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| 1 | Computational high-throughput screening of alloy nanoclusters for electrocatalytic hydrogen evolution显示文摘Here,we report a density functional theory(DFT)-based high-throughput screening method to successfully identify a type of alloy nanoclusters as the electrocatalyst for hydrogen evolution reaction(HER).Totally 7924 candidates of Cu-based alloy clusters of Cu55-nMn(M=Co,Ni,Ru,and Rh)are optimized and evaluated to screening for the promising catalysts.By comparing different structural patterns,Cu-based alloy clusters prefer the core–shell structures with the dopant metal in the core and Cu as the shell atoms.Generally speaking,the HER performance of the Cu-based nanoclusters can be significantly improved by doping transition metals,and the active sites are the bridge sites and three-fold sites on the outer-shell Cu atoms.Considering the structural stability and the electrochemical activity,core–shell CuNi alloy clusters are suggested to be the superior electrocatalyst for hydrogen evolution.A descriptor composing of surface charge is proposed to efficiently evaluate the HER activity of the alloy clusters supported by the DFT calculations and machine-learning techniques.Our screening strategy could accelerate the pace of discovery for promising HER electrocatalysts using metal alloy nanoclusters. | Xinnan Mao Lu Wang Yafeng Xu Pengju Wang Youyong Li Jijun Zhao | 2021 | npj Computational Materials2021，，1： | 3 |
| 2 | Physical Growth of Children in Urban,Suburban and Rural China's Mainland:A Study of 20 Years' Change显示文摘Objective To describe secular trends on physical growth of children in China during the year of 1985‐2005 and to analyze the urban‐suburban‐rural difference and its change. Methods The measurements of height, weight and chest circumference obtained from two serial national cross‐sectional surveys for children aged 0 to 7 years in China were used to analyze the secular trends, and the growth differences among urban, suburban and rural children were compared. Results The average weight and height for both boys and girls from urban, suburban and rural areas have significantly increased in most age groups during the past 20 years; The average chest circumference increased slightly, ranging from 0.0 to 2.0 cm. From 1985 to 2005, the urban‐suburban difference in height had become smaller, and that in weight showed similar trend for children under 3 years old but became larger after 3 years old; the suburban‐rural difference both in height and weight became larger after 6 months old. The increment per decade in height was the greatest in the suburban group while the greatest increment in weight was the urban group. Conclusion Positive secular trends were observed among urban, suburban and rural areas in Chinese children under 7 years old during the 1980s and the 2000s, reflecting a rapid socio‐economic development in China. | LI Hui ZONG XinNan ZHANG Jing ZHU ZongHan | 2011 | Biomedical and Environmental Sciences2011，24，1： | 2 |
| 3 | MG149 inhibits histone acetyltransferase KAT8-mediated IL-33 acetylation to alleviate allergic airway inflammation and airway hyperresponsiveness显示文摘Asthma is one of the most common heterogeneous airway diseases.Worldwide,the prevale nee of doctor-diagnosed asthma in adults was reported to be 4.3%in 2OO3.^(1)In China,the overall prevalence of asthma duri nq 2012 a nd 2015 was 4.2%,represe nting 45.7 million Chinese adults.^(2)Although comprehensive approaches have been used in clinical practice,a considerable number of people are still hospitalized for acute exacerbation of asthma every year.In China,15.5%of asthmatics reported at least one emergency room visit and 7.2%reported at least one hospital admission due to exacerbation of respiratory symptoms.^(2)A need exists to clarify the mechanism of asthma's pathogenesis and to identify more appropriate and precise therapies for asthma. | Yahui Liu Juan Du Xinnan Liu Lingbiao Wang Yichao Han Chunrong Huang Rui Liang Fang Zheng Guochao Shi Bin Li | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 2 |
| 4 | Regulatory effect of traditional Chinese medicines on signaling pathways of process from chronic atrophic gastritis to gastric cancer显示文摘Chronic atrophic gastritis(CAG),a common disease of digestive system,is an extremely important cause of gastric cancer(GC).The occurrence and development of CAG involves the abnormality of multiple signaling pathways.Traditional Chinese medicines(TCMs)has the advantages of mild action,multi-target and small adverse reaction,etc.,which broadens the way for the treatment of the disease,and TCMs can play a therapeutic role by regulating multiple signaling pathways.In this review,based on the related experiments of TCMs and Chinese herbal compounds in recent years,the related literatures were searched and 10 kinds of signaling pathways involved were summarized,in order to provide a reference for further research on reversing or delaying the progress of CAG and preventing gastric cancer. | Xinnan Liu Shuping Wang Jingyang Li Jingze Zhang Dailin Liu | 2022 | Chinese Herbal Medicines2022，14，1： | 2 |
| 5 | Radiation-hardened property of single-walled carbon nanotube film-based field-effect transistors under low-energy proton irradiation显示文摘Strong C-C bonds,nanoscale cross-section and low atomic number make single-walled carbon nanotubes(SWCNTs)a potential candidate material for integrated circuits(ICs)applied in outer space.However,very little work combines the simulation calculations with the electrical measurements of SWCNT field-effect transistors(FETs),which limits further understanding on the mechanisms of radiation effects.Here,SWCNT film-based FETs were fabricated to explore the total ionizing dose(TID)and displacement damage effect on the electrical performance under low-energy proton irradiation with different fluences up to 1×1015 p/cm2.Large negative shift of the threshold voltage and obvious decrease of the on-state current verified the TID effect caused in the oxide layer.The stability of the subthreshold swing and the off-state current reveals that the displacement damage caused in the CNT layer is not serious,which proves that the CNT film is radiation-hardened.Specially,according to the simulation,we found the displacement damage caused by protons is different in the source/drain contact area and channel area,leading to varying degrees of change for the contact resistance and sheet resistance.Having analyzed the simulation results and electrical measurements,we explained the low-energy proton irradiation mechanism of the CNT FETs,which is essential for the construction of radiation-hardened CNT film-based ICs for aircrafts. | Xiaorui Zhang Huiping Zhu Song’ang Peng Guodong Xiong Chaoyi Zhu Xinnan Huang Shurui Cao Junjun Zhang Yunpeng Yan Yao Yao Dayong Zhang Jingyuan Shi Lei Wang Bo Li Zhi Jin | 2021 | Journal of Semiconductors2021，42，11： | 2 |
| 6 | Integrated thermal disturbante analysis of optical system of astronomical telescope显示文摘 | Dehua Yang Zibo Jiang Xinnan Li | 2008 | Proceedings of SHE2008，7017，： | 1 |
| 7 | Mirror seeing control of large infrared solar telescope 显示文摘 | ZHANG Haiying LI Xinnan MENG Xiaohui | 2010 | SPIE2010，7733，77： | 1 |
| 8 | Quantitative micro-electrochemical study of duplex stainless steel 2205 in 3.5wt%NaCl solution显示文摘Duplex stainless steels(DSSs)are suffering from various localized corrosion attacks such as pitting,selective dissolution,crevice corrosion during their service period.It is of great value to quantitatively analyze and grasp the micro-electrochemical corrosion behavior and related mechanism for DSSs on the micrometer or even smaller scales.In this work,scanning Kelvin probe force microscopy(SKPFM)and energy dispersive spectroscopy(EDS)measurements were performed to reveal the difference between the austenite phase and ferrite phase in microregion of DSS 2205.Then traditional electrochemical impedance spectroscopy(EIS)and potentiodynamic polarization(PDP)tests were employed for micro-electrochemical characterization of DSS 2205 with different proportion phases inϕ40 andϕ10μm micro holes.Both of them can only be utilized for qualitative or semi-quantitative micro-electrochemical characterization of DSS 2205.Coulostatic perturbation method was employed for quantitative micro-electrochemical characterization of DSS 2205.What is more,the applicable conditions of coulostatic perturbation were analyzed in depth by establishing a detailed electrochemical interface circuit.A series of microregion coulostatic perturbations for DSS 2205 with different proportion phases inϕ10μm micro holes showed that as the austenite proportion increases,the corresponding polarization resistance of microregion increases linearly. | Shuangyu Cai Keke Lu Xinnan Li Lei Wen Feifei Huang Ying Jin | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，11： | 1 |
| 9 | Revealing Functional Significance of Interleukin-2 Glycopro-teoforms Enabled by Expressed Serine Ligation显示文摘Naturally occurring interleukin-2(IL-2)is a pleiotropic glycoprotein that regulates immune responses by controlling the differentia-tion and homeostasis of T cells.Non-glycosylated IL-2 has been used in clinical settings for three decades.However,the function of the O-glycan of native IL-2 remains elusive.Herein,to stress this issue,we report a highly efficient semi-synthesis of homogeneous glycosylated IL-2 with various glycoproteoforms on a multi-milligram scale.The glycopeptide fragment was prepared by chemical synthesis and then merged with recombinant fragment via a serine ligation to generate the desired glycoprotein in a single opera-tion.Biological evaluation of the homogenous glycoprotein library reveals that the activity of IL-2 in activating individual T cell subset is glycan dependent,thus highlighting the possibility of further improving current clinical medicine. | Jie Zhao Jiazhi Liu Xinnan Liu Qi Cao Hongbo Zhao Lizhen Liu Farong Ye Can Wang Hong Shao Dongxiang Xue Houchao Tao Bin Li Biao Yu Ping Wang | 2022 | Chinese Journal of Chemistry2022，40，7： | 1 |
| 10 | Grain-size distribution characteristics of red sandy sediments in Dongjiang River valley,southern Nanling Mountains,during the MIS2 stage显示文摘Layer LJ3 of Linjiang stratigraphic section in Dongjiang River valley in the south of the Nanling Mountains is a set of red sandy sediments.Measured by thermoluminescence(TL) dating,it was found to be formed in MIS2-9,500 ± 800 yr to 19,600 ± 1,800 yr B.P.After analy-sis of the grain sizes of the 16 samples(LJ3-100 to LJ3-85) in this layer,it was discovered that(1) The contents of each grain group in dif-ferent samples are similar.(2) The values of Md,Mz,,Sk,and Kg vary from LJ3-100 to LJ3-85 in a narrow range.(3) The segments of each sample in the accumulative curves extend parallel with similar slopes.All the three aspects reveal the Aeolian characteristics of Layer LJ3.Therefore,it is thought that Layer LJ3 consists of red sandy sediments formed in MIS2 in the south of Nanling Mountain,which reflects the arid climate at that time. | ShuHuan Du 1,BaoSheng Li 1,2,DongFeng Niu 1,XiaoHao Wen 1,FengNian Wang 1,XianJiao Ou 1,Yi Yang 1,YueJun Si 1,XinNan Zhao 1 1.Department of Geography,South China Normal University,Guangzhou,Guangdong 510631,China 2.State Key Laboratory of Loess and Quaternary Geology,Institute of Earth Environment,Chinese Academy of Sciences,Xi’an,Shaanxi 710061,China | 2009 | Research in Cold and Arid Regions2009，1，5： | 1 |
| 11 | Production plan for perishable agricultural products with two types of harvesting显示文摘Many crops in China have two or more harvesting methods;however,little research has focused on this phenomenon.The current study proposes an operational model that looks to maximize grower profits.This model considers a production plan for a perishable crop that has two harvesting methods:harvesting unripe produce at a lower operational cost but with a long lead time,and harvesting ripe crops at a higher operational cost but with quick turnaround.This study proposes a heuristic algorithm by which to pinpoint the optimal plan for the model;the model results indicate that for a crop with two harvesting methods,significant savings can be obtained by applying an optimal production plan.The current study’s main contribution is a production model for crops that feature two harvesting methods and for which the market poses varying demands. | Jing Li Xinnan Gao Biao Guo Muyuan Wu | 2020 | Information Processing in Agriculture2020，7，1： | 1 |
| 12 | Surface promotion of copper nanoparticles with alumina clusters derived from layered double hydroxide accelerates CO_(2)reduction to ethylene in membrane electrode assemblies显示文摘Electrochemical CO_(2)reduction has the vast potential to neutralize CO_(2)emission and valorizes this greenhouse gas into chemicals and fuels under mild conditions.Its commercial realization hinges on catalyst innovation as well as device engineering for enabling reactions at industrially relevant conditions.Copper has been widely examined for the selective production of multicarbon chemicals particularly ethylene,while there is still a substantial gap between the expected and the attainable.In this work,we report that the surface promotion of copper with alumina clusters is a viable strategy to enhance its electrocatalytic performance.AlOx-promoted Cu catalyst is derived from Cu-Al layered double hydroxide nanosheets after alkali etching and cathodic conversion.It can catalyze CO_(2)to ethylene and multicarbon products with great selectivity and stability far superior to pristine copper in both an H-cell and a zero-gap membrane electrode assembly(MEA)electrolyzer.The surface promotion effect is understood via computational simulations showing that alumina clusters can stabilize key reaction intermediates(*COOH and*OCCOH)along the reaction pathway. | Jie Zhang Xinnan Mao Binbin Pan Jie Xu Xue Ding Na Han Lu Wang Yuhang Wang Yanguang Li | 2023 | Nano Research2023，16，4： | 1 |
| 13 | Field scanner design for MUSTANG of the Green Bank Telescope显示文摘MUSTANG (Multiplex SQUID TES Array at Ninety GHz) is a bolometer camera for the Green Bank Telescope (GBT) working at a frequency of 90 GHz.The detector has a field of view of 40 arcsec.To cancel out random emission change from atmosphere and other sources,requires a fast scanning reflecting system with a few arcminute ranges.In this paper,the aberrations of an off-axis system are reviewed.The condition for an optimized system is provided.In an optimized system,as additional image transfer mirrors are introduced,new aberrations of the off-axis system may be reintroduced,resulting in a limited field of view.In this paper,different scanning mirror arrangements for the GBT system are analyzed through the ray tracing analysis.These include using the subreflector as the scanning mirror,chopping a flat mirror and transferring image with an ellipse mirror,and chopping a flat mirror and transferring image with a pair of face-to-face paraboloid mirrors.The system analysis shows that chopping a flat mirror and using a well aligned pair of paraboloids can generate the required field of view for the MUSTANG detector system,while other systems all suffer from larger off-axis aberrations added by the system modification.The spot diagrams of the well aligned pair of paraboloids produced are only about one Airy disk size within a scanning angle of about 3 arcmin. | CHENG JingQuan LI Yang LI XinNan MASON Brian | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，11： | 0 |
| 14 | Model of NBTI combined with mobility degradation显示文摘The mobility degradation induced by negative bias temperature instability(NBTI) is usually ignored in traditional NBTI modeling and simulation, resulting in overestimation of the circuit lifetime, especially after longterm operation. In this paper, the mobility degradation is modeled in combination with the universal NBTI model.The coulomb scattering induced by interface states is revealed to be the dominant component responsible for mobility degradation. The proposed mobility degradation model fits the measured data well and provides an accurate solution for evaluating coupling of NBTI with HCI(hot carrier injection) and SHE(self-heating effect), which indicates that mobility degradation should be considered in long-term circuit aging simulation. | Xuezhong Wu Chenyue Ma Shucheng Gao Xiangbin Li Fu Sun Lining Zhang Xinnan Lin | 2018 | Journal of Semiconductors2018，39，12： | 0 |
| 15 | Characteristics of Polysaccharides Variation in Sludge in Sludge Drying Reed Beds显示文摘 | Rui Chen Yubo Cui Wei Gao Xinnan Deng Jiangang Li | 2015 | 环境科学前沿(中英文版)2015，4，1： | 0 |
| 16 | Chemical constituents and pharmacological activities of medicinal plants from Rosa genus显示文摘The genus Rosa(Rosaceae family)includes about 200 species spread in the world,and this genus shows unique advantages in medicine and food.To date,several scholars concentrated on compounds belonging to flavonoids,triterpenes,tannins,polysaccharide,phenolic acids,fatty acids,organic acids,carotenoids,and vitamins.Pharmacological effects such as antineoplastic and anti-cancer properties,antiinflammatory,antioxidant,liver protection,regulate blood sugar,antimicrobial activity,antiviral activity,as well as nervous system protection and cardiovascular protection were wildly reported.This article reviews the chemical constituents,pharmacological effects,applications and safety evaluations of Rosa plants,which provides a reference for the comprehensive utilization of medicine and food resources and gives a scientific basis for the development of medicinal plants of the genus Rosa. | Yansheng Wang Yanmin Zhao Xinnan Liu Jingyang Li Jingze Zhang Dailin Liu | 2022 | Chinese Herbal Medicines2022，14，2： | 0 |
| 17 | Mechanical properties of(B_(4)C+Al_(2)O_(3))/Al neutron absorbing materials with various microstructures constructed by hot forging,rolling and extrusion显示文摘Neutron absorbing materials(NAMs)are necessary in the nuclear industry for the storage and transportation of spent fuel.Among all the NAMs,B_(4)C/Al composites are widely used because of the specific neutron absorption capacity[1–4].Compared with traditional low-strength functional NAMs such as B_(4)C/1100Al and B_(4)C/6061Al,NAMs with enough high-temperature(350℃)strength are competent for further structural usage and exhibit huge advantages in the dry storage of spent fuel because of heat transfer ability and weight reduction[5]. | ZAN YuNing LI XinNan ZHOU Cong LIU ZhenYu WANG QuanZhao XIAO BoLü MA ZongYi | 2022 | Science China(Technological Sciences)2022，65，5： | 0 |
| 18 | Management of triplet excitons transition:fine regulation of Förster and dexter energy transfer simultaneously显示文摘Understanding and management of triplet excitons transition in the same molecule remain a great challenge.Hence,for the first time,by host engineering,manageable transitions of triplet excitons in a naphthalimide derivative NDOH were achieved,and monitored through the intensity ratio(ITADF/IRTP)between thermally activated delayed fluorescence(TADF)and room-temperature phosphorescence(RTP).Energy differences between lowest triplet excited states of host and guest were changed from 0.03 to 0.17 eV,and ITADF/IRTP of NDOH decreased by 200 times,thus red shifting the afterglow color.It was proposed that shorter conjugation length led to larger band gaps of host materials,thus contributing to efficient Dexter and inefficient Förster energy transfer.Interestingly,no transition to singlet state and only strongest RTP with quantum yield of 13.9%could be observed,when PBNC with loosest stacking and largest band gap acted as host.This work provides novel insight for the management and prediction of triplet exciton transitions and the development of smart afterglow materials. | Jiaqiang Wang Yujie Yang Xinnan Sun Xiaoning Li Liyao Zhang Zhen Li | 2024 | Light(Science & Applications)2024，13，2： | 0 |
| 19 | Structural diversification of bioactive bibenzyls through modular co-culture leading to the discovery of a novel neuroprotective agent显示文摘Bibenzyls,a kind of important plant polyphenols,have attracted growing attention for their broad and remarkable pharmacological activities.However,due to the low abundance in nature,uncontrollable and environmentally unfriendly chemical synthesis processes,these compounds are not readily accessible.Herein,one high-yield bibenzyl backbone-producing Escherichia coli strain was constructed by using a highly active and substrate-promiscuous bibenzyl synthase identified from Dendrobium officinale in combination with starter and extender biosynthetic enzymes.Three types of efficiently postmodifying modular strains were engineered by employing methyltransferases,prenyltransferase,and glycosyltransferase with high activity and substrate tolerance together with their corresponding donor biosynthetic modules.Structurally different bibenzyl derivatives were tandemly and/or divergently synthesized by co-culture engineering in various combination modes.Especially,a prenylated bibenzyl derivative(12)was found to be an antioxidant that exhibited potent neuroprotective activity in the cellular and rat models of ischemia stroke.RNA-seq,quantitative RT-PCR,and Western-blot analysis demonstrated that 12 could up-regulate the expression level of an apoptosis-inducing factor,mitochondria associated 3(Aifm3),suggesting that Aifm3 might be a new target in ischemic stroke therapy.This study provides a flexible plug-and-play strategy for the easy-to-implement synthesis of structurally diverse bibenzyls through a modular co-culture engineering pipeline for drug discovery. | Yuyu Liu Xinnan Li Songyang Sui Jingshu Tang Dawei Chen Yuying Kang Kebo Xie Jimei Liu Jiaqi Lan Lei Wu Ridao Chen Ying Peng Jungui Dai | 2023 | Acta Pharmaceutica Sinica B2023，13，4： | 0 |
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