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| 1 | Geochemical baseline determination and contamination of heavy metals in the urban topsoil of Fuxin City,China显示文摘Urban topsoil is the most frequent interface between human society and natural environment.The accumulation of heavy metals in the urban topsoil has a direct effect on residents'life and health.The geochemical baseline of heavy metals is an objective description of the general level of heavy metals in the urban topsoil.Meanwhile,the determination of geochemical baseline is necessary for regional environmental management,especially in coal cities prone to heavy metal pollution.Heavy metal pollution has become an environmental problem in Fuxin City,China for a long time.To establish the geochemical baseline of heavy metals in the topsoil of Fuxin City and to evaluate the ecological risk of the topsoil,we collected 75 topsoil samples(0–20 cm)and analyzed the concentrations of Cu,Ni,Zn,Pb,Cr,Cd,Hg and As through X-ray fluorescence spectrometry,atomic absorption spectrometry and inductively coupled plasma optical emission spectrometry.We determined the geochemical baseline of heavy metals in the topsoil of Fuxin City by using iteration removal,box-whisker plot,cumulative frequency curve and reference metal normalization;evaluated the contamination risk and ecological risk of the topsoil by using the baseline factor index,Nemerow index and Hakanson potential ecological risk index;and identified the source category of heavy metals in the topsoil by using a pedigree clustering heatmap.Results showed that the geochemical baseline values were 42.86,89.34,92.23,60.55,145.21,0.09,0.08 and 4.17 mg/kg for Cu,Ni,Zn,Pb,Cr,Cd,Hg and As,respectively.The results of Nemerow index and Hakanson potential ecological risk index indicated that the urban topsoil in the study area was slightly contaminated and suffering low potential ecological risk.The main contaminated areas dominated in the middle part and northeast part of the study area,especially in the western Haizhou Strip Mine.The result of baseline factor index indicated that Hg and Cd were the major pollution elements.Using a pedigree clustering heatmap,we divided the sources of these heavy metals into three types:type I for Ni and Cr,largely represented the enrichment of heavy metals from natural sources;type II for Cu,Pb,Zn,Cd and As,mainly represented the enrichment of heavy metals from anthropogenic sources;and type III for Hg,represented the form of both natural and anthropogenic inputs. | ZHANG Hua YU Miao XU Hongjia WEN Huan FAN Haiyan WANG Tianyi LIU Jiangang | 2020 | Journal of Arid Land2020，12，6： | 5 |
| 2 | Histone demethylase KDM2B promotes triple negative breast cancer proliferation by suppressing p 15^INK4B, p 16^INK4A, and p57^KIP2 transcription显示文摘 | Qingping Zheng Hongjia Fan Zhenzhen Meng Lin Yuan Cuicui Liu You Peng Weiwei Zhao Lulu Wang Jing Li Jing Feng | 2018 | Acta Biochimica et Biophysica Sinica2018，50，9： | 3 |
| 3 | Correction of cardiac defects through right thoracotomy in children 显示文摘 | Liu Yinglong Zhang Hongjia Sun Hansong | 1998 | J Thorac Cardiovasc Surg1998，116，： | 1 |
| 4 | Intellectual property protection for deep semantic segmentation models显示文摘Deep neural networks have achieved great success in varieties of artificial intelligent fields. Since training a good deep model is often challenging and costly, such deep models are of great value and even the key commercial intellectual properties. Recently, deep model intellectual property protection has drawn great attention from both academia and industry, and numerous works have been proposed. However, most of them focus on the classification task. In this paper, we present the first attempt at protecting deep semantic segmentation models from potential infringements. In details, we design a new hybrid intellectual property protection framework by combining the trigger-set based and passport based watermarking simultaneously. Within it, the trigger-set based watermarking mechanism aims to force the network output copyright watermarks for a pre-defined trigger image set, which enables black-box remote ownership verification. And the passport based watermarking mechanism is to eliminate the ambiguity attack risk of trigger-set based watermarking by adding an extra passport layer into the target model. Through extensive experiments, the proposed framework not only demonstrates its effectiveness upon existing segmentation models, but also shows strong robustness to different attack techniques. | Hongjia RUAN Huihui SONG Bo LIU Yong CHENG Qingshan LIU | 2023 | Frontiers of Computer Science2023，17，1： | 1 |
| 5 | Morphological, crystalline, thermal and physicochemical properties of cellulose nanocrystals obtained from sweet potato residue显示文摘 | Hongjia Lu Yu Gui Longhui Zheng Xiong Liu | 2013 | Food Research International2013，，1： | 1 |
| 6 | Tianhe- 1A Interconnect and Message Passing Services显示文摘 | Min Xie Yutong Lu Kerfei Wang Lu Liu Hongjia Cao | 2012 | IEEE Micro2012，32，1： | 1 |
| 7 | Optical spectroscopy and visible upconversion studies of YVO4:Er^3+ nanocrystals synthesized by a hydrothermal process 显示文摘 | SUN Yajuan LIU Hongjia WANG Xin | 2006 | Chem Mater2006，18，11： | 1 |
| 8 | Investigation of the Potential and Mechanism of Clove for Mitigating Airborne Particulate Matter Emission from Stationary Sources显示文摘植物的障碍(VB ) 有潜力减轻从区域来源射出的空气污染物质,包括喂操作(AFO ) 的集中的动物。然而,机制充分没被调查,从而在实践限制植被系统的应用程序。有可重复、可控制的条件的一个试验性的方法被开发测量微粒事(下午)集中的变化在在风中的 VB 迎风、顺风与扫描电子显微镜( SEM )在叶子掘并且观察积累的下午,因此在减轻从 AFO 射出的下午评估 VB 的能力。分支规模植被,劈开(syzygium aromaticum ) 因为它的叶子是专业之一,被选择因素影响下午分散。结果证明分支规模障碍多孔的媒介有能力防碍气流和还原剂下午,它能被风速度,粒子尺寸部分和表面区域密度影响劈开。而且,劈开元素能适应风和微结构劈开(例如叶子的层次结构) 在 PM 免职上影响了。这些结果显示在这研究开发的方法可以被用来在从静止来源减轻下午评估植被的潜力,并且植被的一些特征能是为探索减少微粒的工程申请的进一步学习的同样仿生的原型。 | Jin Tong Xin Liu Ronaldo Maghirang Kaiqi Wei Linna Liu Chun Wang Yunhai Ma Donghui Chen Hongjia Yan Li Guo | 2017 | Journal of Bionic Engineering2017，14，2： | 1 |
| 9 | Fine-mapping of SRT7 for short roots and identification of its candidate in rice显示文摘Three allelic short root mutants were identified by screening mutants with defective root elongation of the rice japonica cultivar Nipponbare mutant library generated via 60 Co γ-ray irradiation mutagenesis. These mutants, designated srt7-1 (short root 7-1), srt7-2 and srt7-3, respectively, had an extremely short seminal root, adventitious roots and lateral roots. Histological observation revealed the cell length of srt7 mutant roots was significantly shorter than that of wild-type roots. Genetic analysis indicated the short root phenotype was controlled by a single recessive nuclear gene. The SRT7 gene was mapped to a 20-kb interval between the markers STS6 and STS7 on chromosome 4 by a map-based cloning method. Sequencing of the six predicted genes in this region found that all of the three allelic mutants contained a 1-bp or 2-bp deletion in the same gene encoding a putative mem- brane-bound endo-1,4-β-glucanase. The SRT7 gene was expressed ubiquitously, with higher levels of transcript accumulation in roots at different developmental stages. However, no difference was found in the SRT7 transcription level between the mutant and wild type. Collectively, these results indicate the endo-1,4-β-glucanase encoding gene (LOC_Os04g41970) is likely the candidate for SRT7 that functions posttranscriptionally in rice root elongation. | LIU HongJia ZHENG HuaKun WANG Hua GUO Peng ZUO JianRu TAO YueZhi | 2011 | Chinese Science Bulletin2011，56，31： | 1 |
| 10 | Isolation and expression analysis of defense-related genes in sorghum– Colletotrichum sublineolum interaction显示文摘 | Lei Li Fuyuan Zhu Hongjia Liu Apple Chu Clive Lo | 2013 | Physiological and Molecular Plant Pathology2013，，： | 1 |
| 11 | Mesh model building and migration and accumulation simulation of 3D hydrocarbon carrier system显示文摘Migration and accumulation simulation of oil and gas in carrier systems has always been a difficult subject in the quantitative study of petroleum geology. In view of the fact that the traditional geological modeling technology can not establish the interrelation of carriers in three dimensional space, we have proposed a hybrid-dimensional mesh modeling technology consisting of body(stratum), surfaces(faults and unconformities), lines and points, which provides an important research method for the description of geometry of sand bodies, faults and unconformities, the 3 D geological modeling of complex tectonic areas, and the simulation of hydrocarbon migration and accumulation. Furthermore, we have advanced a 3 D hydrocarbon migration pathway tracking method based on the hybrid-dimensional mesh of the carrier system. The application of this technology in western Luliang Uplift of Junggar Basin shows that the technology can effectively characterize the transport effect of fault planes, unconformities and sand bodies, indicate the hydrocarbon migration pathways, simulate the process of oil accumulation, reservoir adjustment and secondary reservoir formation, predict the hydrocarbon distribution. It is found through the simulation that the areas around the paleo-oil reservoir and covered by migration pathways are favorable sites for oil and gas distribution. | GUO Qiulin LIU Jifeng CHEN Ningsheng WU Xiaozhi REN Hongjia WEI Yanzhao CHEN Gang GONG Deyu YUAN Xuanjun | 2018 | Petroleum Exploration and Development2018，45，6： | 0 |
| 12 | BGB-A445,a novel non-ligand-blocking agonistic anti-OX40 antibody,exhibits superior immune activation and antitumor effects in preclinical models显示文摘t OX40 is a costimulatory receptor that is expressed primarily on activated CD4+,CD8+,and regulatory T cells.The ligation of OX40 to its sole ligand OX40L potentiates T cell expansion,differentiation,and activation and also promotes dendritic cells to mature to enhance their cytokine production.Therefore,the use of agonistic anti-Ox40 antibodies for cancer immunotherapy has gained great interest.However,most of the agonistic anti-OX40 antibodies in the clinic are OX40L-competitive and show limited efficacy.Here,we discovered that BGB-A445,a non-ligand-competitive agonistic anti-OX40 antibody currently under clinical investigation,induced optimal T cell activation without impairing dendritic cell function.In addition,BGB-A445 dose-dependently and significantly depleted regulatory T cells in vitro and in vivo via antibody-dependent cellular cytotoxicity.In the MC38 syngeneic model established in humanized OX40 knock-in mice,BGB-A445 demonstrated robust and dose-dependent antitumor efficacy,whereas the ligand-competitive anti-Ox40 antibody showed antitumor efficacy characterized by a hook effect.Furthermore,BGB-A445 demonstrated a strong combination antitumor effect with an anti-PD-1 antibody.Taken together,our findings show that BGB-A445,which does not block OX40-OX40L interaction in contrast to clinical-stage anti-OX40 antibodies,shows superior immune-stimulating effects and antitumor efficacy and thus warrants further clinical investigation. | Beibei Jiang Tong Zhang Minjuan Deng Wei Jin Yuan Hong Xiaotong Chen Xin Chen Jing Wang Hongjia Hou Yajuan Gao Wenfeng Gong Xing Wang Haiying Li Xiaosui Zhou Yingcai Feng Bo Zhang Bin Jiang Xueping Lu Lijie Zhang Yang Li Weiwei Song Hanzi Sun Zuobai Wang Xiaomin Song Zhirong Shen Xuesong Liu Kang Li Lai Wangl Ye Liu | 2023 | Frontiers of Medicine2023，17，6： | 0 |
| 13 | Inflammatory risk stratification individualizes anti-inflammatory pharmacotherapy for acute type A aortic dissection显示文摘The systemic benefits of anti-inflammatory pharmacotherapy vary across cardiovascular diseases in clinical practice.We aimed to evaluate the application of artificial intelligence to acute type A aortic dissection(ATAAD)patients to determine the optimal target population who would benefit from urinary trypsin inhibitor use(ulinastatin).Patient characteristics at admission in the Chinese multicenter 5A study database(2016-2022)were used to develop an inflammatory risk model to predict multiple organ dysfunction syndrome(MODS). | Hong Liu Haiyang Li Lu Han Yingyuan Zhang Ying Wu Liang Hong Jinong Yang Jisheng Zhong Yuqi Wang Dongkai Wu Guoliang Fan Junquan Chen Shengqiang Zhang Xingxing Peng Zhihua Zeng Zhiwei Tang Zhanjie Lu Lizhong Sun Sichong Qian Yongfeng Shao Hongjia Zhang on behalf of the Additive Anti-inflammatory Action for Aortopathy&Arteriopathy(A)Investigators | 2023 | The Innovation2023，4，4： | 0 |
| 14 | Variability of Prorocentrum donghaiense response to allelopathic action from Alexandrium pacificum in laboratory culture显示文摘The dinoflagellates Alexandrium pacificum and Prorocentrum donghaiense are two well-known harmful algal blooms(HABs)-forming species,both were usually found in the same sea areas in form of HABs in China.To date,there is no mechanistic model that can fully explain the occurrence of P.donghaiense blooms with A.pacificum.We found that different strains of P.donghaiense had different intrinsic growth rates of 0.107-0.215/d,and these strains exhibited different responses to the allelopathic action from A.pacificum.Some strains of P.donghaiense could grow well despite some degrees of inhibition in a short period,suggesting the two algal species P.donghaiense and A.pacificum could coexist,even if A.pacificum was allelopathic.Our findings may advance the understanding of phenotypes in P.donghaiense and provide a potential mechanism involved in the coexistence of P.donghaiense and A.pacificum in the same area. | Hongjia HUANG Chuqiao GAN Jiahui HUANG Chen ZOU Hongye LI Jiesheng LIU Weidong YANG | 2021 | Journal of Oceanology and Limnology2021，39，4： | 0 |
| 15 | Current strategies for improving limitations of proteolysis targeting chimeras显示文摘Proteolysis targeting chimeras(PROTACs)are bifunctional degrader molecules via hijacking the ubiquitinproteasome system(UPS)to specifically eliminate targeted proteins.PROTACs have gained momentum as a new modality of attractive technologies in the drug discovery landscape,since it allows to degrade disease-related proteins effectively.Although some PROTACs drugs reached the clinical research,they are still facing some bottlenecks and challenges that should not be neglected,such as poor oral bioavailability and potential toxic side effects.To overcome these limitations,herein,we provide an overview of recent strategies for improving the durability of PROTACs by enhancing cell permeability and reducing toxic side effects.Meanwhile,the impact of these strategies on improving oral bioavailability as well as their advantages and drawbacks will also be discussed.This review will give a useful reference toolbox for PROTACs design and further promote its clinical application. | Chunlan Pu Shirui Wang Lei Liu Zhonghui Feng Hongjia Zhang Qianyuan Gong Yueshan Sun Yuanbiao Guo Rui Li | 2023 | Chinese Chemical Letters2023，34，6： | 0 |
| 16 | Aldh2 deficiency plays a dual role in lung tumorigenesis and tumor progression显示文摘Alcohol consumption contributes to global mortality and cancer development.Acetaldehyde(ACE),the oxidized metabolite of alcohol,is highly reactive towards DNA,resulting in DNA adducts.ACE can be detoxified to acetate by acetaldehyde dehydrogenase type 2(ALDH2).ALDH2 deficiency can lead to ACE accumulation and DNA damage. | Hongjia Zhang Xueqian Sun Zhanming Li Tingting Liu Fang Zhang Xinyu Meng Kaimi Li Jianhua Xu Wei He Bo Jing Tong Wang Na Ni Beibei Sun Feng Yao Yadi Wu Qi Wang Jing Du Eugene Y.Chin Binhua P.Zhou Ping Jiang Lishun Wang Jiong Deng | 2024 | Genes & Diseases2024，11，3： | 0 |
| 17 | An Opinion Spam Detection Method Based on Multi-Filters Convolutional Neural Network显示文摘With the continuous development of e-commerce,consumers show increasing interest in posting comments on consumption experience and quality of commodities.Meanwhile,people make purchasing decisions relying on other comments much more than ever before.So the reliability of commodity comments has a significant impact on ensuring consumers’equity and building a fair internet-trade-environment.However,some unscrupulous online-sellers write fake praiseful reviews for themselves and malicious comments for their business counterparts to maximize their profits.Those improper ways of self-profiting have severely ruined the entire online shopping industry.Aiming to detect and prevent these deceptive comments effectively,we construct a model of Multi-Filters Convolutional Neural Network(MFCNN)for opinion spam detection.MFCNN is designed with a fixed-length sequence input and an improved activation function to avoid the gradient vanishing problem in spam opinion detection.Moreover,convolution filters with different widths are used in MFCNN to represent the sentences and documents.Our experimental results show that MFCNN outperforms current state-of-the-art methods on standard spam detection benchmarks. | Ye Wang Bixin Liu Hongjia Wu Shan Zhao Zhiping Cai Donghui Li Cheang Chak Fong | 2020 | Computers, Materials & Continua2020，，10： | 0 |
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