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| 1 | Prospective study of differential diagnosis of hepatic tumors by pattern-based classification of contrast-enhanced sonography显示文摘AIM: To prospectively evaluate the usefulness of a pattern-based classification of contrast-enhanced sonographic findings for differential diagnosis of hepatic tumors. METHODS: We evaluated the enhancement pattern of the contrast-enhanced sonography images in 586 patients with 586 hepatic lesions, consisting of 383 hepatocellular carcinomas, 89 metastases, and 114 hemangiomas. After injecting a galactose-palmitic acid contrast agent, lesions were scanned by contrast- enhanced harmonic gray-scale sonography in three phases: arterial, portal, and late. The enhancement patterns of the initial 303 lesions were classified retrospectively, and multiple logistic regression analysis was used to identify enhancement patterns that allowed differentiation between hepatic tumors. We then used the pattern-based classification of enhancement we had retrospectively devised to prospectively diagnose 283 liver tumors. RESULTS: Seven enhancement patterns were found to be significant predictors of different hepatic tumors. The presence of homogeneous or heterogeneous enhancement both in the arterial and portal phase was the typical enhancement pattern for hepatocellular carcinoma, while the presence of peritumoral vessels in the arterial phase and ring enhancement or a perfusion defect in the portal phase was the typical enhancement pattern for metastases, and the presence of peripheral nodular enhancement both in the arterial and portal phase was the typical enhancement pattern forhemangioma. The sensitivity, specificity, and accuracy of prospective diagnosis based on the combinations of enhancement patterns, respectively, were 93.2%, 96.2%, and 94.0% for hepatocellular carcinoma, 87.9%, 99.6%, and 98.2% for metastasis, and 95.6%, 94.1%, and 94.3% for hemangioma. CONCLUSION: The pattern-based classification of the contrast-enhanced sonographic findings is useful for differentiating among hepatic tumors. | Kazushi Numata Tetsuo Isozaki Manabu Morimoto Kazuya Sugimori Reiko Kunisaki Toshio Morizane Katsuaki Tanaka | 2006 | World Journal of Gastroenterology2006，12，39： | 18 |
| 2 | Long-term outcomes and prognostic factors of patients with obstructive colorectal cancer: A multicenter retrospective cohort study显示文摘AIM: To investigate the long-term oncologic outcomes and prognostic factors in patients with obstructive colorectal cancer(CRC) at multiple Japanese institutions.METHODS: We identified 362 patients diagnosed with obstructive colorectal cancer from January 1, 2002 to December 31, 2012 in Yokohama Clinical Oncology Group's department of gastroenterological surgery. Among them, 234 patients with stage Ⅱ/Ⅲ disease who had undergone surgical resection of their primary lesions were analyzed, retrospectively. We report the long-term outcomes, the risk factors for recurrence, and the prognostic factors.RESULTS: The five-year disease free survival and cancer-specific survival were 50.6% and 80.3%, respectively. A multivariate analysis showed the ASAPS(HR = 2.23, P = 0.026), serum Albumin ≤ 4.0 g/d L(HR = 2.96, P = 0.007), T4 tumor(HR = 2.73, P = 0.002) and R1 resection(HR = 6.56, P = 0.02) to be independent risk factors for recurrence. Furthermore, poorly differentiated cancers(HR = 6.28, P = 0.009), a T4 tumor(HR = 3.46, P = 0.011) and R1 resection(HR = 6.16, P = 0.006) were independent prognostic factors in patients with obstructive CRC.CONCLUSION: The outcomes of patients with obstructive CRC was poor. T4 tumor and R1 resection were found to be independent prognostic factors for both recurrence and survival in patients with obstructive CRC. | Ishibe Atsushi Ota Mitsuyoshi Yamaguchi Kazuya Kaida Syuhei Kamiya Noriyuki Momiyama Masashi Watanabe Akira Sekizawa Kentaro Kamimukai Nobuyuki Sugimasa Natsuko Watanabe Jun Ichikawa Yasushi Kunisaki Chikara Endo Itaru | 2016 | World Journal of Gastroenterology2016，22，22： | 9 |
| 3 | Bile duct hamartomas(von Mayenburg complexes) mimicking liver metastases from bile duct cancer:MRC findings显示文摘我们在场是的有胆总管癌症的一个 72 岁的人的一个盒子开始相信了吃多重肝转移基于计算断层摄影术调查结果,并且在磁性的回声胆管造影术(MRC ) 在谁揭示胆汁管 hamartomas 的诊断。在为 pancreaticoduodenectomy 的探索,肝触诊在肝的表面揭示了传播小瘤。这些小瘤在在两片肝脑叶的表面上散布的直径显示出大约 0.5 厘米的灰色白人的榴状的损害,它被看起来像从胆汁管癌的多重肝转移。肝活体检视的冰冻切片揭示了多重胆汁管,稍微扩大的腔在多重胆汁管 hamartomas (BDH ) 的成胶的基质特征嵌入。仅仅二份报告描述了胆汁管 hamartomas 的 MRC 特征。所有成像过程, MRC 为胆汁管 hamartomas 的成像诊断提供最相关的特征。 | Yasuhiko Nagano Kenichi Matsuo Katsuya Gorai Kazuya Sugimori Chikara Kunisaki Hideyuki Ike Katsuaki Tanaka Toshio Imada Hiroshi Shimada | 2006 | World Journal of Gastroenterology2006，12，8： | 4 |
| 4 | Risk factors for lymph node metastasis in histologically poorly differentiated type early gastric cancer显示文摘 | C. Kunisaki M. Takahashi Y. Nagahori T. Fukushima H. Makino R. Takagawa T. Kosaka H. Ono H. Akiyama Y. Moriwaki A. Nakano | 2009 | Endoscopy2009，，06： | 4 |
| 5 | Comparison of Surgical Results of D2 Versus D3 Gastrectomy (Para-Aortic Lymph Node Dissection) for Advanced Gastric Carcinoma: A Multi-Institutional Study显示文摘 | Chikara Kunisaki Hirotoshi Akiyama Masato Nomura Goro Matsuda Yuichi Otsuka Hidetaka Ono Yutaka Nagahori Hideo Hosoi Masazumi Takahashi Fumihiko Kito Hiroshi Shimada | 2006 | Annals of Surgical Oncology2006，，5： | 2 |
| 6 | Impact of lymphovascular invasion in patients with stage I gastric cancer显示文摘 | Chikara Kunisaki Hirochika Makino Jun Kimura Ryo Takagawa Takashi Kosaka Hidetaka A. Ono Hirotoshi Akiyama Tadao Fukushima Yutaka Nagahori Masazumiu Takahashi | 2010 | Surgery2010，，2： | 2 |
| 7 | Omentum-preserving gastrectomy for advanced gastric cancer: a propensity-matched retrospective cohort study显示文摘 | Shinichi Hasegawa Chikara Kunisaki Hidetaka Ono Takashi Oshima Shoichi Fujii Masataka Taguri Satoshi Morita Tsutomu Sato Roppei Yamada Norio Yukawa Yasushi Rino Munetaka Masuda | 2013 | Gastric Cancer2013，，3： | 2 |
| 8 | Expression of circadian genes correlates with liver metastasis and outcomesin colorectal cancer显示文摘 | Takashi Oshima Seiich Takenoshita Makoto Akaike Chikara Kunisaki Shoich Fujii Akito Nozaki Kazushi Numata Manabu Shiozawa Yasushi Rino Katsuaki Tanaka Munetaka Masuda Toshio Imada | 2011 | Oncology Reports2011，，5： | 2 |
| 9 | Short-term results of a randomized study between laparoscopic and open surgery in elderly colorectal cancer patients显示文摘 | Shoichi Fujii Atsushi Ishibe Mitsuyoshi Ota Shigeru Yamagishi Kazuteru Watanabe Jun Watanabe Amane Kanazawa Yasushi Ichikawa Mari Oba Satoshi Morita Yojiro Hashiguchi Chikara Kunisaki Itaru Endo | 2014 | Surgical Endoscopy2014，，2： | 2 |
| 10 | Clinical significance of the metastatic lymph-node ratin in early gastric cancer 显示文摘 | Kunisaki C Makino H Akiyama H | 2008 | J Gastrointest Surg2008，12，3： | 1 |
| 11 | Fetal surgery显示文摘 | Kunisaki SM Jennings RW | 2008 | J Intensive Care Med2008，23，1： | 1 |
| 12 | Appropriate lymph node dissection for early gastric cancer based on lymph node metastases显示文摘 | Kunisaki C Shimada H Nomura M | 2001 | Surgery2001，129，2： | 1 |
| 13 | Phase II study ofbiweekly docetaxel and S-1 combination chemotherapy as first line treatment for advanced gastric cancer显示文摘 | Kunisaki C Takahashi M Makino H etal | 2010 | Cancer Chemother Pharmacol2010，28，4： | 1 |
| 14 | Collagen as the majoreible component of sea cucumber {Stichopus japonicus)显示文摘 | SAITO M KUNISAKI N URANO N | 2002 | Journal ofFood Science2002，67，： | 1 |
| 15 | Collagen as the major edible component of sea cucumber (Stichopusjaponicus)显示文摘 | SATTO M KUNISAKI N URANO N | 2002 | Food Chemistry and Toxicology2002，67，4： | 1 |
| 16 | Lymph node dissection in surgical treatment for remnant stomach cancer显示文摘 | Kunisaki C Shimada H Nomura M | | 0，，： | 1 |
| 17 | Clinicopathological significance of the gene expression ofmatrix metalloproteinases and reversion-inducing cysteine-richprotein with Kazal motifs in patients with colorectal cancer:MMP-2 gene expression is a useful predictor of liver metastasisfrom colorectal cancer 显示文摘 | Oshima T Kunisaki C? Yoshihara K | 2008 | Oncol Rep2008，19，5： | 1 |
| 18 | Collagen as the major edible component of sea cucumber(Stichopus japonicus)显示文摘 | Saito M Kunisaki N Urano N | 2002 | J Food Sci2002，67，4： | 1 |
| 19 | Characterization of a rainbow trout matrix metalloproteinase capable of de-grading type I collagen 显示文摘 | SAITO M SATO K KUNISAKI N | 2000 | Eur J Bioehem2000，267，23： | 1 |
| 20 | Completeprimary structure of rainbow trout type I collagen consisting ofal (I) a2 (I) a3 (I) heterotrimers显示文摘 | SAITO M TAKENOUCHI Y KUNISAKI N’ | 2006 | European Journal of Bio-chemistry2006，268，10： | 1 |
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