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| 1 | Herbal decoctosome is a novel form of medicine显示文摘Traditionally, herbal medicine is consumed by drinking decoctions produced by boiling herbs with water. The functional components of the decoction are heat stable. Small RNAs(sRNAs) were reported as a new class of functional components in decoctions. However, the mechanisms by which sRNAs survive heat treatment of the decoction and enter cells are unclear.Previous studies showed that plant-derived exosome-like nanoparticles(ELNs), which we call botanosomes, could deliver therapeutic reagents in vivo. Here, we report that heat-stable decoctosomes(ELNs) from decoctions have more therapeutic effects than the decoctions in vitro and demonstrate therapeutic efficacy in vivo. Furthermore, sRNAs, such as HJT-sRNA-m7 and PGY-sRNA-6, in the decoctosome exhibit potent anti-fibrosis and anti-inflammatory effects, respectively. Decoctosome is comprised of lipids, chemical compounds, proteins, and s RNAs. A medical decoctosome mimic is called bencaosome. A single lipid sphinganine(d22:0) identified in the decoctosome was mixed and heated with the synthesized sRNAs to form the simplest bencaosome. This simple bencaosome structure was identified by critical micelle concentration(cmc) assay that sRNAs coassembled with sphinganine(d22:0) to form the lipid layers of vesicles. The heating process facilitates co-assembly of sRNAs and sphinganine(d22:0) until a steady state is reached. The artificially produced sphinganine-HJT-sRNA-m7 and sphinganinePGY-sRNA-6 bencaosomes could ameliorate bleomycin-induced lung fibrosis and poly(I:C)-induced lung inflammation, respectively, following oral administration in mice. Our study not only demonstrates that the herbal decoctosome may represent a combinatory remedy in precision medicine but also provides an effective oral delivery route for nucleic acid therapy. | Xiaoyun Li Zhu Liang Jianchao Du Zhiqing Wang Song Mei Zhiqing Li Yan Zhao DANDan Zhao Yiming Ma Jun Ye Jiantao Xu Yu Zhao Jiahui Chang Yuhao Qin Lanlan Yu Chenxuan Wang Chengyu Jiang | 2019 | Science China(Life Sciences)2019，62，3： | 26 |
| 2 | Plant-derived phosphocholine facilitates cellular uptake of anti-pulmonary fibrotic HJT-sRNA-m7显示文摘Pulmonary fibrosis, a progressive chronic disease with a high mortality rate, has limited treatment options. Currently, lung transplantation remains the only effective treatment. Here we report that a small RNA, HJT-sRNA-m7, from a Chinese herbal medicine Hong Jing Tian(HJT, RHODIOHAE CRENULATAE RADIX ET RHIZOMA, Rhodiola crenulata) can effectively reduce the expressions of fibrotic hallmark genes and proteins both in alveolar in vitro and in mouse lung tissues in vivo. We also discovered over one hundred oil-soluble chemicals from HJT decoctions, most of which are found in lipid extracts from other Chinese herbals decoctions, including Pu Gong Ying(PGY, TARAXACI HERBA, Taraxacum mongolicum), Chuan Xin Lian(CXL, changed to 'ANDROGRAPHIS HERBA, Andrographis paniculata'), and Jin Yin Hua(JYH, lonicera japonica or Honeysuckle). We identified the active component in these decoctions as two forms of phosphocholines, PC(18:0/18:2) and PC(16:0/18:2). These PCs potentially could form liposomes with small RNAs to enter human alveolar and gastric cells. Our experimental results suggest an unprecendent lipid complex route through which botanic small RNA can enter human bodies.Our results provide an innovative treatment strategy for oral delivery of siRNAs as therapeutic medication. | Jianchao Du Zhu Liang Jiantao Xu Yan Zhao Xiaoyun Li Yanli Zhang DANDan Zhao Ruxuan Chen Yang Liu Trupti Joshi Jiahui Chang Zhiqing Wang Yanxu Zhang Jindong Zhu Qiang Liu Dong Xu Chengyu Jiang | 2019 | Science China(Life Sciences)2019，62，3： | 21 |
| 3 | Drug targeting through platelet membrane-coated nanoparticles for the treatment of rheumatoid arthritis显示文摘The effective drug treatment of rheumatoid arthritis (RA) is hindered by poordelivery efficiency to the diseased site and the serious side effects caused bywide-spread drug distribution. Traditional drug-targeting strategies, such asligand modification, are complex, laborious, and inefficient. Inspired by theintrinsic relationship between platelets and RA, platelet-mimetic nanoparticles(PNPs) were developed for targeted drug delivery in RA. Through plateletreceptor-mediated adhesion, an intact platelet membrane was coated onto poly(lactic-co-glycolic add) nanopartides, endowing the resulting PNPs with variousfunctional receptors. By coating with platelet membranes, the nanoparticleswere stabilized and had a better circulation profile, providing a benefit forpassive targeting. In vitro binding of PNPs to inflamed endothelium, and in vivoaccumulation in joints of a collagen-induced arthritis (CIA) mouse model of RAwere significantly improved via P-selectin and GVPI recognition, indicating thatthe PNPs could effectively target to RA tissues through multiple mechanisms,similar to natural platelets. Moreover, FK506, a model drug, was loaded into thePNPs and used to treat RA. Pharmacodynamic studies demonstrated that theFK506-PNPs had a notable anti-arthritic effect in CIA mice. This study provides anew biomimetic targeting strategy with great potential for the treatment of RA. | Yuwei He Ruixiang Li Jianming Liang Ying Zhu Shuya Zhang Zicong Zheng Jing Qin Zhiqing Pang Jianxin Wang | 2018 | Nano Research2018，11，11： | 9 |
| 4 | THE TYPHOON DISASTERS AND RELATED EFFECTS IN CHINA显示文摘China is one of the countries which were affected very seriously by tropical cyclones. In this paper, the active features of tropical cyclones which affected and landfell over China, the distinguishing characteristics of typhoon disasters and related formation laws have been studied, and the impact of trphoon disasters on China’s socio-economic development have been discussed. The study reveals that typhoon disasters which affected China are characterized by high freqency in occurrence, violent in sudden occurrence, remarkable effects in China,widescope in impact and severe intensities in disasters, and this type of disaster was caused by huge gales, rainstorms, storm surges and reatal chain-disasters.Typhoon disasters have not only caused great casualties but also exerted severe effects on every economic departments in China. There is an annual increasing tendency in direct economic loss caused by taphoon disasters and since 1990, the annual average economic loss has totalled up to over lo billion RMB yuan. | Liang Biqi Wen Zhiqing Liang Jingqing (Department of Atmospheric Science, Zhongshan University, Guanghou 510275People’s Republic of China) | 1996 | Journal of Geographical Sciences1996，6，1： | 7 |
| 5 | Genome-wide detection of additional fetal chromosomal abnormalities by cell-free DNA testing of 15,626 consecutive pregnant women显示文摘Cell-free DNA(cfDNA) testing for common fetal trisomies(T21, T18, T13) is highly effective. However, the usefulness of cfDNA testing in detecting other chromosomal abnormalities is unclear. We evaluated the performance of cfDNA testing for genome-wide abnormalities, and analyzed the incremental yield by reporting extra abnormalities. We performed genome-wide cfDNA testing in 15,626 consecutive pregnancies prospectively enrolled in this study. cfDNA testing results were reported and counseling was given depending on the presence of extra chromosomal abnormalities. cfDNA testing identified 190 cases(1.2%)of chromosomal abnormalities including 100 common trisomies and 90 additional abnormalities. By expanding the cfDNA reporting range to genome-wide abnormalities, the false positive rate increased to 0.39%(P<0.001) and positive predictive value(PPV) was reduced to 65.58%(P=0.42). However, the detection yield increased from 0.44% to 0.65%(P=0.014), and cfDNA testing detected 38.61%(39/101) additional abnormalities with no ultrasound and biochemical screening findings. cfDNA testing outperformed biochemical screening by showing 60 times higher true positive rate and fewer false negative results.Genome-wide cfDNA testing significantly increased the diagnostic yield by detecting extra abnormalities, especially those without diagnostic indications. Genome-wide cfDNA testing has fewer false positive and false negative results compared with biochemical screening. | Hong Yao Ya Gao Jia Zhao Rong Zhang Huixin Xu Huamei Hu Yanmei Luo Yuying Yuan Meili Fu Hongyun Zhang Hui Jiang Wei Wang Huanming Yang Jian Wang Zhiqing Liang Fang Chen | 2019 | Science China(Life Sciences)2019，62，2： | 4 |
| 6 | Cloning and characterization of vernalization-related gene (ver203F) cDNA 3'end显示文摘Based on the cDNA fragment sequence of vernalization-related gene verc203 cloned by differential screening in our lab, the 5′primer has been designed. The cDNA 3′end of ver203 gene (1 197 bp) has been cloned by the RACE method. And it is identified by Northern blotting that its expression is special in vernalization treatment. After comparing the sequence in the nucleotide sequence databases of Genbank, EMBL and DDBJ, the gene has homology with Hordeum vulgare jesmonate-induced protein gene. It is suggested that this gene might be related to the signal transduction mediated by jamonate. | YONG Weidong, CHONG Kang , LIANG Tiebing, XU Zhihong , TAN Kehui and ZHU Zhiqing Research Center for Molecular and Developmental Biology, Institute of Botany, Chinese Academy of Sciences , Beijing 100093, China Shanghai Institute of Plant Physiology , Chinese Academy of Sciences , Shanghai 200032, China Corresponding authors | 1999 | Chinese Science Bulletin1999，44，14： | 3 |
| 7 | Circadian locomotor output cycles kaput accelerates atherosclerotic plaque formation by upregulating plasminogen activator inhibitor-1 expression显示文摘 | Qixia Jiang Hua Liu Shengyun Wang Jiamei Wang Yehua Tang Zhiqing He Feng Wu Zhigang Huang Xiaoliang Cong Ru Ding Chun Liang | 2018 | Acta Biochimica et Biophysica Sinica2018，50，9： | 3 |
| 8 | Erratum to:Herbal decoctosome is a novel form of medicine显示文摘Following the published article,we noticed an error duplication in Figure 5G“control”and“PGY-6”that was introduced during the revised process,with an attempt to replace it with higher-resolution images.Here we provide the original data in the first submitted manuscript(Figure 5G). | Xiaoyun Li Zhu Liang Jianchao Du Zhiqing Wang Song Mei Zhiqing Li Yan Zhao Dandan Zhao Yiming Ma Jun Ye Jiantao Xu Yu Zhao Jiahui Chang Yuhao Qin Lanlan Yu Chenxuan Wang Chengyu Jiang | 2020 | Science China(Life Sciences)2020，63，9： | 2 |
| 9 | Recent advances on rare earths in solid lithium ion conductors显示文摘Solid lithium-ion-conducting material is the key component in the fabrication of next-gene ration all solid state lithium ion batteries(LIBs)which would exhibit superior safety and performance compared with the currently widely used ones that resort to essentially inflammable and volatile organic solvents.To date,great efforts have been made in developing solid conductors with high lithium ion conductivity,such as polymers and inorganic materials.Rare earths play a very important role in this area and have attracted extensive interest since the recent decades for their unique properties in the realm of solidstate inorganic lithium-ion-conducting electrolyte materials.In this introduction,we focus on the role of rare earths in solid conductors for lithium ion,especially in a few most studied systems such as perovskites,garnets,silicates,borohydride and the recently reported halides in which rare earths act as a key framing component.Besides,the effect of rare earths as dopants is also discussed in some recently studied systems.Valence,coordination,and size are the most important factors that influence the crystal structure and property of these lithium ion conductors.The aim of this review is to highlight the great potentials of these unique elements of rare earths,and to help improve the performance of existing materials and explore new applications in the development of new LIBs with high performances. | Qian Zhang Zhiqing Gao Xiaomeng Shi Chao Zhang Kang Liu Jun Zhang Liang Zhou Chunjie Ma Yaping Du | 2021 | Journal of Rare Earths2021，39，1： | 2 |
| 10 | Animal exercise studies in cardiovascular research:Current knowledge and optimal design--A position paper of the Committee on Cardiac Rehabilitation,Chinese Medical Doctors’Association显示文摘Growing evidence has demonstrated exercise as an effective way to promote cardiovascular health and protect against cardiovascular diseases However,the underlying mechanisms of the beneficial effects of exercise have yet to be elucidated.Animal exercise studies are widely used to investigate the key mechanisms of exercise-induced cardiovascular protection.However,standardized procedures and well-established evaluation indicators for animal exercise models are needed to guide researchers in carrying out effective,high-quality animal studies using exercise to prevent and treat cardiovascular diseases.In our review,we present the commonly used animal exercise models in cardiovascular research and propose a set of standard procedures for exercise training,emphasizing the appropriate measurements and analysis in these chronic exercise models.We also provide recommendations for optimal design of animal exercise studies in cardiovascular research,including the choice of exercise models,control of exercise protocols,exercise at different stages of disease,and other considerations,such as age,sex,and genetic background.We hope that this position paper will promote basic research on exercise-induced cardiovascular protection and pave the way for successful translation of exercise studies from bench to bedside in the prevention and treatment of cardiovascular diseases. | Yihua Bei Lei Wang Rongjing Ding Lin Che Zhiqing Fan Wei Gao Qi Liang Shenghui Lin Suixin Liu Xiao Lu Yuqin Shen Guifu Wu Jian Yang Guolin Zhang Wei Zhao Lan Guo Junjie Xiao | 2021 | Journal of Sport and Health Science2021，10，6： | 2 |
| 11 | Advances of nanoparticles as drug delivery systems for disease diagnosis and treatment显示文摘Decades have passed since the first nanoparticles-base medicine was approved for human cancer treatment, and the research and development of nanoparticles for drug delivery are always undergoing.Nowadays, the significant advances complicate nanoparticles’ branches, including liposomes, solid lipid nanoparticles, inorganic nanoparticles, micelles, nanovaccines and nano-antibodies, etc. These nanoparticles show numerous capabilities in treatment and diagnosis of stubborn diseases like cancer and neurodegenerative diseases, emerging as novel drug carriers or therapeutic agents in future. In this review, the complicated branches of nanoparticles are classified and summarized, with their property and functions concluded. Besides, there are also some delivery strategies that make nanoparticles smarter and more efficient in drug delivery, and frontiers in these strategies are also summarized in this review. Except these excellent works in newly-produced drug delivery nanoparticles, some points of view and future expectations are made in the end. | Rui Liu Cong Luo Zhiqing Pang Jinming Zhang Shaobo Ruan Meiying Wu Lei Wang Tao Sun Nan Li Liang Han Jinjin Shi Yuanyu Huang Weisheng Guo Shaojun Peng Wenhu Zhou Huile Gao | 2023 | Chinese Chemical Letters2023，34，2： | 2 |
| 12 | Qualitative analysis of a ratio-dependent Holling–Tanner model显示文摘 | Zhiqing Liang Hongwei Pan | 2007 | Journal of Mathematical Analysis and Applications2007，，2： | 1 |
| 13 | Synthesis of 15P-Conjugated PPy-modified Gold Nanoparticles and Their Application to Photothermal Therapy of Ovarian Cancer显示文摘 | WANG Li WANG Liping XU Tianshu GUO Changrun LIU Chuanzhi ZHANG Hao LI Jing LIANG Zhiqing | 2014 | Chemical Research in Chinese Universities2014，30，6： | 1 |
| 14 | Targeting the brain with PEG–PLGA nanoparticles modified with phage-displayed peptides显示文摘 | Jingwei Li Liang Feng Li Fan Yuan Zha Liangran Guo Qizhi Zhang Jun Chen Zhiqing Pang Yuchen Wang Xinguo Jiang Victor C. Yang Longping Wen | 2011 | Biomaterials2011，，21： | 1 |
| 15 | Targeting the brain with PEG–PLGA nanoparticles modified with phage-displayed peptides显示文摘 | Jingwei Li Liang Feng Li Fan Yuan Zha Liangran Guo Qizhi Zhang Jun Chen Zhiqing Pang Yuchen Wang Xinguo Jiang Victor C. Yang Longping Wen | 2011 | Biomaterials2011，，21： | 1 |
| 16 | The Outcome of Laparoscopic Radical Hysterectomy and Lymphadenectomy for Cervical Cancer: A Prospective Analysis of 295 Patients显示文摘 | Yong Chen MD Huichen Xu MD Yuyan Li MD Dan Wang MD Junnan Li MD Jizhao Yuan MD Zhiqing Liang MD | 2008 | Annals of Surgical Oncology2008，，10： | 1 |
| 17 | The phase holdups in a gas-liquid-solid circulating fluidized bed显示文摘 | Liang Wugeng Yu Zhiqing Jin Yong Wang Zhanwen Wu Qunwei | | 0，，03： | 1 |
| 18 | Advanced glycation end products depress function of endothelial progenitor cells via p38 and ERK 1/2 mitogen-activated protein kinase pathways显示文摘 | Chengbo Sun Chun Liang Yusheng Ren Yi Zhen Zhiqing He Hua Wang Hongbing Tan Xiaoming Pan Prof. Dr. Zonggui Wu | 2009 | Basic Research in Cardiology2009，，1： | 1 |
| 19 | The Outcome of Laparoscopic Radical Hysterectomy and Lymphadenectomy for Cervical Cancer: A Prospective Analysis of 295 Patients显示文摘 | Yong Chen MD Huichen Xu MD Yuyan Li MD Dan Wang MD Junnan Li MD Jizhao Yuan MD Zhiqing Liang MD | 2008 | Annals of Surgical Oncology2008，，10： | 1 |
| 20 | Targeting the brain with PEG–PLGA nanoparticles modified with phage-displayed peptides显示文摘 | Jingwei Li Liang Feng Li Fan Yuan Zha Liangran Guo Qizhi Zhang Jun Chen Zhiqing Pang Yuchen Wang Xinguo Jiang Victor C. Yang Longping Wen | 2011 | Biomaterials2011，，21： | 1 |
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