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| 1 | Prescribing physical activity to prevent and manage gestational diabetes显示文摘Gestational diabetes mellitus(GDM)is the most prevalent metabolic disorder during pregnancy.Women diagnosed with GDM have a substantially greater risk of developing type 2 diabetes within 5-10 years after delivery,and the risk is increased by excess body weight.Uncontrolled hyperglycemia during pregnancy is potentially harmful to both mother and fetus,resulting in a greater need for Caesarian-section deliveries,delivery of larger infants with more excess body fat,a greater risk of infant death and stillbirth,and an elevated risk of infant hypoglycemia immediately after birth.Fortunately,engaging in physical activity prior to and during pregnancy may lower the risk of developing GDM.Pregnant women should also be advised how to safely increase their physical activity during pregnancy and the postpartum period.An initial approach to becoming more physically active can simply be to encourage women to incorporate more unstructured physical activity into daily living,both before and during pregnancy.Giving women an appropriate exercise prescription can encourage them to participate in physical activity safely and effectively throughout pregnancy to prevent and/or manage GDM.Engaging in 30 min of moderate intensity physical activity on most,if not all,days of the week has been adopted as a recommendation for all pregnant women. | Sheri R Colberg Kristin Castorino Lois Jovanovi | 2013 | World Journal of Diabetes2013，4，6： | 12 |
| 2 | Complex role for the immune system in initiation and progression of pancreatic cancer显示文摘The immune system plays a complex role in the development and progression of pancreatic cancer. Inflammation can promote the formation of premalignant lesions and accelerate pancreatic cancer development. Conversely, pancreatic cancer is characterized by an immunosuppressive environment, which is thought to promote tumor progression and invasion. Here we review the current literature describing the role of the immune response in the progressive development of pancreatic cancer, with a focus on the mechanisms that drive recruitment and activation of immune cells at the tumor site, and our current understanding of the function of the immune cell types at the tumor. Recent clinical and preclinical data are reviewed, detailing the involvement of the immune response in pancreatitis and pancreatic cancer, including the role of specific cytokines and implications for disease outcome. Acute pancreatitis is characterized by a predominantly innate immune response, while chronic pancreatitis elicits an immune response that involves both innate and adaptive immune cells, and often results in profound sys-temic immune-suppression. Pancreatic adenocarcinoma is characterized by marked immune dysfunction driven by immunosuppressive cell types, tumor-promoting immune cells, and defective or absent inflammatory cells. Recent studies reveal that immune cells interact with cancer stem cells and tumor stromal cells, and these interactions have an impact on development and progression of pancreatic ductal adenocarcinoma(PDAC). Finally, current PDAC therapies are reviewed and the potential for harnessing the actions of the immune response to assist in targeting pancreatic cancer using immunotherapy is discussed. | Kristin S Inman Amanda A Francis Nicole R Murray | 2014 | World Journal of Gastroenterology2014，20，32： | 11 |
| 3 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 4 | TGF-β1 and 25-Hydroxycholesterol stimulate osteoblast-like vascular cells to calcify显示文摘 | Kristine B Raji R | 1994 | J Clin Invest1994，93，： | 1 |
| 5 | Results of the Medications At Transi- tions and Clinical Handoffs (MATCH) Study: An Analysis of Medication Reconciliation Errors and Risk Factors at Hospital Admission显示文摘 | Kristine M Molly R David W | 2010 | J Gen Intern Med2010，25，5： | 1 |
| 6 | Application of 5'-nuclease PC R for quantitative detection of Listeria monocytogenes in pure cultures, water, skim milk, and unpasteurized whole milk 显示文摘 | Nogva H K Kristine K R Naterstad K | 2000 | Appl Environ Microbiol2000，66，10： | 1 |
| 7 | Combined High Pressure and Thermal Processing on Inactivation of Type A and Proteolytic Type Spores of Clostridium botulinum显示文摘 | Reddy N Rukma Marshall Kristin M Morrissey Travis R Loeza Viviana Patazca Eduardo Skinner Guy E Krishnamurthy Kathiravan Larkin John W | 2013 | Journal of Food Protection2013，76，8： | 1 |
| 8 | Phytoremediation of contaminated soils and groundwater: lessons from the field显示文摘 | Jaco V Rolf H Nele W Jana B Kristin A Ann R | 2009 | Environmental Science and Pollution Research2009，16，7： | 1 |
| 9 | Effects of suspen- ded sediment characteristics and bed sediment transport on streambed clogging 显示文摘 | Kristin J R Aaron I P Jianhong R | 2005 | Hydrological Processes2005，，19： | 1 |
| 10 | Analysis of Groundwater' Resource Decline in an Intermountain Aquifer System in Central Iran显示文摘 | Marc V C Mahdi R Kristine M | | Geologica Belgica0，15，3： | 1 |
| 11 | Determination of chloramphenicol residues in meat, seafood, egg, honey * milk, plasma and urine with liquid chromatography-tandem mass spectrometry, and the validation of the method based on 2002/657/EC显示文摘 | Helene T R Kristin E Tone N A | 2006 | Journal of chromatography A2006，1118，： | 1 |
| 12 | Microbial aclivity and functional composition among northern peatland ecosystems显示文摘 | Melany C F Kristin F R | 2003 | Soil Biology & Biochemistry2003，35，： | 1 |
| 13 | Alcohol teratogenesis: mechanisms of damage and strategies for intervention 显示文摘 | Charles R Goodlett Kristin H | 2005 | Exp Biol Med2005，230，： | 1 |
| 14 | Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case–control studies显示文摘 | Celeste Leigh Pearce Claire Templeman Mary Anne Rossing Alice Lee Aimee M Near Penelope M Webb Christina M Nagle Jennifer A Doherty Kara L Cushing-Haugen Kristine G Wicklund Jenny Chang-Claude Rebecca Hein Galina Lurie Lynne R Wilkens Michael E Carney Mar | 2012 | Lancet Oncology2012，，： | 1 |
| 15 | Analysis of chromate-induced DNA-protein crosslinks with the comet assay 显示文摘 | Oliver M Kristin R Gtinter S | 2000 | Mutation Research2000，471，： | 1 |
| 16 | Continuous glucose profiles in obese and normal-weight pregnant women on a controlled diet:Metabolic determinants of fetal growth显示文摘 | Kristin A H Lori G Dalan R J | 2011 | Diabetes Care2011，34，10： | 1 |
| 17 | Quantifying the air quality co-benefits of the clean development mechanism in China显示文摘 | NATHAN R KRISTIN A | 2010 | Environmental Science&Technology2010，，44： | 1 |
| 18 | Primary murine small intestinal epithelial cells, maintained in long-Term culture, are susceptible to rotavirus infection显示文摘 | KRISTINE K MACARTNEY DAME C BAUMGART SIMON R CARDING | 2000 | Journal of Virology2000，74，12： | 1 |
| 19 | Alpha 1-antitrypsin and protease complexation is in- duced by lipopolysaccharide, interleukin-lb, and tumor necrosis factor-a in monocytes显示文摘 | DAREN L K DAVID R R KRISTIN R C | 1998 | Am J Re- spir Crit Care Med1998，157，： | 1 |
| 20 | Expression of extracellular matrix metalloproteases inducer on micrometastatic and primary mammary carcinoma cells显示文摘 | NATALIE R KRISTINE Z | 2004 | Clinical Cancer Res2004，10，10： | 1 |
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