|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Berberine protects rat heart from ischemia/ reperfusion injury via activating JAK2/STAT3 signaling and attenuating endoplasmic reticulum stress显示文摘目的: Berberine (BBR ) ,从根茎 coptidis 孤立的导出 isoquinoline 的碱,施加 cardioprotective 效果。因为 endoplasmic 蜂窝胃(嗯)应力在导致的心肌的 ischemia/reperfusion ( MI/R )起一个枢轴的作用 apoptosis ,检验 BBR 的保护的效果是否源于 modulating 有趣嗯在 MI/R 损害期间强调层次,并且在这 process.Methods 定义发信号的机制:雄的老鼠与 BBR 被对待( 200 mg· ; kg −1·d−1, ig )为 2 个星期,然后使外科遭到了到 MI/R 。心脏的尺寸和功能用 echocardiography 被估计。心肌的梗塞尺寸和 apoptosis 被检验。在心织物的全部的浆液 LDH 层次和 CK 活动, superoxide 生产, MDA 层次和抗氧化剂草皮活动是坚定的。一在里面 vitro 学习在胚胎的导出心肌层的房间 H9C2 暴露了到模仿的 ischemia/reperfusion (先生) 的有教养的老鼠上被执行。apoptotic 的表达式,嗯压力相关、发信号的蛋白质用西方的污点 analyses.Results 被估计: 有 BBR 的预告的处理显著地减少了 MI/R-induced 心肌的梗塞尺寸,改进心脏的函数,和压制的心肌的 apoptosis 和氧化损坏。而且,有 BBR 的预告的处理压制了 MI/R-induced 嗯应力,证实了由下面调整心肌的津贴和 eIF2α 的 phosphorylation 层次;并且在心纸巾的 ATF4 和砍的表示。有 BBR 的预告的处理也激活与 AG490 在心纸巾,和合作处理表明小径的 JAK2/STAT3,一个特定的 JAK2/STAT3 禁止者,在 MI/R-induced 上堵住了 BBR 的 BBR,而且抑制的不仅保护的效果嗯应力。在 H9C2 房间,有 BBR 的处理(50 μ mol/L ) 显著地减少的导致先生的房间 apoptosis,氧化应力并且嗯应力,被 transfection 与 JAK2 siRNA.Conclusion 废除, BBR 改善在由激活表明小径和 attenuating 的 AK2/STAT3 的老鼠的 MI/R 损害嗯导致压力的 apoptosis。 | Guo-long ZHAO Li-ming YU Wen-li GAO Wei-xun DUAN Bo JIANG Xu-dong LIU Bin ZHANG Zhen-hua LIU Meng-en ZHAI Zhen-xiao JIN Shi-qiang YU Yun WANG | 2016 | Acta Pharmacologica Sinica2016，37，3： | 47 |
| 2 | Reduced expression of E-cadherin/catenin complex in hepatocellular carcinomas显示文摘AIM: To examine the immunoreactivity of E-cadherin and four subtypes of catenin family in human hepatocellular carcinomas (HCCs) and to investigate the correlation between expression of E-cadherin/ catenin complex and clinicopathologic parameters of HCC patients. METHODS: An immunohistochemical study for E-cadherin and catenins was performed on 97 formalin-fixed, paraffin-embedded specimens of HCC. RESULTS: Reduced expression of E-cadherin, α-, β-, γ-catenin and p120 was observed in 69%, 76%, 63%, 71% and 73%, respectively. Both expressions of E-cadherin and catenin components were significantly correlated with tumor grade (P = 0.000). It showed significant difference between expression of catenin members and tumor stage (P = 0.003, P = 0.017, P = 0.007 and P = 0.000, respectively). The reduced expression of E-cadherin in HCCs was significantly correlated with intrahepatic metastasis (IM) and capsular invasion (P = 0.008, P = 0.03, respectively). A close correlation was also observed between the expression of catenins and the tumor size (P = 0.002, P = 0.034, P = 0.016 and P = 0.000, respectively). In addition, the expression of each catenin was found correlated with IM (P = 0.012, P = 0.049, P =0.026 and P = 0.014, respectively). No statistically significant difference was observed between the expression level of E-cadherin/catenin complex and lymph node permission, vascular invasion and satellite nodules. Interestingly, only expression of p120 showed correlation with AFP value (P = 0.035). The expression of E-cadherin was consistent with α-, β-, γ-catenin and p120 expression (P = 0.000). Finally, the abnormal expression of E-cadherin/catenin complex was significantly associated with patients' survival (P = 0.0253, P = 0.0052, P = 0.003, P = 0.0105 and P = 0.0016, respectively). Nevertheless, no component of E-cadherin/catenin complex was the independent prognostic factor of HCC patients. CONCLUSION: Down-regulated expressions of E-cadherin, catenins and p120 occur frequently in HCCs and contribute to the progression and development of tumor. It may be more exact and valuable to detect the co-expression of E-cadherin/catenin complex than to explore one of them in predicting tumor invasion, metastasis and patient's survival. | Bo Zhai He-Xin Yan Shu-Qin Liu Lei Chen Meng-Chao Wu Hong-Yang Wang | 2008 | World Journal of Gastroenterology2008，14，37： | 33 |
| 3 | Predictive factors improving survival after gastric and hepatic surgical treatment in gastric cancer patients with synchronous liver metastases显示文摘背景为有胃的癌症和同步的肝转移的病人的预后是很 poor.However ,标准治疗学的策略一直不是在为从胃的癌症遗体 controversial.Methods 的肝转移的肝的外科的治疗以后的临床的利益和预示的因素不管肝的外科的治疗经历了 gastrectomy 的 105 个病人记录的井 established.The 因为有在我们在 1995 和 2010 之间的中心的同步肝唯一的转移的胃的癌症 P 0.001 ) .However ,肝的外科的治疗不是为经历了 D1 lymphadenectomy 的病人的一个预示的因素(中部的幸存, 8 个 vs.8 月; P=0.495 ) .For 加肝的外科的治疗经历了 gastrectomy 的 35 个病人, D2 lymphadenectomy ( P 0.001 ),淋巴节点转移( P=-0.015 ),并且肝转移( H1 vs.H2 和 H3 )( P=-0.017 )的程度是独立重要预示的因素因为加肝的外科的治疗的 survival.Conclusions D2 lymphadenectomy 可以为 long-te | Liu Jing Li Jing-hui Zhai Ru-jun Wei Bo Shao Ming-zhe Chen Lin | 2012 | Chinese Medical Journal2012，，2： | 27 |
| 4 | Mechanisms of resistance to sorafenib and the corresponding strategies in hepatocellular carcinoma显示文摘Sorafenib, the unique drug as first-line treatment for advanced hepatocellular carcinoma (HCC), has opened a window of hope after searching for effective agents to combat HCC for decades. However, the overall outcomes are far from satisfactory. One of the explanations is the genetic heterogeneity of HCC, which has led to identifying predictive biomarkers for primary resistance to sorafenib, and then applying the concept of personalized medicine, or seeking therapeutic strategies such as combining sorafenib with other anticancer agents. Some of the combinations have demonstrated a better effectiveness than sorafenib alone, with good tolerance. The acquired resistance to sorafenib has also drawn attention. As a multikinase inhibitor, sorafenib targets several cellular signaling pathways but simultaneously or sequentially the addiction switches and compensatory pathways are activated. Several mechanisms are involved in the acquired resistance to sorafenib, such as crosstalks involving PI3K/Akt and JAK-STAT pathways, hypoxia-inducible pathways, epithelial-mesenchymal transition, etc . Based on the investigated mechanisms,some other molecular targeted drugs have been applied as second-line treatment for treat HCC after the failure of sorafenib therapy and more are under evaluation in clinical trials. However, the exact mechanisms accounting for sorafenib resistance remains unclear. Further investigation on the crosstalk and relationship of associated pathways will better our understanding of the mechanisms and help to find effective strategies for overcoming sorafenib resistance in HCC. | Bo Zhai Xue-Ying Sun | 2013 | World Journal of Hepatology2013，5，7： | 24 |
| 5 | Expansion and differentiation of human hepatocyte-derived liver progenitor-like cells and their use for the study of hepatotropic pathogens显示文摘The study of pathophysiological mecha nisms in huma n liver disease has bee n constrained by the in ability to expa nd primary hepatocytes in vitro while maintaining proliferative capacity and metabolic function. We and others have previously shown that mouse mature hepatocytes can be con verted to liver progenitor-like cells in vitro with defined chemical factors. Here we describe a protocol achieving efficient conversion of human primary hepatocytes into liver progenitor-like cells (HepLPCs) through delivery of developmentally relevant cues, including NAD +-dependent deacetylase SIRT1 signaling. These HepLPCs could be expanded sign ifica ntly duri ng in vitro passage. The expa nded cells can readily be con verted back into metabolically functional hepatocytes in vitro and upon tran splantati on in vivo. Under three-dime nsional culture conditions, differentiated cells gen erated from HepLPCs regai ned the ability to support infect io n or reactivatio n of hepatitis B virus (HBV). Our work dem on strates the utility of the con versi on betwee n hepatocyte and liver proge nitor-like cells for studying HBV biology and an tiviral therapies. These fin dings will facilitate the study of liver diseases and regenerative medicine. | Gong-Bo Fu Wei-Jian Huang Min Zeng Xu Zhou Hong-Ping Wu Chang-Cheng Liu Han Wu Jun Weng Hong-Dan Zhang Yong-Chao Cai Charles Ashton Min Ding Dan Tang Bao-Hua Zhang Yi Gao Wei-Feng Yu Bo Zhai Zhi-Ying He Hong-Yang Wang He-Xin Yan | 2019 | Cell Research2019，29，1： | 18 |
| 6 | Magnetic resonance imaging for local complications of acute pancreatitis: A pictorial review显示文摘Acute pancreatitis is a common disease characterized by sudden upper abdominal pain and vomiting. Alcoholism and choledocholithiasis are the most common factors for this disease. The choice of treatment for acute pancreatitis might be affected by local complications, such as local hemorrhage in or around the pancreas, and peripancreatic infection or pseudoaneurysm. Diagnostic imaging modalities for acute pancreatitis have a significant role in confirming the diagnosis of the disease, helping detect the extent of pancreatic necrosis, and for diagnosing local complications. Magnetic resonance imaging (MRI) might be indicated in acute pancreatitis for detecting and characterizing local complications of acute pancreatitis that involve necrotic, hemorrhagic, infectious, vascular, and pseudocyst disorders. The general MRI sequences for pancreatitis require the combined use of T1-weighted, T2-weighted sequences, and magnetic resonance chol-angiopancreatography. For imaging of pancreatic necrosis, the combination of T1-weighted and T2-weighted findings with dynamic contrast-enhanced imaging gives a comprehensive evaluation of the extent of necrosis and full range of inflammatory extension. For imaging of infectious complications, dynamic contrast-enhanced examinations might help differentiate pancreatic cellulitis or abscesses, from pancreatic fluid collection or simple pseudocysts. For vascular abnormalities, the combination of cross-sectional pancreatic parenchyma imaging with MRA represents a single diagnostic modality for the full evaluation of peripancreatic artery and vein involvement, such as arterial pseudoaneurysms and venous thromboses. The purpose of this pictorial review is to examine the MRI appearances of various local complications of acute pancreatitis and to discuss the practical setup of MRI in local complications of acute pancreatitis. | Xiao, Bo Zhang, Xiao-Ming Tang, Wei Zeng, Nan-Lin Zhai, Zhao-Hua | 2010 | World Journal of Gastroenterology2010，16，22： | 17 |
| 7 | Radiofrequency ablation for hepatic hemangiomas: A consensus from a Chinese panel of experts显示文摘Recent studies have shown that radiofrequency(RF) ablation therapy is a safe, feasible, and effective procedure for hepatic hemangiomas, even huge hepatic hemangiomas. RF ablation has the following advantages in the treatment of hepatic hemangiomas: minimal invasiveness, definite efficacy, high safety, fast recovery, relatively simple operation, and wide applicability. It is necessary to formulate a widely accepted consensus among the experts in China who have extensive expertise and experience in the treatment of hepatic hemangiomas using RF ablation, which is important to standardize the application of RF ablation for the management of hepatic hemangiomas, regarding the selection of patients with suitable indications to receive RF ablation treatment, the technical details of the techniques, therapeutic effect evaluations, management of complications, etc. A final consensus by a Chinese panel of experts who have the expertise of using RF ablation to treat hepatic hemangiomas was reached by means of literature review, comprehensive discussion, and draft approval. | Jun Gao Rui-Fang Fan Jia-Yin Yang Yan Cui Jian-Song Ji Kuan-Sheng Ma Xiao-Long Li Long Zhang Chong-Liang Xu Xin-Liang Kong Shan Ke Xue-Mei Ding Shao-Hong Wang Meng-Meng Yang Jin-Jin Song Bo Zhai Chun-Ming Nin Shi-Gang Guo Zong-Hai Xin Jun Lu Yong-Hong Dong Hua-Qiang Zhu Wen-Bing Sun | 2017 | World Journal of Gastroenterology2017，23，39： | 15 |
| 8 | Evaluation and analysis of intraspecific competition in maize: A case study on plant density experiment显示文摘Intraspecific competition is a common phenomenon in agricultural production,and maize is one of the most sensitive grass species to intraspecific competition due to its low tillering ability.This study evaluated and analyzed intraspecific competition in maize,and screened competitive indices that could be used to evaluate intraspecific competition in a maize population.A 2-year field experiment was conducted using the maize hybrid Zhongdan 2 at 12 plant densities ranging from 1.5 to 18.0 plants(pl)m^(–2).The results showed that the response of single-plant grain yield and dry matter at harvest to increased plant density decreased exponentially and that the harvest index decreased linearly.The response of population-level grain yield to plant density was curvilinear,producing a maximum value at the optimum population density.However,the yielddensity equation agreed well with the Steinhart-Hart equation curves,but not with the quadratic equation curves reported by most previous studies.Competitive indices are used to evaluate competition in a plant population or plant species.The present results show that competitive intensity(CI)and absolute severity of competition(ASC)increased with increasing plant density;however,relative yield(RY)and relative reproductive efficiency(RR_(eff))decreased.The different responses of these indices reflect different aspects of competition.According to the analysis of CI,ASC,RY,and RR_(eff),higher CI and ASC values indicate higher intraspecific competition,whereas higher RY and RR_(eff) values indirectly reflect lower intraspecific competition.These competitive indices evaluate not only the intraspecific competitive intensity under different plant densities of the same cultivar but also those of different cultivars under the same plant density.However,some overlap exists in the calculations of ASC,CI,and RY,so one could simply select any one of these indices to evaluate intraspecific competition in a maize population.In conclusion,the present study provides a method to evaluate intraspecific competition in maize populations,which may be beneficial for breeding high-yield maize varieties in the future. | ZHAI Li-chao XIE Rui-zhi MING Bo LI Shao-kun MA Da-ling | 2018 | Journal of Integrative Agriculture2018，17，10： | 10 |
| 9 | Controversy over the use of intraoperative blood salvage autotransfusion during liver transplantation for hepatocellular carcinoma patients显示文摘Intraoperative blood salvage autotransfusion (IBSA) is used in various surgical procedures. However, because of the risk of reinfusion of salvaged blood contaminated by tumor cells, the use of IBSA in hepatocellular carcinoma (HCC) patients undergoing liver transplantation (LT) is controversial. The critical points include whether tumor cells can be cleared by IBSA, whether IBSA increases the risk of recurrence or metastasis, and what are the indications for IBSA. Moreover, is it warranted to take the risk of tumor dissemination by using IBSA to avoid allogeneic blood transfusion? Do the remaining tumor cells after additional filtration by leukocyte depletion filters still possess potential tumorigenicity? Does IBSA always work well? We have reviewed the literature and tried to address these questions. The available data indicate that IBSA is safe in LT for HCC, but randomized, controlled and prospective trials are urgently required to clarify the uncertainty. | Bo Zhai Xue-Ying Sun | 2013 | World Journal of Gastroenterology2013，19，22： | 9 |
| 10 | Reduced expression of P120 catenin in cholangiocarcinoma correlated with tumor clinicopathologic parameters显示文摘AIM:To investigate the relationship between the expression of P120 and the clinicopathologic parameters in intrahepatic cholangiocarcinoma(ICC) . METHODS:An immunohistochemical study of E-cadherin and P120 catenin was performed on 42 specimens of ICC with a Dako Envision kit. RESULTS:The expression of E-cadherin and P120 was reduced in 27 cases(64.3%) and 31 cases(73.8%) ,respectively. Both E-cadherin and P120 expressions were significantly correlated with the tumor histological grade(χ2 = 9.333,P = 009 and χ2 = 11.71,P = 0.003) ,TNM stage(χ2= 8.627,P = 0.035 and χ2 = 13.123,P = 0.004) ,intrahepatic metastasis(χ2= 7.292,P = 0.007 and χ2 = 4.657,P = 0.041,respectively) and patients' survival(χ2= 6.351,P = 0.002 and χ2 = 4.023,P = 0.000,respectively) . In addition,the expression of P120 was in concordance with that of E-cadherin(χ2 = 13.797,P = 0.000) ,indicating that the expression of P120 may be dependent on that of E-cadherin. Finally,only P120 expression was found to be an independent prognostic factor in Cox regression model(r = 0.088,P = 0.049) . CONCLUSION:Down-regulated expression of E-cadherin and P120 occurs frequently in ICC and contributes to the progression and development of tumor. Both of them may be valuable biologic markersfor predicting tumor invasion,metastasis and patients' survival,but only P120 is an independent prognostic factor for ICC. | Bo Zhai He-Xin Yan Shu-Qin Liu Lei Chen Meng-Chao Wu Hong-Yang Wang | 2008 | World Journal of Gastroenterology2008，14，23： | 8 |
| 11 | Upper-Ocean Dynamical Features and Prediction of the Super El Nino in 2015/16:A Comparison with the Cases in 1982/83 and 1997/98显示文摘The 2015/16 super El Ni?o event has been widely recognized as comparable to the 1982/83 and 1997/98 El Ni?o events.This study examines the main features of upper-ocean dynamics in this new super event,contrasts them to those in the two historical super events,and quantitatively compares the major oceanic dynamical feedbacks based on a mixed-layer heat budget analysis of the tropical Pacific.During the early stage,this new event is characterized by an eastward propagation of SST anomalies and a weak warm-pool El Ni?o;whereas during its mature phase,it is characterized by a weak westward propagation and a westward-shifted SST anomaly center,mainly due to the strong easterly wind and cold upwelling anomalies in the far eastern Pacific,as well as the westward anomalies of equatorial zonal current and subsurface ocean temperature.The heat budget analysis shows that the thermocline feedback is the most crucial process inducing the SST anomaly growth and phase transition of all the super events,and particularly for this new event,the zonal advective feedback also exerts an important impact on the formation of the strong warming and westward-shifted pattern of SST anomalies.During this event,several westerly wind burst events occur,and oceanic Kelvin waves propagate eastwards before being maintained over eastern Pacific in the mature stage.Meanwhile,there is no evidence for westward propagation of the off-equatorial oceanic Rossby waves though the discharging process of equatorial heat during the development and mature stages.The second generation El Ni?o prediction system of the Beijing Climate Center produced reasonable event real-time operational prediction during 2014–16,wherein the statistical prediction model that considers the preceding oceanic precursors plays an important role in the multi-method ensemble prediction of this super. | Hong-Li REN Run WANG Panmao ZHAI Yihui DING Bo LU | 2017 | Journal of Meteorological Research2017，31，2： | 6 |
| 12 | A method of multi-objective reliability tolerance design for electronic circuits显示文摘Tolerance design plays an important role in reliability design for electronic circuits. The traditional method only focuses on the consistency of output response. It is not able to meet the needs of increasing development of electronic products. This paper researches the state of related fields and proposes a method of multi-objective reliability tolerance design. The characteristics of output response and operating stresses on critical components are both defined as design objectives. Critical components and their operating stresses are determined by failure mode and effect analysis (FMEA) and fault tree analysis (FTA). Sensitivity analysis is carried out to determine sensitive parameters that affect the design objectives significantly. Monte Carlo and worst-case analysis are utilized to explore the tolerance levels of sensitive parameters. Design of experiment and regression analysis are applied in this method. The optimal tolerance levels are selected in accord with a quality-cost model to improve consistency of output response and reduce failure rates of critical components synchronously. The application in light-emitting diode (LED) drivers indicates details and potential. It shows that the proposed method provides a more effective way to improve performance and reliability of electronic circuits. | Zhai Guofu Zhou Yuege Ye Xuerong Hu Bo | 2013 | Chinese Journal of Aeronautics2013，26，1： | 6 |
| 13 | Effect of temperature field on solidification structure of pure Al under pulse magneto-oscillation显示文摘This article discusses the effect of temperature field on the Pulse Magneto-Oscillation(PMO) induced solidification refinement of pure aluminium to provide more information for the industrial application of the PMO solidification technology.The temperature field is altered mainly by applied variable cooling conditions and pulse parameters.Experimental results show that the refinement effect in the case of full sand mould applied is weakened with the decreasing of cooling rate,however,in the alternative case,the sand mould whose sand bottom was replaced by a graphite block is favorable to the survival of equiaxed nucleus.The refinement mechanism is discussed in terms of the relationship between temperature field and the formation process of solidified structure.The formation or survival of nucleus depends on both temperature field and Joule heat produced by PMO,both low pulse frequency and high pulse current were experimentally confirmed to be effective;and PMO was demonstrated high potential in industrial application. | Li Bo Yin Zhenxing Gong Yongyong LJ Kefeng Zheng Hongxing Li Renxing Zhai Qijie | 2011 | China Foundry2011，8，2： | 6 |
| 14 | Reservoir Characteristics and Preservation Conditions of Longmaxi Shale in the Upper Yangtze Block, South China显示文摘The Upper Ordovician-Lower Silurian Longmaxi Shale in the Upper Yangtze block represents one of the most important shale gas plays in China. The shale composition,porosity,organic thermal maturity,and methane sorption were investigated at the Qilongcun section in the Dingshan area,southeastern Sichuan Basin. The results show that the Upper Ordovician-Lower Silurian Longmaxi Shale contains:(1) sapropelic I organic matter;(2) a 40-m thick bedded sequence where total organic carbon(TOC) content is > 2%;(3) a 30-m thick layer at the base of the Longmaxi Shale with a brittle mineral content higher than 50%; and(4) a mean methane adsorption capacity of 1.80 cm^3/g(7 MPa pressure). A positive correlation between TOC and sorbed gas indicates that organic matter content exerts an important control on methane storage capacity. Based on the analysis of the shale reservoir characteristics,the lower member of the Longmaxi Shale can thus be considered a favorable stratum for shale gas exploration and exploitation. It has similar reservoir characteristics with the Longmaxi Shale in the Jiaoshiba area tested with a high-yield industrial gas flow. However,based on tectonic analysis,differences in the level of industrial gas flow between the low-yield study area and the high-yield Jiaoshiba area may result from different tectonic preservation conditions. Evidence from these studies indicates the shale gas potential of the Longmaxi Shale is constrained by the reservoir and preservation conditions. | RAN Bo LIU Shugen Luba JANSA SUN Wei YANG Di WANG Shiyu YE Yuehao Christopher XIAO ZHANHG Jian ZHAI Cangbo LUO Chao ZHANG Changjun | 2016 | Acta Geologica Sinica(English Edition)2016，90，6： | 6 |
| 15 | Curcumin inhibits the replication of enterovirus 71 in vitro显示文摘Human enterovirus 71(EV71)is the main causative pathogen of hand,foot,and mouth disease(HFMD)in children.The epidemic of HFMD has been a public health problem in Asia-Pacific region for decades,and no vaccine and effective antiviral medicine are available.Curcumin has been used as a traditional medicine for centuries to treat a diversity of disorders including viral infections.In this study,we demonstrated that curcumin showed potent antiviral effect again EV71.In Vero cells infected with EV71,the addition of curcumin significantly suppressed the synthesis of viral RNA,the expression of viral protein,and the overall production of viral progeny.Similar with the previous reports,curcumin reduced the production of ROS induced by viral infection.However,the antioxidant property of curcumin did not contribute to its antiviral activity,since N-acetyl-L-cysteine,the potent antioxidant failed to suppress viral replication.This study also showed that extracellular signal-regulated kinase(ERK)was activated by either viral infection or curcumin treatment,but the activated ERK did not interfere with the antiviral effect of curcumin,indicating ERK is not involved in the antiviral mechanism of curcumin.Unlike the previous reports that curcumin inhibited protein degradation through ubiquitin–proteasome system(UPS),we found that curcumin had no impact on UPS in control cells.However,curcumin did reduce the activity of proteasomes which was increased by viral infection.In addition,the accumulation of the short-lived proteins,p53 and p21,was increased by the treatment of curcumin in EV71-infected cells.We further probed the antiviral mechanism of curcumin by examining the expression of GBF1 and PI4KB,both of which are required for the formation of viral replication complex.We found that curcumin significantly reduced the level of both proteins.Moreover,the decreased expression of either GBF1 or PI4KB by the application of siRNAs was sufficient to suppress viral replication.We also demonstrated that curcumin showed anti-apoptotic activity at the early stage of viral infection.The results of this study provide solid evidence that curcumin has potent anti-EV71 activity.Whether or not the down-regulated GBF1 and PI4KB by curcumin contribute to its antiviral effect needs further studies. | Ying Qin Lexun Lin Yang Chen Shuo Wu Xiaoning Si Heng Wu Xia Zhai Yan Wang Lei Tong Bo Pan Xiaoyan Zhong Tianying Wang Wenran Zhao Zhaohua Zhong | 2014 | Acta Pharmaceutica Sinica B2014，4，4： | 5 |
| 16 | Snstainable Land Use in Hilly Red Soil Region of South-eastern China显示文摘SnstainableLandUseinHillyRedSoilRegionofSonth-easternChinaZHANGTAO-LIN;ZHAOQI-GUO;ZHAIYU-SHUN;CHENBIN-FEIandSUNBO(Instituteof... | ZHANG TAO-LIN ZHAO QI-GUO ZHAI YU-SHUN CHEN BIN-FEI and SUN BO(Institute of Soil Science, Academia Sinica, P. O. Box 821, Nanjing 210008 ( China)) | 1995 | Pedosphere1995，5，1： | 5 |
| 17 | Identification of a DNase activated in Xenopus egg extracts undergoing apoptosis显示文摘A cell-free apoptosis system was established by adding dATP and cytochrome c to Xenopus laevis egg extracts S-150. Accompanied by an incubation process, an apoptosis-specific DNase was activated in egg extracts which depended on Mg 2+ and inhibited by Zn 2+. Two nucleases existing in egg extracts were revealed by in-gel nuclease assay. Further experiments showed that 27 ku nuclease which was different from other Ca 2+/Mg 2+-dependent nucleases was a possible candidate involved in apoptosis. | Shan Zhu Zhengfan Jiang Bo Zhang Zhigang Lu Zhonghe Zhai | 1998 | Chinese Science Bulletin1998，43，6： | 4 |
| 18 | Study on the interaction between engineering construction and ecosystem changes in the Longitudinal Range-Gorge Region显示文摘这份报纸拿在作为主要科学问题设计构造和生态系统变化之间的相互作用。基于 DPSIR ( Drive-Press-State-Impact-Response )框架,这研究分析在从开车,出版社,状态,影响和反应的方面设计构造和生态系统变化之间的相互作用的通匝,向前带相互作用模型,相互作用情形分析方法和相互作用索引(开车反应索引, IIDR ,开车影响索引, IIDI ,影响反应索引,红外,影响索引, IIII ),并且预付相应计算模型和相互作用索引 sy 并且也,这份报纸采用不同相互作用索引到尊重影响在上和对设计建设的反应,并且作为例子在纵的范围峡区域(LRGR ) 拿 Manwan 水力发出的电力车站和道路交通建设分析并且验证相互作用模型。由建设的结果和 Manwan 水力发出的电力的操作的系统的分析,车站是分别地 3.67, 3.92, 14.35 和 0.35。没有在相互作用系统,和利用的通匝元素的显著变化水力发出的电力车站基于想象有益于地区性的环境和社会的持续发展没有考虑环境费用,散开效果,潜在的否定效果和潜力,水力发出的电力的回答驻扎建设。通过一些案例研究,我们造了的相互作用模型在相互作用显示出很好的实际价值量的分析并且相互作用索引系统构造。 | CUI BaoShan HU Bo ZHAI HongJuan WEI GuoLiang WANG Juan School of Environment,Beijing Normal University State Key Joint Laboratory of Environmental Simulation and Pollution Contro,Beijing 100875,China | 2007 | Chinese Science Bulletin2007，52，A02： | 3 |
| 19 | Changes of Climate Extremes in China显示文摘 | Panmao Zhai Anjian Sun Fumin Ren Xiaonin Liu Bo Gao Qiang Zhang | 1999 | Climatic Change1999，，1： | 3 |
| 20 | Spontaneous Vesicle Formation in Mixed Aqueous Solution of Poly-tailed Cationic and Anionic Surfactants显示文摘Spontaneous vesicles from the mixed aqueous solution of poly-tailed cationic surfactant PTA and anionic surfactant AOT are firstly obtained. Vesicle formation and characterizations are demonstrated by negative-staining TEM and dynamic light scattering. A monodisperse vesicle system is obtained with a polydispersity of 0.082. Ultrasonication can promote the vesicle formation. Mechanism of vesicle formation is discussed from the viewpoint of molecular interaction. | Wen Jun CHEN Gan Zuo LI Li Min ZHAI Bo Qin LI Jun XU Rui XIA | 2003 | Chinese Chemical Letters2003，14，3： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员