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| 1 | Correlation between radiologic features on contrastenhanced CT and pathological tumor grades in pancreatic neuroendocrine neoplasms显示文摘Contrast-enhanced computed tomography(CT)contributes to the increasing detection of pancreatic neuroendocrine neoplasms(PNENs).Nevertheless,its value for differentiating pathological tumor grades is not well recognized.In this report,we have conducted a retrospective study on the relationship between the 2017 World Health Organization(WHO)classification and CT imaging features in 94 patients.Most of the investigated features eventually provided statistically significant indicators for discerning PNENs G3 from PNENs G1/G2,including tumor size,shape,margin,heterogeneity,intratumoral blood vessels,vascular invasion,enhancement pattern in both contrast phases,enhancement degree in both phases,tumor-to-pancreas contrast ratio in both phases,common bile duct dilatation,lymph node metastases,and liver metastases.Ill-defined tumor margin was an independent predictor for PNENs G3 with the highest area under the curve(AUC)of 0.906 in the multivariable logistic regression and receiver operating characteristic curve analysis.The portal enhancement ratio(PER)was shown the highest AUC of 0.855 in terms of quantitative features.Our data suggest that the traditional contrastenhanced CT still plays a vital role in differentiation of tumor grades and heterogeneity analysis prior to treatment. | Wenbin Xu Han Yan Lulu Xu Mingna Li Wentao Gao Kuirong Jiang Junli Wu Yi Miao | 2021 | The Journal of Biomedical Research2021，35，3： | 2 |
| 2 | Hydroxyl radical scavenging activity of β-N-oxalyl-L-α, β-diamino propionic acid显示文摘 | Zhou Gongke Kong Yingzhen Cui Kuirong | 2001 | Phytochemistry2001，58，5： | 1 |
| 3 | CEACAM6 induces epithelial-mesenchymal transition and mediates invasionand metastasis in pancreatic cancer显示文摘 | Jianmin Chen Qiang Li Yong An Nan Lv Xiaofeng Xue Jishu Wei Kuirong Jiang Junli Wu Wentao Gao Zhuyin Qian Cuncai Dai Zekuan Xu Yi Miao | 2013 | International Journal of Oncology2013，，3： | 1 |
| 4 | Journal of Geophysical Resarch显示文摘 | Glider S A Gill J Coe R S Zhao Xixi Liu Zhongwei Wang Genxian Yuan Kuirong Liu Wenlong Kuang Guodun Wu Haoruo | 1996 | Tectonophsics1996，101，16： | 1 |
| 5 | Modified methods for isolation of pancreatic stellate cells from human and rodent pancreas显示文摘Primary cultures of pancreatic stellate cells(PSCs) remain an important basis for in vitro study.However,effective methods for isolating abundant PSCs are currently lacking.We report on a novel approach to isolating PSCs from normal rat pancreases and human pancreatic ductal adenocarcinoma(PDAC) tissue.After anaesthesia and laparotomy of the rat,a blunt cannula was inserted into the pancreatic duct through the anti-mesentery side of the duodenum,and the pancreas was slowly infused with an enzyme solution until all lobules were fully dispersed.The pancreas was then pre-incubated,finely minced and incubated to procure a cell suspension.PSCs were obtained after the cell suspension was filtered,washed and subject to gradient centrifugation with Nycodenz solution.Fresh human PDAC tissue was finely minced into 1×1×l mm^3 cubes with sharp blades.Tissue blocks were placed at the bottom of a culture plate with fresh plasma(EDTA-anti-coagulated plasma from the same patient,mixed with CaCL) sprinkled around the sample.After culture for 5-10 days under appropriate conditions,activated PSCs were harvested.An intraductal perfusion of an enzyme solution simplified the procedure of isolation of rat PSCs,as compared with the multiple injections technique,and a modified outgrowth method significantly shortened the outgrowth time of the activated cells.Our modification in PSC isolation methods significantly increased the isolation efficiency and shortened the culture period,thus facilitating future PSC-related research. | Liangtao Zhao Baobao Cai Zipeng Lu Lei Tian Song Guo Pengfei Wu Dong Qian Qingcheng Xu Kuirong Jiang Yi Miao | 2016 | The Journal of Biomedical Research2016，30，6： | 1 |
| 6 | From'step-up'to'step-jump':a leap-forward intervention for infected necrotizing pancreatitis显示文摘Acute pancreatitis(AP)can vary widely in its severity,from being clinically self-limiting to a rapidly fatal course.[1]Necrotizing pancreatitis(NP)is the most serious form and is associated with a poor prognosis;the mortality rate is approximately 15%,or up to 30%for cases of infected necrotizing pancreatitis(INP),which often progresses to sepsis and multiple organ failure,the major cause of death and severe complications.[2]The approach to the management of INP has significantly changed during the last 20 years and continues to evolve with the accumulation of experience,new techniques,and research data.Major surgical intervention and debridement were once the mainstay of therapy for patients with symptomatic necrotic foci,but a minimally invasive approach that focuses on percutaneous and/or endoscopic drainage or debridement is now favored.[2]The'step-up'approach,which involves minimally invasive techniques,represents a new paradigm for the treatment of patients with INP,and open pancreatic debridement is now considered to be the final step in the treatment of NP.[2] | Dongya Huang Qiang Li Zipeng Lu Kuirong Jiang Junli Wu Wentao Gao Bin Xiao Yi Miao | 2022 | Chinese Medical Journal2022，，3： | 0 |
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