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| 1 | Olfactory ensheathing cells genetically modified to secrete GDNF to promote spinal cord repair显示文摘Olfactory ensheathing cell (OEC) transplantation has emerged as a very promising therapy for spinal cord repair. In this study, we tested the ability of genetically modified OECs to secrete high levels of glial cell line-derived neu-rotrophic factor (GDNF) to promote spinal cord repair. The GDNF gene was transduced into OECs using | CAOLi LIULi CHENZhe-Yu WANGLi-Mei YEJun-Li QIUHai-Yan LUChang-Lin HECheng | 2004 | 第二军医大学学报2004，25，5： | 64 |
| 2 | Molecular heterogeneity of anti-PD-1/PD-L1 immunotherapy efficacy is correlated with tumor immune microenvironment in East Asian patients with non-small cell lung cancer显示文摘Objective:The aim of this study was to investigate how the tumor immune microenvironment differs regarding tumor genomics,as well as its impact on prognoses and responses to immunotherapy in East Asian patients with non-small cell lung cancer(NSCLC).Methods:We performed an integrated analysis using publicly available data to identify associations between anti-programmed death 1(PD-1)/programmed death-ligand 1(PD-L1)immunotherapy efficacy and classic driver oncogene mutations in East Asian NSCLC patients.Four pooled and clinical cohort analyses were used to correlate driver oncogene mutation status and tumor microenvironment based on PD-L1 and CD8+tumor-infiltrating lymphocytes(TILs).Immune infiltrating patterns were also established for genomic NSCLC subgroups using the CIBERSORT algorithm.Results:Based on East Asian NSCLC patients,TIDE analyses revealed that for anti-PD-1/PD-L1 immunotherapy,epidermal growth factor receptor(EGFR)-mutant and anaplastic lymphoma kinase(ALK)-rearranged tumors yielded inferior responses;however,although Kirsten rat sarcoma viral oncogene homolog(KRAS)-mutant tumors responded better,the difference was not statistically significant(EGFR:P=0.037;ALK:P<0.001;KRAS:P=0.701).Pooled and clinical cohort analyses demonstrated tumor immune microenvironment heterogeneities correlated with oncogenic patterns.The results showed remarkably higher PD-L1-and TIL-positive KRAS-mutant tumors,suggesting KRAS mutations may drive an inflammatory phenotype with adaptive immune resistance.However,the EGFR-mutant or ALK-rearranged groups showed a remarkably higher proportion of PD-L1-/TIL-tumors,suggesting an uninflamed phenotype with immunological ignorance.Notably,similar to triple wild-type NSCLC tumors,EGFR L858R-mutant tumors positively correlated with an inflammatory phenotype,suggesting responsiveness to anti-PD-1/PD-L1 immunotherapy(P<0.05).Furthermore,the CIBERSORT algorithm results revealed that EGFR-mutant and ALK-rearranged tumors were characterized by an enriched resting memory CD4+T cell population(P<0.001),as well as a lack of CD8+T cells(P<0.01),and activated memory CD4+T cells(P=0.001).Conclusions:Our study highlighted the complex relationships between immune heterogeneity and immunotherapeutic responses in East Asian NSCLC patients regarding oncogenic dependence. | Runsen Jin Chengming Liu Sufei Zheng Xinfeng Wang Xiaoli Feng Hecheng Li Nan Sun Jie He | 2020 | Cancer Biology & Medicine2020，17，3： | 10 |
| 3 | Exponential distribution-based genetic algorithm for solving mixed-integer bilevel programming problems显示文摘Two classes of mixed-integer nonlinear bilevel programming problems are discussed.One is that the follower's functions are separable with respect to the follower's variables,and the other is that the follower's functions are convex if the follower's variables are not restricted to integers.A genetic algorithm based on an exponential distribution is proposed for the aforementioned problems.First,for each fixed leader's variable x,it is proved that the optimal solution y of the follower's mixed-integer programming can be obtained by solving associated relaxed problems,and according to the convexity of the functions involved,a simplified branch and bound approach is given to solve the follower's programming for the second class of problems.Furthermore,based on an exponential distribution with a parameterλ,a new crossover operator is designed in which the best individuals are used to generate better offspring of crossover.The simulation results illustrate that the proposed algorithm is efficient and robust. | Li Hecheng Wang Yuping | 2008 | Journal of Systems Engineering and Electronics2008，19，6： | 4 |
| 4 | Recent Advancements on Photothermal Conversion and Antibacterial Applications over MXenes-Based Materials显示文摘The pernicious bacterial proliferation and emergence of super-resistant bacteria have already posed a great threat to public health,which drives researchers to develop antibiotic-free strategies to eradicate these fierce microbes.Although enormous achievements have already been achieved,it remains an arduous challenge to realize efficient sterilization to cut off the drug resistance generation.Recently,photothermal therapy(PTT)has emerged as a promising solution to efficiently damage the integrity of pathogenic bacteria based on hyperthermia beyond their tolerance.Until now,numerous photothermal agents have been studied for antimicrobial PTT.Among them,MXenes(a type of two-dimensional transition metal carbides or nitrides)are extensively investigated as one of the most promising candidates due to their high aspect ratio,atomic-thin thickness,excellent photothermal performance,low cytotoxicity,and ultrahigh dispersibility in aqueous systems.Besides,the enormous application scenarios using their antibacterial properties can be tailored via elaborated designs of MXenes-based materials.In this review,the synthetic approaches and textural properties of MXenes have been systematically presented first,and then the photothermal properties and sterilization mechanisms using MXenes-based materials are documented.Subsequently,recent progress in diverse fields making use of the photothermal and antibacterial performances of MXenes-based materials are well summarized to reveal the potential applications of these materials for various purposes,including in vitro and in vivo sterilization,solar water evaporation and purification,and flexible antibacterial fabrics.Last but not least,the current challenges and future perspectives are discussed to provide theoretical guidance for the fabrication of efficient antimicrobial systems using MXenes. | Shuyan Hao Hecheng Han Zhengyi Yang Mengting Chen Yanyan Jiang Guixia Lu Lun Dong Hongling Wen Hui Li Jiurong Liu Lili Wu Zhou Wang Fenglong Wang | 2022 | Nano-Micro Letters2022，14，11： | 4 |
| 5 | Signaling pathways and targeted therapies in lung squamous cell carcinoma: mechanisms and clinical trials显示文摘Lung cancer is the leading cause of cancer-related death across the world.Unlike lung adenocarcinoma,patients with lung squamous cell carcinoma(LSCC)have not benefitted from targeted therapies.Although immunotherapy has significantly improved cancer patients’outcomes,the relatively low response rate and severe adverse events hinder the clinical application of this promising treatment in LSCC.Therefore,it is of vital importance to have a better understanding of the mechanisms underlying the pathogenesis of LSCC as well as the inner connection among different signaling pathways,which will surely provide opportunities for more effective therapeutic interventions for LSCC.In this review,new insights were given about classical signaling pathways which have been proved in other cancer types but not in LSCC,including PI3K signaling pathway,VEGF/VEGFR signaling,and CDK4/6 pathway.Other signaling pathways which may have therapeutic potentials in LSCC were also discussed,including the FGFR1 pathway,EGFR pathway,and KEAP1/NRF2 pathway.Next,chromosome 3q,which harbors two key squamous differentiation markers SOX2 and TP63 is discussed as well as its related potential therapeutic targets.We also provided some progress of LSCC in epigenetic therapies and immune checkpoints blockade(ICB)therapies.Subsequently,we outlined some combination strategies of ICB therapies and other targeted therapies.Finally,prospects and challenges were given related to the exploration and application of novel therapeutic strategies for LSCC. | Zhenyi Niu Runsen Jin Yan Zhang Hecheng Li | 2022 | Signal Transduction and Targeted Therapy2022，7，11： | 3 |
| 6 | Controlled WISP-1 shRNA Delivery Using Thermosensitive Biodegradable Hydrogel in the Treatment of Osteoarthritis显示文摘 | Gong Yubao Ma Hecheng Liu Jianguo | 2015 | Journal of Bionic Engineering2015，12，2： | 3 |
| 7 | Hydrothermal treatment of metallic-monolith catalyst support with self-growing porous anodic-alumina film显示文摘Metallic-monolith catalyst support with self-growing porous anodic alumina(PAA)film was prepared by anodizing Al plate.The effect of hydrothermal treatment(HTT)on the crystalline state and textural properties of PAA film was investigated by XRD,BET,SEM and TG.The HTT treatment above 50°C and the subsequent calcination above 300°C could convert the amorphous skeleton alumina intoγ-alumina and increase the specific surface area(SBET).However,SEM images showed the HTT modification was a non-uniform process along the thickness of PAA film.The promotion effect of HTT on SBETwas non-linear,and the slope of SBETgradually decreased with the HTT temperature or time increased.The limited HTT effect should be attributed to a changed pore structure caused by an unfavorable pore sealing limitation.Pore widening treatment(PWT)before HTT could break the pore sealing limitation,because of the reduced internal diffusion resistance of hydrothermal reaction.The synergistic combination of PWT and HTT developed a PAA support with a large SBETcomparable to commercialγ-alumina.In the catalytic combustion of toluene,the Pt-based catalyst prepared by using the PWT and HTT comodified PAA support gave higher Pt dispersion and more favorable catalytic activity than that treated by HTT alone.The presence of a bimodal pore structure was suggested to be a decisive reason. | Chuanqi Zhang Yuanjing Pu Feng Wang Hecheng Ren Hua Ma Yu Guo | 2020 | Chinese Journal of Chemical Engineering2020，28，5： | 2 |
| 8 | Shining light on transition metal sulfides:New choices as highly efficient antibacterial agents显示文摘Globally,millions of people die of microbial infection-related diseases every year.The more terrible situation is that due to the overuse of antibiotics,especially in developing countries,people are struggling to fight with the bacteria variation.The emergence of super-bacteria will be an intractable environmental and health hazard in the future unless novel bactericidal weapons are mounted.Consequently,it is critical to develop viable antibacterial approaches to sustain the prosperous development of human society.Recent researches indicate that transition metal sulfides(TMSs)represent prominent bactericidal application potential owing to the meritorious antibacterial performance,acceptable biocompatibility,high solar energy utilization efficiency,and excellent photo-to-thermal conversion characteristics,and thus,a comprehensive review on the recent advances in this area would be beneficial for the future development.In this review article,we start with the antibacterial mechanisms of TMSs to provide a preliminary understanding.Thereafter,the state-of-the-art research progresses on the strategies for TMSs materials engineering so as to promote their antibacterial properties are systematically surveyed and summarized,followed by a summary of the practical application scenarios of TMSs-based antibacterial platforms.Finally,based on the thorough survey and analysis,we emphasize the challenges and future development trends in this area. | Hecheng Han Jingjing Yang Xiaoyan Li Yuan Qi Zhengyi Yang Zejun Han Yanyan Jiang Martina Stenzel Hui Li Yixin Yin Yi Du Jiurong Liu Fenglong Wang | 2021 | Nano Research2021，14，8： | 2 |
| 9 | On the Simulation of Fragmentation During the Process of Ceramic Tile Impacted by Blunt Projectile with SPH Method in LS-DYNA显示文摘Ceramics are extensively used in protective structures which are often subjected to projectile impacts.During an impact process of a ceramic target by a projectile,fragmentation occurs in both the target and the projectile.It is challenging to simulate such events and predict residual mass and velocity of the projectile.In this work,we attempt to use smoothed particle hydrodynamics(SPH)in LS-DYNA to reproduce fragmentation of the target and the projectile and predict residual mass and velocity of the projectile during a projectile impact of a ceramic target.SPH models for an alumina ceramic tile impacted by a blunt tungsten heavy alloy projectile are established.SPH simulation results of residual mass and velocity of the projectile as well as ejecta and bulge movements of the ceramic tile are obtained and compared with experimental data and simulation results of other numerical approaches.It is found that SPH simulation can properly reproduce the impact fragmentation of the target and the projectile,and shows advantages over existing numerical approaches in the prediction accuracy of residual mass and velocity.Moreover,effects of some numerical aspects of SPH,including particle spacing,contact treatment and parameters in artificial viscosity and smoothing length,on simulation results are identified.A simple approach using identical smoothing length and balanced artificial viscosity is proposed to reduce particle spacing sensitivity.The observed parametric effects and the proposed approach will provide guidance to set appropriate parameters values for SPH simulation of impact fragmentation. | Yihua Xiao Hecheng Wu Xuecheng Ping | 2020 | Computer Modeling in Engineering & Sciences2020，，3： | 2 |
| 10 | Dl-3-n-butylphthalide, a natural antioxidant, protects dopamine neurons in rotenone models for Parkinson’s disease显示文摘 | Nian Xiong Jinsha Huang Chunnuan Chen Ying Zhao Zhaowen Zhang Min Jia Zhentao Zhang Lingling Hou Hecheng Yang Xuebing Cao Zhihou Liang Yongxue Zhang Shenggang Sun Zhicheng Lin Tao Wang | 2012 | Neurobiology of Aging2012，，8： | 1 |
| 11 | Evaluation of tissue polypeptide specific antigen,CYFRA21-1 and carcinoembryonic antigen in non-small cell lung carcinoma:does the combine use of cytokaratin markers give any additional information?显示文摘 | Nisman B Lafair J Hecheng N | 1998 | Cancer1998，82，10： | 1 |
| 12 | Xylocoside G Reduces Amyloid-β Induced Neurotoxicity by Inhibiting NF-κB Signaling Pathway in Neuronal Cells显示文摘 | Yan Yu Liang Zhou Miao Sun Ting Zhou Kaiyin Zhong Hecheng Wang Yi Liu Xinying Liu RuiZhong Xiao Jia Ge PengFei Tu Dong Sheng Fan Yuan Lan Chen Hui Dehua Chui | 2012 | Journal of Alzheimer’s Disease2012，，2： | 1 |
| 13 | bFGF promotes the differentiation and effectiveness of human bone marrow mesenchymal stem cells in a rotenone model for Parkinson’s disease显示文摘 | Nian Xiong Hecheng Yang Ling Liu Jing Xiong Zhaowen Zhang Xiaowei Zhang Min Jia Jinsha Huang Zhentao Zhang Asrah A. Mohamed Zhicheng Lin Tao Wang | 2013 | Environmental Toxicology and Pharmacology2013，，2： | 1 |
| 14 | Distribution of phthalate esters in alluvial sediment: A case study at JiangHan Plain, Central China显示文摘 | Hui Liu Hecheng Liang Ying Liang Dan Zhang Cheng Wang Hesheng Cai Stepan. L. Shvartsev | 2009 | Chemosphere2009，，4： | 1 |
| 15 | Self‐healing supramolecular elastomers based on the multi‐hydrogen bonding of low‐molecular polydimethylsiloxanes: Synthesis and characterization显示文摘 | Anqiang Zhang Lin Yang Yaling Lin Lishan Yan Hecheng Lu Lianshi Wang | 2013 | J Appl Polym Sci2013，，5： | 1 |
| 16 | Microstructure properties of nano-crystalline silicon/SiO2 multilayer's fabricated by laser-induced crystallization显示文摘 | Hecheng Zou Liangcai Wu | 2005 | Thin Solid Films2005，491，： | 1 |
| 17 | A comment on 'cost efficiency in data envelopment analysis with data uncertainty'显示文摘 | FANG LEI LI HECHENG | 2012 | European Journal of Operational Research2012，220，2： | 1 |
| 18 | Dl-3-n-butylphthalide, a natural antioxidant, protects dopamine neurons in rotenone models for Parkinson’s disease显示文摘 | Nian Xiong Jinsha Huang Chunnuan Chen Ying Zhao Zhaowen Zhang Min Jia Zhentao Zhang Lingling Hou Hecheng Yang Xuebing Cao Zhihou Liang Yongxue Zhang Shenggang Sun Zhicheng Lin Tao Wang | 2012 | Neurobiology of Aging2012，，8： | 1 |
| 19 | Pattern of lymph node metastases in patients with squamous cell carcinoma of the thoraeie esophagus who underwent three-field lymphadenectomy 显示文摘 | Hecheng Li Yawei Zhang Hui Cai | 2007 | Eur Surg Res2007，39，1： | 1 |
| 20 | A genetic algorithm based on optimality conditions for nonlinear bilevel programming problems 显示文摘 | LI HECHENG WANG YUPING | 2010 | International Journal of Applied Mathematics and Informatics2010，28，34： | 1 |
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