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| 1 | Molecular heterogeneity of anti-PD-1/PD-L1 immunotherapy efficacy is correlated with tumor immune microenvironment in East Asian patients with non-small cell lung cancer显示文摘Objective:The aim of this study was to investigate how the tumor immune microenvironment differs regarding tumor genomics,as well as its impact on prognoses and responses to immunotherapy in East Asian patients with non-small cell lung cancer(NSCLC).Methods:We performed an integrated analysis using publicly available data to identify associations between anti-programmed death 1(PD-1)/programmed death-ligand 1(PD-L1)immunotherapy efficacy and classic driver oncogene mutations in East Asian NSCLC patients.Four pooled and clinical cohort analyses were used to correlate driver oncogene mutation status and tumor microenvironment based on PD-L1 and CD8+tumor-infiltrating lymphocytes(TILs).Immune infiltrating patterns were also established for genomic NSCLC subgroups using the CIBERSORT algorithm.Results:Based on East Asian NSCLC patients,TIDE analyses revealed that for anti-PD-1/PD-L1 immunotherapy,epidermal growth factor receptor(EGFR)-mutant and anaplastic lymphoma kinase(ALK)-rearranged tumors yielded inferior responses;however,although Kirsten rat sarcoma viral oncogene homolog(KRAS)-mutant tumors responded better,the difference was not statistically significant(EGFR:P=0.037;ALK:P<0.001;KRAS:P=0.701).Pooled and clinical cohort analyses demonstrated tumor immune microenvironment heterogeneities correlated with oncogenic patterns.The results showed remarkably higher PD-L1-and TIL-positive KRAS-mutant tumors,suggesting KRAS mutations may drive an inflammatory phenotype with adaptive immune resistance.However,the EGFR-mutant or ALK-rearranged groups showed a remarkably higher proportion of PD-L1-/TIL-tumors,suggesting an uninflamed phenotype with immunological ignorance.Notably,similar to triple wild-type NSCLC tumors,EGFR L858R-mutant tumors positively correlated with an inflammatory phenotype,suggesting responsiveness to anti-PD-1/PD-L1 immunotherapy(P<0.05).Furthermore,the CIBERSORT algorithm results revealed that EGFR-mutant and ALK-rearranged tumors were characterized by an enriched resting memory CD4+T cell population(P<0.001),as well as a lack of CD8+T cells(P<0.01),and activated memory CD4+T cells(P=0.001).Conclusions:Our study highlighted the complex relationships between immune heterogeneity and immunotherapeutic responses in East Asian NSCLC patients regarding oncogenic dependence. | Runsen Jin Chengming Liu Sufei Zheng Xinfeng Wang Xiaoli Feng Hecheng Li Nan Sun Jie He | 2020 | Cancer Biology & Medicine2020，17，3： | 10 |
| 2 | Exponential distribution-based genetic algorithm for solving mixed-integer bilevel programming problems显示文摘Two classes of mixed-integer nonlinear bilevel programming problems are discussed.One is that the follower's functions are separable with respect to the follower's variables,and the other is that the follower's functions are convex if the follower's variables are not restricted to integers.A genetic algorithm based on an exponential distribution is proposed for the aforementioned problems.First,for each fixed leader's variable x,it is proved that the optimal solution y of the follower's mixed-integer programming can be obtained by solving associated relaxed problems,and according to the convexity of the functions involved,a simplified branch and bound approach is given to solve the follower's programming for the second class of problems.Furthermore,based on an exponential distribution with a parameterλ,a new crossover operator is designed in which the best individuals are used to generate better offspring of crossover.The simulation results illustrate that the proposed algorithm is efficient and robust. | Li Hecheng Wang Yuping | 2008 | Journal of Systems Engineering and Electronics2008，19，6： | 4 |
| 3 | Recent Advancements on Photothermal Conversion and Antibacterial Applications over MXenes-Based Materials显示文摘The pernicious bacterial proliferation and emergence of super-resistant bacteria have already posed a great threat to public health,which drives researchers to develop antibiotic-free strategies to eradicate these fierce microbes.Although enormous achievements have already been achieved,it remains an arduous challenge to realize efficient sterilization to cut off the drug resistance generation.Recently,photothermal therapy(PTT)has emerged as a promising solution to efficiently damage the integrity of pathogenic bacteria based on hyperthermia beyond their tolerance.Until now,numerous photothermal agents have been studied for antimicrobial PTT.Among them,MXenes(a type of two-dimensional transition metal carbides or nitrides)are extensively investigated as one of the most promising candidates due to their high aspect ratio,atomic-thin thickness,excellent photothermal performance,low cytotoxicity,and ultrahigh dispersibility in aqueous systems.Besides,the enormous application scenarios using their antibacterial properties can be tailored via elaborated designs of MXenes-based materials.In this review,the synthetic approaches and textural properties of MXenes have been systematically presented first,and then the photothermal properties and sterilization mechanisms using MXenes-based materials are documented.Subsequently,recent progress in diverse fields making use of the photothermal and antibacterial performances of MXenes-based materials are well summarized to reveal the potential applications of these materials for various purposes,including in vitro and in vivo sterilization,solar water evaporation and purification,and flexible antibacterial fabrics.Last but not least,the current challenges and future perspectives are discussed to provide theoretical guidance for the fabrication of efficient antimicrobial systems using MXenes. | Shuyan Hao Hecheng Han Zhengyi Yang Mengting Chen Yanyan Jiang Guixia Lu Lun Dong Hongling Wen Hui Li Jiurong Liu Lili Wu Zhou Wang Fenglong Wang | 2022 | Nano-Micro Letters2022，14，11： | 4 |
| 4 | Signaling pathways and targeted therapies in lung squamous cell carcinoma: mechanisms and clinical trials显示文摘Lung cancer is the leading cause of cancer-related death across the world.Unlike lung adenocarcinoma,patients with lung squamous cell carcinoma(LSCC)have not benefitted from targeted therapies.Although immunotherapy has significantly improved cancer patients’outcomes,the relatively low response rate and severe adverse events hinder the clinical application of this promising treatment in LSCC.Therefore,it is of vital importance to have a better understanding of the mechanisms underlying the pathogenesis of LSCC as well as the inner connection among different signaling pathways,which will surely provide opportunities for more effective therapeutic interventions for LSCC.In this review,new insights were given about classical signaling pathways which have been proved in other cancer types but not in LSCC,including PI3K signaling pathway,VEGF/VEGFR signaling,and CDK4/6 pathway.Other signaling pathways which may have therapeutic potentials in LSCC were also discussed,including the FGFR1 pathway,EGFR pathway,and KEAP1/NRF2 pathway.Next,chromosome 3q,which harbors two key squamous differentiation markers SOX2 and TP63 is discussed as well as its related potential therapeutic targets.We also provided some progress of LSCC in epigenetic therapies and immune checkpoints blockade(ICB)therapies.Subsequently,we outlined some combination strategies of ICB therapies and other targeted therapies.Finally,prospects and challenges were given related to the exploration and application of novel therapeutic strategies for LSCC. | Zhenyi Niu Runsen Jin Yan Zhang Hecheng Li | 2022 | Signal Transduction and Targeted Therapy2022，7，11： | 3 |
| 5 | Shining light on transition metal sulfides:New choices as highly efficient antibacterial agents显示文摘Globally,millions of people die of microbial infection-related diseases every year.The more terrible situation is that due to the overuse of antibiotics,especially in developing countries,people are struggling to fight with the bacteria variation.The emergence of super-bacteria will be an intractable environmental and health hazard in the future unless novel bactericidal weapons are mounted.Consequently,it is critical to develop viable antibacterial approaches to sustain the prosperous development of human society.Recent researches indicate that transition metal sulfides(TMSs)represent prominent bactericidal application potential owing to the meritorious antibacterial performance,acceptable biocompatibility,high solar energy utilization efficiency,and excellent photo-to-thermal conversion characteristics,and thus,a comprehensive review on the recent advances in this area would be beneficial for the future development.In this review article,we start with the antibacterial mechanisms of TMSs to provide a preliminary understanding.Thereafter,the state-of-the-art research progresses on the strategies for TMSs materials engineering so as to promote their antibacterial properties are systematically surveyed and summarized,followed by a summary of the practical application scenarios of TMSs-based antibacterial platforms.Finally,based on the thorough survey and analysis,we emphasize the challenges and future development trends in this area. | Hecheng Han Jingjing Yang Xiaoyan Li Yuan Qi Zhengyi Yang Zejun Han Yanyan Jiang Martina Stenzel Hui Li Yixin Yin Yi Du Jiurong Liu Fenglong Wang | 2021 | Nano Research2021，14，8： | 2 |
| 6 | A comment on 'cost efficiency in data envelopment analysis with data uncertainty'显示文摘 | FANG LEI LI HECHENG | 2012 | European Journal of Operational Research2012，220，2： | 1 |
| 7 | Pattern of lymph node metastases in patients with squamous cell carcinoma of the thoraeie esophagus who underwent three-field lymphadenectomy 显示文摘 | Hecheng Li Yawei Zhang Hui Cai | 2007 | Eur Surg Res2007，39，1： | 1 |
| 8 | A genetic algorithm based on optimality conditions for nonlinear bilevel programming problems 显示文摘 | LI HECHENG WANG YUPING | 2010 | International Journal of Applied Mathematics and Informatics2010，28，34： | 1 |
| 9 | Number of Negative Lymph Nodes is Associated with Survival in Thoracic Esophageal Squamous Cell Carcinoma Patients Undergoing Three-Field Lymphadenectomy显示文摘 | Zhengfei Zhu Haiquan Chen Weiwei Yu Xiaolong Fu Jiaqing Xiang Hecheng Li Yawei Zhang Menghong Sun Qiao Wei Weixin Zhao Kuaile Zhao | 2014 | Annals of Surgical Oncology2014，，9： | 1 |
| 10 | 生产高纯Ge-132的专利方法介绍显示文摘评述了制备高纯羧乙基锗倍半氧化物(Ge-132)的专利方法。 | Li Hecheng(Beijing General Research Institute for Non-Ferrous Metals, Beijing 100088) | 1998 | 广东微量元素科学1998，5，2： | 0 |
| 11 | Treatmentsforresectableesophageal cancer:from traditional systemic therapy to immunotherapy显示文摘Esophageal cancer(EC)has a high incidence and poor prognosis.The two major histological types,squamous cell carcinoma and adenocarcinoma,differ in their epidemiology and treatment options.Patients with locally advanced EC benefit from multimodal therapy concepts including neoadjuvant chemotherapy,neoadjuvant chemoradiotherapy,and perioperative chemotherapy.Currently,immunotherapy for the solid tumor is a hot spot.Treatment with adjuvant immune checkpoint inhibitors(ICIs)is the first immunotherapy for resectable EC listed in the latest National Comprehensive Cancer Network Guidelines for the Esophageal and Esophagogastric Junction Cancers.Recent clinical trials have established ICIs for three treatment models of resectable EC.Their short-term results demonstrated ideal efficacy and tolerable toxicity,though some concerns remain.This review summarizes the novel data on the ICIs for resectable EC and lists the registered related clinical trials.Hopefully,this review can provide a reference for ongoing research on the treatment options for resectable EC. | Yan Yan Xijia Feng Chengqiang Li Toni Leru Hecheng Li | 2022 | Chinese Medical Journal2022，135，18： | 0 |
| 12 | Group Decision-Making Method with Incomplete Intuitionistic Fuzzy Preference Relations Based on a Generalized Multiplicative Consistent Concept显示文摘Based on the analyses of existing preference group decision-making(PGDM)methods with intuitionistic fuzzy preference relations(IFPRs),we present a new PGDM framework with incomplete IFPRs.A generalized multiplicative consistent for IFPRs is defined,and a mathematical programming model is constructed to supplement the missing values in incomplete IFPRs.Moreover,in this study,another mathematical programming model is constructed to improve the consistency level of unacceptably multiplicative consistent IFPRs.For group decisionmaking(GDM)with incomplete IFPRs,three reliable sources influencing the weights of experts are identified.Subsequently,a method for determining the weights of experts is developed by simultaneously considering three reliable sources.Furthermore,a targeted consensus process(CPR)is developed in this study with reference to the actual situation of the consensus level of each IFPR.Meanwhile,in response to the proposed multiplicative consistency definition,a novel method for determining the optimal priority weights of alternatives is redefined.Lastly,based on the above theory,a novel GDM method with incomplete IFPRs is developed,and the comparative and sensitivity analysis results demonstrate the utility and superiority of this work. | Xiaoyun Lu Jiuying Dong Hecheng Li Shuping Wan | 2022 | Computer Modeling in Engineering & Sciences2022，，9： | 0 |
| 13 | Management of esophageal mucosa with high-grade dysplasia显示文摘Objective:Early detection and treatment in patients with esophageal cancer is the most effective way to improve the prognosis. Patients with high-grade dysplasia(HGD) in esophageal mucosa might be involved with early esophageal cancer,but the management of the disease is controversial. The purpose of our study was to explore the management of esophageal mucosa with HGD. Methods:We retrospectively analyzed 10 patients with HGD in esophageal mucosa,who underwent esophagectomy in Cancer Hospital of Fudan University from 1999 to 2006. The surgical approach,postoperative morbidity,in-hospital complications and pathological results of the patients were analyzed. Basing on our data together with other studies,we aimed at looking for an appropriate management for patients with HGD. Results:Of the 10 patients who received esophagectomy,the pathological results showed that 2(20%) cases were in situ carcinoma and 8(80%) cases were invasive cancer with no regional lymph nodes involved. 30-day mortality was 0. One patient experienced cervical anastomotic leakage,but healed in 2 weeks. There was no pulmonary complication. Conclusion:Most patients with HGD actually have occult carcinoma. High percentage of patients with HGD would develop into cancer during their lifetime. Esophagectomy is now a selective approach for the treatment of the patients with HGD. | Jiaqing Xiang,Hecheng Li,Shilei Liu,Yawei Zhang,Hong Hu,Longfei Ma,Longsheng Miao Department of Thoracic Surgery,Cancer Hospital of Fudan University Department of Oncology,Shanghai Medical College,Fudan University,Shanghai 200032,China | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，3： | 0 |
| 14 | Development and characterization of urethral stricture model in rabbits显示文摘目的将在兔子建立尿道的苛评的一个试验性的模型。21 只成年雄的新西兰兔子全部的方法 A 被包括进组。在静脉内的麻醉以后, urethroscopy 与小儿科的 resectoscope (F13 ) 被执行。十五个动物随机作为学习组被选择。A 1cm-long 球根的尿道的环绕的电凝法被执行到这些动物直到 mucosa 的溃疡。留下没有电凝法, 6 个动物经历了录像 urethroscopy,用作控制。在第 30 天,后退 urethrogram 和 urethroscopy 被执行评估尿道的苛评形成,组织学的考试(他和染色的天狼星红) 被做估计尿道的病理学的变化。在学习的二只兔子组织的结果死了,没有死亡发生在控制。基于 urethrogram 和 urethroscopy,在控制的兔子都不组织发达尿道的苛评,当重要苛评形成在学习组的每种情况中被观察时。组织学的检查在控制情况中显示出一个正常尿道,当在学习组的苛评地点肌肉和 submucous 组织的广泛的纤维变性与很多成纤维细胞渗入被观察时。在纤维变性织物的高骨胶原表示是由染色的天狼星红的 assayed。内视镜的电凝法能成功地导致的结论 A 1cm-long 在兔子模型的尿道的苛评形成。这个方法为尿道的苛评的基本、临床的学习提供一个理想的动物模型。 | Fu Delai Wang Ziming Chong Tie Li Hecheng Zhang Huibo Zhang Peng Gan Weimin | 2010 | Journal of Medical Colleges of PLA(China)2010，25，6： | 0 |
| 15 | The diverse role of RNA methylation in esophageal cancer显示文摘Esophageal cancer is one of the major life-threatening diseases in the world.RNA methylation is the most common post-transcriptional modification and a wide-ranging regulatory system controlling gene expression.Numerous studies have revealed that dysregulation of RNA methylation is critical for cancer development and progression.However,the diverse role of RNA methylation and its regulators in esophageal cancer remains to be elucidated and summarized.In this review,we focus on the regulation of major RNA methylation,including m6A,m5C,and m7G,as well as the expression patterns and clinical implications of its regulators in esophageal cancer.We systematically summarize how these RNA modifications affect the'life cycle'of target RNAs,including mRNA,microRNA,long non-coding RNA,and tRNA.The downstream signaling pathways associated with RNA methylation during the development and treatment of esophageal cancer are also discussed in detail.Further studies on how these modifications function together in the microenvironment of esophageal cancer will draw a clearer picture of the clinical application of novel and specific therapeutic strategies. | Wangyang Meng Yichao Han Bin Li Hecheng Li | 2023 | Acta Biochimica et Biophysica Sinica2023，55，6： | 0 |
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