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| 1 | Mechanical behavior of coal under different mining rates:A case study from laboratory experiments to field testing显示文摘During the development of hot dry rock,the research on thermal fatigue damage caused by thermal shock of cold and heat cycles is the basis that ensures the long-term utilization of geothermal resources,but there are not enough relevant studies at present.Based on this,the thermal damage tests of granite at different temperatures(250,350,450°C)and quenching cycles(1,5,10,15 cycles)were carried out.Preliminary reveals the damage mechanism and heat transfer law of the quenching cycle effect on hot dry rock.The results show that with the increase of temperature and cycles,the uneven thermal expansion of minerals and the thermal shock caused by quenching promote the crack development of granite,resulting in the decrease of P-wave velocity,thermal conductivity and uniaxial compressive strength of granite.Meanwhile,the COMSOL was used to simulate the heat transfer of hot dry rock under different heat treatment conditions.It concluded that the increase in the number of quenching cycles reduced the heat transfer capacity of the granite,especially more than 10 quenching cycles,which also reflects that the thermal fatigue damage leads to a longer time for the temperature recovery of the hot dry rock mass.In addition,the three-dimensional nonlinear fitting relationship among thermal conductivity,temperature and cycle number was established for the first time,which can better reveal the change rule of thermal conductivity after quenching thermal fatigue effect of hot dry rock.The research results provide theoretical support for hot dry rock reservoir reconstruction and production efficiency evaluation. | Mingzhong Gao Jing Xie Yanan Gao Wenyong Wang Cong Li Bengao Yang Junjun Liu Heping Xie | 2021 | International Journal of Mining Science and Technology2021，31，5： | 39 |
| 2 | Effect of Heat Treatment Temperature on Properties of Chinese Calcined Flint Clay Based Plastic Refractories显示文摘Effects of different heat treatment temperatures on properties of Chinese calcined flint clay based plastic refractories were investigated using Chinese calcined flint clay as starting material,aluminum sulfate and fireclay as binding system. The results showed that with temperature rising,Chinese calcined flint clay based plastic refractories shrinked firstly and then expanded. The modulus of rupture (MOR) and the cold crushing strength (CCS) increased firstly and then decreased from 110 ℃ to 600 ℃,then increased obviously. Thermal expansion coefficient increased from 110 ℃ to 760 ℃,decreased from 760 ℃ to 1 300 ℃,and increased from 1 300 ℃ to 1 500 ℃. | ZHANG Wei DAI Wenyong YU Xinfeng LI Liang | 2009 | China's Refractories2009，18，2： | 23 |
| 3 | Effect of Reclamation Time and Land Use on Soil Properties in Changjiang River Estuary,China显示文摘The objective of this study is to analyze soil physical and chemical properties,soil comprehensive functions and impact factors after different years of reclamation.Based on the survey data taken from 216 soil sampling points in the Fengxian Reclamation Area of the Changjiang (Yangtze) River Estuary,China in April 2009 and remotely sensed TM data in 2006,while by virtue of multivariate analysis of variance (MANOVA),geo-statistical analysis (GA),prin-cipal component analysis (PCA) and canonical correspondence analysis (CCA),it was concluded that:1) With the in-crease in reclamation time,soil moisture,soil salinity,soil electric conductivity and soil particle size tended to decline,yet soil organic matter tended to increase.Soil available phosphorous tended to increase in the early reclamation period,yet it tended to decline after about 49 years of reclamation.Soil nitrate nitrogen,soil ammonia nitrogen and pH changed slightly in different reclamation years.Soil physical and chemical properties reached a steady state after about 30 years of reclamation.2) According to the results of PCA analysis,the weighted value (0.97 in total) that represents soil nutrient factors (soil nitrate nitrogen,soil organic matter,soil available phosphorous,soil ammonia nitrogen,pH and soil particle size) were higher than the weighted value (0.48 in total) of soil limiting factors (soil salinity,soil elec-tric conductivity and soil moisture).The higher the F value is,the better the soil quality is.3) Different land use types play different roles in the soil function maturity process,with farmlands providing the best contribution.4) Soil physi-cal and chemical properties in the reclamation area were mainly influenced by reclamation time,and then by land use types.The correlation (0.1905) of the composite index of soil function (F) with reclamation time was greater than that with land use types (-0.1161). | SUN Yongguang LI Xiuzhen ülo MANDER HE Yanlong JIA Yue MA Zhigang GUO Wenyong XIN Zaijun | 2011 | Chinese Geographical Science2011，21，4： | 17 |
| 4 | Metamorphic Characteristics and Tectonic Implications of the Kadui Blueschist in the Central Yarlung Zangbo Suture Zone,Southern Tibet显示文摘The Kadui blueschist is located in the central section of Yarlung Zangbo suture zone(YZSZ), southern Tibet, and has been subjected to the subduction of the Neo-Tethyan Ocean below the Asian Plate and provides important clues for better understanding the evolution of the India-Asia convergence zone. In this paper, the systematical petrographic and mineral chemical studies were carried out on the Kadui blueschist, which reveal a mineral assemblage of sodic amphibole, chlorite, epidote, albite and quartz with accessory minerals of titanite, calcite and zircon. Electron microprobe analyses demonstrate that amphibole shows zoned from actinolite core to ferrowinchite/riebeckite rim composition indicating that the sodic amphibole has formed during a prograde metamorphic event. The protolith of the blueschist is an intermediate-basic pyroclastic rock. The calculated pseudosection indicates a clockwise P-T path and constrains peak metamorphic conditions of about 5.9 kbar at 345 ℃. This condition is transitional between pumpellyite-actinolite, greenschist and blueschist facies with a burial depth of 20–22 km and a thermal gradient of 15–16 ℃/km. This thermal gradient belongs to high pressure intermediate P/T facies series and is possibly related to a warm subduction setting of young oceanic slabs. Our new findings indicate that the Kadui blueschist in the central part of YZSZ experienced a rapid subduction and exhumation process as a response to a northward subduction of the Neo-Tethyan oceanic lithosphere during the initial India-Asia collision stage. | Guangming Sun Xu-Ping Li WenYong Duan Shuang Chen Zeli Wang Lingquan Zhao Qingda Feng | 2018 | Journal of Earth Science2018，29，5： | 12 |
| 5 | Effects of combined drip irrigation and sub-surface pipe drainage on water and salt transport of saline-alkali soil in Xinjiang, China显示文摘Developing effective irrigation and drainage strategies to improve the quality of saline-alkali soil is vital for enhancing agricultural production and increasing economic returns. In this study, we explored how irrigation and drainage modes (flood irrigation, drip irrigation, and sub-surface pipe drainage under drip irrigation) improve the saline-alkali soil in Xinjiang, China. We aimed to study the transport characteristics of soil water and salt under different irrigation and drainage modes, and analyze the effects of the combination of irrigation and drainage on soil salt leaching, as well as its impacts on the growth of oil sunflower. Our results show that sub-surface pipe drainage under drip irrigation significantly reduced the soil salt content and soil water content at the 0–200 cm soil depth. Under sub-surface pipe drainage combined with drip irrigation, the mean soil salt content was reduced to below 10 g/kg after the second irrigation, and the soil salt content decreased as sub-surface pipe distance decreased. The mean soil salt content of flood irrigation exceeded 25 g/kg, and the mean soil desalination efficiency was 3.28%, which was lower than that of drip irrigation. The mean soil desalination rate under drip irrigation and sub-surface pipe drainage under drip irrigation was 19.30% and 58.12%, respectively. After sub-surface drainage regulation under drip irrigation, the germination percentage of oil sunflower seedlings was increased to more than 50%, which further confirmed that combined drip irrigation and sub-surface pipe drainage is very effective in improving the quality of saline-alkali soil and increasing the productivity of agricultural crops. | HENG Tong LIAO Renkuan WANG Zhenhua WU Wenyong LI Wenhao ZHANG Jinzhu | 2018 | Journal of Arid Land2018，10，6： | 12 |
| 6 | Effect and Prospect of Basic Geological Survey Based on Airborne Gravimetry in China显示文摘The airborne gravimetry was an important leap and innovation in the world's history of geophysical exploration.China's first test of the airborne gravity geological survey in the onshore-offshore transitional area of the western and southern part of the Bohai Sea was successful and effective in geology.Based on the airborne gravity data,and combining previous ground gravity,seismic and drilling data etc.,we carried out the geological interpretation by forward and inverse methods.The result shows that the airborne Bouguer gravity anomaly was clear,the fracture interpretation was reliable,and the inversion depth of the main geological interfaces was relatively accurate.This airborne gravity geological survey not only filled the exploring gaps in the onshore-offshore transitional area,and realized the geological and tectonic junction between the sea and the land,but also discovered four local gravity anomalies,11 fractures and three sags or subsags,and so on.The good geological effect of airborne gravimetry not restricted by terrain condition shows that it can be served as a new geophysical method in the exploration of complex terrain physiognomy area such as mountain,jungle,desert,marsh,onshore-offshore transitional area and so on,and has an extensive application prospect in China in the future. | LI Wenyong ZHOU Jianxin XIONG Shengqing GUO Zhihong LU Wenfen XU Jianchun LIU Yanxu | 2012 | Acta Geologica Sinica(English Edition)2012，86，1： | 11 |
| 7 | Metamorphic Petrology of Clinopyroxene Amphibolite from the Xigaze Ophiolite,Southern Tibet: P-T Constraints and Phase Equilibrium Modeling显示文摘The clinopyroxene amphibolite from the Bailang terrane is located in the central section of the Yarlung Zangbo suture zone(YZSZ),southern Tibet.The study of it is expected to provide important clues for the subduction of the Neo-Tethyan Ocean below the Asian Plate and thus for better understanding of the development of the India-Asia collision zone.Based on integrated textural,mineral compositional,metamorphic reaction history and geothermobarometric studies of the clinopyroxene amphibolite within a serpentinite mélange,four overprinted metamorphic stages are established.They are the first metamorphic record of M1 stage indicated by a relict assemblage of plagioclase+clinopyroxene+amphibole,an early M2 stage characterized by an assemblage of medium-grained clinopyroxene+amphibole+plagioclase+quartz as well as rutile inclusion in titanite,which is formed during burial process,an isobaric cooling M3 stage which is characterized by an assemblage of clinopyroxene+amphibole+plagioclase+titanite,and a decomposing retrograde stage M4,which is represented by the amphibolite+plagioclase symplectite+titanite+rutile+quartz.By applying the THERMOCALC(versions 6.2 and 6.3)technique in the NCFMASHTO system,the P-T conditions estimated from M1 to M4 stages are ca.8.6 kbar/880℃,10.8–13.4 kbar/800–840℃,12.7–13.2 kbar/650–660℃ and<11.2 kbar/640℃,respectively.The mineral assemblages and their P-T conditions define a counterclockwise P-T path for the clinopyroxene amphibolite of the Xigaze ophiolite,suggesting that the rocks underwent a cooling process during burial from magmatic protolith,and a decompressing stage after the pressure peak metamorphic conditions,which implies that the Bailang terrane of the Xigaze ophiolite may have experienced subduction/collision-related tectonic processes.The peak metamorphism reaches to the transitional P-T conditions among amphibolite facies,granulite facies and eclogite facies with a burial depth of 30–40 km.After exhumation of the ophiolitic unit to the shallow crustal levels,the clinopyroxene amphibolite exposes to a high fO2 condition on the basis of the stable epidotebearing assemblage in the T-MO2 diagrams.A late subgreenschist facies overprinting subsequently occurs,the relevant mineral assemblage is prehnite+albite+chlorite+epidote+quartz. | Yancheng Zhang Xu-Ping Li Guangming Sun Zeli Wang Wenyong Duan | 2019 | Journal of Earth Science2019，30，3： | 7 |
| 8 | Study of Residual Basin and Tectonolayering Based on Airborne Gravity and Magnetic Data显示文摘This paper takes the South Yellow Sea as an example to show a new method for comprehensive geological-geophysical research such as residual basin and tectonolayering using airborne gravity and magnetic data in China. Based on airborne gravity and magnetic data, by measuring and analyzing stratigraphic density and susceptibility, the depths to the pre-Sinian magnetic basement top, the pre-Jurassic top and the Cenozoic bottom, are obtained by forward and inverse methods constrained by seismic and drilling data; and furthermore, the residual thicknesses of the Sinian-Triassic, the Jurassic-Cretaceous and the Cenozoic are calculated. Based on airborne gravity and magnetic anomalies, the faults in the pre-Sinian magnetic basement, the Jurassic-Cretaceous and the Cenozoic are respectively interpreted by the qualitative and quantitative methods. On the basis of the above study, and combining regional important tectonic events, four tectonolayers are divided in the vertical succession in South Yellow Sea, namely the pre-Sinian magnetic basement, the Sinian-Triassic, the Jurassic-Cretaceous and the Cenozoic. The result shows that there are thick Cenozoic and Jurassic-Cretaceous strata and thin residual Sinian-Triassic strata in the Suzhong-Huangnan depression area, but there are thin or only sporadic Mesozoic-Cenozoic terrestrial strata and thick Sinian-Triassic marine strata reserved in Subei-Huangzhong uplift area and Sunan-Wunansha uplift area. The four tectonolayers are very different in structures as well as distributions in plane. | LI Wenyong ZHOU Jianxin XIONG Shengqing LIU Yanxu XU Jianchun | 2013 | Acta Geologica Sinica(English Edition)2013，87，4： | 6 |
| 9 | Growth Inhibition, Induction of Apoptosis by Green Tea Constituent (-)-Epigallocatechin-3-gallate in Cultured Rabbit Lens Epithelial Cells显示文摘Purpose: To evaluate effect of green tea extract (-)-Epigallocatechin-3-gallate (EGCG) in cultured rabbit lens epithelial cells in order to pave a new way to postcapsular opacity (PCO) prevention.Methods: Cell survival rate was measured by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) coloimetric assay. Cell apoptosis was detected by electron microscopy, Hochest 33258 stain and flow cytometer. DNA fragment was detected using agarose gel electrophoresis.Result: Proliferation of the cultured rabbit lens epithelia cells was inhibited by EGCG in a dose and time dependent manner. Morphologic study showed that the cells became shrunk, round shaped with their nuclei condensed and broken. Apoptotic bodies were also seen under electron microscope and in Hochest 33258 stain assay 24 hours after EGCG was added to the medium. DNA ladders were shown in agarose gel eletrophoresis. In flow cytometry assay, apoptosis peak was also evident.Conclusion: Green Tea Constituent(-) | Wenyong Huang, Shaozhen Li, Junwen Zeng, Yizhi Liu, Mingxing Wu, Ming ZhangZhongshan Ophthalmic Center, Sun Yat-sen University of Medical Sciences, Guangzhou 510060, China | 2000 | 眼科学报2000，16，3： | 6 |
| 10 | Superimposed versus residual basin:The North Yellow Sea Basin显示文摘北方黄海盆是中生代和新生代盆。把外形基于盆边缘,沉积变瘦,盆和 vitrinite 反射的尺寸和形状,诺思黄海盆不是剩余盆。盆的开发的分析三结构的层,独立石油系统,边界差错活动, MesozoicCenozoic 沉积中心的移植,在不同时期期间形成的不同的盆结构,和二阶段的扩大的盆和一个阶段消沉盆的重叠,北方黄海盆作为附加的盆被认出。 | Wenyong Li Wenfen Lu Yanxu Liu Jianchun Xu | 2012 | Geoscience Frontiers2012，3，1： | 6 |
| 11 | Hydrocarbon Exploration in the South Yellow Sea Based on Airborne Gravity,China显示文摘Differences between the Cenozoic and pre-Cenozoic strata and structures in the middlesouth South Yellow Sea are analyzed using high-resolution airborne gravity data combined with data from offshore wells, seismic exploration and the regional geological background, using forward and inverse methods. We discuss why hydrocarbon exploration has so far failed in the South Yellow Sea, and put forward alternative future exploration plans. The results show that there are thick Cenozoic strata over Jurassic–Cretaceous continental strata in the southern basin of the South Yellow Sea, contrasted with thick Mid-Paleozoic marine strata preserved in the middle uplift area. In the mid-southern South Yellow Sea, airborne Bouguer gravity anomalies are fragmentized with scattered local anomalies. Many tensile normal faults and minor fault blocks occur in the Cenozoic strata. In contrast, reverse faults and nappe structures are found in pre-Cenozoic strata. The essential reasons for the lack of a breakthrough in hydrocarbon exploration are the complexity of geological structures, hydrocarbon accumulation environments, seismic-geologic conditions, and the difficulty of interpreting and understanding these features, rather than an imbalance of exploration framework. Hydrocarbon exploration should be targeted at Mid-Cenozoic continental strata, especially of Paleogene age, in the middle to southern parts of the South Yellow Sea. Special attention should be paid to the favorable structural belts SYI1, SYI2, SYI3 and SYI4 in the southern basin of the South Yellow Sea, where detailed seismic exploration or drilling should be carried out. Attention should also be given to Mid-Paleozoic marine strata in the middle uplift area of the South Yellow Sea. Key strategies that could lead to a hydrocarbon exploration breakthrough are improving exploration resolution, conducting detailed studies of fine structures, and accurately locating minor structures. | Wenyong Li Yanxu Liu Bing Li Feng Luo | 2016 | Journal of Earth Science2016，27，4： | 6 |
| 12 | PHF20 collaborates with PARP1 to promote stemness and aggressiveness of neuroblastoma cells through activation of SOX2 and OCT4显示文摘 | Wenyong Long Wei Zhao Bo Ning Jing Huang Junjun Chu Linfeng Li Qianquan Ma Changsheng Xing Helen Y. Wang Qing Liu Rong-Fu Wang | 2018 | Journal of Molecular Cell Biology2018，10，2： | 5 |
| 13 | Postoperative Complications and Survival Analysis of Surgical Resection for Hilar Cholangiocarcinoma:A Retrospective Study of Fifty-Nine Consecutive Patients显示文摘Objective Hilar cholangiocarcinoma(HC)is invariably fatal without surgical resection.The primary aim of the current study was to determine the safety of variable surgical resections for patient with HC and their survival after surgical resection.In addition,prognostic factor for the overall survival was also evaluated.Methods The study included 59 consecutive patients who were newly diagnosed with HC and underwent surgical resections with curative intend between February 2009 and February 2017.Patients were followed up at 3-6 months intervals after hospital discharge.Postoperative complications and overall survival were determined.Associations of clinicopathologic and surgeon-related factors with overall survival were evaluated through univariate analysis and Cox regression analysis.Results Of patients with Bismuth and Corlette(B&C)type HI(n=19)and IV(n=25)HC lesions,33(55.9%)were treated with hilar resection combined with major liver resection(MLR),while the other 11 patients with type HI and IV,and those with type I(n=8)and II(n=7)HC lesions were treated with hilar resection.The overall surgical mortality was 5.1%and surgical morbidity was 35.6%.There was no statistical difference in the mortality between MLR group and hilar resection group(6.1%vs.3.8%;X2=0.703,P=0.145).The median follow-up period was 18 months(range,1-94 months).The 1-,3-,5-year survival rate was 59.3%,36.5%,and 17.7%,respectively.The overall survival after resections was 18 months.In HC patients with B&C type III and IV lesions,the median survival was 23 months for hilar resection with MLR and 8 months for hilar resection alone;the 1-,3-,5-year cumulative survival rate was 63.9%,23.3%,and 15.5%,respectively for hilar resection with MLR,and 11.1%,0,and 0,respectively for hilar resection alone,with significant diflerene observed(HR,9.902;95%CI,2.636-19.571,P=0.001).Four factors were independently associated with overall survival:preoperative serum Cal9-9(HR,7.039;95%CI,2.803-17.678,P<0.001),histopathologic grade(HR,4.964;95%CI,1.046-23.552,?=0.044),surgical margins(P=0.031),andAJCC staging(P=0.015).Conclusions R0 resection is efficacious in surgical treatment of HC.MLR in combination with caudate lobe resection may increase the chance of R0 resection and improve survival of HC patients with B&C type IK and IV lesions.Preoperatively prepared for biliary drainage may ensure the safety of MLR in most HC patients.Novel adjuvant therapies are needed to improve the survival of HC patients with poor prognostic factors. | Weihua Zhu Wenyong Xie Zhedong Zhang Shu Li Dafang Zhang Yijun Liu Jiye Zhu Xisheng Leng | 2020 | Chinese Medical Sciences Journal2020，35，2： | 4 |
| 14 | Theoretical and simulation research of hydrodynamic instabilities in inertial-confinement fusion implosions显示文摘Inertial fusion energy(IFE)has been considered a promising,nearly inexhaustible source of sustainable carbon-free power for the world's energy future.It has long been recognized that the control of hydrodynamic instabilities is of critical importance for ignition and high-gain in the inertial-confinement fusion(ICF)hot-spot ignition scheme.In this mini-review,we summarize the progress of theoretical and simulation research of hydrodynamic instabilities in the ICF central hot-spot implosion in our group over the past decade.In order to obtain sufficient understanding of the growth of hydrodynamic instabilities in ICF,we first decompose the problem into different stages according to the implosion physics processes.The decomposed essential physics processes that are associated with ICF implosions,such as Rayleigh-Taylor instability(RTI),Richtmyer-Meshkov instability(RMI),Kelvin-Helmholtz instability(KHI),convergent geometry effects,as well as perturbation feed-through are reviewed.Analytical models in planar,cylindrical,and spherical geometries have been established to study different physical aspects,including density-gradient,interface-coupling,geometry,and convergent effects.The influence of ablation in the presence of preheating on the RTI has been extensively studied by numerical simulations.The KHI considering the ablation effect has been discussed in detail for the first time.A series of single-mode ablative RTI experiments has been performed on the Shenguang-Ⅱlaser facility.The theoretical and simulation research provides us the physical insights of linear and weakly nonlinear growths,and nonlinear evolutions of the hydrodynamic instabilities in ICF implosions,which has directly supported the research of ICF ignition target design.The ICF hot-spot ignition implosion design that uses several controlling features,based on our current understanding of hydrodynamic instabilities,to address shell implosion stability,has been briefly described,several of which are novel. | LiFeng Wang WenHua Ye XianTu He JunFeng Wu ZhengFeng Fan Chuang Xue HongYu Guo WenYong Miao YongTeng Yuan JiaQin Dong Guo Jia Jing Zhang YingJun Li Jie Liu Min Wang YongKun Ding WeiYan Zhang | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，5： | 4 |
| 15 | Activation of p53 by SIRT1 Inhibition Enhances Elimination of CML Leukemia Stem Cells in Combination with Imatinib显示文摘 | Ling Li Lisheng Wang Liang Li Zhiqiang Wang Yinwei Ho Tinisha McDonald Tessa L. Holyoake WenYong Chen Ravi Bhatia | 2012 | Cancer Cell2012，，2： | 2 |
| 16 | Recent diagnostic developments at the 100 kJ-level laser facility in China显示文摘A 100 kJ-level laser facility has been designed to study inertial confinement fusion physics in China.This facility incorporates various diagnostic techniques,including optical,x-ray imaging,x-ray spectrum,and fusion product diagnostics,as well as general diagnostics assistance systems and central control and data acquisition systems.This paper describes recent developments in diagnostics at the facility. | Feng Wang Shaoen Jiang Yongkun Ding Shenye Liu Jiamin Yang Sanwei Li Tianxuan Huang Zhurong Cao Zhenghua Yang Xin Hu Wenyong Miao Jiyan Zhang Zhebin Wang Guohong Yang Rongqing Yi Qi Tang Longyu Kuang Zhichao Li Dong Yang Yulong Li Xiaoshi Peng Kuan Ren Baohan Zhang | 2020 | Matter and Radiation at Extremes2020，5，3： | 2 |
| 17 | Ferroptosis promotes T-cell activation-induced neurodegeneration in multiple sclerosis显示文摘While many drugs are effective at reducing the relapse frequency of multiple sclerosis (MS), there is an unmet need for treatments that slow neurodegeneration resulting from secondary disease progression. The mechanism of neurodegeneration in MS has not yet been established. Here, we discovered a potential pathogenetic role of ferroptosis, an iron-dependent regulated cell death mechanism, in MS. We found that critical ferroptosis proteins (acyl-CoA synthetase long-chain family member 4, ACSL4) were altered in an existing genomic database of MS patients, and biochemical features of ferroptosis, including lipid reactive oxygen species (ROS) accumulation and mitochondrial shrinkage, were observed in the experimental autoimmune encephalitis (EAE) mouse model. Targeting ferroptosis with ferroptosis inhibitors or reducing ACSL4 expression improved the behavioral phenotypes of EAE mice, reduced neuroinflammation, and prevented neuronal death. We found that ferroptosis was an early event in EAE, which may promote T-cell activation through T-cell receptor (TCR) signaling in vitro and in vivo. These data indicate that ferroptosis may be a potential target for treating MS. | Jinyuan Luoqian Wenyong Yang Xulong Ding Qing-zhang Tuo Zheng Xiang Zhaoyue Zheng Yu-jie Guo Li Li Pengbo Guan Scott Ayton Biao Dong Huiyuan Zhang Hongbo Hu Peng Lei | 2022 | Cellular & Molecular Immunology2022，19，8： | 2 |
| 18 | Impact Factors on Distribution and Characteristics of Natural Plant Community in Reclamation Zones of Changjiang River Estuary显示文摘To identify impact factors on the distribution and characters of natural plants community in reclamation area, with survey data from 67 plant quadrats in July 2009, soil properties data from 216 sampling points in April 2009, and TM (30 m) data in 2006, the composition and characteristics of natural plants community in different time of the Fengxian area in the Changjiang (Yangtze) River estuary were analyzed with two-way indicator species analysis (TWINSPAN), multivariate analysis of variance (MANOVA), detrended canonical correspondence analysis (DCCA) and canonical correspondence analysis (CCA). The results show that: 1) The plant communities in the reclaimed area are mainly mesophytes and helophytic-mesophytic transitional communities, showing a gradient distribution trend with the change in reclamation years. Species richness (MA), species diversity (H) and above-ground biomass also increase with the increase of reclamation years. Nevertheless, they appear to decline slightly in the middle and late reclamation period (> 30 years). 2) With the rise in land use levels, the changes in species richness and species diversity tend to increase at first and then decrease; species dominance (D), however, tends to decline; and above-ground biomass increases slightly. 3) The distribution of the plant community is mainly influenced by the following factors: land use levels (R = 0.55, p < 0.05), soil moisture (R = 0.53, p < 0.05), soil salinity (R = 0.43, p < 0.05) and reclamation time (R = 0.40, p < 0.05). | SUN Yongguang LI Xiuzhen HE Yanlong JIA Yue MA Zhigang GUO Wenyong XIN Zaijun | 2012 | Chinese Geographical Science2012，22，2： | 2 |
| 19 | Targeting lactate dehydrogenase A (LDHA) exerts antileukemic effects on T-cell acute lymphoblastic leukemia显示文摘Background:T-cell acute lymphoblastic leukemia(T-ALL)is an uncommon and aggressive subtype of acute lymphoblastic leukemia(ALL).In the serum of T-ALL patients,the activity of lactate dehydrogenase A(LDHA)is increased.We proposed that targeting LDHA may be a potential strategy to improve T-ALL outcomes.The current study was conducted to investigate the antileukemic effect of LDHA gene-targeting treatment on T-ALL and the underlying molecular mechanism.Methods:Primary T-ALL cell lines Jurkat and DU528 were treated with the LDH inhibitor oxamate.MTT,colony formation,apoptosis,and cell cycle assays were performed to investigate the effects of oxamate on T-ALL cells.Quantitative real-time PCR(qPCR)and Western blotting analyses were applied to determine the related signaling pathways.A mitochondrial reactive oxygen species(ROS)assay was performed to evaluate ROS production after T-ALL cells were treated with oxamate.A T-ALL transgenic zebrafish model with LDHA gene knockdown was established using CRISPR/Cas9 gene-editing technology,and then TUNEL,Western blotting,and T-ALL tumor progression analyses were conducted to investigate the effects of LDHA gene knockdown on T-ALL transgenic zebrafish.Results:Oxamate significantly inhibited proliferation and induced apoptosis of Jurkat and DU528 cells.It also arrested Jurkat and DU528 cells in G0/G1 phase and stimulated ROS production(all P<0.001).Blocking LDHA significantly decreased the gene and protein expression of c-Myc,as well as the levels of phosphorylated serine/threonine kinase(AKT)and glycogen synthase kinase 3 beta(GSK-3β)in the phosphatidylinositol 3′-kinase(PI3K)signaling pathway.LDHA gene knockdown delayed disease progression and down-regulated c-Myc mRNA and protein expression in T-ALL transgenic zebrafish.Conclusion:Targeting LDHA exerted an antileukemic effect on T-ALL,representing a potential strategy for T-ALL treatment. | Haizhi Yu Yafei Yin Yifang Yi Zhao Cheng Wenyong Kuang Ruijuan Li Haiying Zhong Yajuan Cui Lingli Yuan Fanjie Gong Zhihua Wang Heng Li Hongling Peng Guangsen Zhang | 2020 | Cancer Communications2020，40，10： | 2 |
| 20 | Intraocular Pressure, Central Corneal Thickness, and Glaucoma in Chinese Adults: The Liwan Eye Study显示文摘 | Dandan Wang Wenyong Huang Yuetao Li Yingfeng Zheng Paul J. Foster Nathan Congdon Mingguang He | 2011 | American Journal of Ophthalmology2011，，3： | 2 |
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