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| 1 | Masked Sentence Model Based on BERT for Move Recognition in Medical Scientific Abstracts显示文摘Purpose:Mo ve recognition in scientific abstracts is an NLP task of classifying sentences of the abstracts into different types of language units.To improve the performance of move recognition in scientific abstracts,a novel model of move recognition is proposed that outperforms the BERT-based method.Design/methodology/approach:Prevalent models based on BERT for sentence classification often classify sentences without considering the context of the sentences.In this paper,inspired by the BERT masked language model(MLM),we propose a novel model called the masked sentence model that integrates the content and contextual information of the sentences in move recognition.Experiments are conducted on the benchmark dataset PubMed 20K RCT in three steps.Then,we compare our model with HSLN-RNN,BERT-based and SciBERT using the same dataset.Findings:Compared with the BERT-based and SciBERT models,the F1 score of our model outperforms them by 4.96%and 4.34%,respectively,which shows the feasibility and effectiveness of the novel model and the result of our model comes closest to the state-of-theart results of HSLN-RNN at present.Research limitations:The sequential features of move labels are not considered,which might be one of the reasons why HSLN-RNN has better performance.Our model is restricted to dealing with biomedical English literature because we use a dataset from PubMed,which is a typical biomedical database,to fine-tune our model.Practical implications:The proposed model is better and simpler in identifying move structures in scientific abstracts and is worthy of text classification experiments for capturing contextual features of sentences.Originality/value:T he study proposes a masked sentence model based on BERT that considers the contextual features of the sentences in abstracts in a new way.The performance of this classification model is significantly improved by rebuilding the input layer without changing the structure of neural networks. | Gaihong Yu Zhixiong Zhang Huan Liu Liangping Ding | 2019 | Journal of Data and Information Science2019，4，4： | 14 |
| 2 | Expert consensus on the glycemic management of critically ill patients显示文摘Introduction The incidence of hyperglycemia is 40-60%in critically ill patients and is up to 60-80%in those who have undergone car-diac surgery.[1]The results of an epidemiological study in the United States showed that 28.6%of diabetic patients and 9.3%of non-diabetic patients had elevated mean daily glucose on the day of ICU admission.[2]In critically ill patients,elevated blood glucose is primarily the result of stress,and stress-induced hy-perglycemia is an independent risk factor associated with prog-nosis,regardless of a previous diagnosis of diabetes.Nutritional therapy has become an integral treatment option for patients in the ICU,[3,4]though nearly 30%of patients with enteral nu-trition and 44-50%with parenteral nutrition(PN)experience elevated glucose.[5,6]Intensive insulin therapy(IIT)is an impor-tant treatment for controlling hyperglycemia in critically ill pa-tients,but it also carries a corresponding risk of hypoglycemia. | Zhixiong Wu Jiao Liu Dong Zhang Kai Kang Xiangrong Zuo Qianghong Xu Aijun Pan Wei Fang Fen Liu You Shang Haiyan Yin Juntao Hu Jinglun Liu Jiangquan Fu Wei Zhang Yuan Zong Min Shao Feng Zhao Mei Meng Yanfei Mao Yingchuan Li Dechang Chen | 2022 | Journal of Intensive Medicine2022，2，3： | 9 |
| 3 | Design and experiment of variable rate orchard sprayer based on laser scanning sensor显示文摘During different growth periods,canopy size and density in orchards are variable,which need application conditions(flow rate and air flow)to be adjusted to match the canopy’s characteristics.In order to improve orchard sprayer’s automatic operating performance,an automatic variable-rate orchard sprayer(VARS)fixed with 40 electromagnetic valves and 8 brushless fans was developed based on the canopy’s spatial dimensions.Each solenoid valve and brushless motor can be individually adjusted in real-time through pulse width modulation(PWM)signals emitted by a control system to adjust each nozzle’s spout and fan rotation speed.A high-precision laser scanning sensor(light detecting and ranging,LIDAR)was adopted as the detector to measure the canopy volume using the variable rate algorithm principle.Field experiments were conducted in an apple orchard,and conventional air blast sprayer(CABS)and directed air-jet sprayer(DAJS)were tested as a comparison.Results showed that on average,46%less spraying solution was applied compared to conventional applications,while penetration rate was similar to DAJS.Normalized deposition in the canopy with variable application was higher than that of conventional applications,indicating that electronic sprayers are more efficient than conventional sprayers.It was also observed that VARS could significantly reduce off-target loss.The field experiment showed that the newly developed variable-rate sprayer can greatly reduce pesticide use and protect the environment for the orchard fruit production,and also provide a reference for design and performance optimization for plant protection machinery. | Longlong Li Xiongkui He Jianli Song Yajia Liu Aijun Zeng Liu Yang Chaohui Liu Zhixiong Liu | 2018 | International Journal of Agricultural and Biological Engineering2018，11，1： | 8 |
| 4 | Mining rice new germplasm containing S_5~n gene by functional molecular marker and sequencing显示文摘Inter-subspecific hybrids between indica and japonica varieties yield strong biological heterosis, but it is difficult to utilize the hybrids directly in commercial production due to sterility of F1. A special gene S5n may overcome the hybrids sterility, which is caused by the interaction between S5 loci. Recently, S5n had been cloned, and it was revealed containing a large DNA deletion sequence that made the gene nonfunctional, compared to S5i or S5j. We designed a pair of primers flanking the deletion sequence of S5n, and then applied to distinguish the varieties with S5n or non-S5n, convincing result suggested that the primers could be served as functional molecular marker to efficiently identify the new germplasm with S5n. Using the functional marker, we surveyed 197 varieties from China National Micro-core Rice Collection, and found ten of which represented S5n including following varieties: Haobuka, Sanbangqishiluo, Mubanggu, Xiaohonggu, Mowanggu’neiza, Laozaogu, Fanhaopi, Feie’nuo2, Baoxie-7B, Teqingxuanhui. Among them, two varieties Sanbangqishiluo and Laozaogu was previously reported to contain S5n gene. Further sequence analysis on the DNA sequence covering both sides of deletion in S5n of the 10 varieties confirmed that the detected sequences in above varieties was identical with those of varieties containing S5n, such as 02428 and Linglun. These results suggested that the gene in S5 locus of the ten varieties was also nonfunctional and it proved the presence of S5n gene. | YANG YouXin WU JinWen CHEN ZhiXiong WANG Lan LI JinQuan LIU XiangDong LU YongGen | 2009 | Chinese Science Bulletin2009，54，18： | 5 |
| 5 | Multi-dimensional, light-controlled switch of fluorescence resonance energy transfer based on orderly assembly of 0D dye@micro-micelles and 2D ultrathin-layered nanosheets显示文摘荧光回声精力转移(烦恼) 系统在视觉察觉,聪明的材料,和生物成像有宽广应用,所有哪个帮助通过多重尺寸并且在多样的方向的光的传播。此处,我们示威了多维(0D 和 2D ) 由采用 layer-by-layer (LBL ) 在一部多层的 ultrathin 电影(UTF ) 以内烦恼集会技术。(tert 丁基 acrylate-co-ethyl acrylate-co-methacrylic 酸)(PTBEM ) anionic 块共聚物 micelle poly 为二度(8-hydroxyquinolate ) 的加入被选择为一个分子的搬运人锌(Znq 2) 和开戒指的 merocyanine (MC )( 是表示了(Znq 2/MC)@PTBEM) 。或者,静电的汇编与 cationic 被执行分层的双氢氧化物(LDH ) nanosheets (是表示了[(Znq 2/MC)@PTBEM/LDH] n ) 。这[(Znq 2/MC)@PTBEM/LDH] n 系统提供多维的繁殖媒介并且保证 FRET 施主和领受人位于他们的 F 以内 ? 在每个方向的 rster 半径。系统表明能经由轮流出现被交换的 FRET 进程紫外 / 可见(UV/vis ) 照耀与悦耳的 blue-green/red 荧光,象 81.7% 一样高导致 FRET 效率。这被期望这个汇编方法,它在 2D 上使用 0D 微粒分层的材料,能为进一步的开发被扩大到另外的系统多维烦恼。 | Zhixiong Li Ruizheng Liang Simin Xu Wendi Liu Dongpeng Yan Min Wei David G. Evans Xue Duan | 2016 | Nano Research2016，9，12： | 4 |
| 6 | The adaptive transition of glioblastoma stem cells and its implications on treatments显示文摘Glioblastoma is the most malignant tumor occurring in the human central nervous system with overall median survival time<14.6 months.Current treatments such as chemotherapy and radiotherapy cannot reach an optimal remission since tumor resistance to therapy remains a challenge.Glioblastoma stem cells are considered to be responsible for tumor resistance in treating glioblastoma.Previous studies reported two subtypes,proneural and mesenchymal,of glioblastoma stem cells manifesting different sensitivity to radiotherapy or chemotherapy.Mesenchymal glioblastoma stem cells,as well as tumor cells generate from which,showed resistance to radiochemotherapies.Besides,two metabolic patterns,glutamine or glucose dependent,of mesenchymal glioblastoma stem cells also manifested different sensitivity to radiochemotherapies.Glutamine dependent mesenchymal glioblastoma stem cells are more sensitive to radiotherapy than glucose-dependent ones.Therefore,the transition between proneural and mesenchymal subtypes,or between glutamine-dependent and glucose-dependent,might lead to tumor resistance to radiochemotherapies.Moreover,neural stem cells were also hypothesized to participate in glioblastoma stem cells mediated tumor resistance to radiochemotherapies.In this review,we summarized the basic characteristics,adaptive transition and implications of glioblastoma stem cells in glioblastoma therapy. | Zeyu Wang Hao Zhang Shengchao Xu Zhixiong Liu Quan Cheng | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 3 |
| 7 | Profiling of hepatocellular carcinoma neoantigens reveals immune microenvironment and clonal evolution related patterns显示文摘Objective: Neoantigens derived from tumor-specific genomic alterations have demonstrated great potential for immunotherapeutic interventions in cancers. However, the comprehensive profile of hepatocellular carcinoma(HCC) neoantigens and their complex interplay with immune microenvironment and tumor evolution have not been fully addressed.Methods: Here we integrated whole exome sequencing data, transcriptome sequencing data and clinical information of 72 primary HCC patients to characterize the HCC neoantigen profile, and systematically explored its interactions with tumor clonal evolution, driver mutations and immune microenvironments.Results: We observed that higher somatic mutation/neoantigen load was associated with better clinical outcomes and HCC patients could be further divided into two subgroups with distinct prognosis based on their neoantigen expression patterns. HCC subgroup with neoantigen expression probability high(NEP-H) showed more aggressive pathologic features including increased incidence of tumor thrombus(P=0.038), higher recurrence rate(P=0.029),more inclined to lack tumor capsule(P=0.026) and with more microsatellite instability sites(P=0.006). In addition,NEP-H subgroup was also characterized by higher chance to be involved in tumor clonal evolution [odds ratio(OR)=46.7, P<0.001]. Gene set enrichment analysis revealed that upregulation of MYC and its targets could suppress immune responses, leading to elevated neoantigen expression proportion in tumor cells. Furthermore, we discovered an immune escape mechanism that tumors could become more inconspicuous by evolving subclones with less immunogenicity. We observed that smaller clonal mutation clusters with higher immunogenicity in tumor were more likely to involve in clonal evolution. Based on identified neoantigen profiles, we also discovered series of neoantigenic hotspot genes, which could serve as potential actionable targets in future.Conclusions: Our results revealed the landscape of HCC neoantigens and discovered two clinically relevant subgroups with distinct neoantigen expression patterns, suggesting the neoantigen expression should be fully considered in future immunotherapeutic interventions. | Zhenli Li Geng Chen Zhixiong Cai Xiuqing Dong Lei He Liman Qiu Yongyi Zeng Xiaolong Liu Jingfeng Liu | 2021 | Chinese Journal of Cancer Research2021，33，3： | 3 |
| 8 | Seismic behaviors of utility tunnel-soil system: With and without joint connections显示文摘Seismic responses of utility tunnel-soil system were studied via shaking table model tests with considerations of two kinds of double box utility tunnels:with and without joint connections.These two testing utility tunnel models were made of galvanized iron wire and micro-concrete,and the ground was simulated by the dry standard sand through layered tamping treatment.The utility tunnel-soil system was subjected to horizontal vibration in uniaxial direction perpendicular to the longitudinal direction of tunnel model.Via instrumentations of earth pressure gauges,accelerometers and strain gauges,the earth pressure response,acceleration response and bending moment response were measured.The testing results show that the joint connections in the utility tunnel along the longitudinal direction play an important role in determining the characteristic of earth pressure response and bending moment response,whereas the effect of joint connections on acceleration response is less significant.In addition,the partition wall exhibits the consistent acceleration response with the side-wall of double box utility tunnel model under seismic condition.Based on the testing results,it is suggested that the joint connection should be taken reasonably into consideration during design and construction for engineering practice. | Liang Han Hanlong Liu Wengang Zhang Xuanming Ding Zhixiong Chen Li Feng Zhenyu Wang | 2022 | Underground Space2022，7，5： | 3 |
| 9 | Automatic Keyphrase Extraction from Scientific Chinese Medical Abstracts Based on Character-Level Sequence Labeling显示文摘Purpose:Automatic keyphrase extraction(AKE)is an important task for grasping the main points of the text.In this paper,we aim to combine the benefits of sequence labeling formulation and pretrained language model to propose an automatic keyphrase extraction model for Chinese scientific research.Design/methodology/approach:We regard AKE from Chinese text as a character-level sequence labeling task to avoid segmentation errors of Chinese tokenizer and initialize our model with pretrained language model BERT,which was released by Google in 2018.We collect data from Chinese Science Citation Database and construct a large-scale dataset from medical domain,which contains 100,000 abstracts as training set,6,000 abstracts as development set and 3,094 abstracts as test set.We use unsupervised keyphrase extraction methods including term frequency(TF),TF-IDF,TextRank and supervised machine learning methods including Conditional Random Field(CRF),Bidirectional Long Short Term Memory Network(BiLSTM),and BiLSTM-CRF as baselines.Experiments are designed to compare word-level and character-level sequence labeling approaches on supervised machine learning models and BERT-based models.Findings:Compared with character-level BiLSTM-CRF,the best baseline model with F1 score of 50.16%,our character-level sequence labeling model based on BERT obtains F1 score of 59.80%,getting 9.64%absolute improvement.Research limitations:We just consider automatic keyphrase extraction task rather than keyphrase generation task,so only keyphrases that are occurred in the given text can be extracted.In addition,our proposed dataset is not suitable for dealing with nested keyphrases.Practical implications:We make our character-level IOB format dataset of Chinese Automatic Keyphrase Extraction from scientific Chinese medical abstracts(CAKE)publicly available for the benefits of research community,which is available at:https://github.com/possible1402/Dataset-For-Chinese-Medical-Keyphrase-Extraction.Originality/value:By designing comparative experiments,our study demonstrates that character-level formulation is more suitable for Chinese automatic keyphrase extraction task under the general trend of pretrained language models.And our proposed dataset provides a unified method for model evaluation and can promote the development of Chinese automatic keyphrase extraction to some extent. | Liangping Ding Zhixiong Zhang Huan Liu Jie Li GaihongYu | 2021 | Journal of Data and Information Science2021，6，3： | 3 |
| 10 | Molecular evolution of rice S_5~n and functional comparison among different sequences显示文摘The wide compatibility gene, S 5 n , can overcome embryo sac sterility between indica and japonica subspecies of rice. Therefore, it is very important to characterize the features of the S 5 n sequence to reveal the origin and evolution of S 5 n . In this paper, 26 cultivated rice haplotypes and 22 wild rice accessions harboring S 5 n were used to sequence S 5 n . The results showed that 15 genotypes among the 48 materials were fully consistent with control cultivar 02428 (CK). The other 33 accessions had different degrees of variation in the S 5 n sequence. Variations in the coding region mainly occurred in the second exon and eight materials showed a 10-bp deletion at 1710–1719 bp, including wild (O. nivara) and cultivated rice, such as IRW501 and Yuetai B. S 5 n sequences were not biased and evolved neutrally. The 48 materials could be divided into 4 categories using a phylogenetic tree of the amino acid sequences. Most of the wild rice clustered together, and the cultivated rice clustered into another group. Eight cultivated rice and O. nivara (wild rice) clustered in another group, which were found to lack 10 consecutive bases in exon 2. Eight rice varieties with high numbers of differences in their S 5 n coding regions were crossed with testers (typically indica and japonica) to produced test cross F 1 populations. The F 1 s were examined for their ability to overcome indica-japonica hybrid sterility. The result showed that the embryo sac fertility of S 5 n -containing hybrids increased significantly compared with control hybrids, but there were no differences among the materials with divergent sequences, indirectly proving that S 5 n is a non-functional gene. | TONG JingFei LI YanHong YANG YouXin SHAHID Muhammad Qasim CHEN ZhiXiong WANG Lan LI JinQuan LIU XiangDong LU YongGen | 2011 | Chinese Science Bulletin2011，56，19： | 2 |
| 11 | Molecular diagnosis and treatment of meningiomas:an expert consensus(2022)显示文摘Meningiomas are the most common primary intracranial neoplasm with diverse pathological types and complicated clinical manifestations.The fifth edition of the WHO Classification of Tumors of the Central Nervous System(WHO CNS5),published in 2021,introduces major changes that advance the role of molecular diagnostics in meningiomas.To follow the revision of WHO CNS5,this expert consensus statement was formed jointly by the Group of Neuro-Oncology,Society of Neurosurgery,Chinese Medical Association together with neuropathologists and evidence-based experts.The consensus provides reference points to integrate key biomarkers into stratification and clinical decision making for meningioma patients. | Jiaojao Deng Lingyang Hua Liuguan Bian Hong Chen Ligang Chen Hongwei Cheng Changwu Dou Dangmurenjiapu Geng Tao Hong Hongming Ji Yugang Jiang Qing Lan Gang Li Zhixiong Liu Songtao Qi Yan Qu Songsheng Shi Xiaochuan Sun Hajun Wang Yongping You Hualin Yu Shuyuan Yue Jianming Zhang Xiaohua Zhang Shuo Wang Ying Mao Ping Zhong Ye Gong Group of Neuro-Oncology Society of Neurosurgery Chinese Medical Association | 2022 | Chinese Medical Journal2022，135，16： | 1 |
| 12 | Development of polyclonal antibody based enzyme-linked immunosorbent assay for the analysis of the agricultural insecticide imidacloprid:food quality and safety显示文摘 | Li Zhixiong Liu Yingli Sun Yuanming | | 0，，： | 1 |
| 13 | Development of polyclonal antibody based enzymelinked immunosorbent assay for the analysis of the agricultural insec- ticide imidacloprid: food quality and safety 显示文摘 | Zhixiong Li MSc yingli Liu DSe Yuanming Sun phD | 2007 | Asia Pac J Clin Nutr2007，16，1： | 1 |
| 14 | Wheel Slip Measurement in 4WD Tractor Based on LABVIEW显示文摘 | Zhixiong Lu Yang Lu Jiangxue Chang Xuefeng Bai Yiguan Liu | 2013 | International Journal of Automation and Control Engineering2013，，3： | 1 |
| 15 | Shorter alkyl chain in thieno[3,4-c]pyrrole-4,6-dione(TPD)-based large bandgap polymer donors – Yield efficient non-fullerene polymer solar cells显示文摘Typically,conjugated polymers are composed of conjugated backbones and alkyl side chains.In this contribution,a cost-effective strategy of tailoring the length of alkyl side chain is utilized to design highperforming thieno[3,4-c]pyrrole-4,6-dione(TPD)-based large bandgap polymer donors PBDT-BiTPD(Cχ)(χ=48,52,56),in which x represents the alkyl side chain length in term of the total carbon number.A combination of light absorption,device,and morphology examinations make clear that the shorter alkyl side chains yield(i) higher crystallinity and more predominant face-on crystallite orientation in their neat and BHJ blend films,(ii) higher charge mobilities(6.7×10^(-4) cm~2 V^(-1) s^(-1) for C48 vs.3.2×10^(-4) cm~2 V^(-1) s^(-1) for C56),and negligible charge recombination,consequently,(iii) significantly improved fill-factor(FF) and short current(J_(SC)),while almost the same open circuit voltage(V_(OC)) of ca.0.82 V in their corresponding BHJ devices.In parallel,as alkyl side chain lengths decrease from C56 to C48,power conversion efficiencies(PCEs) increased from 7.8% for C56 to 11.1% for C52,and further to14.1% for C48 in their BHJ solar cells made with a narrow bandgap non-fullerene acceptor Y6.This systematic study declares that shortening the side chain,if providing appropriate solubility in device solution processing solvents,is of essential significance for developing high-performing polymer donors and further improving device photovoltaic performance. | Jiaji Zhao Xuelong Huang Qingduan Li Shengjian Liu Ziqiang Fan Di Zhang Shanshan Ma Zhixiong Cao Xuechen Jiao Yue-Peng Cai Fei Huang | 2021 | Journal of Energy Chemistry2021，30，2： | 1 |
| 16 | Exon skipping of AGAMOUS homolog PrseAG in developing double flowers of Prunus lannesiana (Rosaceae)显示文摘 | Zhixiong Liu Dandan Zhang Di Liu Fenglan Li Hai Lu | | Plant Cell Reports0，，： | 1 |
| 17 | Advances in Research on the Effects of Calcium on Vegetable Quality and Human Health显示文摘Calcium is an important element that affects vegetable quality and human health.In this paper,the basic nutrition and functions of calcium,the effects of calcium deficiency on vegetable growth and human health,the effect of calcium supply on vegetable quality and the outlook for calcium-rich vegetables were overviewed,aiming at providing guidance for the cultivation of high-quality calcium-rich vegetables. | Weiling YUAN Zhixiong LIU Leifu CHEN Shuang CHEN Zhengming QIU | 2019 | Agricultural Biotechnology2019，8，3： | 1 |
| 18 | A microcalorimetric method for studying the biological effects of La^3+ on escherichia coli显示文摘 | Zhao Ruming Liu Yi Xie Zhixiong | 2000 | J Biochem Biophys Methods2000，40，： | 1 |
| 19 | Development of polyclonal antibody based enzyme linked immunosorbent assay for the analysis of the agricultural insecticide imidacloprid: food quality and safety显示文摘 | Zhixiong Li Yingli Liu Yuanming Sun | 2007 | Asia Pac J Clin Ntur2007，，： | 1 |
| 20 | Operation resource alloca- tion optimization of discrete event system based on sim- ulation显示文摘 | Liu Zhixiong Wang Shaomei | 2005 | Joumal of Wuhan University of Technology2005，29，2： | 1 |
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