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| 1 | Integrated single-cell RNA sequencing analysis reveals distinct cellular and transcriptional modules associated with survival in lung cancer显示文摘Lung adenocarcinoma(LUAD)and squamous carcinoma(LUSC)are two major subtypes of non-small cell lung cancer with distinct pathologic features and treatment paradigms.The heterogeneity can be attributed to genetic,transcriptional,and epigenetic parameters.Here,we established a multi-omics atlas,integrating 52 single-cell RNA sequencing and 2342 public bulk RNA sequencing.We investigated their differences in genetic amplification,cellular compositions,and expression modules.We revealed that LUAD and LUSC contained amplifications occurring selectively in subclusters of AT2 and basal cells,and had distinct cellular composition modules associated with poor survival of lung cancer.Malignant and stage-specific gene analyses further uncovered critical transcription factors and genes in tumor progression.Moreover,we identified subclusters with proliferating and differentiating properties in AT2 and basal cells.Overexpression assays of ten genes,including sub-cluster markers AQP5 and KPNA2,further indicated their functional roles,providing potential targets for early diagnosis and treatment in lung cancer. | Li Zhang Yiming Zhang Chengdi Wang Ying Yang Yinyun Ni Zhoufeng Wang Tingting Song Menglin Yao Zhiqiang Liu Ningning Chao Yongfeng Yang Jun Shao Zhidan Li Ran Zhou Li Chen Dan Zhang Yuancun Zhao Wei Liu Yupeng Li Ping He Jing-wen Lin Yuan Wang Kang Zhang Lu Chen Weimin Li | 2022 | Signal Transduction and Targeted Therapy2022，7，2： | 2 |
| 2 | 2020 Roadmap on two-dimensional nanomaterials for environmental catalysis显示文摘Environmental catalysis has drawn a great deal ofattention due to its clean ways to produce useful chemicals or carry out some chemical processes.Photocatalysis and electrocatalysis play important roles in these fields.They can decompose and remove organic pollutants from the aqueous environment,and prepare some fine chemicals.Moreover,they also can carry out some important reactions,such as 02 reduction reaction(ORR),O2 evolution reaction(OER),H2 evolution reaction(HER),CO2 reduction reaction(C02 RR),and N2 fixation(NRR).For catalytic reactions,it is the key to develop high-performance catalysts to meet the demand fortargeted reactions.In recentyears,two-dimensional(2 D) materials have attracted great interest in environmental catalysis due to their unique layered structures,which offer us to make use of their electronic and structural characteristics.Great progress has been made so far,including graphene,black phosphorus,oxides,layered double hydroxides(LDHs),chalcogenides,bismuth-based layered compounds,MXenes,metal organic frameworks(MOFs),covalent organic frameworks(COFs),and others.This content drives us to invite many famous groups in these fields to write the roadmap on two-dimensional nanomaterials for environmental catalysis.We hope that this roadmap can give the useful guidance to researchers in future researches,and provide the research directions. | Yulu Yang Mingguang Wu Xingwang Zhu Hui Xu Si Ma Yongfeng Zhi Hong Xia Xiaoming Liu Jun Pan Jie-Yinn Tang Siang-Piao Chai Leonardo Palmisano Francesco Parrino Junli Liu Jianzhong Ma Ze-Lin Wang Ling Tan Yu-Fei Zhao Yu-Fei Song Pardeep Singh Pankaj Raizada Deli Jiang Di Li R.A.Geioushy Jizhen Ma Jintao Zhang Song Hu Rongjuan Feng Gang Liu Minghua Liu Zhenhua Li Mingfei Shao Neng Li Jiahe Peng Wee-Jun Ong Nikolay Kornienko Zhenyu Xing Xiujun Fan Jianmin Ma | 2019 | Chinese Chemical Letters2019，30，12： | 2 |
| 3 | Four-Beam Model for Vibration Analysis of a Cantilever Beam with an Embedded Horizontal Crack显示文摘As one of the main failure modes, embedded cracks occur in beam structures due to periodic loads. Hence it is useful to investigate the dynamic characteristics of a beam structure with an embedded crack for early crack detection and diagnosis. A new four-beam model with local flexibilities at crack tips is developed to investigate the transverse vibration of a cantilever beam with an embedded horizontal crack; two separate beam segments are used to model the crack region to allow opening of crack surfaces. Each beam segment is considered as an Euler-Bernoulli beam. The governing equations and the matching and boundary conditions of the four-beam model are derived using Hamilton's principle. The natural frequencies and mode shapes of the four-beam model are calculated using the transfer matrix method. The effects of the crack length, depth, and location on the first three natural frequencies and mode shapes of the cracked cantilever beam are investigated. A continuous wavelet transform method is used to analyze the mode shapes of the cracked cantilever beam. It is shown that sudden changes in spatial variations of the wavelet coefficients of the mode shapes can be used to identify the length and location of an embedded horizontal crack. The first three natural frequencies and mode shapes of a cantilever beam with an embedded crack from the finite element method and an experimental investigation are used to validate the proposed model. Local deformations in the vicinity of the crack tips can be described by the proposed four-beam model, which cannot be captured by previous methods. | LIU Jing ZHU Weidong CHARALAMBIDES Panos G SHAO Yimin XU Yongfeng WU Kai XIAO Huifang | 2016 | Chinese Journal of Mechanical Engineering2016，29，1： | 2 |
| 4 | Periostin expression is upregulated and associated with myocardial fibrosis in human failing hearts显示文摘 | Sheng Zhao Hengfang Wu Wenlong Xia Xiangjian Chen Shushu Zhu Shijiang Zhang Yongfeng Shao Wenzhu Ma Di Yang Jinan Zhang | 2013 | Journal of Cardiology2013，，： | 1 |
| 5 | High-speed wire electrical discharge machining of insulating zirconia with a novel assisting electrode 显示文摘 | GUO Yongfeng HOU Pengju SHAO Dongxiang | 2014 | Materials and Manufacturing Processes2014，29，5： | 1 |
| 6 | Bioprosthetic Valve Size Selection to Optimize Aortic Valve ReplacementSurgical Outcome: A Fluid-Structure Interaction Modeling Study显示文摘Aortic valve replacement(AVR)remains a major treatment option for patients with severe aortic valve disease.Clinical outcome of AVR is strongly dependent on implanted prosthetic valve size.Fluid-structure interaction(FSI)aortic root models were constructed to investigate the effect of valve size on hemodynamics of the implanted bioprosthetic valve and optimize the outcome of AVR surgery.FSI models with 4 sizes of bioprosthetic valves(19(No.19),21(No.21),23(No.23)and 25 mm(No.25))were constructed.Left ventricle outflow track flow data from one patient was collected and used as model flow conditions.Anisotropic Mooney–Rivlin models were used to describe mechanical properties of aortic valve leaflets.Blood flow pressure,velocity,systolic valve orifice pressure gradient(SVOPG),systolic cross-valve pressure difference(SCVPD),geometric orifice area,and flow shear stresses from the four valve models were compared.Our results indicated that larger valves led to lower transvalvular pressure gradient,which is linked to better post AVR outcome.Peak SVOPG,mean SCVPD and maximum velocity for Valve No.25 were 48.17%,49.3%,and 44.60%lower than that from Valve No.19,respectively.Geometric orifice area from Valve No.25 was 52.03%higher than that from Valve No.19(1.87 cm2 vs.1.23 cm2).Implantation of larger valves can significantly reduce mean flow shear stress on valve leaflets.Our initial results suggested that larger valve size may lead to improved hemodynamic performance and valve cardiac function post AVR.More patient studies are needed to validate our findings. | Caili Li Dalin Tang Jing Yao Christopher Baird Haoliang Sun Chanjuan Gong Luyao Ma Yanjuan Zhang Liang Wang Han Yu Chun Yang Yongfeng Shao | 2021 | Computer Modeling in Engineering & Sciences2021，，4： | 1 |
| 7 | Isotopic geochemistry, zircon U–Pb ages and Hf isotopes of A-type granites from the Xitian W–Sn deposit, SE China: Constraints on petrogenesis and tectonic significance显示文摘 | Yun Zhou Xinquan Liang Shichong Wu Yongfeng Cai Xirong Liang Tongbin Shao Ce Wang Jiangang Fu Ying Jiang | 2015 | Journal of Asian Earth Sciences2015，，： | 1 |
| 8 | Artificial neuron synapse transistor based on silicon nanomembrane on plastic substrate显示文摘Silicon nanomembrane(SiNM)transistors gated by chitosan membrane were fabricated on plastic substrate to mimic synapse behaviors.The device has both a bottom proton gate(BG)and multiple side gates(SG).Electrical transfer properties of BG show hysteresis curves different from those of typical SiO_2 gate dielectric.Synaptic behaviors and functions by linear accumulation and release of protons have been mimicked on this device:excitatory post-synaptic current(EPSC)and paired pulse facilitation behavior of biological synapses were mimicked and the paired-pulse facilitation index could be effectively tuned by the spike interval applied on the BG.Synaptic behaviors and functions,including short-term memory and long-term memory,were also experimentally demonstrated in BG mode.Meanwhile,spiking logic operation and logic modulation were realized in SG mode. | Minjie Liu Gaoshan Huang Ping Feng Qinglei Guo Feng Shao Ziao Tian Gongjin Li Qing Wan Yongfeng Mei | 2017 | Journal of Semiconductors2017，38，6： | 1 |
| 9 | Two exact solutions of the DPL non-Fourier heat conduction equation with special conditions显示文摘This paper presents two exact explicit solutionsfor the three dimensional dual-phase lag(DLP)heat conduc-tion equation,during the derivation of which the method oftrial and error and the authors' previous experiences are uti-lized.To the authors' knowledge,most solutions of 2D or3D DPL models available in the literature are obtained bynumerical methods,and there are few exact solutions upto now.The exact solutions in this paper can be used asbenchmarks to validate numerical solutions and to developnumerical schemes,grid generation methods and so forth.In addition,they are of theoretical significance since theycorrespond to physically possible situations.The main goalof this paper is to obtain some possible exact explicit solu-tions of the dual-phase lag heat conduction equation as thebenchmark solutions for computational heat transfer,ratherthan specific solutions for some given initial and boundaryconditions.Therefore,the initial and boundary conditionsare indeterminate before derivation and can be deduced fromthe solutions afterwards.Actually,all solutions given in thispaper can be easily proven by substituting them into thegoverning equation. | Youtong Zhang Changsong Zheng Yongfeng Liu Liang Shao Chenhua Gou | 2009 | Acta Mechanica Sinica2009，25，2： | 1 |
| 10 | Physical Activity,Sedentary Behavior,and the Risk of Cardiovascular Disease in Type 2 Diabetes Mellitus Patients:The MIDiab Study显示文摘The aim of this study was to explore the associations of moderate-to-vigorous-intensity physical activity(MVPA)time and sedentary(SED)time with a history of cardiovascular disease(CVD)and multifactorial(i.e.,blood pressure(BP),body mass index(BMI),low-density lipoprotein cholesterol(LDL-C),and glycated hemoglobin A1c(HbA1c))control status among type 2 diabetes mellitus(T2DM)patients in China.A cross-sectional analysis of 9152 people with type 2 diabetes from the Multifactorial Intervention on Type 2 Diabetes(MIDiab)study was performed.Patients were grouped according to their self-reported MVPA time(low,<150 min·week−1;moderate,150 to<450 min·week−1;high,≥450 min·week−1)and SED time(low,<4 h·d–1;moderate,4 to<8 h·d–1;high,≥8 h·d–1).Participants who self-reported a history of CVD were identified as having a CVD risk.Odds ratios(ORs)and 95%confidence intervals(CIs)of CVD risk and multifactorial control status associated with MVPA time and SED time were estimated using mixed-effect logistic regression models,adjusting for China’s geographical region characteristics.The participants had a mean±standard deviation(SD)age of(60.87±8.44)years,44.5%were women,and 25.1%had CVD.After adjustment for potential confounding factors,an inverse association between high MVPA time and CVD risk that was independent of SED time was found,whereas this association was not observed in the moderate-MVPA group.A higher MVPA time was more likely to have a positive effect on the control of BMI.Compared with the reference group(i.e.,those with MVPA time≥450 min·week−1 and SED time<4 h·d–1),CVD risk was higher in the low-MVPA group:The OR associated with an SED time<4 h·d–1 was 1.270(95%CI,1.040–1.553)and that associated with an SED time≥8 h·d–1 was 1.499(95%CI,1.149–1.955).We found that a high MVPA time(i.e.,≥450 min·week−1)was associated with lower odds of CVD risk regardless of SED time among patients with T2DM. | Yafei Wu Guijun Qin Guixia Wang Libin Liu Bing Chen Qingbo Guan Zhongshang Yuan Xu Hou Ling Gao Chao Xu Haiqing Zhang Xu Zhang Qiu Li Yongfeng Song Fei Jing Shizhan Ma Shanshan Shao Meng Zhao Qingling Guo Nanwei Tong Hongyan Zhao Xiaomin Xie Chao Liu Zhongyan Shan Zhifeng Cheng Xuefeng Yu Shulin Chen Tao Yang Yangang Wang Dongmei Li Zhaoli Yan Lixin Guo Qiuhe Ji Wenjuan Wang Jiajun Zhao | 2023 | Engineering2023，，1： | 1 |
| 11 | The influence of the capping ligands on the optoelectronic performance,morphology,and ion liberation of CsPbBr_(3)perovskite quantum dots显示文摘Perovskite quantum dots(PeQDs)endowed with capping ligands exhibit impressive optoelectronic properties and enable for costefficient solution processing and exciting application opportunities.We synthesize and characterize three different PeQDs with the same cubic CsPbBr_(3)core,but which are distinguished by the ligand composition and density.PeQD-1 features a binary didodecyldimethylammonium bromide(DDAB)and octanoic acid capping ligand system,with a high surface density of 1.53 nm^(-2),whereas PeQD-2 and PeQD-3 are coated by solely DDAB at a gradually lower surface density.We show that PeQD-1 endowed with highest ligand density features the highest dispersibility in toluene of 150 g/L,the highest photoluminescence quantum yield of 95%in dilute solution and 59%in a neat film,and the largest core-to-core spacing in neat thin films.We further establish that ions are released from the core of PeQD-1 when it is exposed to an electric field,although it comprises a dense coating of one capping ligand per four surface core atoms.We finally exploit these combined findings to the development of a light-emitting electrochemical cell(LEC),where the active layer is composed solely of solution-processed pure PeQDs,without additional electrolytes.In this device,the ion release is utilized as an advantage for the electrochemical doping process and efficient emissive operation of the LEC. | Yongfeng Liu Shi Tang Zhaoju Gao Xiuwen Shao Xiaolin Zhu Joan Ràfols Ribé Thomas Wågberg Ludvig Edman Jia Wang | 2023 | Nano Research2023，16，7： | 0 |
| 12 | Inflammatory risk stratification individualizes anti-inflammatory pharmacotherapy for acute type A aortic dissection显示文摘The systemic benefits of anti-inflammatory pharmacotherapy vary across cardiovascular diseases in clinical practice.We aimed to evaluate the application of artificial intelligence to acute type A aortic dissection(ATAAD)patients to determine the optimal target population who would benefit from urinary trypsin inhibitor use(ulinastatin).Patient characteristics at admission in the Chinese multicenter 5A study database(2016-2022)were used to develop an inflammatory risk model to predict multiple organ dysfunction syndrome(MODS). | Hong Liu Haiyang Li Lu Han Yingyuan Zhang Ying Wu Liang Hong Jinong Yang Jisheng Zhong Yuqi Wang Dongkai Wu Guoliang Fan Junquan Chen Shengqiang Zhang Xingxing Peng Zhihua Zeng Zhiwei Tang Zhanjie Lu Lizhong Sun Sichong Qian Yongfeng Shao Hongjia Zhang on behalf of the Additive Anti-inflammatory Action for Aortopathy&Arteriopathy(A)Investigators | 2023 | The Innovation2023，4，4： | 0 |
| 13 | Zircon saturation model in silicate melts:a review and update显示文摘Zircon stability in silicate melts-which can be quantitatively constrained by laboratory measurements of zircon saturation-is important for understanding the evolution of magma.Although the original zircon saturation model proposed by Watson and Harrison(Earth Planet Sci Lett 64(2):295-304,1983) is widely cited and has been updated recently,the three main models currently in use may generate large uncertainties due to extrapolation beyond their respective calibrated ranges.This paper reviews and updates zircon saturation models developed with temperature and compositional parameters.All available data on zircon saturation ranging in composition from mafic to silicic(and/or peralkaline to peraluminous)at temperatures from 750 to 1400℃ were collected to develop two refined models(1 and 2) that may be applied to the wider range of compositions.Model 1 is given by lnCZr(melt)=(14.297±0.308)+(0.964 ± 0.066).M-(11113±374)/r,and model 2 given by lnCZr(melt)=(18.99±0.423)-(1.069±0.102)·lnG-(12288±593)/T,where CZr(melt) is the Zr concentration of the melt in ppm and parameters M [=(Na+K+2 Ca)/(Al·Si)](cation ratios) and G [=(3·Al2 O3+SiO2)/(Na2-O+K2 O+CaO+MgO+FeO)](molar proportions)represent the melt composition.The errors are at one sigma,and T is the temperature in Kelvin.Before applying these models to natural rocks,it is necessary to ensure that the zircon used to date is crystallized from the host magmatic rock.Assessment of the application of both new and old models to natural rocks suggests that model 1 may be the best for magmatic temperature estimates of metaluminous to peraluminous rocks and that model 2 may be the best for estimating magmatic temperatures of alkaline to peralkaline rocks. | Tongbin Shao Ying Xia Xing Ding Yongfeng Cai Maoshuang Song | 2020 | Acta Geochimica2020，39，3： | 0 |
| 14 | Relation or Influence of RVOTO in the Inflammatory Response to Reoxygenation in Patients with Tetralogy of Fallot显示文摘Background:This study evaluated differential inflammatory response to cardiopulmonary bypass reoxygenation in tetralogy of Fallot repair.Methods:We performed a retrospective study at a cardiovascular center from 2012 to 2018,including 500 patients aged 1 week–18 years who received complete repair of tetralogy of Fallot.Patients were grouped according to tertiles of preoperative RVOT gradient on echocardiography into mild,moderate,and severe stenosis.We measured the highest perfusate oxygenation(PpO_(2))during aortic occlusion as independent variable.Primary outcome was systemic inflammatory response syndrome(SIRS)within 7 days postoperatively or the time of death or discharge.Results:Overall,rate of SIRS was 24.2% without significant differences among three groups(P>0.05).Older age,male,and smaller indexed left ventricular end-diastolic volume is independent risk factor of SIRS.There were significant interactions between RVOT stenosis and PpO2 on SIRS(P interaction=0.011):higher PpO_(2) was associated with a greater SIRS risk among combined moderate and severe stenotic children(OR 1.46395%CI[1.080,1.981]per-SD increase,P=0.014)but not among mild stenotic children(OR 0.900[0.608,1.333]per-SD increase;P=0.600),independent of covariates.Conclusion:The association of PpO_(2) with SIRS was modified by RVOT obstruction severity in tetralogy of Fallot repair. | Hong Liu Luyao Ma Jinghang Li Bingqi Sun Siqiang Zheng Yongfeng Shao | 2021 | Congenital Heart Disease2021，16，5： | 0 |
| 15 | Biomechanical characterization of a novel ring connector for sutureless aortic anastomosis显示文摘The surgical treatment for aortic diseases remains a challenge for any cardiac surgeon. The use of sutureless ring connector in aortic anastomosis can simplify the procedure and shorten anastomosis time. Therefore, we developed a novel device for sutureless aortic anastomosis. A series of experiments were carried out for tensile and leakproofcapacity assessments to verify the feasibility of the ring connector by using fresh swine aorta samples. In in vivo test,the ring connector was implanted in 6 swine with follow-up of 6 months. Radiographic and pathological studies of the aorta were performed. In the tensile tests, the strength was 32.7±5.9 Newton(N) in the sutureless anastomosis group,compared with 73.3±12.5 N in the control group by traditional manual suture. In the leakproof-capacity assessment,no sign of either leakage or bursting was evident at 280 mmHg of internal pressure in the aorta samples. In in vivo tests,it took 9.47±0.3 minutes for the sutureless anastomosis, compared with 15.58± 1.39 minutes for hand-sewn suturing. Insertion was easy and rapid. Radiographic and pathological studies were performed at first month, third month and sixth month after surgery, each time obtained from the two swine, showed patency of the anastomosis and no signs of stenosis, blood leakage, migration or pseudoaneurysm formation, except one paralyzed swine developed of thrombo-occlusion at the site of the sutureless anastomosis. The result indicates that this novel ring connector offers considerable promise for sutureless aortic anastomosis. | Huan Liu Shijiang Zhang Yongfeng Shao Xiaohu Lu Weidong Gu Buqing Ni Qun Gu Junjie Du | 2018 | The Journal of Biomedical Research2018，32，6： | 0 |
| 16 | Atypical pituitary hormone–target tissue axis显示文摘A long-held belief is that pituitary hormones bind to their cognate receptors in classical target glands to actuate their manifold functions.However,a number of studies have shown that multiple types of pituitary hormone receptors are widely expressed in non-classical target organs.Each pituitary gland-derived hormone exhibits a wide range of nonconventional biological effects in these non-classical target organs.Herein,the extra biological functions of pituitary hormones,thyroid-stimulating hormone,follicle-stimulating hormone,luteinizing hormone,adrenocorticotrophic hormone,and prolactin when they act on non-classical organs were summarized,defined by the novel concept of an“atypical pituitary hormone–target tissue axis.”This novel proposal explains the pathomechanisms of abnormal glucose and lipid metabolism,obesity,hypertension,fatty liver,and atherosclerosis while offering a more comprehensive and systematic insights into the coordinated regulation of environmental factors,genetic factors,and neuroendocrine hormones on human biological functions.The continued exploration of the physiology of the“atypical pituitary hormone–target tissue axis”could enable the identification of novel therapeutic targets for metabolic diseases. | Chao Xu Zhao He Yongfeng Song Shanshan Shao Guang Yang Jiajun Zhao | 2023 | Frontiers of Medicine2023，17，1： | 0 |
| 17 | Petrogeochemistry, geochronology and its geological significance of the granite from Baishipo Ag deposit, Dabie orogen显示文摘1 Introduction Granitoid magmas have been widely used as a natural probe for tracing the crustal evolution process(Martin et al.,2005).Mesozoic granitoids are widespread in the | LIU Qingquan SHAO Yongjun ZHOU Ke Ping LI Yongfeng | 2017 | Acta Geologica Sinica(English Edition)2017，91，S1： | 0 |
| 18 | Wide-range color-tunable afterglow emission by the modulation of triplet exciton transition processes based on buckybowl structure显示文摘Buckybowl structures as non-uniform electrostatic potential distributions of poly-cyclic aromatic materials show a unique photoelectric performance.In this work,OTC was utilized for dynamic modulation of triplet exciton transition processes.Five host molecules with different functional units were selected,thus providing dif-ferent intermolecular interactions in the host/guest systems.Therefore,the delayed emissions were regulated from 536 to 624 nm via the tuning of the triplet exciton transition processes of OTC in different hosts.Experimental data and theoretical calculations revealed that the varied triplet transition behaviors resulted from the competition between the intersystem crossing(ISC)process of OTC-monomer and the reverse intersystem crossing(RISC)process of OTC-aggregates.This work proves the superior structure of buckybowl-based luminophore for controlling triplet exciton transition processes and supplies a new perspective for persistent afterglow luminophore design. | Yongfeng Zhang Chenchen Xiong Wenbo Wang Wenbo Dai Yue Ren Junming Xia Gengchen Li Jianbing Shi Bin Tong Xiaoyan Zheng Xiangfeng Shao Zhengxu Cai Yuping Dong | 2023 | Aggregate2023，4，4： | 0 |
| 19 | Biodegradable interference distraction implant:a promising replacement for conventional implant in patients with insufficient alveolar bone height显示文摘Background Dental implants have been widely used in the last few decades.However,patients with insufficient bone height need reconstructive surgeries before implant insertion.Distraction implant(Dl)has been invented to simplify the treatment procedure,but the shortcomings of Dl have limited its clinical use.We introduced biodegradable polyester to a novel Dl,called biodegradable interference distraction implant(BIDI).The purpose of this study was to assess the radiological,histological,and biomechanical properties of BIDI in animal models.Methods BIDIs were manufactured and inserted into the atrophied mandibles of 6 dogs. | Yongfeng Li Tao Li Bo Shao Yingying Sun Yuan Gao Yongqiang Zhang Qi Gao Shuning Shen Qiang Niu Mingming Shen Liang Kong | 2013 | 医用生物力学2013，28，S1： | 0 |
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