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| 1 | ZIKA virus isolated from mosquitoes:a field and laboratory investigation in China,2016显示文摘A field investigation of arboviruses was conducted in Dejiang, Guizhou Province in the summer of 2016. A total of 8,795 mosquitoes, belonging to four species of three genera, and 1,300 midges were collected. The mosquito samples were identified on site according to their morphology, and the pooled samples were ground and centrifuged in the laboratory. The supernatant was incubated with mosquito tissue culture cells(C6/36) and mammalian cells(BHK-21) for virus isolation. The results indicated that 40%(3,540/8,795) were Anopheles sinensis, 30%(2,700/8,795) were Culex pipiens quinquefasciatus, and 29%(2,530/8,795)were Armigeres subbalbeatus. Furthermore, a total of eight virus isolates were obtained, and genome sequencing revealed two Zika viruses(ZIKVs) isolated from Culex pipiens quinquefasciatus and Armigeres subbalbeatus, respectively; three Japanese encephalitis viruses(JEVs) isolated from Culex pipiens quinquefasciatus; two Banna viruses(BAVs) isolated from Culex pipiens quinquefasciatus and Anopheles sinensis, respectively; and one densovirus(DNV) isolated from Culex pipiens quinquefasciatus.The ZIKVs isolated from the Culex pipiens quinquefasciatus and Armigeres subbalbeatus mosquitoes represent the first ZIKV isolates in China's Mainland. This discovery presents new challenges for the prevention and control of ZIKV in China, and prompts international cooperation on this global issue. | Shihong Fu Song Song Hong Liu Yuanyuan Li Xiaolong Li Xiaoyan Gao Ziqian Xu Guoping Liu Dingming Wang Zhenzao Tian Jingzhu Zhou Ying He Wenwen Lei Huanyu Wang Bin Wang Xiaoqing Lu Guodong Liang | 2017 | Science China(Life Sciences)2017，60，12： | 25 |
| 2 | Two types of summertime heating over the Asian large-scale orography and excitation of potential-vorticity forcing I. Over Tibetan Plateau显示文摘Based on numerical simulation, this study explored the characteristics and interactions of surface sensible heating and atmospheric latent heating over the main part of the Tibetan Plateau, i.e., terrain at elevations >2 km in summer. The impacts of these two types of heating on local vertical motion and monsoonal meridional circulation were compared. Theoretical analysis and numerical experimentation demonstrated that by changing the configuration of the upper-tropospheric air temperature and circulation, the two types of heating could generate both minimum absolute vorticity and abnormal potential vorticity forcing near the tropopause, enhance the meridional circulation of the Asian summer monsoon, and produce an eastward-propagating Rossby wave train within the mid-latitude westerly flow. Consequently, the manifestations of these features were shown to influence the circulation of the Northern Hemisphere. | WU GuoXiong ZHUO HaiFeng WANG ZiQian LIU YiMin | 2016 | Science China Earth Sciences2016，59，10： | 13 |
| 3 | 7YSZ coating prepared by PS-PVD based on heterogeneous nucleation显示文摘Plasma spray-physical vapor deposition(PS-PVD) as a novel coating process based on low-pressure plasma spray(LPPS) has been significantly used for thermal barrier coatings(TBCs).A coating can be deposited from liquid splats, nano-sized clusters, and the vapor phase forming different structured coatings, which shows obvious advantages in contrast to conventional technologies like atmospheric plasma spray(APS) and electron beam-physical vapor deposition(EBPVD). In addition, it can be used to produce thin, dense, and porous ceramic coatings for special applications because of its special characteristics, such as high power, very low pressure, etc. These provide new opportunities to obtain different advanced microstructures, thus to meet the growing requirements of modern functional coatings. In this work, focusing on exploiting the potential of gas-phase deposition from PS-PVD, a series of 7 YSZ coating experiments with various process conditions was performed in order to better understand the deposition process in PS-PVD, where coatings were deposited on different substrates including graphite and zirconia. Meanwhile, various substrate temperatures were investigated for the same substrate. As a result, a deposition mechanism of heterogeneous nucleation has been presented showing that surface energy is an important influencing factor for coating structures. Besides, undercooling of the interface between substrate and vapor phase plays an important role in coating structures. | Ziqian DENG Xiaofeng ZHANG Kesong ZHOU Min LIU Chunming DENG Jie MAO Zhikun CHEN | 2018 | Chinese Journal of Aeronautics2018，31，4： | 10 |
| 4 | Two types of summertime heating over Asian large-scale orography and excitation of potential-vorticity forcing II.Sensible heating over Tibetan-Iranian Plateau显示文摘Based on analysis and simulation,the interaction of thermal forcing between the Tibetan Plateau(TP) and Iranian Plateau(IP) in summer is investigated.Associated influences on water vapor transport in the Asian subtropical monsoon region and the formation of a cold center in the lower stratosphere over Eurasia are also investigated.Results show that surface sensible heating(SH) over the two plateaus not only have mutual influences but also feedback to each other.SH over the IP can reduce the SH and increase the LH over the TP,whereas the SH over the TP can increase surface heating over the IP,thereby reaching quasi-equilibrium among the SH and LH over the TP,IP SH and atmosphere vertical motion.Therefore,the so-called Tibetan-Iranian Plateau coupling system(TIPS) is constructed,which influences atmosphere circulation.In the TIPS system,interaction between surface SH and LH over the TP plays a leading role.SH of the IP and TP influences on other regions not only have superimposed effects but also mutually offset.Accounting for contributions to the convergence of water vapor transport in the Asian subtropical monsoon region,TP SH contributes more than twice that of the IP.The combined influence of SH over TP and IP represents the major contribution to the convergence of water vapor transport in that region.In addition,the heating effect of TIPS increases the upper tropospheric temperature maximum and lifts the tropopause,cooling the lower stratosphere.Combined with large-scale thermal forcing of the Eurasian continent,the TIPS produces a strong anticyclonic circulation and the South Asian High that warms the upper troposphere and cools the lower stratosphere,thereby affecting regional and global weather and climate. | LIU YiMin WANG ZiQian ZHUO HaiFeng WU GuoXiong | 2017 | Science China Earth Sciences2017，60，4： | 7 |
| 5 | Coating deposition regularity depended on orientation difference in PS-PVD plasma jet显示文摘The YSZ coatings are prepared by the plasma spray-physical vapor deposition(PS-PVD)technology based on a specific experimental design.The structure,thickness and growth angle of YSZ coatings on the entire circumferential surface of the cylindrical sample are studied.The results indicated that the structure,thickness and deflection growth angle of YSZ coatings are related to the orientation of deposition location.The numerical simulation of the multiphase mixed fluid near the substrate is carried out and the deposition regularity and mechanism of YSZ coatings prepared by PS-PVD is deduced.The growth rate is related to the local characteristics of the plasma flow field,and is directly proportional to the field pressure and inversely proportional to the field velocity.The growth angle of the coating is generally affected by the flow direction of the plasma jet.Especially,the normal component of velocity vector,V_(norm),mainly affects the speed at which the coating grows vertically upwards.The tangential component of velocity vector,V_(tan),determines the degree that the coating growth direction deviates from the vertical direction.When V_(tan)≠0,the coating forms a fine column with a certain deflection angle and finally develops into an oblique columnar structure. | Jie MAO Min LIU Ziqian DENG Kui WEN Changguang DENG Kun YANG Zhikun CHEN | 2020 | Chinese Journal of Aeronautics2020，33，12： | 6 |
| 6 | Mechanism of vertical crack formation in Yb_(2)SiO_(5) coatings deposited via plasma spray-physical vapor deposition显示文摘Plasma spray-physical vapor deposition(i.e.,PS-PVD)is a promising method for obtaining advanced environmental barrier coatings(EBCs).The EBCs must meet some requirements in the application,in which the thermal cycle performance affects the service lifetime.The preparation of artificial vertical cracks in Yb_(2)SiO_(5) coatings is an effective approach for meeting the requirements above because vertical cracks provide a strain tolerance.To clarify the formation mechanism of vertical cracks during the PSPVD,the effects of coating thickness and substrate temperature on the formation of vertical cracks were investigated.In addition,the interactions of spray powder and plasma flame during coating deposition were also characterized by optical spectroscopy.It is indicated that vertical cracks are formed due to a thermal expansion mismatch between Yb_(2)SiO_(5) and mullite coating,transient cooling after deposition and the nucleation of evaporated Yb_(2)SiO_(5) as well. | Xiaofeng Zhang Chao Wang Ruijun Ye Chunming Deng Xinghua Liang Ziqian Deng Shaopeng Niu Jinbing Song Guo Liu Min Liu Kesong Zhou Jian Lu Junli Feng | 2020 | Journal of Materiomics2020，6，1： | 6 |
| 7 | High-temperature oxidation behavior and analysis of impedance spectroscopy of 7YSZ thermal barrier coating prepared by plasma spray-physical vapor deposition显示文摘Quasi-columnar structure 7YSZ(yttria stabilized zirconia) thermal barrier coatings(TBCs) are prepared by plasma spray-physical vapor deposition(PS-PVD) onto pretreated and un-pretreated bond coating, respectively. An isothermal oxidation experiment of 7YSZ TBCs is carried out in the atmosphere of 950 °C in order to simulate the high-temperature oxidation process of engine blades. The isothermal oxidation process of 7YSZ thermal barrier coatings is investigated systematically by impedance spectroscopy. The electrochemical physical model and equivalent circuit of columnar 7YSZ coatings are established. Results show that the isothermal oxidation kinetic curve of columnar 7YSZ thermal barrier coatings appears to follow the parabolic law. A pretreatment of bond coating can reduce the growth rate of the thermally grown oxide(TGO) layer, restraining the initiation and propagation of microcracks between YSZ and TGO layers. The oxidation rate constants of 7YSZ coatings with pretreated and un-pretreated bond coating are 0.101×10^(-12) cm^2·s^(-1) and 0.115 × 10^(-13) cm^2 ·s^(-1), respectively. Impedance analysis shows that the content of oxygen vacancies decreases and the density increases after the TGO layer is oxidized for 150 h. In addition, shrinkage microcracks formed by sintering during the oxidation process is the main reason for an increase of the capacitance and a decrease of the resistance in the grain boundary of YSZ. | Wenlong CHEN Min LIU Jifu ZHANG Ziqian DENG Jie MAO | 2018 | Chinese Journal of Aeronautics2018，31，8： | 5 |
| 8 | Nuclear Aurora kinase A switches m^(6)A reader YTHDC1 to enhance an oncogenic RNA splicing of tumor suppressor RBM4显示文摘Aberrant RNA splicing produces alternative isoforms of genes to facilitate tumor progression,yet how this process is regulated by oncogenic signal remains largely unknown.Here,we unveil that non-canonical activation of nuclear AURKA promotes an oncogenic RNA splicing of tumor suppressor RBM4 directed by m^(6)A reader YTHDC1 in lung cancer.Nuclear translocation of AURKA is a prerequisite for RNA aberrant splicing,specifically triggering RBM4 splicing from the full isoform(RBM4-FL)to the short isoform(RBM4-S)in a kinase-independent manner. | SiSi Li YangFan Qi JiaChuan Yu YuChao Hao Bin He MengJuan Zhang ZhenWei Dai TongHui Jiang SuYi Li Fang Huang Ning Chen Jing Wang MengYing Yang DaPeng Liang Fan An JinYao Zhao WenJun Fan YuJia Pan ZiQian Deng YuanYuan Luo Tao Guo Fei Peng ZhiJie Hou ChunLi Wang FeiMeng Zheng LingZhi Xu Jie Xu QingPing Wen BiLian Jin Yang Wang Quentin Liu | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 4 |
| 9 | Deep learning for smart agriculture:Concepts,tools,applications,and opportunities显示文摘In recent years,Deep Learning(DL),such as the algorithms of Convolutional Neural Networks(CNN),Recurrent Neural Networks(RNN)and Generative Adversarial Networks(GAN),has been widely studied and applied in various fields including agriculture.Researchers in the fields of agriculture often use software frameworks without sufficiently examining the ideas and mechanisms of a technique.This article provides a concise summary of major DL algorithms,including concepts,limitations,implementation,training processes,and example codes,to help researchers in agriculture to gain a holistic picture of major DL techniques quickly.Research on DL applications in agriculture is summarized and analyzed,and future opportunities are discussed in this paper,which is expected to help researchers in agriculture to better understand DL algorithms and learn major DL techniques quickly,and further to facilitate data analysis,enhance related research in agriculture,and thus promote DL applications effectively. | Nanyang Zhu Xu Liu Ziqian Liu Kai Hu Yingkuan Wang Jinglu Tan Min Huang Qibing Zhu Xunsheng Ji Yongnian Jiang Ya Guo | 2018 | International Journal of Agricultural and Biological Engineering2018，11，4： | 3 |
| 10 | Dependence of magnetic field just inside the magnetopause on subsolar standoff distance:Global MHD results显示文摘The subsolar magnetopause is the boundary between the solar wind and the Earth's magnetosphere,where reduced solar wind dynamic pressure is equal to the magnetic pressure of the Earth's outer magnetosphere.We use a global magnetohydrodynamic (MHD)model to estimate the ratio f of the compressed magnetic field just inside the subsolar magnetopause to the purely dipolar magnetic field.We also compare our numerical results to a similar work by Shue,which used Time History of Events and Macroscale Interactions during Substorms(THEMIS)data.Our results show that the ratio f is linearly proportional to the subsolar magnetopause standoff distance(r0)for both the northward and southward interplanetary magnetic field,properties consistent with Shue but with a smaller proportionality constant.However,previous theoretical studies show that f is nearly independent of the subsolar standoff distance.The global model results also show that f is smaller for the southward Interplanetary Magnetic Field(IMF)under the same r0,and that the proportionality constant for the southward IMF is larger than that for the northward IMF.Both conclusions agree with statistical results from observations by Shue. | WANG Ming LU JianYong LIU ZiQian PEI ShiXin | 2012 | Chinese Science Bulletin2012，57，12： | 2 |
| 11 | Effects of the interplanetary magnetic field clock angle on the shape of bow shock显示文摘Using the global magnetohydrodynamics(MHD) simulation model, we investigated the effects of the interplanetary magnetic field(IMF) clock angle on the shape of bow shock, including its rotational asymmetry and subsolar point. For general northward IMF( z component Bz > 0), the rotational symmetry of the bow shock is broken by the effects of fast magnetosonic Mach number(Mms), and the cross-sectional line of the bow shock is an ellipse with the semi-major axis along the direction perpendicular to the IMF. The ratio or D-value between semi-major and semi-minor axis can be used to illustrate the extent of asymmetry of the bow shock. On the basis of the multiple parameters fitting, we obtain the changing relationship of both semi-axes with the clock angle and the distance away from the Earth. For general southward IMF(Bz < 0), the cross sectional line of the bow shock is highly asymmetrical under the multiple effects of magnetopause and Mms. The effects of IMF clock angle on subsolar point depend mainly on the changing subsolar point of magnetopause as an obstacle. The distance of subsolar point of bow shock from the Earth increases with the increasing IMF clock angle for Bz > 0, and decreases with the increasing IMF clock angle for Bz < 0. | WANG JiangYan HUANG ZhaoHui WANG Chi LIU ZiQian | 2015 | Science China Earth Sciences2015，58，7： | 2 |
| 12 | A Triformylphloroglucinol-based Covalent Organic Polymer:Synthesis,Characterization and Its Application in Visible-light-driven Oxidative Coupling Reactions of Primary Amines显示文摘A triformylphloroglucinol-based AiB2-typed covalent organic polymer(TFG-BPTH)was successfully constructed by the condensation reaction of triformylphloroglucinol(TFG)and 2.5-bis(2-propynyloxy)terephthalo-hydrazide(BPTH)under solvothermal conditions.The structure of the TFG-BPTH was confirmed by spectra tech-niques including FTIR and solid-state IC CP/MAS NMR spectroscopy.The mophological features of TFG-BPTH were analyzed using scanning electron microscopy(SEM)and transmission electron microscopy(TEM).The TFG-BPTH possessed good thermal and chemical stability,and exhibited good photocatalytic activity as a metal-free heterogeneous catalyst for oxidation of amines to valuable imines under visible light irradiation using O2 as greer oxidant.In addition,the catalyst could be readily recovered from the reaction mixture by simple filtration and reused for at least five cycles without any observable change in structure and catalytic activity. | LI Xiaodong SU Qing LIU Ziqian LUO Kexin LI Guanghua WU Qiaolin | 2020 | Chemical Research in Chinese Universities2020，36，6： | 1 |
| 13 | New insights from the widening homogeneity perspective to target intratumor heterogeneity显示文摘Precision medicine has shed new light on the treatment of heterogeneous cancer patients.However,intratumor heterogeneity strongly constrains the clinical benefit of precision medicine.Thus,rethinking therapeutic strategies from a different facet within the precision medicine framework will not only diversify clinical interventions,but also provide an avenue for precision medicine.Here,we explore the current approaches for targeting intratumor hetero-geneity and their limitations.Furthermore,we propose a theoretical strategy with a“homogenization”feature based on iatrogenic evolutionary selection to target intratumor heterogeneity. | Mengying Tong Ziqian Deng Xiaolong Zhang Bin He Mengying Yang Wei Cheng Quentin Liu | 2018 | Cancer Communications2018，38，1： | 1 |
| 14 | Robust perfluorinated porous organic networks: Succinct synthetic strategy and application in chlorofluorocarbons adsorption显示文摘Fluorinated porous organic networks(F-PONs)have demonstrated unique properties and applications,but approaches capable of affording F-PONs with high fluorine content and robust nanoporous architecture under metal-free and easy handling conditions are still rarely reported.Herein,using polydivinylbenzene(PDVB)as an easily available precursor,a novel and straightforward approach was developed to afford F-PONs via a dehydrative Friedel-Crafts reaction using perfluorinated benzylic alcohols as the cross-linking agent promoted by Bronsted acid(trifluoromethanesulfonic acid).The afforded material(F-PDVB)featured high fluorine content(22 at.%),large surface area(771 m^(2)·g^(-1)),and good chemical/thermal stability,rendering them as promising candidates for the adsorption of CO_(2),hydrocarbons,fluorocarbons,and chlorofluorocarbons,with weight capacities up to 520 wt.%being achieved.This simple methodology can be extended to fabricate fluorinated hyper-crosslinked polymers(F-HCPs)from rigid aromatic monomers.The progress made in this work will open new opportunities to further expand the involvement of fluorinated materials in large scale applications. | Yali Luo Zhenzhen Yang Xian Suo Hao Chen Tao Wang Ziqian Wang Yunfei Liu Yinong Lyu llja Popovs Sheng Dai | 2021 | Nano Research2021，14，9： | 1 |
| 15 | Probing the Interfacial Forces and Surface Interaction Mechanisms in Petroleum Production Processes显示文摘Despite the advances that have been made in renewable energy over the past decade,crude oil or petroleum remains one of the most important energy resources to the world.Petroleum production presents many challenging issues,such as the destabilization of complex oil-water emulsions,fouling phenomena on pipelines and other facilities,and water treatment.These problems are influenced by the molecular forces at the oil/water/solid/gas interfaces involved in relevant processes.Herein,we present an overview of recent advances on probing the interfacial forces in several petroleum production processes(e.g.,bitumen extraction,emulsion stabilization and destabilization,fouling and antifouling phenomena,and water treatment)by applying nanomechanical measurement technologies such as a surface forces apparatus(SFA)and an atomic force microscope(AFM).The interaction forces between bitumen and mineral solids or air bubbles in the surrounding fluid media determine the bitumen liberation and flotation efficiency in oil sands production.The stability of complex oil/water emulsions is governed by the forces between emulsion drops and particularly between interface-active species(e.g.,asphaltenes).Various oil components(e.g.,asphaltenes)and emulsion drops interact with different substrate surfaces(e.g.,pipelines or membranes),influencing fouling phenomena,oil-water separation,and wastewater treatment.Quantifying these intermolecular and interfacial forces has advanced the mechanistic understanding of these interfacial interactions,facilitating the development of advanced materials and technologies to solve relevant challenging issues and improve petroleum production processes.Remaining challenges and suggestions on future research directions in the field are also presented. | Diling Yang Xuwen Peng Qiongyao Peng Tao Wang Chenyu Qiao Ziqian Zhao Lu Gong Yueliang Liu Hao Zhang Hongbo Zeng | 2022 | Engineering2022，，11： | 1 |
| 16 | The inhomogeneous diffusion of chemically crosslinked polyacrylamide hydrogel based on poroviscosity theory显示文摘The diffusion of hydrogels is a phenomenon not only profound in novel applications of mechanical engineering but also very common in nature. Comprehensive studies of the swelling properties under stable states have been carried out in the past several years;however, ambiguities in the understanding of the kinetic behaviour of the diffusion phenomenon of hydrogels still remain.The potential applications of hydrogels are confined due to the lack of perceptiveness of the kinetic behaviour of diffusion in hydrogels. Based on our previous work, in this study, we initiate the theoretical kinetic study of the inhomogeneous diffusion of hydrogels. With poroviscosity introduced, we develop a theory for the inhomogeneous diffusion of hydrogels. After implementing this theory into the finite element solution, we could predict the water content in the hydrogel as a function of time and location. The quantitative prediction of the inhomogeneous diffusion and the formulas are given in the numerical study.Furthermore, the corresponding experiments are carried out to substantiate this theory. It can be observed that the theoretical prediction meets fairly well with our experimental data. Finally, we carry out a systematic parameter study to discuss the effect of three important parameters on the diffusion property. The increase of the interaction parameter is seen to constrain the diffusion while increase of the chemical potential is seen to facilitate the process. The change of the diffusion coefficient D, on the other hand, does not affect the process much. By comparing the conclusions above with the experimental data, we can narrow down the range of the values of χ and D. | ZHENG ShouJing LI ZiQian LIU ZiShun | 2019 | Science China(Technological Sciences)2019，62，8： | 1 |
| 17 | Robust Control of Electrical Machine with Load Uncertainty显示文摘 | Ziqian Liu Qunjing Wang | 2008 | Journal of Electrical Engineering2008，59，2： | 1 |
| 18 | Recent advances of hydrogel network models for studies on mechanical behaviors显示文摘Current constitutive theories face challenges when predicting the extremely large deformation and fracture of hydrogels,which calls for the demands to reveal the fundamental mechanism of the various mechanical behaviors of hydrogels from bottom up.Proper hydrogel network model provides a better approach to bridge the gap between the micro-structure and the macroscopic mechanical responses.This work summarizes the theoretical and numerical researches on the hydrogel network models,aiming to provide new insights into the effect of microstructure on the swelling-deswelling process,hyperelasticity,viscoelasticity and fracture of hydrogels.Hydrogel network models are divided into full-atom network models,realistic network models and abstract network models.Full-atom network models have detailed atomic structure but small size.Realistic network models with different coarse-graining degree have large model size to explain the swelling-deswelling process,hyperelasticity and viscoelasticity.Abstract network models abstract polymer chains into analytical interactions,leading to the great leap of model size.It shows advantages to reproduce the crack initiation and propagation in hydrogels by simulating chain scission.Further research directions on the network modeling are suggested.We hope this work can help integrate the merits of network modeling methods and continuum mechanics to capture the various mechanical behaviors of hydrogels. | Jincheng Lei Ziqian Li Shuai Xu Zishun Liu | 2021 | Acta Mechanica Sinica2021，37，3： | 1 |
| 19 | Worldwide impacts of atmospheric vapor pressure deficit on the interannual variability of terrestrial carbon sinks显示文摘Interannual variability of the terrestrial ecosystem carbon sink is substantially regulated by various environmental variables and highly dominates the interannual variation of atmospheric carbon dioxide(CO_(2))concentrations.Thus,it is necessary to determine dominating factors affecting the interannual variability of the carbon sink to improve our capability of predicting future terrestrial carbon sinks.Using global datasets derived from machine-learning methods and process-based ecosystem models,this study reveals that the inter annual variability of the atmospheric vapor pressure deficit(VPD)was significantly negatively correlated with net ecosystem production(NEP)and substantially impacted the inter annual variability of the atmospheric CO_(2)growth rate(CGR).Further analyses found widespread constraints of VPD interannual variability on terrestrial gross primary production(GPP),causing VPD to impact NEP and CGR.Partial correlation analysis confirms the persistent and widespread impacts of VPD on terrestrial carbon sinks compared to other environmental variables.Current Earth system models underestimate the interannual variability in VPD and its impacts on GPP and NEP.Our results highlight the importance of VPD for terrestrial carbon sinks in assessing ecosystems'responses to future climate conditions. | Bin He Chen Chen Shangrong Lin Wenping Yuan Hans WChen Deliang Chen Yafeng Zhang Lanlan Guo Xiang Zhao Xuebang Liu Shilong Piao Ziqian Zhong Rui Wang Rui Tang | 2022 | National Science Review2022，9，4： | 1 |
| 20 | The genomic characteristics and pathogenicity of a mammalian orthoreovirus within a new lineage from wild pika in plateau显示文摘Emerging and re-emerging viruses from wild animals have seriously threatened the health of humans and domesticated animals in recent years.Herein,we isolated a new mammalian orthoreovirus(MRV),Pika/MRV/GCCDC7/2019(PMRV-GCCDC7),in the Qinghai-Tibet Plateau wild pika(Ochotona curzoniae).Though the PMRVGCCDC7 shows features of a typical reovirus with ten gene segments arranged in 3:3:4 in length,the virus belongs to an independent evolutionary branch compared to other MRVs based on phylogenetic tree analysis.The results of cellular susceptibility,species tropism,and replication kinetics of PMRV-GCCDC7 indicated the virus could infect four human cell lines(A549,Huh7,HCT,and LoVo)and six non-human cell lines,including Vero-E6,LLCMK2,BHK-21,N2a,MDCK,and RfKT cell,derived from diverse mammals,i.e.monkey,mice,canine and bat,which revealed the potential of PMRV-GCCDC7 to infect a variety of hosts.Infection of BALB/c mice with PMRVGCCDC7 via intranasal inoculation led to relative weight loss,lung tissue damage and inflammation with the increase of virus titer,but no serious respiratory symptoms and death occurred.The characterization of the new reovirus from a plateau-based wild animal has expanded our knowledge of the host range of MRV and provided insight into its risk of trans-species transmission and zoonotic diseases. | Kexin Zong Yuanyuan Guo Jingdong Song Maoshun Liu Junfeng Hao Jie Zhang Xin Li Shiyan Zhu Shuting Huo Ziqian Xu Peipei Liu Yingze Zhao Yuhai Bi Jiapeng Qu George F.Gao Jun Liu | 2023 | Virologica Sinica2023，38，6： | 0 |
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