1/2,1) mixed-spin chain. And by adjusting the nonuniform parameter b, one is able to obtain more entanglement at a higher temperature. | GUO KeTao LIANG MingChao XU HongYu ZHU ChengBo | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，3： | 4 |
| 6 | Synthesis of layered double hydroxides/graphene oxide nanocomposite as a novel high-temperature CO_2 adsorbent显示文摘In this contribution, a novel high-temperature CO2 adsorbent consisting of Mg-Al layered double hydroxide(LDH) and graphene oxide(GO)nanosheets was prepared and evaluated. The nanocomposite-type adsorbent was synthesized based on the electrostatically driven self-assembly between positively charged Mg-Al LDH single sheet and negatively charged GO monolayer. The characteristics of this novel adsorbent were investigated using XRD, FE-SEM, HRTEM, FT-IR, BET and TGA. The results showed that both the CO2 adsorption capacity and the multicycle stability of LDH were increased with the addition of GO owing to the enhanced particle dispersion and stabilization. In particular, the absolute CO2 capture capacity of LDH was increased by more than twice by adding 6.54 wt% GO as support. GO appeared to be especially effective for supporting LDH sheets. Moreover, the CO2 capture capacity of the adsorbent could be further increased by doping with 15 wt%K2CO3. This work demonstrated a new approach for the preparation of LDH-based hybrid-type adsorbents for CO2 capture. | Junya Wang Xueyi Mei Liang Huang Qianwen Zheng Yaqian Qiao Ketao Zang Shengcheng Mao Ruoyan Yang Zhang Zhang Yanshan Gao Zhanhu Guo Zhanggen Huang Qiang Wang | 2015 | Journal of Energy Chemistry2015，24，2： | 4 |
| 7 | Landscape and Fruit Developmental Regulation of Alternative Splicing in Tomato by Genome-Wide Analysis显示文摘In eukaryotes, alternative splicing(AS) is one of the posttranscriptional regulatory mechanisms that play important roles by generating transcriptome diversity. To obtain a global view of AS and its dynamics during tomato fruit development, we analyzed the AS events using a large amount of transcriptome datasets. Same with other plant species, about half of the expressed multiexonic genes were alternatively spliced in tomato. Besides that, our further analyzation of RNA-seq datasets of ovule and pericarp at early fruit developmental stages reveals that the dynamic alteration of AS events occurred in specific tissues and AS was regulated spatially and temporally during early fruit development in tomato. By investigating the sequence variations at splice sites causing differential AS events between tomato cultivar ‘Moneymaker' and wild species Solanum pimpinellifolium PI365967, we uncover that AS may play the regulatory roles during domestication of tomato. Taken together, our results provided the global AS pattern in tomato and highlighted the importance of AS during tomato fruit development and domestication. | WANG Ketao JIAO Zhicheng XU Meng WANG Yongsheng LI Ren CUI Xia GU Lianfeng ZHANG Shuaibin | 2016 | Horticultural Plant Journal2016，2，6： | 2 |
| 8 | Orchestrated cellular,biochemical,and biomechanical optimizations endow platelet-rich plasma-based engineered cartilage with structural and biomechanical recovery显示文摘Recently,biomaterials for cartilage regeneration has been intensively investigated.However,the development of scaffolds that capture regenerated cartilage with biomechanical and structural recovery has rarely been reported.To address this challenge,platelet-rich plasma(PRP)-based cartilage constructs with a well-orchestrated symphony of cellular,biochemical and biomechanical elements were prepared by simultaneously employing chondrogenic progenitor cells(CPCs)as a cell source,optimizing platelet concentration,and adding an enzyme-ion activator.It was shown that this triple-optimized PRP+CPC construct possessed increased biomechanical properties and suitable biochemical signals.The following in vitro study demonstrated that the triple-optimized PRP+CPC constructs generated cartilage-like tissue with higher expression levels of chondrogenic-specific markers,more deposition of cartilage-specific extracellular matrix(ECM),and greater biomechanical values than those of the other constructs.Twelve weeks after the construct was implanted in a cartilage defect in vivo,histological analysis,qPCR,and biomechanical tests collectively showed that the triple-optimized constructs yielded a more chondrocyte-like cell phenotype with a higher synthesis of Col-Ⅱand aggrecan.More importantly,the triple-optimized constructs facilitated cartilage regeneration with better biomechanical recovery than that of the other constructs.These results demonstrate the efficacy of the triple-optimization strategy and highlight the simplicity and potency of this PRP+CPC construct for cartilage regeneration. | Ketao Wang Ji Li Yuxing Wang Yaqiang Wang Yuanyuan Qin Fei Yang Mingzhu Zhang Heng Zhu Zhongli Li | 2021 | Bioactive Materials2021，6，11： | 2 |
| 9 | Variations in Both FTL1 and SP5G,Two Tomato FT Paralogs,Control Day-Neutral Flowering显示文摘Dear Editor,Selection for flowering time is a major goal of plant breeding efforts to spread cultivars far from their origin.Day-neutral tomato cultivars,which have reduced long-day(LD)and short-day(SD)flowering responses,have spread globally from the center of origin of tomato.Allelic variation of SELF-PRUNING 5G(SP5G),one of FLOWERING LOCUS T (FT) paralogs. | Jia Song Shuaibin Zhang Xiaotian Wang Shuai Sun Zhiqiang Liu Ketao Wang Hongjian Wan Guozhi Zhou Ren Li Hong Yu Xia Cui | 2020 | Molecular Plant2020，13，7： | 2 |
| 10 | Numerical simulation and inversion of offshore area depth based on x-band microwave radar显示文摘A detection method of offshore area depth utilizing the x-band microwave radar is proposed. The method is based on the sea clutter imaging mechanism of microwave radar, and combined with dispersion equation of the liner wave theorem and least square method(LSM), consequently get the inversion results of water depth in the detected region. The wave monitoring system OSMAR-X exploited by the Ocean State Laboratory, Wuhan University, based on a microwave radar has proven to be a powerful tool to monitor ocean waves in time and space. Numerical simulation and inversion of offshore area depth are carried out here; since JONSWAP model can give description of stormy waves in different growth phase, it is suitable for simulation. Besides, some results from measured data detected by OSMAR-X x-band radar located at Longhai of Fujian Province, China, validates this method. The tendency of the average water depths inferred from the radar images is in good agreement with the tide level detected by Xiamen tide station. These promising results suggest the possibility of using OSMAR-X to monitor operationally morphodynamics in coastal zones. This method can be applied to both shore-based and shipborne x-band microwave radar. | WANG Li WU Xiongbin PI Xiaoshan MA Ketao LIU Jianfei TIAN Yun | 2015 | Acta Oceanologica Sinica2015，34，3： | 2 |
| 11 | Effects of saponin on blood pressure in patients with essential hypertension and white coat hypertension显示文摘 | HAN Ketao | 1998 | American Journal of Chinese Medicine1998，26，2： | 1 |
| 12 | Patient derived hurrmn turnout tissue xenografts in immunodeficient mice:a systematic review显示文摘 | In Ketao Teng Lisong Shen Yanping | 2010 | Clini- cal & Translational Ontology2010，12，7： | 1 |
| 13 | Coupling Engine - rotor Dynamic Behavior for Integrated Flight/Propulsion Study 显示文摘 | Ketao Liu J V R Prasad Manoj Mittal | 1995 | AIAA Conference paper1995，8，： | 1 |
| 14 | Heterogeneity between primary colon carcinoma and paired lymphatic andhepatic metastases显示文摘 | Huanrong Lan Ketao Jin Bojian Xie Na Han Binbin Cui Feilin Cao Lisong Teng | 2012 | Molecular Medicine Reports2012，，5： | 1 |
| 15 | Expression of gamma-aminobutyric acid type A receptor α_2 subunit in the dorsal root ganglion of rats with sciatic nerve injury显示文摘The γ-aminobutyric acid neurotransmitter in the spinal cord dorsal horn plays an important role in pain modulation through primary afferent-mediated presynaptic inhibition. The weakening of γ-aminobutyric acid-mediated presynaptic inhibition may be an important cause of neuropathic pain. γ-aminobutyric acid-mediated presynaptic inhibition is related to the current strength of γ-aminobutyric acid A receptor activation. In view of this, the whole-cell patch-clamp technique was used here to record the change in muscimol activated current of dorsal root ganglion neurons in a chronic constriction injury model. Results found that damage in rat dorsal root ganglion neurons following application of muscimol caused concentration-dependent activation of current, and compared with the sham group, its current strength and γ-aminobutyric acid A receptor protein expression decreased. Immunofluorescence revealed that γ-aminobutyric acid type A receptor α2 subunit protein expression decreased and was most obvious at 12 and 15 days after modeling. Our experimental findings confirmed that the γ-aminobutyric acid type A receptor α2 subunit in the chronic constriction injury model rat dorsal root ganglion was downregulated, which may be one of the reasons for the reduction of injury in dorsal root ganglion neurons following muscimol-activated currents. | Yu Lian | 2012 | Neural Regeneration Research2012，7，32： | 1 |
| 16 | Effects of saponin on blood pressure in patients with essential hypertension and white coat hypertension显示文摘 | Han Ketao | 1998 | American Journal of Chinese Medicine1998，26，2： | 1 |
| 17 | Screw-system-variation enabled reconfiguration of the Bennett plano-spherical hybrid linkage and its evolved parallel mechanism显示文摘 | ZHANG Ketao DAI Jian S | 2015 | ASME Journal of Mechanical Design2015，137，6： | 1 |
| 18 | Topology and constraint analysis of phase change in the metamorphic chain and its evolved mechanism显示文摘 | ZHANG Ketao DAI Jiansheng FANG Yuefa | 2010 | ASME Journal of Mechanical Design2010，132，12： | 1 |
| 19 | Constraint analysis and bifurcation motion of the 3PUP parallel mechanism显示文摘 | ZHANG Ketao DAI Jiansheng FANG Yuefa | 2012 | Mechanism and Machine Theory2012，49，： | 1 |
| 20 | Ultrasoundguided vacuum-assisted breast biopsy using Mammotome biopsy system for detection of breast cancer:results from two high volume hospitals显示文摘 | Shaobo Pan Wenguang Liu Ketao Jin | 2014 | Int J Clin Exp Med2014，7，1： | 1 |
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