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| 1 | Cenozoic sedimentary records and geochronological constraints of differential uplift of the Qinghai-Tibet Plateau显示文摘Geological mapping data (1:250000) in the Qinghai-Tibet Plateau and its adjacent regions reveal the sediment sequences, distribution and tectonic evolution of the 92 Tertiary remnant basins. Southern Tibet and the Yecheng area in Xinjiang, located at southern and northwestern margins of the Qinghai-Tibet Plateau, respectively, were parts of the Neo-Tethys remnant sea in the Paleogene. In southern Tibet, both the subabyssal and abyssal sequences occur at the Gyangze, Saga, Guoyala, and Sangmai areas. The deep-water facies successions outcrop in the west, whereas the shallow-water facies sequences in the east, indicating the east to the west retreat of the Neo-Tethys Ocean. The retreat of the Neo-Tethys Ocean in the east was contributed to the earlier tectonic uplift of the eastern Qinghai-Tibet Plateau. The uplift process of the Plateau from the Late Cretaceous to Pliocene is described as follows: During the Late Cretaceous, tectonic uplift of the Qinghai-Tibet Plateau occurred in the northeastern part and the configuration of the Qinghai-Tibet Plateau was characterized by rise in the northeast and depression in the west. In the Paleocene-Eocene interval, the Tengchong-Baingoin and Kuyake-Golmud areas experienced local tectonic uplifting, the West Kunlun uplift zone broadened easterly, the Qilian uplift zone broadened southerly, and the Songpan-Garzê uplift zone shrank easterly. The Oligocene configuration of the Qinghai-Tibet Plateau was characterized by mountain chains rising along its margins and sedimentary basins in the central part because of tectonic uplifts of the Gangdisê and the Himalaya blocks. Meanwhile, the Kunlun-Altyn-Qilian uplift zones have also broadened southerly and northerly. In contrast, the great uplift zones of the Gangdisê, the Himalaya, the Karakorum, and the Kunlun blocks characterize the paleogeographic contours of the Qinghai-Tibet Plateau during the Miocene-Pliocene. Additionally, the thermochronological data on tectonic uplift events in southern Tibet, West Kunlun Mountains, Altyn Tagh, eastern Tibet, and western Sichuan all suggest that the most intense deformation occurred at 13-8 Ma and since 5 Ma, respectively, corresponding to two great uplift periods in Neogene. As a result, turnover of paleogeographic configuration of the Qinghai-Tibet Plateau occurred during the Neogene, experiencing a change from high contours in the east in the pre-Oligocene to high contours in the west at the end-Pliocene. The uplift of the Qinghai-Tibet Plateau during the Cenozoic was episodic, and the uplifts of various blocks within the Plateau were spatially and chronologically different. | ZHANG KeXin WANG GuoCan CAO Kai LIU Chao XIANG ShuYuan HONG HanLie KOU XiaoHu XU YaDong CHEN FenNing MENG YanNing CHEN RuiMing | 2008 | Science China Earth Sciences2008，51，11： | 31 |
| 2 | Rough surface of copper-bearing titanium alloy with multifunctions of osteogenic ability and antibacterial activity显示文摘Implant-related infection and early bone integration are the main risk factors of implants for long-term service,to overcome these difficulties,SLA-TiCu surface was prepared by sandblasting and large-grits etching(SLA)treatment on a novel antibacterial titanium-copper alloy(TiCu),which is the most prevalent surface treatment with micro/submicron hierarchical structures to titanium-based implants.Effects of SLA-TiCu surface on the adhesion,proliferation,apoptosis and differentiation of MC3T3-E1 cells as well as the antibacterial activity against a common orthopedic pathogen(Staphylococcus aureus)were studied.Compared to the following surfaces:sandblasting and large-grits etched pure titanium(SLATi),mechanically ground pure titanium and TiCu alloy(M-Ti and M-TiCu),these results indicated that SLA-TiCu surface obviously enhanced the bone-related gene expressions(alkaline phosphates(ALP),collagen typeⅠ(COLⅠ),Runt-related transcription factor 2(RUN x 2),and osteopontin(OPN)).Moreover,SLA-TiCu surface could maintain a sustainable release of Cu2+ions and effectively inhibited the viability of bacteria.This study demonstrated that SLA-TiCu surface possessed multifunctional characteristics of improved osteogenic ability and antibacterial activity,making it promising as a novel implant material for hard tissue repairs such as orthopedics and dental implants. | Hui Liu Rui Liu Ihsan Ullah Shuyuan Zhang Ziqing Sun Ling Ren Ke Yang | 2020 | Journal of Materials Science & Technology2020，47，13： | 6 |
| 3 | Bimetallic nickel molybdate supported Pt catalyst for efficient removal of formaldehyde at low temperature显示文摘Efficient removal of formaldehyde from indoor environments is of significance for human health.In this work,a typical binary transition metal oxide that could provide various oxidation states,β-NiMoO4,was employed as a support to immobilize the active Pt component(Pt/NiMoO4)for catalytic formaldehyde elimination at low ambient temperature(15℃).The results showed that the hydrothermal preparation temperature and time had a noticeable impact on the morphology and catalytic activity of the samples.The catalyst prepared with hydrothermal temperature of 150℃for 4 hr(Pt-150-4)exhibited superior catalytic activity and stability mainly due to its distinctly porous structure,relative abundance of adsorbed surface hydroxyls/water,and high oxidation ability,which resulted from the interaction of Pt with Ni and Mo of the bimetallic NiMoO4 support.Our results might shed light on the rational design of multifunctional catalysts for removal of indoor air pollutants at low ambient temperature. | Gang Huang Zhaoxiong Yan Shuyuan Liu Tingting Luo Liang An Zhihua Xu | 2020 | Journal of Environmental Sciences2020，32，1： | 6 |
| 4 | Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies显示文摘Neutralizing monoclonal antibodies(nAbs)to severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)represent promising candidates for clinical intervention against coronavirus disease 2019(COVID-19).We isolated a large number of nAbs from SARS-CoV-2-infected individuals capable of disrupting proper interaction between the receptor binding domain(RBD)of the viral spike(S)protein and the receptor angiotensin converting enzyme 2(ACE2).However,the structural basis for their potent neutralizing activity remains unclear.Here,we report cryo-EM structures of the ten most potent nAbs in their native full-length IgG-form or in both IgG-form and Fab-form bound to the trimeric S protein of SARS-CoV-2.The bivalent binding of the full-length IgG is found to associate with more RBDs in the“up”conformation than the monovalent binding of Fab,perhaps contributing to the enhanced neutralizing activity of IgG and triggering more shedding of the S1 subunit from the S protein.Comparison of a large number of nAbs identified common and unique structural features associated with their potent neutralizing activities.This work provides a structural basis for further understanding the mechanism of nAbs,especially through revealing the bivalent binding and its correlation with more potent neutralization and the shedding of S1 subunit. | Renhong Yan Ruoke Wang Bin Ju Jinfang Yu Yuanyuan Zhang Nan Liu Jia Wang Qi Zhang Peng Chen Bing Zhou Yaning Li Yaping Shen Shuyuan Zhang Long Tian Yingying Guo Lu Xia Xinyue Zhong Lin Cheng Xiangyang Ge Juanjuan Zhao Hong-Wei Wang Xinquan Wang Zheng Zhang Linqi Zhang Qiang Zhou | 2021 | Cell Research2021，31，5： | 4 |
| 5 | Biodegradable magnesium alloy WE43 porous scaffolds fabricated by laser powder bed fusion for orthopedic applications:Process optimization,in vitro and in vivo investigation显示文摘Laser powder bed fusion(L-PBF)of magnesium(Mg)alloy porous scaffolds is expected to solve the dual challenges from customized structures and biodegradable functions required for repairing bone defects.However,one of the key technical difficulties lies in the poor L-PBF process performance of Mg,contributed by the high susceptibility to oxidation,vaporization,thermal expansion,and powder attachment etc.This work investigated the influence of L-PBF energy input and scanning strategy on the formation quality of porous scaffolds by using WE43 powder,and characterized the microstructure,mechanical properties,biocompatibility,biodegradation and osteogenic effect of the as-built WE43 porous scaffolds.With the customized energy input and scanning strategy,the relative density of struts reached over 99.5%,and the geometrical error between the designed and the fabricated porosity declined to below 10%.Massive secondary phases including intermetallic precipitates and oxides were observed.The compressive strength(4.37-23.49 MPa)and elastic modulus(154.40-873.02 MPa)were comparable to those of cancellous bone.Good biocompatibility was observed by in vitro cell viability and in vivo implantation.The biodegradation of as-built porous scaffolds promoted the osteogenic effect,but the structural integrity devastated after 12 h by the immersion tests in Hank’s solution and after 4 weeks by the implantation in rabbits’femur,indicating an excessively rapid degradation rate. | Jinge Liu Bingchun Liu Shuyuan Min Bangzhao Yin Bo Peng Zishi Yu Caimei Wang Xiaolin Ma Peng Wen Yun Tian Yufeng Zheng | 2022 | Bioactive Materials2022，7，10： | 4 |
| 6 | Mechanical tests on the reconstructed anterior cruciate ligament fixed with allogenetic cortical bone cross-pin on the femoral side显示文摘 | Liu Chang Liu Yujie Zhang Yingze Qu Feng Li Shuyuan Wang Junliang Qi Wei Wang Aiyuan Wang Xin Liang Jianjun Liang Dongqi Zhu Juanli Liu Yang | 2014 | Chinese Medical Journal2014，，15： | 3 |
| 7 | Optimization of annealing treatment and comprehensive properties of Cu-containing Ti6Al4V-xCu alloys显示文摘The Ti6Al4V-Cu alloy was reported to show good antibacterial properties, which was promising to reduce the hazard of the bacterial infection problem. For the purpose of preparing Ti6Al4V-Cu alloy with satisfied comprehensive properties, it’s important to study the heat treatment and the appropriate Cu content of the alloy. In this study, high Cu content Ti6Al4V-x Cu(x = 4.5, 6, 7.5 wt%) alloys were prepared, and firstly the annealing heat treatments were optimized in the α+β+Ti2Cu triple phase region to obtain satisfied tensile mechanical properties. Then the effect of Cu content on the tribological property, corrosion resistance, antibacterial activity and cytotoxicity of the Ti6Al4 V-x Cu alloys were systematically studied to obtain the appropriate Cu content. The results showed that the optimal annealing temperatures for Ti6Al4 V-x Cu(x = 4.5, 6, 7.5 wt%) alloys were 720, 740 and 760℃, respectively, which was resulted from the proper volume fractions of α,β and Ti2Cu phases in the microstructure. The additions of 4.5 wt% and 6 wt% Cu into the medical Ti6Al4 V alloy could enhance the wear resistance and corrosion resistance of the alloy, but the addition of 7.5 wt% Cu showed an opposite effect. With the increase of the Cu content, the antibacterial property was enhanced due to the increased volume fraction of Ti2Cu phase in the microstructure, but when the Cu content was increased to 7.5 wt%, cytotoxicity was presented. A medium Cu content of 6 wt%, with annealing temperature of 740℃ make the alloy possesses the best comprehensive properties of tensile properties, wear resistance, corrosion resistance, antibacterial property and biocompatibility, which is promising for future medical applications. | Cong Peng Yang Liu Hui Liu Shuyuan Zhang Chunguang Bai Yizao Wan Ling Ren Ke Yang | 2019 | Journal of Materials Science & Technology2019，35，10： | 3 |
| 8 | Depositional System of the Carboniferous Huanglong Formation,Eastern Sichuan Basin:Constraints from Sedimentology and Geochemistry显示文摘Using analyses of the lithology,sequences,paleoenvironment,and tectonic setting,the depositional system of the Carboniferous Huanglong Formation in the eastern Sichuan Basin was identified.The lithological characteristics of the Lower Member,Middle Member,and Upper Member were analyzed and classified.Before the use of carbon,oxygen,and strontium isotopes in the analysis,all of the geochemical data were tested for validity.On the basis of the Z values obtained from carbon and oxygen isotopes,the paleoenvironments of the three members were elucidated.Lower Member was dominantly an enclosed marine environment with intense evaporation and little freshwater input into the sea.Middle Member developed in a semi-enclosed to normal marine environment with many rivers.Upper Member was formed in a normal marine environment.The east Sichuan Basin was enclosed by paleouplifts before the deposition of the Huanglong Formation,forming a relatively enclosed depositional setting.Paleogullies developed in the Silurian strata that underlie the Carboniferous rocks;these paleogullies can be identified.On the basis of a comprehensive analysis,we propose that the Huanglong Formation developed in a platform system.Four microfacies were identified:supratidal flat,dolostone flat,grain shoal,and shelf microfacies.The high-permeability and high-porosity characteristics of the grain shoal microfacies are favorable for hydrocarbon accumulation,while the supratidal flat and shelf microfacies developed very few high-quality reservoirs.The paleogullies,in which increased amounts of grain shoal microfacies developed,controlled the distribution of high-quality reservoirs. | WANG Kun HU Suyun LI Wei LIU Wei HUANG Qingyu MA Kui SHI Shuyuan | 2016 | Acta Geologica Sinica(English Edition)2016，90，5： | 3 |
| 9 | Clinical outcomes of early weight-bearing after arthroscopic microfracture during the treatment of osteochondral lesions of the talus显示文摘 | Li Shuyuan Li Hongliang Liu Yujie Qu feng Wang Junliang Liu Chang | 2014 | Chinese Medical Journal2014，，13： | 3 |
| 10 | Effect of Different Factors on Nitrogen Removal Rate in Constructed Wetlands显示文摘Factors affecting total nitrogen(TN) removal rates in constructed wetland were investigated by intermittent operation in the subsurface flow(SSF) constructed wetland system.The results demonstrated that removal rates of TN increased with the rising of TN pollution load(1.40-12.40 g/m2) when the retention time was determined by 60% TN removal efficiency(n=180,p<0.05) in SSF wetlands.The maximum TN removal rate was 1.71 g/(m2·d) in SSF Phragmites australis-soil-slag system.TN removal rates were affected by total phosphorus load in case of higher TN load.TN removal rates in SSF Phragmites australis wetlands were greater than that in SSF Calamagrostis angustifolia wetlands at the same experimental cycle.Effect of wetland substrates on TN removal rates varied with the pollutants loading in SSF constructed wetland system,plant species and plant-growing period. | LIU Shuyuan YAN Baixing WANG Lixia | 2010 | 湿地科学2010，8，2： | 3 |
| 11 | Effects of surface roughening on antibacterial and osteogenic properties of Ti-Cu alloys with different Cu contents显示文摘In order to reduce implant-related infections and improve early osseointegration,we performed HF+anodic oxidation on the surface of the new antibacterial Ti-Cu alloy to make the titanium-based implants have a micro/submicron structure.On this basis,a series of surface-modified Ti-x Cu alloys with different Cu contents(3,5 and 7 wt%)were fabricated and a comprehensive study was conducted on MC3 T3-E1 cell adhesion,proliferation,apoptosis and its antibacterial activity against Staphylococcus aureus.Results showed that the Ti-x Cu alloys by HF etching+anodized possessed multifunctional characteristics of antibiofilm and antibacterial abilities,excellent biocompatibility and osteogenesis promoting abilities.Increment of Cu content significantly contributed to the antibacterial and osteogenic properties of HF etching+anodized Ti-Cu alloys.Cell proliferation rates of HF etching+anodized Ti-7 Cu alloys were lower than those of Ti-3 Cu and Ti-5 Cu alloys,while the early cell apoptosis rates were higher than Ti-3 Cu and Ti-5 Cu groups.All the above results finally presented that the HF etching+anodized Ti-5 Cu alloy exhibited extremely strong antibacterial properties,good biological compatibility and osteogenic ability,as well as the most excellent ductility and corrosion resistance,providing a great potential application for the future dental implantation. | Wei Zhang Shuyuan Zhang Hui Liu Ling Ren Qiang Wang Yang Zhang | 2021 | Journal of Materials Science & Technology2021，，29： | 3 |
| 12 | Study on Property of Salicylaldehyde Schiff Base Metal Complexes for Catalytic Oxidation of Model Sulfides显示文摘Seven kinds of Schiff base metal complexes(C1-C7)were synthesized by the reaction of substituted salicylaldehyde Schiff base with cobalt nitrate,nickel nitrate,and copper nitrate,respectively.The oxygen carrying performance,and the catalytic property of complexes for the oxidation of model sulfides 1-hexanethiol,dibutyl sulfide,and 2-methylthiophene along with their influencing factors were explored,while the oxidized products of the model sulfides were also analyzed and characterized.The results show that the catalytic oxidation property of the complexes is determined by their oxygen carrying performance and solubility in n-octane.The oxygen carrying performance of the complexes is mainly affected by the central ion species,the electronic effects,and the spatial effects of the substituents as well as the degree of conjugation.More specifically,the oxygen carrying performance can be improved by enhancing the oxygenation capacity of the central metal ions,increasing the electron donating ability of the ligand substituent,and diminishing the steric hindrance as well as extending the conjugated chain.Complexes C7 were found to be with high oxygen carrying capacity and high solubility in n-octane,which shows the best catalytic oxidation property,and the oxidation conversion rates for 1-hexylthiol,dibutyl sulfide,and 2-methylthiophene are 74.2%,65.1%,and 22.7%,respectively.Upon using the oxidation catalyst of Schiff base metal complexes,three sulfides can be oxidized by oxygen to form sulfones and sulfoxides.1-Hexanethiol and dibutyl sulfide will continue to be oxidized to form sulfates and sulfites. | Jia Chaoyang Liang Shuyuan Liu Lei Shao Xue Zhang Longli Wang Fangzhu Jiang Cuiyu | 2021 | China Petroleum Processing & Petrochemical Technology2021，23，1： | 2 |
| 13 | Removal of nitrogen and COD in horizontal subsurface flow constructed wetlands under different influent C/N ratios显示文摘 | Hui Zhu Baixing Yan Yingying Xu Jiunian Guan Shuyuan Liu | 2013 | Ecological Engineering2013，，： | 2 |
| 14 | Molecular diagnosis and treatment of meningiomas:an expert consensus(2022)显示文摘Meningiomas are the most common primary intracranial neoplasm with diverse pathological types and complicated clinical manifestations.The fifth edition of the WHO Classification of Tumors of the Central Nervous System(WHO CNS5),published in 2021,introduces major changes that advance the role of molecular diagnostics in meningiomas.To follow the revision of WHO CNS5,this expert consensus statement was formed jointly by the Group of Neuro-Oncology,Society of Neurosurgery,Chinese Medical Association together with neuropathologists and evidence-based experts.The consensus provides reference points to integrate key biomarkers into stratification and clinical decision making for meningioma patients. | Jiaojao Deng Lingyang Hua Liuguan Bian Hong Chen Ligang Chen Hongwei Cheng Changwu Dou Dangmurenjiapu Geng Tao Hong Hongming Ji Yugang Jiang Qing Lan Gang Li Zhixiong Liu Songtao Qi Yan Qu Songsheng Shi Xiaochuan Sun Hajun Wang Yongping You Hualin Yu Shuyuan Yue Jianming Zhang Xiaohua Zhang Shuo Wang Ying Mao Ping Zhong Ye Gong Group of Neuro-Oncology Society of Neurosurgery Chinese Medical Association | 2022 | Chinese Medical Journal2022，135，16： | 1 |
| 15 | Survivin, a key component of the Wnt/β?catenin signaling pathway, contributesto traumatic brain injury-induced adult neurogenesis in the mouse dentate gyrus显示文摘 | Lin Zhang Rong Yan Qi Zhang Haining Wang Xiaokui Kang Jia Li Shuyuan Yang Jianning Zhang Zhenlin Liu Xinyu Yang | 2013 | International Journal of Molecular Medicine2013，，4： | 1 |
| 16 | H infinity Control for Sandwiched Maglev Stage with Dynamic Damping显示文摘An H infinity(H∞)controller for a sandwiched maglev positioning stage is proposed.The maglev positioning stage has a special structure:a sandwiched maglev stage,consisting of repulsive linear motors and attractive linear motors,which have better levitation performance.Forces on the sandwiched maglev stage are analyzed and modeled.The positioning controller is designed based on the feedback linearized model with a dynamic damping system.The design of the H infinity controller for stage positioning is derived as a series of linear matrix inequalities(LMIs)which are efficiently solved in Matlab.The proposed controller and its effectiveness is demonstrated compared to PID method. | Ningran Song Shuyuan Ma Zongqing Zhang Shansi Zhang Changmeng Liu | 2019 | Journal of Beijing Institute of Technology2019，28，2： | 1 |
| 17 | Astatine-211 Labeling of a Monoclonal Antibody and Its Fab Fragment: Synthesis,Immunoreactivity and Experimental Therapy显示文摘 | Liu Ning Jin Jiannan Zhang Shuyuan | 1995 | J Labeled Compd Radiopharm1995，36，： | 1 |
| 18 | 211 At Labeling of a Monoclonal Antibody and Its Fab Fragment: Cytotoxicity on Human Gastric Cancer Cells and Biodistribution in Nude Mice With Tumor Xenografts显示文摘 | Liu Ning Jin Jiannan Zhang Shuyuan | 2001 | J Radioananl Nucl Chem2001，247，1： | 1 |
| 19 | The layer effect in nutrient removal by two indigenous plant species in horizontal flow constructed wetlands显示文摘 | Shuyuan Liu Baixing Yan Lixia Wang | 2011 | Ecological Engineering2011，，12： | 1 |
| 20 | Synthesis of hydroxyapatite in microemulsion and the study of adsorption on cadmium in wastewater显示文摘 | Zheng Xianpeng Liu Shuyuan Liu Qing | 2009 | Bioinformatics and Biomedical Engineering2009，3，： | 1 |
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