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| 1 | Deferoxamine promotes recovery of traumatic spinal cord injury by inhibiting ferroptosis显示文摘Ferroptosis is an iron-dependent novel cell death pathway. Deferoxamine, a ferroptosis inhibitor, has been reported to promote spinal cord injury repair. It has yet to be clarified whether ferroptosis inhibition represents the mechanism of action of Deferoxamine on spinal cord injury recovery. A rat model of Deferoxamine at thoracic 10 segment was established using a modified Allen's method. Ninety 8-week-old female Wistar rats were used. Rats in the Deferoxamine group were intraperitoneally injected with 100 mg/kg Deferoxamine 30 minutes before injury. Simultaneously, the Sham and Deferoxamine groups served as controls. Drug administration was conducted for 7 consecutive days. The results were as follows:(1) Electron microscopy revealed shrunken mitochondria in the spinal cord injury group.(2) The Basso, Beattie and Bresnahan locomotor rating score showed that recovery of the hindlimb was remarkably better in the Deferoxamine group than in the spinal cord injury group.(3) The iron concentration was lower in the Deferoxamine group than in the spinal cord injury group after injury.(4) Western blot assay revealed that, compared with the spinal cord injury group, GPX4, xCT, and glutathione expression was markedly increased in the Deferoxamine group.(5) Real-time polymerase chain reaction revealed that, compared with the Deferoxamine group, mRNA levels of ferroptosis-related genes Acyl-CoA synthetase family member 2(ACSF2) and iron-responsive element-binding protein 2(IREB2) were up-regulated in the Deferoxamine group.(6) Deferoxamine increased survival of neurons and inhibited gliosis. These findings confirm that Deferoxamine can repair spinal cord injury by inhibiting ferroptosis. Targeting ferroptosis is therefore a promising therapeutic approach for spinal cord injury. | Xue Yao Yan Zhang Jian Hao Hui-Quan Duan Chen-Xi Zhao Chao Sun Bo Li Bao-You Fan Xu Wang Wen-Xiang Li Xuan-Hao Fu Yong Hu Chang Liu Xiao-Hong Kong Shi-Qing Feng | 2019 | Neural Regeneration Research2019，14，3： | 35 |
| 2 | Liproxstatin-1 is an effective inhibitor of oligodendrocyte ferroptosis induced by inhibition of glutathione peroxidase 4显示文摘Our previous studies showed that ferroptosis plays an important role in the acute and subacute stages of spinal cord injury.High intracellular iron levels and low glutathione levels make oligodendrocytes vulnerable to cell death after central nervous system trauma.In this study,we established an oligodendrocyte(OLN-93 cell line)model of ferroptosis induced by RSL-3,an inhibitor of glutathione peroxidase 4(GPX4).RSL-3 significantly increased intracellular concentrations of reactive oxygen species and malondialdehyde.RSL-3 also inhibited the main antiferroptosis pathway,i.e.,SLC7A11/glutathione/glutathione peroxidase 4(xCT/GSH/GPX4),and downregulated acyl-coenzyme A synthetase long chain family member 4.Furthermore,we evaluated the ability of several compounds to rescue oligodendrocytes from ferroptosis.Liproxstatin-1 was more potent than edaravone or deferoxamine.Liproxstatin-1 not only inhibited mitochondrial lipid peroxidation,but also restored the expression of GSH,GPX4 and ferroptosis suppressor protein 1.These findings suggest that GPX4 inhibition induces ferroptosis in oligodendrocytes,and that liproxstatin-1 is a potent inhibitor of ferroptosis.Therefore,liproxstatin-1 may be a promising drug for the treatment of central nervous system diseases. | Bao-You Fan Yi-Lin Pang Wen-Xiang Li Chen-Xi Zhao Yan Zhang Xu Wang Guang-Zhi Ning Xiao-Hong Kong Chang Liu Xue Yao Shi-Qing Feng | 2021 | Neural Regeneration Research2021，16，3： | 19 |
| 3 | Effects of polyphyllin I on growth inhibition of human non-small lung cancer cells and in xenograft显示文摘Polyphyllin 我(PPI ) ,从巴黎 polyphyllin 的根茎提取的小分子的单体,在以前的学习显示出强壮的 anticancer 效果。人的肺腺癌 A549 房间,人的肺有鳞的房间癌 SK-MES-1 房间,和人的肺大房间癌 H460 房间与 PPI 有教养然后对待。房间增长和 apoptosis 被 3- 测量[4,5-dimethylthiazol-2-yl ]-2,5-diphenyltetrazolium 溴化物试金,流动 cytometry,西方的污点分析,和 DNA 梯子。Athymic 裸体老鼠适用肿瘤与 PPI 被注射,并且肿瘤生长被记录。我们的结果证明 PPI 显著地禁止了房间衬里的三非小的房间肺癌症(NSCLC ) 的增长,与为 A549, H460,和 SK-MES-1 的 1.24, 2.40,和 2.33 g/ml 的禁止的集中(IC50 ) 房间分别地。在为 24 h 与 PPI 的 2.5 g/ml 被对待以后, A549 房间的 apoptotic 率是 39.68% ,它比控制的显著地高。肿瘤生长显著地与在裸体老鼠与 cisplatin (DDP ) 或 PBS 对待的组相比在对待 PPI 的组被禁止。在在 vitro 并且在 vivo 的 NSCLC 房间的 PPI 展览 antitumor 能力,它可能与 apoptosis 有关由 PPI 导致了。 | Minjian Kong Junqiang Fan Aiqiang Dong Haifeng Cheng Rongzhen Xu | 2010 | Acta Biochimica et Biophysica Sinica2010，42，11： | 15 |
| 4 | Reducing the radiation dose with the adaptive statistical iterative reconstruction technique for chest CT in adults: a parameter study显示文摘 | Liu Wenyun Ding Xiaobo Kong Boyu Fan Baoyan Chen Liang | 2014 | Chinese Medical Journal2014，，7： | 15 |
| 5 | Radiofrequency ablation for hepatic hemangiomas: A consensus from a Chinese panel of experts显示文摘Recent studies have shown that radiofrequency(RF) ablation therapy is a safe, feasible, and effective procedure for hepatic hemangiomas, even huge hepatic hemangiomas. RF ablation has the following advantages in the treatment of hepatic hemangiomas: minimal invasiveness, definite efficacy, high safety, fast recovery, relatively simple operation, and wide applicability. It is necessary to formulate a widely accepted consensus among the experts in China who have extensive expertise and experience in the treatment of hepatic hemangiomas using RF ablation, which is important to standardize the application of RF ablation for the management of hepatic hemangiomas, regarding the selection of patients with suitable indications to receive RF ablation treatment, the technical details of the techniques, therapeutic effect evaluations, management of complications, etc. A final consensus by a Chinese panel of experts who have the expertise of using RF ablation to treat hepatic hemangiomas was reached by means of literature review, comprehensive discussion, and draft approval. | Jun Gao Rui-Fang Fan Jia-Yin Yang Yan Cui Jian-Song Ji Kuan-Sheng Ma Xiao-Long Li Long Zhang Chong-Liang Xu Xin-Liang Kong Shan Ke Xue-Mei Ding Shao-Hong Wang Meng-Meng Yang Jin-Jin Song Bo Zhai Chun-Ming Nin Shi-Gang Guo Zong-Hai Xin Jun Lu Yong-Hong Dong Hua-Qiang Zhu Wen-Bing Sun | 2017 | World Journal of Gastroenterology2017，23，39： | 15 |
| 6 | Relationship between intraduodenal peri-ampullary diverticulum and biliary disease in 178 patients undergoing ERCP显示文摘BACKGROUND:The presence of intraduodenal peri-ampullary diverticulum is often observed during upper digestive tract barium meal studies and endoscopic retrograde cholangiopancreatography(ERCP).A few papers in China and overseas reported that the diverticulum had something to do with the incidence of cholelithiasis. This study was undertaken to further test this notion and ascertain the relationship between intraduodenal peri- ampullary diverticulum and biliary disease,especially the formation of bile duct pigment stones. METHODS:A total of 178 patients who had undergone ERCP or endoscopic sphincterotomy(EST)were studied retrospectively.They were divided into 6 groups according to the category of biliary disease,and the incidence rates of intraduodenal peri-ampullary diverticulum were calculated. RESULTS:There were 44 patients with intraduodenal peri- ampullary diverticulum in 81 patients with primary bile duct pigment stones(54.32%),4 in 8 patients with bile duct stones and gallbladder stones(50%),7 in 33 patients with bile duct stones secondary to gallbladder stones(21.21%), 3 in 21 patients with inflammation and stricture of the end of the bile duct and papilla(14.29%),1 in 22 patients with carcinoma of the end of the bile duct and papilla(4.54%), and 5 in 13 patients with post-cholecystectomy syndrome or sphincter of Oddi dysfunction(38.46%). CONCLUSIONS:The incidence rate of intraduodenal peri- ampullary diverticulum in patients with primary bileduct pigment stones is higher than that in patients with bile duct stones secondary to gallbladder stones,patients with inflammation and stricture of the end of the bile duct and papilla,and patients with carcinoma of the end of the bile duct and papilla.These findings indicate that the anatomical abnormalities and malfunction of the sphincter of Oddi play an important role in the formation of bile duct pigment stones. | Wu, Shuo-Dong Su, Yang Fan, Ying Zhang, Zhen-Hai Wang, Hao-Lin Kong, Jing Tian, Yu | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，3： | 14 |
| 7 | HBx activates FasL and mediates HepG2 cell apoptosis through MLK3-MKK7-JNKs signal module显示文摘AIM:To investigate the possible mechanism by which hepatitis B virus X protein(HBx)mediates apoptosis of HepG2 cells.METHODS:HBx expression vector pcDNA3.1-X was transfected into HepG2 cells to establish an HBx highexpression cellular model as pcDNA3.1-X transfected group.The pcDNA3.1-X and pSilencer3.1-shHBX(HBx antagonist)were cotransfected into HepG2 cells to establish an HBx low-expression model as RNAi group.Untransfected HepG2 cells and HepG2 cells transfected with negative control plasmid were used as controls.Apoptosis rate,the expression of Fas/FasL signaling pathway-related proteins and the phosphorylation levels of MLK3,MKK7 and JNKs,which are upstream molecules of death receptor pathways and belong to the family of mitogen-activated protein kinases(MAPKs),were measured in each group.RESULTS:Compared with HepG2 cell group and RNAi group,apoptosis rate,the expression of Fas and FasL proteins,and the activation of MLK3,MKK7 and JNKs were increased in the pcDNA3.1-X transfected group.The activation of JNKs and expression of FasL protein were inhibited in the pcDNA3.1-X transfected group when treated with a known JNK inhibitor,SP600125.When authors treated pcDNA3.1-X transfected group with K252a,a known MLK3 inhibitor,the activation of MLK3,MKK7 and JNKs as well as expression of FasL protein was inhibited.Furthermore,cell apoptosis rate was also significantly declined in the presence of K252a in the pcDNA3.1-X transfected group.CONCLUSION:HBx can induce HepG2 cell apoptosis via a novel active MLK3-MKK7-JNKs signaling module to upregulate FasL protein expression. | Ren-Xian Tang Fan-Yun Kong Bao-Feng Fan Xiao-Mei Liu Hong-Juan You Peng Zhang Kui-Yang Zheng | 2012 | World Journal of Gastroenterology2012，18，13： | 14 |
| 8 | Quantitative trait loci(QTLs)for quality traits related to protein and starch in wheat显示文摘Quality traits in wheat (Triticum aestivum L.) were studied by quantitative trait locus (QTL) analysis in a recombinant inbred line (RIL) population, a set of 131 lines derived from Chuan 35050 × Shannong 483 cross (ChSh). Grains from RILs were assayed for 21 quality traits related to protein and starch. A total of 35 putative QTLs for 19 traits with a single QTL explaining 7.99–40.52% of phe- notypic variations were detected on 10 chromosomes, 1D, 2A, 2D, 3B, 3D, 5A, 6A, 6B, 6D, and 7B. The additive effects of 30 QTLs were positive, contributed by Chuan 35050, the remaining 5 QTLs were negative with the additive effect contributed by Shannong 483. For protein traits, 15 QTLs were obtained and most of them were located on chromosomes 1D, 3B and 6D, while 20 QTLs for starch traits were detected and most of them were located on chromosomes 3D, 6B and 7B. Only 7 QTLs for protein and starch traits were co-located in three regions on chromosomes 1D, 2A and 2D. These protein and starch trait QTLs showed a distinct distribution pattern in certain regions and chromosomes. Twenty-two QTLs were clustered in 6 regions of 5 chromosomes. Two QTL clusters for protein traits were located on chromosomes 1D and 3B, respectively, three clusters for starch traits on chromosomes 3D, 6B and 7B, and one cluster includ- ing protein and starch traits on chromosome 1D. | Haiyan Sun Jianhua Lü Yuding Fan Yan Zhao Fanmei Kong Rijun Li Honggang Wang Sishen Li | 2008 | Progress in Natural Science:Materials International2008，18，7： | 13 |
| 9 | Left atrial appendage morphology in patients with atrial fibrillation in China: implications for stroke risk assessment from a single center study显示文摘 | Kong Bin Liu Yu Hu He Wang Lei Fan Yang Mei Yang Liu Wanli Liao Jiafen Liu Dan Xing Dong Huang He | 2014 | Chinese Medical Journal2014，，24： | 12 |
| 10 | Olfactory ecto-mesenchymal stem cell-derived exosomes ameliorate murine Sjögren’s syndrome by modulating the function of myeloid-derived suppressor cells显示文摘Sjögren’s syndrome(SS)is a systemic autoimmune disease characterized by progressive inflammation and tissue damage in salivary glands and lacrimal glands.Our previous studies showed that myeloid-derived suppressor cells(MDSCs)exhibited impaired immunosuppressive function during disease progression in patients with SS and mice with experimental Sjögren’s syndrome(ESS),but it remains unclear whether restoring the function of MDSCs can effectively ameliorate the development of ESS.In this study,we found that murine olfactory ecto-mesenchymal stem cell-derived exosomes(OE-MSC-Exos)significantly enhanced the suppressive function of MDSCs by upregulating arginase expression and increasing ROS and NO levels.Moreover,treatment with OE-MSC-Exos via intravenous injection markedly attenuated disease progression and restored MDSC function in ESS mice.Mechanistically,OE-MSC-Exo-secreted IL-6 activated the Jak2/Stat3 pathway in MDSCs.In addition,the abundant S100A4 in OE-MSC-Exos acted as a key factor in mediating the endogenous production of IL-6 by MDSCs via TLR4 signaling,indicating an autocrine pathway of MDSC functional modulation by IL-6.Taken together,our results demonstrated that OE-MSC-Exos possess therapeutic potential to attenuate ESS progression by enhancing the immunosuppressive function of MDSCs,possibly constituting a new strategy for the treatment of Sjögren’s syndrome and other autoimmune diseases. | Ke Rui Yue Hong Qiugang Zhu Xiaofei Shi Fan Xiao Hailong Fu Qing Yin Yida Xing Xinfeng Wu Xiaodan Kong Huaxi Xu Jie Tian Shengjun Wang Liwei Lu | 2021 | Cellular & Molecular Immunology2021，18，2： | 12 |
| 11 | Meningeal lymphatic vessels regulate brain tumor drainage and immunity显示文摘Recent studies have shown that meningeal lymphatic vessels(MLVs),which are located both dorsally and basally beneath the skull,provide a route for draining macromolecules and trafficking immune cells from the central nervous system(CNS)into cervical lymph nodes(CLNs),and thus represent a potential therapeutic target for treating neurodegenerative and neuroinflammatory diseases.However,the roles of MLVs in brain tumor drainage and immunity remain unexplored.Here we show that dorsal MLVs undergo extensive remodeling in mice with intracranial gliomas or metastatic melanomas.RNA-seq analysis of MLV endothelial cells revealed changes in the gene sets involved in lymphatic remodeling,fluid drainage,as well as inflammatory and immunological responses.Disruption of dorsal MLVs alone impaired intratumor fluid drainage and the dissemination of brain tumor cells to deep CLNs(dCLNs).Notably,the dendritic cell(DC)trafficking from intracranial tumor tissues to dCLNs decreased in mice with defective dorsal MLVs,and increased in mice with enhanced dorsal meningeal lymphangiogenesis.Strikingly,disruption of dorsal MLVs alone,without affecting basal MLVs or nasal LVs,significantly reduced the efficacy of combined anti-PD-1/CTLA-4 checkpoint therapy in striatal tumor models.Furthermore,mice bearing tumors overexpressing VEGF-C displayed a better response to anti-PD-1/CTLA-4 combination therapy,and this was abolished by CCL21/CCR7 blockade,suggesting that VEGF-C potentiates checkpoint therapy via the CCL21/CCR7 pathway.Together,the results of our study not only demonstrate the functional aspects of MLVs as classic lymphatic vasculature,but also highlight that they are essential in generating an efficient immune response against brain tumors. | Xueting Hu Qiuping Deng Lu Ma Qingqing Li Yidong Chen Yuhan Liao Fan Zhou Chen Zhang Linlin Shao Jun Feng Tubao He Weihai Ning Yan Kong Yingqing Huo Aibin He Bing Liu Jingjing Zhang Ralf Adams Yulong He Fuchou Tang Xiuwu Bian Jincai Luo | 2020 | Cell Research2020，30，3： | 11 |
| 12 | Monodisperse core-shell structured magnetic mesoporous aluminosilicate nanospheres with large dendritic mesochannels显示文摘合理设计和有一个定制的活跃核心和大、树枝状的、修改 mesoporous 的多功能的混合 nanostructures 的精确合成组织了壳能支持催化作用,精力存储,和生物应用。这里,油水双相层化涂层策略被开发了准备 monodisperse 磁性的树枝状的 mesoporous 硅石核心壳结构化的 nanospheres。这些复杂 Fe 3 O 4@SiO2@dendritic-mSiO2 nanospheres 特征大树枝状的开的毛孔(2.7 和 10.3 nm ) 。显著地,硅石壳能与未改变的孔, 14 的 Si/Al 臼齿的比率,和显著地强壮的酸的地点被变换成树枝状的 mesoporous 铝矽酸盐框架,通过一条合成以后的途径。另外,结果的磁性的树枝状的 mesoporous 铝矽酸盐 nanospheres 展览在从废水的磷酸盐移动的突出的性质和有希望的申请。 | Jianping Yang Dengke Shen Yong Wei Wei Li Fan Zhang Biao Kong Shaohua Zhang Wei Teng Jianwei Fan Weixian Zhang Shixue Dou Dongyuan Zhao | 2015 | Nano Research2015，8，8： | 11 |
| 13 | Siwu decoction attenuates oxonate-induced hyperuricemia and kidney inflammation in mice显示文摘The aim of the study was to investigate the effects of Siwu decoction on hyperuricemia, kidney inflammation, and dysfunction in hyperuricemic mice. Siwu decoction at 363.8, 727.5, and 1 455 mg·kg^(–1) was orally administered to potassium oxonate-induced hyperuricemic mice for 7 days. Serum urate, creatinine, and blood urea nitrogen levels and hepatic xanthine oxidase(XOD) activity were measured. The protein levels of hepatic XOD and renal urate transporter 1(URAT1), glucose transporter 9(GLUT9), organic anion transporters 1(OAT1), ATP-binding cassette subfamily G member 2(ABCG2), organic cation transporter 1(OCT1), OCT2, organic cation/carnitine transporter 1(OCTN1), OCNT2, Nod-like receptor family, pyrin domain containing 3(NLRP3), apoptosis-associated speck-like protein(ASC), Caspase-1, and interleukin-1β(IL-1β) were determined by Western blotting. Renal histopathology change was obtained following hematoxylin-eosin staining. Our results indicated that Siwu decoction significantly reduced serum urate, creatinine and blood urea nitrogen levels and increased fractional excretion of uric acid in hyperuricemic mice. It effectively reduced hepatic XOD activity and protein levels in this animal model. Furthermore, Siwu decoction down-regulated URAT1 and GLUT9 protein levels, and up-regulated the protein levels of OAT1, ABCG2, OCT1, OCT2, OCTN1, and OCTN2 in the kidney of the hyperuricemic mice. Additionally, Siwu decoction remarkably reduced renal protein levels of NLRP3, ASC, Caspase-1, and IL-1β in the hyperuricemic mice. These results suggested that Siwu decoction exhibited anti-hyperuricemic and anti-inflammatory effects by inhibiting hepatic XOD activity, regulating renal organic ion transporter expression, and suppressing renal NLRP3 inflammasome activation, providing the evidence for its use in the treatment of hyperuricemia and associated kidney inflammation. | WANG Rong MA Chun-Hua ZHOU Fan KONG Ling-Dong | 2016 | Chinese Journal of Natural Medicines2016，14，7： | 11 |
| 14 | Effect of Shen-Fu Injection(参附注射液)on Hemodynamics in Early Volume Resuscitation Treated Septic Shock Patients显示文摘Objective: To investigate the hemodynamic effect of Shen-Fu Injection(参附注射液, SFI) in early volume resuscitation treated septic shock patients by monitoring pulse indicator continuous cardiac output(PICCO). Methods: All septic shock patients admitted in the Intensive Care Unit of the Affiliated Hospital of Shandong University of Traditional Chinese Medicine from January 1 st, 2014 to December 31 th, 2015, were reviewed, and totally 65 were enrolled in this study. They were assigned to SFI group(33 cases) and control group(32 cases). All 65 patients underwent conventional treatment mainly including volume resuscitation, antibiotics and vasoactive drugs therapy. The patients of the SFI group received additional 100 mL of SFI intravenously every 12 h. In all 65 patients, the PICCO arterial catheter and vein catheter were implanted within 1 h after the diagnosis of septic shock. In the course of early volume resuscitation, hemodynamic data of patients were recorded by PICCO monitor at 0, 12, and 24 h after the catheter implantation. Results: The hemodynamic indices of the two groups showed no significant differences at the beginning of 0 h(P>0.05). At 12 and 24 h, the hemodynamic indices of SFI group were significantly improved in comparison with the control group(P<0.05), including cardiac index(CI), global end diastolic volume index(GEDI), mean arterial pressure(MAP) and heart rate(HR). In addition, there was no significant change of extra-vascular lung water index between the two groups(P>0.05). Conclusion: SFI significantly improved hemodynamic indices such as CI, GEDI, MAP and HR in early volume resuscitation treated septic shock patients. | FAN Kai-liang WANG Jun-hui KONG Li ZHANG Fei-hu HAO Hao ZHAO Hao TIAN Zheng-yun YIN Ming-xin FANG Hua YANG Hui-hui LIU Yang | 2019 | Chinese Journal of Integrative Medicine2019，25，1： | 10 |
| 15 | Suppression of Type 1 Insulin-like Growth Factor Receptor Expression by Small Interfering RNA Inhibits A549 Human Lung Cancer Cell Invasion in vitro and Metastasis in Xenograft Nude Mice显示文摘癌症侵略和转移,包含许多病理学的过程和 cytophysiological 变化,贡献肺癌症的高死亡。类型 1insulin-like 生长因素受体(IGF-1R ) ,把前进和侵略与癌症联系了,是在肺癌症的一个潜在的反侵略和反转移目标。禁止肺癌症房间的侵略性质,我们在由小介入 RNA ( siRNA )技术的 A549 人的肺癌症房间的成功地下面调整的 IGF-1R 基因表达,并且评估了它的效果oninvasion相关的基因表达,在 vitro 侵略的肿瘤房间,并且在有为 IGF-1R 表示发卡 siRNA 的一个原生质标志的异种皮移植 nudemice.A549 房间 transfected 的转移在 mRNA 水平以及蛋白质 level.Inbiological 试金显示出一个显著地减少的 IGF-1R 表达式, transfected A549 房间显示出 cell-matrixadhesion ,移植和侵略的重要减小。与这些结果一致,我们发现那条下面规定大减小附随地在侵略相关的基因表达伴随的 ofIGR-1R , includingMMP-2 , MMP-9 , u-PA ,并且为 IGF-1R 的 plasmidexpressing 发卡 siRNA 的 IGF-1R 特定的下游的 p-Akt.Direct 尾巴静脉注射显著地在结果显示出的 nudemice.Our 禁止了肺转移的形成是的 siRNA 的治疗学的潜力为在禁止肺癌症侵略和转移的基因治疗的一个方法。 | Jianfang QIAN~1 Aiqiang DONG~1 Minjian KONG~1 Zhiyuan MA~2 Junqiang FAN~1 and Guanyu JIANG~3 ~1Department of Cardiothoracic Surgery,Second Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou 310009,China ~2Department of Cardiovascular Surgery,Shanghai Jiaotong University Affiliated First People’s Hospital,Shanghai 200080,China ~3Department of Emergency,Second Affiliated Hospital School of Medicine,Zhejiang University,Hangzhou 310009,China | 2007 | Acta Biochimica et Biophysica Sinica2007，39，2： | 9 |
| 16 | Neuroprotective effect of deferoxamine on erastin-induced ferroptosis in primary cortical neurons显示文摘The iron chelator deferoxamine has been shown to inhibit ferroptosis in spinal cord injury.However,it is unclear whether deferoxamine directly protects neurons from ferroptotic cell death.By comparing the survival rate and morphology of primary neurons and SH-SY5Y cells exposed to erastin,it was found that these cell types respond differentially to the duration and concentration of erastin treatment.Therefore,we studied the mechanisms of ferroptosis using primary cortical neurons from E16 mouse embryos.After treatment with 50μM erastin for 48 hours,reactive oxygen species levels increased,and the expression of the cystine/glutamate antiporter system light chain and glutathione peroxidase 4 decreased.Pretreatment with deferoxamine for 12 hours inhibited these changes,reduced cell death,and ameliorated cellular morphology.Pretreatment with the apoptosis inhibitor Z-DEVD-FMK or the necroptosis inhibitor necrostain-1 for 12 hours did not protect against erastin-induced ferroptosis.Only deferoxamine protected the primary cortical neurons from ferroptosis induced by erastin,confirming the specificity of the in vitro ferroptosis model.This study was approved by the Animal Ethics Committee at the Institute of Radiation Medicine of the Chinese Academy of Medical Sciences,China(approval No.DWLL-20180913)on September 13,2018. | Yan Zhang Bao-You Fan Yi-Lin Pang Wen-Yuan Shen Xu Wang Chen-Xi Zhao Wen-Xiang Li Chang Liu Xiao-Hong Kong Guang-Zhi Ning Shi-Qing Feng Xue Yao | 2020 | Neural Regeneration Research2020，15，8： | 9 |
| 17 | Design and Dynamic Model of a Frog-inspired Swimming Robot Powered by Pneumatic Muscles显示文摘Pneumatic muscles with similar characteristics to biological muscles have been widely used in robots,and thus are promising drivers for frog inspired robots.However,the application and nonlinearity of the pneumatic system limit the advance.On the basis of the swimming mechanism of the frog,a frog-inspired robot based on pneumatic muscles is developed.To realize the independent tasks by the robot,a pneumatic system with internal chambers,micro air pump,and valves is implemented.The micro pump is used to maintain the pressure difference between the source and exhaust chambers.The pneumatic muscles are controlled by high-speed switch valves which can reduce the robot cost,volume,and mass.A dynamic model of the pneumatic system is established for the simulation to estimate the system,including the chamber,muscle,and pneumatic circuit models.The robot design is verified by the robot swimming experiments and the dynamic model is verified through the experiments and simulations of the pneumatic system.The simulation results are compared to analyze the functions of the source pressure,internal volume of the muscle,and circuit flow rate which is proved the main factor that limits the response of muscle pressure.The proposed research provides the application of the pneumatic muscles in the frog inspired robot and the pneumatic model to study muscle controller. | Ji-Zhuang Fan Wei Zhang Peng-Cheng Kong He-Gao Cai Gang-Feng Liu | 2017 | Chinese Journal of Mechanical Engineering2017，30，5： | 8 |
| 18 | A Novel Surgery Classification for Endoscopic Approaches to Middle Ear Cholesteatoma显示文摘This study aimed to develop a novel surgery classification for an endoscopic approach to middle ear cholesteatoma.We retrospectively analyzed the surgical approaches and outcomes of patients with middle ear cholesteatoma.Middle ear cholesteatoma surgeries were divided into four types and two special types as follows:type I,attic retraction pocket,which only requires tympanostomy tube placement or retraction pocket resection and cartilage reconstruction;typeⅡ,cholesteatoma which is limited to the attic or in which endoscopy can confirm complete removal of mastoid cholesteatoma lesions,including type Ⅱa,requiring only use of a curette,and type Ⅱ b,requiring use of an electric drill or chisel;type Ⅲ,cholesteatoma not limited to the attic,in which endoscopy cannot confirm complete removal of mastoid cholesteatoma lesions,requiring the combined use of endoscope and microscope to perform endoscopic tympanoplasty and'Canal Wall Up'mastoidectomy;type Ⅳ,extensive involvement of mastoid cavity cholesteatoma lesions and/or cases with a potential risk of complications,removal of which can only be performed under a microscope for'Canal Wall Down'mastoidectomy.In addition,there were two special types:'difficult external auditory canal'and congenital cholesteatoma in children.In our system,type I and type U middle ear cholesteatoma surgery was completely performed under an endoscope alone.However,estimating the extent of the lesions,determining the choice of mastoid opening and reestablishing ventilation are the key points for an endoscopic approach to middle ear cholesteatoma.The classification of endoscopic middle ear cholesteatoma surgery may benefit the selection of surgical indications. | Yu SUN En-hao WANG Jin-tao YU Gang ZHONG Li-xin ZHU-Yi WANG Niu XUN Hong YU Wen ZHOU Zhen XIE Kun ZHANG Guo-run FAN Yi ZHONG Hong-jun XIAO Wei-jia KONG | 2020 | Current Medical Science2020，40，1： | 8 |
| 19 | Strategies to anode protection in lithium metal battery:A review显示文摘Lithium metal batteries(LMBs)are considered the most promising energy stor-age devices for applications such as electrical vehicles owing to its tremendous theoretical capacity(3860 mAh g−1).However,the serious safety issues and poor cycling performance caused by the dendritic crystal growth during deposi-tion are concerned for any rechargeable batteries with a lithium metal anode.To make widespread adoption a possibility,considerable efforts have been devoted to suppressing lithium(Li)dendrite growth.In this review,the recent strategies to developing dendrite free Li anode,including constructing an artifi-cial solid electrolyte interface,current collector modification,separator film improvement,and electrolyte additive,are summarized.The merits and short-comings for different strategies are reviewed and a general summary and per-spective on the next generation rechargeable batteries are presented. | Jiawei Li Zhao Kong Xiaoxi Liu Bocong Zheng Qi Hua Fan Elias Garratt Thomas Schuelke Keliang Wang Hui Xu Hong Jin | 2021 | InfoMat2021，3，12： | 8 |
| 20 | Convergent genomic signatures of high-altitude adaptation among domestic mammals显示文摘Abundant and diverse domestic mammals living on the Tibetan Plateau provide useful materials for investigating adaptive evolution and genetic convergence.Here,we used 327 genomes from horses,sheep,goats,cattle,pigs and dogs living at both high and low altitudes,including 73 genomes generated for this study,to disentangle the genetic mechanisms underlying local adaptation of domestic mammals.Although molecular convergence is comparatively rare at the DNA sequence level,we found convergent signature of positive selection at the gene level,particularly the EPAS1 gene in these Tibetan domestic mammals.We also reported a potential function in response to hypoxia for the gene C10 orf67,which underwent positive selection in three of the domestic mammals.Our data provide an insight into adaptive evolution of high-altitude domestic mammals,and should facilitate the search for additional novel genes involved in the hypoxia response pathway. | Dong-Dong Wu Cui-Ping Yang Ming-Shan Wang Kun-Zhe Dong Da-Wei Yan Zi-Qian Hao Song-Qing Fan Shu-Zhou Chu Qiu-Shuo Shen Li-Ping Jiang Yan Li Lin Zeng He-Qun Liu Hai-Bing Xie Yun-Fei Ma Xiao-Yan Kong Shu-Li Yang Xin-Xing Dong Ali Esmailizadeh David M Irwin Xiao Xiao Ming Li Yang Dong Wen Wang Peng Shi Hai-Peng Li Yue-Hui Ma Xiao Gou Yong-Bin Chen Ya-Ping Zhang | 2020 | National Science Review2020，7，6： | 7 |
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