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| 1 | MiR-29b suppresses the proliferation and migration of osteosarcoma cells by targeting CDK6显示文摘Osteosarcoma 是骨头的最普通的主要肉瘤,并且它是在青少年和年轻成年人之中的癌症死亡的一个领先的原因。然而,糟糕位于 osteosarcoma carcinogenesis 遗体下面的分子的机制理解。最近, cyclin 依赖的 kinase (CDK6 ) 6 作为重要 oncogene 被识别。我们发现了那 CDK6 蛋白质水平,而非 CDK6 mRNA 水平,比的在 osteosarcoma 纸巾是高得多的在正常邻近的纸巾,它显示在 osteosarcoma 涉及 CDK6 规定的 post-transcriptional 机制。MiRNAs 是镇压的小非编码的 RNA 在 post-transcriptional 水平的基因表示并且广泛地被显示了在许多人的癌症起重要作用。在这研究,我们用生物信息学方法作为 CDK6 的一个新奇管理者调查了 miR-29b 的角色。我们证明 CDK6 能是由经由到在 osteosarcoma 房间的 3-UTR 区域的绑定的 miR-29b 的 downregulated。而且,我们在 osteosarcoma 纸巾识别了在 miR-29b 和 CDK6 蛋白质层次之间的反的关联。最后,我们在 osteosarcoma 房间检验了 CDK6 表示的 miR-29b-driven 压抑的功能。结果表明 miR-29b 由在增长和移植进程指向 CDK6 充当 osteosarcoma 的肿瘤 suppressor。一起拿,我们的结果在 osteosarcoma 在 CDK6 的规定为 miR-29b 加亮一个重要角色并且可以为未来 osteosarcoma 治疗打开新大街。 | Kegan Zhu Lei Liu Junliang Zhang Yanbo Wang Hongwei Liang Gentao Fan Zhenhuan Jiang Chen-Yu Zhang Xi Chen Guangxin Zhou | 2016 | Protein & Cell2016，7，6： | 18 |
| 2 | Change analysis of rice area and production in China during the past three decades显示文摘米饭空间时间的分布,它批评为农业,环境并且食物安全研究,被自然条件以及社会经济的开发影响。把数据基于多来源,一个有效模型说出集成可耕地分发,庄稼数据的行政单位统计,农业灌溉数据和庄稼的空间生产分配模型(垃圾)适用性数据,被用来在国家规模与 10-km 象素得到米饭区域和生产的一系列空间分布它向前从1980年代初被使用并且过去常分析空间、时间的变化的模式。结果证明重要变化在 19802010 期间在中国发生在米饭。总的来说,超过 50% 米饭区域减少了,当将近 70% 米饭生产在 19802010 期间在变化区域增加了时。空间地,特别,大多数增加的区域和生产在吉林和 Heilongjiang 在东北中国;特别,大多数减少的区域和生产在区域位于东南中国很快在广东,福建和浙江的都市化。因此,米饭区域的矩心是自从 1980,向东北移动了约 230 km,并且米饭生产大约 320 km,它移动的工具米饭生产向东北比米饭区域快因为东北中国的重要米饭收益增加。结果也证明那个米饭区域变化在米饭生产变化上有明确的影响。米饭生产的大约 54.5% 增加由于播种区域的扩大,当在在米饭的 83.2% 减少附近生产由于米饭区域的收缩时。这暗示米饭生产增加可能由于区域扩大和另外的非区域因素,但是减少米饭生产能大部分被归因于米饭区域减少。 | LIU Zhenhuan LI Zhengguo TANG Pengqin LI Zhipeng WU Wenbin YANG Peng YOU Liangzhi TANG Huajun | 2013 | Journal of Geographical Sciences2013，23，6： | 15 |
| 3 | Spatio-temporal dynamics of maize cropping system in Northeast China between 1980 and 2010 by using spatial production allocation model显示文摘在地区性的规模上理解庄稼模式和他们的变化是为投射 agro 生态系统动力学的一个批评要求。然而,为印射庄稼区域和产量的分发的工具和方法仍然正在缺乏。基于跨熵的理论,一个空间生产分配模型(垃圾) 为介绍在 19802010 期间在东北中国收割系统的玉米的空间与时间的动力学被开发了。模仿的结果显示了那(1 ) 播种区域向北扩展了到 48 獥的玉米吗? | TAN Jieyang YANG Peng LIU Zhenhuan WU Wenbin ZHANG Li LI Zhipeng YOU Liangzhi TANG Huajun LI Zhengguo | 2014 | Journal of Geographical Sciences2014，24，3： | 12 |
| 4 | Reuse of Fenton sludge as an iron source for NiFe_2O_4 synthesis and its application in the Fenton-based process显示文摘The potentially hazardous iron-containing sludge from the Fenton process requires proper treatment and disposal, which often results in high treatment cost. In this study, a novel method for the reuse of Fenton sludge as an iron source for the synthesis of nickel ferrite particles(NiFe_2O_4) is proposed. Through a co-precipitation method followed by sintering at 800°C, magnetic NiFe_2O_4 particles were successfully synthesized, which was confirmed by powder X-ray diffraction(XRD), scanning electronic microscopy(SEM), energy dispersive spectroscopy(EDS), Fourier transform infrared spectroscopy(FT-IR) and Raman spectroscopy. The synthesized NiFe_2O_4 could be used as an efficient catalyst in the heterogeneous Fenton process. In phenol degradation with H_2O_2 or NiFe_2O_4 alone, the phenol removal efficiencies within the reaction time of 330 min were as low as 5.9% ± 0.1% and 13.5% ±0.4%, respectively. However, in the presence of both NiFe_2O_4 and H_2O_2, phenol removal efficiency as high as 95% ± 3.4% could be achieved, indicating the excellent catalytic performance of NiFe_2O_4 in the heterogeneous Fenton process. Notably, a rapid electron exchange between_Ni II and_Fe III ions in the NiFe_2O_4 structure could be beneficial for the Fenton reaction. In addition, the magnetic catalyst was relatively stable, highly active and recoverable, and has potential applications in the Fenton process for organic pollutant removal. | Hui Zhang Jianguo Liu Changjin Ou Faheem Jinyou Shen Hongxia Yu Zhenhuan Jiao Weiqing Han Xiuyun Sun Jiansheng Li Lianjun Wang | 2017 | Journal of Environmental Sciences2017，29，3： | 10 |
| 5 | Microstructural evolution and growth kinetics of thermally grown oxides in plasma sprayed thermal barrier coatings显示文摘The formation of thermally grown oxide(TGO) during high temperature is a key factor to the degradation of thermal barrier coatings(TBCs)applied on hot section components. In the present study both the Co Ni Cr Al Y bond coat and Zr O_2-8 wt.% Y_2O_3(8YSZ) ceramic coat of TBCs were prepared by air plasma spraying(APS). The composition and microstructure of TGO in TBCs were investigated using scanning electron microscopy(SEM), energy dispersive spectroscopy(EDS) and X-ray diffraction(XRD) analysis. The growth rate of TGO for TBC and pure BC were gained after isothermal oxidation at 1100 °C for various times. The results showed that as-sprayed bond coat consisted of β and γ/γ'phases,β phase reducesd as the oxidation time increased. The TGO comprised α-Al_2O_3 formed in the first 2 h. Co O, Ni O, Cr_2O_3 and spinel oxides appeared after 20 h of oxidation. Contents of Co O and Ni O reduced while that of Cr_2O_3 and spinel oxides increased in the later oxidation stage.The TGO eventually consisted of a sub-Al2O3 layer with columnar microstructure and the upper porous CS clusters. The TGO growth kinetics for two kinds of samples followed parabolic laws, with oxidation rate constant of 0.344 μm/h^(0.5) for TBCs and 0.354 μm/h0.5for pure BCs. | Xiaoju Liu Teng Wang Caicai Li Zhenhuan Zheng Qiang Li | 2016 | Progress in Natural Science:Materials International2016，26，1： | 4 |
| 6 | Study of Karstedt's Catalyst for Hydrosilylation of a Wide Variety of Functionalized Alkenes with Triethoxysilane and Tri meth oxysi lane显示文摘hydrosilylation 是为有机硅混合物的合成的最重要的方法之一。Karstedts 催化剂[磅 n (H2 C=CHSiMe 2 OSiMe 2 CH=CH 2) m ] 是广泛地在 hydrosilylation 被使用的一种铂催化剂。在这份报纸,我们与 trimethoxysilane 和 triethoxysilane 为石蜡和特别 aminated 链烯的加氢学习了 Karstedts 催化剂的催化活动,并且以收益和选择表明了优秀表演。 | Zhenhuan Pan Minglun Liu Chaoyue Zheng Deqing Gao Wei Huang | 2017 | Chinese Journal of Chemistry2017，35，8： | 3 |
| 7 | Effects of Uncertainties in the Position and Orientation of Both the Transmitter and Receivers on Marine Controlled-Source Electromagnetic Data显示文摘Simulation and interpretation of marine controlled-source electromagnetic(CSEM) data often approximate the transmitter source as an ideal horizontal electric dipole(HED) and assume that the receivers are located on a flat seabed.Actually,however,the transmitter dipole source will be rotated,tilted and deviated from the survey profile due to ocean currents.And free-fall receivers may be also rotated to some arbitrary horizontal orientation and located on sloping seafloor.In this paper,we investigate the effects of uncertainties in the transmitter tilt,transmitter rotation and transmitter deviation from the survey profile as well as in the receiver's location and orientation on marine CSEM data.The model study shows that the uncertainties of all position and orientation parameters of both the transmitter and receivers can propagate into observed data uncertainties,but to a different extent.In interpreting marine data,field data uncertainties caused by the position and orientation uncertainties of both the transmitter and receivers need to be taken into account. | XU Zhenhuan LIU Ying LI Yuguo | 2016 | Journal of Ocean University of China2016，15，1： | 3 |
| 8 | Interpretation of the west segment of the coastal fault zone in the coastal region of South China based on the gravity data显示文摘By systemic processing, comprehensive analysis, and interpretation of gravity data, we confirmed the existence of the west segment of the coastal fault zone(west of Yangjiang to Beibu Bay) in the coastal region of South China. This showed an apparent high gravity gradient in the NEE direction, and worse linearity and less compactness than that in the Pearl River month. This also revealed a relatively large curvature and a complicated gravity structure. In the finding images processed by the gravity data system, each fault was well reflected and primarily characterized by isolines or thick black stripes with a cutting depth greater than 30 km. Though mutually cut by NW-trending and NE-trending faults, the apparent NEE stripe-shaped structure of the west segment of the coastal fault zone remained unchanged,with good continuity and an activity strength higher than that of NW and NE-trending faults. Moreover,we determined that the west segment of the coastal fault zone is the major seismogenic structure responsible for strong earthquakes in the coastal region in the border area of Guangdong, Guangxi, and Hainan. | Lisi Bi Zhenhuan Ren Xiuwei Ye Tianyou Liu Jihua Qiao | 2018 | Geodesy and Geodynamics2018，9，2： | 2 |
| 9 | Development of a widely targeted volatilomics method for profiling volatilomes in plants显示文摘Volatile organic compounds play essential roles in plant environment interactions as well as determining the fragrance of plants.Although gas chromatography-mass spectrometry-based untargeted metabolo-mics is commonly used to assess plant volatiles,it suffers from high spectral convolution,low detection sensitivity,a limited number of annotated metabolites,and relatively poor reproducibility.Here,we report a widely targeted volatilomics(WTV)method that involves using a“targeted spectra extraction”algorithm to address spectral convolution,constructing a high-coverage MS2 spectral tag library to expand volatile annotation,adapting a multiple reaction monitoring mode to improve sensitivity,and using regression models to adjust for signal drift.The newly developed method was used to profile the volatilome of rice grains.Compared with the untargeted method,the newly developed WTV method shows higher sensitivity(for example,the signal-to-noise ratio of guaicol increased from 4.1 to 18.8),high annotation coverage(the number of annotated volatiles increased from 43 to 132),and better reproducibility(the number of volatiles in quality control samples with relative standard deviation value below 30.0%increased from 14 to 92 after normalization).Using the WTV method,we studied the metabolic responses of tomato to environmental stimuli and profiled the volatilomes of different rice accessions.The results identified benzothiazole as a potential airborne signal priming tomato plants for enhanced defense and 2-nonanone and 2-heptanone as novel aromatic compounds contributing to rice fragrance.These case studies suggest that the widely targeted volatilomics method is more efficient than those currently used and may considerably promote plant volatilomics studies. | Honglun Yuan Guangping Cao Xiaodong Hou Menglan Huang Pengmeng Du Tingting Tan Youjin Zhang Haihong Zhou Xianqing Liu Ling Liu Yiding Jiangfang Yufei Li Zhenhuan Liu Chuanying Fang Liqing Zhao Alisdair R.Fernie Jie Luo | 2022 | Molecular Plant2022，15，1： | 2 |
| 10 | Geotechnical engineering blasting:a new modal aliasing cancellation methodology of vibration signal de-noising显示文摘In the present study of peak particle velocity(PPV)and frequency,an improved algorithm(principal empirical mode decomposition,PEMD)based on principal component analysis(PCA)and empirical mode decomposition(EMD)is proposed,with the goal of addressing poor filtering de-noising effects caused by the occurrences of modal aliasing phenomena in EMD blasting vibration signal decomposition processes.Test results showed that frequency of intrinsic mode function(IMF)components decomposed by PEMD gradually decreases and that the main frequency is unique,which eliminates the phenomenon of modal aliasing.In the simulation experiment,the signal-to-noise(SNR)and root mean square errors(RMSE)ratio of the signal de-noised by PEMD are the largest when compared to EMD and ensemble empirical mode decomposition(EEMD).The main frequency of the de-noising signal through PEMD is 75 Hz,which is closest to the frequency of the noiseless simulation signal.In geotechnical engineering blasting experiments,compared to EMD and EEMD,the signal de-noised by PEMD has the lowest level of distortion,and the frequency band is distributed in a range of 0-64 Hz,which is closest to the frequency band of the blasting vibration signal.In addition,the proportion of noise energy was the lowest,at 1.8%. | Yi Wenhua Yan Lei Wang Zhenhuan Yang Jianhua Tao Tiejun Liu Liansheng | 2022 | Earthquake Engineering and Engineering Vibration2022，21，2： | 2 |
| 11 | Sulfated modification can enhance the adjuvanticity of lentinan and improve the immune effect of ND vaccine显示文摘 | Zhenhuan Guo Yuanliang Hu Deyun Wang Xia Ma Xiaona Zhao Bingkai Zhao Junmin Wang Ping Liu | 2008 | Vaccine2008，，5： | 1 |
| 12 | Pt nanoparticles supported on submicrometer-sized TiO 2 spheres for effective methanol and ethanol oxidation显示文摘 | Hao Hua Chenguo Hu Zhenhuan Zhao Hong Liu Xiao Xie Yi Xi | 2013 | Electrochimica Acta2013，，： | 1 |
| 13 | Comparative study of big data of global adakites and mineralization-related granite in the Geza arc metallogenic belt, northwest Yunnan, Southwest China显示文摘The Geza arc is an important part of the Sanjiang tectono-magmatic belt and is a newly discovered copper polymetallic ore concentration area in northwest Yunnan province,Southwest China.The area comprises numerous metal ore deposits,including one super-largedeposit,three large deposits,etc.The formation of these deposits was closely related to intermediate–acidic magmatic intrusions.Based on previous studies,the“big data”analysis technique was used for a comparative study of large geochemical datasets of granite related to ore-formation in the Geza porphyry copper deposit and global adakites.As a result,1313 element combinations and 127,765 overlap ratios were obtained.The results show that the Geza porphyry has similar geochemical characteristics to global adakites(the ratios of REE and Ga to major elements are in the range of global adakites).However,theCu,Mo,and Zn contents of the porphyry are significantly higher than those of global adakites,and the porphyry may,therefore,represent an end-member of the global range of adakite composition.In addition,the geochemistry of adakites associated with the porphyry copper deposits overlaps in part with that of global adakites,although most of the data lie outside of the range of global adakites(i.e.lowMn/Cu,Sr/Cu,Na/Cu,and Zr/Cu values,and high Th/Cu,Ba/Cu,Na/Mo,Rb/Mo,Th/Mo,Ta/Mo,Ba/Mo,Mn/Zn,and Ba/Znvalues).The samples with characteristics that deviate significantly from the geochemistry of global adakites show more advanced mineralization and alteration,and a stronger relationship with Cu and Momineralization.The results of geochemical data mining can be used as a prospecting indicator,and provide a new scientific basis for geological prospecting of the deep levels and per-iphery of the Geza Cu polymetallic ore belt. | Liu Xuelong Li Wenchang Zhang Qi Zhang Na Zhang Changzhen Luo Ying Wang Shuaishuai Yang Fucheng Chen Jianhang Li Zhenhuan | 2018 | Big Earth Data2018，2，3： | 1 |
| 14 | Recombinant hirudin treatment modulates aquaporin-4 and aquaporin-9 expression after intracerebral hemorrhage in vivo显示文摘 | Zhe Sun Zhenhuan Zhao Shiguang Zhao Yi Sheng Zonghang Zhao Cheng Gao Jingwen Li Xiangzhen Liu | 2009 | Molecular Biology Reports2009，，5： | 1 |
| 15 | 显示文摘 | Liu Zhenhuan Wang Yanglin Li Zhengguo | 2013 | Environ- mental Earth Sciences2013，68，8： | 1 |
| 16 | Phase inversion of TiO:e nanoparticle stabilized emulsions of alkenyl sue- cinic anhydride显示文摘 | Zhao Zhenhuan Liu Wenxia Liu Zongyin | 2013 | Chemical Engineering Science2013，87，24： | 1 |
| 17 | Cytotoxic triterpenoid saponins from the roots of Platycodon grandiflorum 显示文摘 | Zhang Lin Liu Zhenhuan Tian Jingkui | 2007 | Molecules2007，12，4： | 1 |
| 18 | Tuning electronic configuration of WP_(2) nanosheet arrays via nickel doping for high-efficiency hydrogen evolution reaction显示文摘Modulate the electronic structure and surface energy by nanostructure and heteroatom doping is an efficient strategy to improve electrocatalytic activity of hydrogen evolution reaction(HER).Herein,nickel incorporated WP_(2) self-supporting nanosheet arrays cathode was synthesized on carbon cloth(Ni-WP_(2) NS/CC)by in-situ phosphating reduction of the Ni-doped WO3.It shows that heteroatom doping and the three-dimensional(3D)nanosheet arrays morphology both facilitate to reduce the interfacial transfer resistance and increase electrochemical-active surface areas,which effectively improve electrocatalytic hydrogen evolution reaction(HER)activity.The optimized catalyst,1%Ni-WP_(2) NS/CC,exhibits an outstanding electrocatalytic performance with an overpotential of 110 m V at 10 m A cm^(-2) and a Tafel slope of 65 m V dec^(-1) in the acid solution.DFT calculations further demonstrate the nickel doping can adjust the intrinsic structure of electronics,lower the Gibbs free energy of adsorption of hydrogen(DGH*),and effectively improve the HER performance. | Wei Liu Peng Geng Shiqing Li Wenhui Liu Dayong Fan Huidan Lu Zhenhuan Lu Yongping Liu | 2021 | Journal of Energy Chemistry2021，30，4： | 1 |
| 19 | Nanoscale all-optical logic devices显示文摘Commercial computers based on electronic logic devices have brought great changes to the world. However, traditional electronic devices are suffering from numerous technical challenges in their attempts to continue to satisfy Moore's law. Alloptical logic devices, as promising successors to their electronic counterparts, have become a major focus of optics research. In this paper, we provide a review of current all-optical logic devices. The logic gates in these devices, which are described in the first part of the review, are divided into five categories based on the different principles used in their realization. Complex optical devices with various functions and reconfigurable devices are summarized in the next section. In the final part of this paper, we discuss some of the previous works on all-optical integrated chips with specific functions. This review will provide a complete technological roadmap for all-optical devices and aims to be helpful in possible future developments in this growing field. | Ye Chen YinKe Cheng RongBin Zhu FeiFan Wang HaoTian Cheng ZhenHuan Liu ChongXiao Fan YuXuan Xue ZhongCheng Yu JianKun Zhu XiaoYong Hu QiHuang Gong | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，4： | 1 |
| 20 | Recombinant hirudin treatment modulates aquaporin-4 and aquaporin-9 expression after intracerebral hemorrhage in vivo显示文摘 | Zhe Sun Zhenhuan Zhao Shiguang Zhao Yi Sheng Zonghang Zhao Cheng Gao Jingwen Li Xiangzhen Liu | 2009 | Molecular Biology Reports2009，，5： | 1 |
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