|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | New Family of RPR-Equivalent Parallel Mechanisms:Design and Application显示文摘Parallel mechanisms(PMs)have been used as skeletons or end-effectors in various advanced manufacturing equipment.Compared with their serial counterparts,PMs offer high rigidity,good dynamic response,and large payload capability.Three-degrees-of-freedom(DOFs)parallel mechanisms with two rotational and one translational(2R1T)motion are particularly useful,such as | Qinchuan LI Lingmin XU Qiaohong CHEN Wei YE | 2017 | Chinese Journal of Mechanical Engineering2017，30，2： | 12 |
| 2 | Immunity-and-matrix-regulatory cells derived from human embryonic stem cells safely and effectively treat mouse lung injury and fibrosis显示文摘Lung injury and fibrosis represent the most significant outcomes of severe and acute lung disorders,including COVID-19.However,there are still no effective drugs to treat lung injury and fibrosis.In this study,we report the generation of clinical-grade human embryonic stem cells(hESCs)-derived immunity-and matrix-regulatory cells(IMRCs)produced under good manufacturing practice requirements,that can treat lung injury and fibrosis in vivo.We generate IMRCs by sequentially differentiating hESCs with serum-free reagents.IMRCs possess a unique gene expression profile distinct from that of umbilical cord mesenchymal stem cells(UCMSCs),such as higher expression levels of proliferative,immunomodulatory and anti-fibrotic genes.Moreover,intravenous delivery of IMRCs inhibits both pulmonary inflammation and fibrosis in mouse models of lung injury,and significantly improves the survival rate of the recipient mice in a dose-dependent manner,likely through paracrine regulatory mechanisms.IMRCs are superior to both primary UCMSCs and the FDA-approved drug pirfenidone,with an excellent efficacy and safety profile in mice and monkeys.In light of public health crises involving pneumonia,acute lung injury and acute respiratory distress syndrome,our findings suggest that IMRCs are ready for clinical trials on lung disorders. | Jun Wu Dingyun Song Zhongwen Li Baojie Guo Yani Xiao Wenjing Liu Lingmin Liang Chunjing Feng Tingting Gao Yanxia Chen Ying Li Zai Wang Jianyan Wen Shengnan Yang Peipei Liu Lei Wang Yukai Wang Liang Peng Glyn Nigel Stacey Zheng Hu Guihai Feng Wei Li Yan Huo Ronghua Jin Ng Shyh-Chang Qi Zhou Liu Wang Baoyang Hu Huaping Dai Jie Hao | 2020 | Cell Research2020，30，9： | 7 |
| 3 | Controlled synthesis of Zeolite adsorbent from lowgrade diatomite:A case study of self-assembled sodalite microspheres显示文摘Highly efficient and sustainable conversion technologies to generate uniform sodalite(Na8(AlSiO4)6(OH)2)zeolite micro spheres with low-grade waste natural diatomite as raw materials via a solution-mediated crystallization route were developed in the present study.The synthesis process can be considered as an in-situ zeolitization of diatomite precursor without involving any me so scale template and any post-synthetic modification.The mass ratios of diatomite and AlCl3·6 H2 O have remarkable effect on the morphology,crystal structure and porosity of sodalite zeolite product.The preferred sodalite microspheres with uniform mesoporous of size 3.5-5.5 nm and large surface area of 162.5 m2/g exhibit well removal performance for heavy metal ions(Pb(II),Cd(II),Zn(II),and Cu(II)),with the highest adsorption abilities for Pb(II)ions of 365 mg/g.In addition,the effect of contact time,initial ion concentration,competitive adsorption and solution pH were evaluated.The removal performance results from synergistic effects of dominating cation-exchange and additional surface chemisorption.The study may broadly help unveil chemical control reactions of the zeolitization processes of diatomite,and thus facilitates the development of promising zeolite materials for the use in natural and engineered aquatic environments by recvcling waste diatomite resources. | Lingmin Sun Junshu Wu Jinshu Wang Gong Yu Jingchao Liu Yucheng Du Yongli Li Hongyi Li | 2020 | Journal of Environmental Sciences2020，32，5： | 3 |
| 4 | Association of long non-coding RNA HOTAIR and MALAT1 variants with cervical cancer risk in Han Chinese women显示文摘Long noncoding RNA(lncRNA) HOTAIR and MALAT1 are implicated in the development of multiple cancers. Genetic variants within HOTAIR and MALAT1 may affect the gene expression, thereby modifying genetic susceptibility to cervical cancer. A case-control study was designed, including 1 486 cervical cancer patients and 1 536 healthy controls. Based on RegulomeDB database, 11 SNPs were selected and genotyped by using Sequenom’s Mass ARRAY. Univariate and multivariate logistic regression models were used to calculate the odds ratio(OR) and 95% confidence interval(CI). We found that the A allele of rs35643724 in HOTAIR was associated with increased risk of cervical cancer, while the C allele of rs1787666 in MALAT1 was associated with decreased risk. Compared to individuals with 0–1 unfavorable allele, those with 3–4 unfavorable alleles showed18% increased odds of having cervical cancer. Our findings suggest that HOTAIR rs35643724 and MALAT1 rs1787666 might represent potential biomarkers for cervical cancer susceptibility. | Meiqun Jia Lulu Ren Lingmin Hu Hongxia Ma Guangfu Jin Dake Li Ni Li Zhibin Hu Dong Hang | 2019 | The Journal of Biomedical Research2019，33，5： | 2 |
| 5 | The construction of drug-resistant cancer cell lines by CRISPR/Cas9 system for drug screening显示文摘Cancer therapy is often hampered by the rapid emergence of drug resistance. Drug-resistant cellular models are essential for understanding the drug resistance and developing new therapeutics. The low efficiency and long time required in creating these models are major obstacles hindering drug resistance research and drug screening. Herein, we report an approach that can accelerate(shortening the time from years to 3 weeks) the establishment of cancer cell line-based, inheritable drug resistance models by specific knockout of MED12 gene using CRISPR/Cas9 system. The resultant MED12^(KO) A375(melanoma)cell line was resistant to inhibitors of B-Raf proto-oncogene, serine/threonine kinase(BRAF), whereas the resultant MED12^(KO) PC9(non-small cell lung cancer) cell line was resistant to inhibitors of epidermal growth factor receptor(EGFR). Evaluation of anti-cancer drugs and their combinations shows that certain combinations of BRAF inhibitors and TGF-β receptor(TGF-βR) inhibitors are active in suppressing the growth of MED12^(KO) A375 cells, and a few combinations of EGFR inhibitors and TGF-βR inhibitors were active in suppressing the growth of MED12^(KO) PC9 cells. The drug-resistant models will be useful in screening novel drugs and drug combinations for multi-drug-resistant cancer therapy. | Lingmin Zhang Ying Li Qinghua Chen Yong Xia Wenfu Zheng Xingyu Jiang | 2018 | Science Bulletin2018，63，21： | 2 |
| 6 | Investigation of 1- Phenyl-3-Methyl-5-Pyrazolone as a corrosion inhib- itor for mild steel in 1M hydrochloric acid 显示文摘 | Cao Kun Li Weihua Yu Lingmin | 2012 | Inter- national Journal of Electrochemical Science2012，7，1： | 1 |
| 7 | X-RAY POWDER DIFFRACTION STUDY FOR RE COMPOUND GdNiSn显示文摘The compound GdNiSn has been studied by X-ray powder diffraction technique.The crystal structure and the X-ray diffraction data for this compound at room temperature are reported.The compound GdNiSn is orthorhombic with lattice parameters a=7.2044(1)A,b=7.6895(6)A,c=4.4772(4)A,space group Pna2_(1) and 4 formula units of GdNiSn in unit cell.The Smith and Snyder figure of index F_(30) for this compound is 35(0.015,59). | Zeng Lingmin Zhuang Yinghong Li Junqin Zhang Liping Hao Jianmin | 1996 | Transactions of Nonferrous Metals Society of China1996，6，1： | 1 |
| 8 | The pathological assessment and clinical significance of progesterone replacement therapy for endometrial endometrioid carcinoma and precancerous lesions 显示文摘 | GUO Donghui LI Lingmin ZHANG Huijuan | 2015 | Chinese Journal of Pathology32015，44，3： | 1 |
| 9 | Polymorphisms involved in the miR-218 - LAMB3 pathway and susceptibility of cervical cancer, a case–control study in Chinese women显示文摘 | Xiaoyi Zhou Xiaojun Chen Lingmin Hu Suping Han Fulin Qiang Yuling Wu Li Pan Hongbing Shen Ying Li Zhibin Hu | 2010 | Gynecologic Oncology2010，，2： | 1 |
| 10 | CRYSTAL STRUCTURE AND X-RAY POWDER DIFFRACTION DATA FOR RE COMPOUND HoNiSb显示文摘CRYSTALSTRUCTUREANDX-RAYPOWDERDIFFRACTIONDATAFORRECOMPOUNDHoNiSb￥Zeng,Lingmin;Li,Jungqin;Zhang,Liping;Zhuang,Yinghong;Hao,Jia... | Zeng, Lingmin Li, Jungqin Zhang, Liping Zhuang, Yinghong Hao, Jianmin (Institute of Materials Science, Guangxi University, Nanning 530004)(Tianjin Electronic Materzals Research Institute) | 1995 | 中国有色金属学会会刊:英文版1995，5，3： | 1 |
| 11 | Polymorphisms involved in the miR-218 - LAMB3 pathway and susceptibility of cervical cancer, a case–control study in Chinese women显示文摘 | Xiaoyi Zhou Xiaojun Chen Lingmin Hu Suping Han Fulin Qiang Yuling Wu Li Pan Hongbing Shen Ying Li Zhibin Hu | 2010 | Gynecologic Oncology2010，，2： | 1 |
| 12 | Next-generation sequencing revealed factors associated with cumulative incidence of relapse and leukemia-free survival in patients with newly diagnosed acute myeloid leukemia显示文摘BackgroundSeveral prognostic biomarkers have been validated for acute myeloid leukemia(AML),a heterogeneous hematopoietic malignancy.However,the factors associated with the cumulative incidence of relapse(CIR)and leukemia-free survival(LFS)in real-world patients with AML have not been well defined.MethodsThis study examined clinical and mutational data of 246 patients with newly diagnosed AML who received the traditional“3+7”regimen in PLA General Hospital from January 2008 to August 2020.Factors associated with CIR and LFS in patients newly diagnosed with AML were analyzed using next-generation sequencing.ResultsAdditional sex combs-like 1(ASXL1)and Serine/arginine-rich splicing factor 2(SRSF2)mutations were found to be associated with an increased risk of CIR and a reduced LFS in univariate analysis,while only SRSF2 mutations were associated with these factors in the multivariate analysis.Hyperleukocytosis maintained an independent effect on LFS in the multivariate analysis.Hematopoietic stem cell transplantation conferred a significant prognostic benefit on both CIR and LFS in our cohort.Furthermore,we validated the risk classification of patients with AML receiving traditional induction regimens across a broad age range.Based on next-generation sequencing results,we concluded that SRSF2 mutations were predictive of an increased risk of relapse,inferior LFS rates,and non-relapse mortality in patients with newly diagnosed AML.ConclusionThese findings indicate that patients with SRSF2 mutations might not benefit from the conventional“3+7”regimen.Our results may help in developing molecular stratification strategies and could guide treatment decisions for patients with newly diagnosed AML. | Sai Huang Peng Chen Lu Wang Lingmin Xu Mingyu Jia Jing Chen Nan Wang Fei Li Lixia Liu Jiayue Qin Chengcheng Wang Shanbo Cao Liping Dou Daihong Liu | 2023 | Cancer Pathogenesis and Therapy2023，1，1： | 0 |
| 13 | River restoration challenges with a specific view on hydromorphology显示文摘1 Introduction 1.1 River ecosystem degradation Over the past century,almost throughout the whole world,streams and rivers have been heavily polluted and morphologically degraded due to industrial,household and agricultural sources,leading to significant declines in biodiversity,water quality and ultimately water supply[1-5].In the last decades,river system design has been practiced from an engineering viewpoint that focuses on water abstraction,sanitation,generation of energy,transportation and safety,rather than from a socio-ecological perspective.The technical management altered the understanding of a functioning river system itself and its social context. | Jianhua LI Stephan HOERBINGER Clemens WEISSTEINER Lingmin PENG Hans Peter RAUCH | 2020 | Frontiers of Structural and Civil Engineering2020，14，5： | 0 |
| 14 | Natural ventilation driven by a restricted heat source elevated to different levels显示文摘The thermal buoyancy generated by the difference in air density in a building can drive hot-pressed natural ventilation,which is an energy-efficient means of ventilation used to obtain higher air quality.Therefore,the effect of a single-point heat source with limited sides at different heights on stratified flow was studied in a naturally ventilated room in this paper.Based on the classical plume diffusion law of an independent point heat source and the mirroring principle,a calculation model of the thermal stratification height with a restricted source elevated to different levels was derived and validated.The quantitative effects of the heat source height from the floor,the effective opening area and other factors on the natural ventilation of hot pressure were analyzed.A threshold X_(T)for the separation between a point source and a sidewall was defined to estimate whether the thermal plume was independent or restricted by a sidewall.And a method for calculating the threshold xt was obtained.This research can provide a reference basis for designing natural ventilation for buildings with a restricted heat source at different levels to achieve a desired indoor environment. | Changqing Yang Wenhao Luo Angui Li Xiaopan Gao Lunfei Che Lingmin Qiao Teng Gao Yubo Liu | 2022 | Building Simulation2022，15，2： | 0 |
| 15 | Next-generation sequencing reveals relapse and leukemia-free survival risks in newly diagnosed acute myeloid leukemia treated with CAG regimen combined with decitabine显示文摘Background:Acute myeloid leukemia(AML)is a heterogeneous hematopoietic malignancy whose prognosis is associated with several biomarkers.Decitabine,a deoxyribonucleic acid(DNA)methyltransferase(DNMT)in-hibitor,combined with cytarabine,aclarubicin hydrochloride,and granulocyte colony-stimulating factor(DCAG),has been used in patients newly diagnosed with AML.This regimen has been especially used in older and fragile patients who are immunocompromised or have co-morbidities,as well as those with specific gene mutations.However,the integration of molecular risk stratification and treatment guidance for the DCAG regimen has not been well defined.Therefore,this study aimed to investigate the genetic mutations associated with AML and establish appropriate treatment strategies for patients newly diagnosed with AML.Methods:This study analyzed the clinical data and genetic mutations based on next-generation sequencing(NGS)in 124 newly diagnosed patients with AML who received the DCAG regimen at the People's Liberation Army(PLA)General Hospital from January 2008 to August 2020.Factors associated with the cumulative incidence of relapse(CIR)and leukemia-free survival(LFS)in patients newly diagnosed with AML were analyzed.Results:The most adverse prognosis of DCAG-treated patients was observed in those with FLT3-ITD,KIT,PTPN11,GATA2,or IDH1 mutations during univariable analysis,whereas PTPN11 mutation was solely significant in multivariable analysis,with an increased likelihood of CIR(P=0.001)and reduced LFS duration(P=0.077).Hyperleukocytosis was maintained as an independent risk factor for increased CIR risk(P=0.044)and decreased LFS duration(P=0.042)in multivariable analysis.In this study,we validated the risk classification of patients with AML receiving an epigenetic modifier-based induction regimen across a broad age range.Conclusion:NGS demonstrated a dismal overall outcome in patients with the rare PTPN11 mutations,indicating the need for new therapies that target this high-risk subtype of AML.These results offer a potential molecular stratification and treatment guidance for patients with AML. | Sai Huang Peng Chen Lu Wang Lingmin Xu Nan Wang Fei Li Liping Dou Daihong Liu | 2024 | Cancer Pathogenesis and Therapy2024，2，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员