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| 1 | P wave velocity structure of upper and middle crust beneath the Three Gorges reservoir dam and adjacent regions显示文摘The three-dimensional P wave velocity structures of upper and middle crust beneath the Three Gorges reservoir dam and adjacent regions were reconstructed by means of the seismic tomography, using the absolute P-arrivals from the events observed by the Three Gorges seismic network. Our preliminary study of the deep structure shows: (1) the lithology of the Huangling anticline, integral and highly so-lidified, exhibits a uniformity. Down to a depth of 20 km, the Huangling anticline still shows high- velocity anomalies. Note that the characteristics of the velocity images with the different depths are not the same; (2) the depth of the sedimentary rocks beneath the entire Zigui basin is not constant, which is less than 6 km; (3) the top boundary of the crystalline basement varies from 0 to 7 km, whereas the bottom one between 14 and 16 km; (4) the partially molten substances of the upper mantle are located in the Badong-Zigui and its adjacent regions as well as nearby Peishi area. The development and evo-lution of the current tectonics are associated with the cooling and solidifying process of the molten substances within the upper mantle; (5) the different velocity structures of the deep crust in both east and west side of the Jiuwanxi fault are to be investigated in order to understand the origin of gravita-tional gradient zone in the Three Gorge areas; and (6) the velocities within the upper crust would be affected by reservoir water permeability. | LI Qiang ZHAO Xu CAI JinAn LIU RuiFeng LONG GuiHua AN YanRu | 2009 | Science China Earth Sciences2009，52，4： | 11 |
| 2 | Impact of warm mesoscale eddy on tropical cyclone intensity显示文摘The spatial-temporal patterns of tropical cyclone(TC) intensity changes caused by the warm ocean mesoscale eddy(WOME) distribution are evaluated using two sets of idealized numerical experiments. The results show that the TC was intensified and weakened when a WOME was close to and far away from the TC center, respectively.The area where the WOME enhanced(weakened) TC intensity is called the inner(outer) area in this study.Amplitudes of the enhancement and weakening caused by the WOME in the inner and outer area decreased and increased over time, while the ranges of the inner and outer area diminished and expanded, respectively. The WOME in the inner area strengthened the secondary circulation of the TC, increased heat fluxes, strengthened the symmetry, and weakened the outer spiral rainband, which enhanced TC intensity. The effect was opposite if the WOME was in the outer area, and it weakened the TC intensity. The idealized simulation employed a stationary TC, and thus the results may only be applied to TCs with slow propagation. These findings can improve our understanding of the interactions between TC and the WOME and are helpful for improving TC intensity forecasting by considering the effect of the WOME in the outer areas. | Jia Sun Guihua Wang Xuejun Xiong Zhenli Hui Xiaomin Hu Zheng Ling Long Yu Guangbing Yang Yanliang Guo Xia Ju Liang Chen | 2020 | Acta Oceanologica Sinica2020，39，8： | 3 |
| 3 | Spatio-temporal dynamic patterns of farmland and rural settlements in Su–Xi–Chang region: Implications for building a new countryside in coastal China显示文摘 | Hualou Long Yansui Liu Xiuqin Wu Guihua Dong | 2008 | Land Use Policy2008，，2： | 1 |
| 4 | Visco-acoustic transmission waveform inversion of velocity structure in space-frequency domain显示文摘According to the least square criterion of minimizing the misfit between modeled and observed data,this paper provides a preconditioned gradient method to invert the visco-acoustic velocity structure on the basis of using sparse matrix LU factorization technique to directly solve the visco-acoustic wave forward problem in space-frequency domain.Numerical results obtained in an inclusion model inversion and a layered homogeneous model inversion demonstrate that different scale media have their own frequency responses,and the strategy of using low-frequency inverted result as the starting model in the high-frequency inversion can greatly reduce the non-uniqueness of their solutions.It can also be observed in the experi-ments that the fast convergence of the algorithm can be achieved by using diagonal elements of Hessian matrix as the pre-conditioned operator,which fully incorporates the advantage of quadratic convergence of Gauss-Newton method. | Guihua Long Xiaofan Li Meigen Zhang Tong Zhu | 2009 | Earthquake Science2009，22，1： | 0 |
| 5 | Melatonin ameliorates tau-related pathology via the miR-504-3p and CDK5 axis in Alzheimer’s disease显示文摘Background:Intracellular accumulation of the microtubule-associated protein tau and its hyperphosphorylated forms is a key neuropathological feature of Alzheimer’s disease(AD).Melatonin has been shown to prevent tau hyperphosphorylation in cellular and animal models.However,the molecular mechanisms by which melatonin attenuates tau hyperphosphorylation and tau-related pathologies are not fully understood.Methods:Immunofluorescence,immunoblotting analysis and thioflavin-S staining were employed to examine the effects of early and late treatment of melatonin on tau-related pathology in hTau mice,in which nonmutated human tau is overexpressed on a mouse tau knockout background.High-throughput microRNA(miRNA)sequencing,quantitative RT-PCR,luciferase reporter assay and immunoblotting analysis were performed to determine the molecular mechanism.Results:We found that both early and late treatment of melatonin efficiently decreased the phosphorylation of soluble and insoluble tau at sites related to AD.Moreover,melatonin significantly reduced the number of neurofibrillary tangles(NFTs)and attenuated neuronal loss in the cortex and hippocampus.Furthermore,using miRNA microarray analysis,we found that miR-504-3p expression was upregulated by melatonin in the hTau mice.The administration of miR-504-3p mimics dramatically decreased tau phosphorylation by targeting p39,an activator of the well-known tau kinase cyclin-dependent kinase 5(CDK5).Compared with miR-504-3p mimics alone,co-treatment with miR-504-3p mimics and p39 failed to reduce tau hyperphosphorylation.Conclusions:Our results suggest for the first time that melatonin alleviates tau-related pathologies through upregulation of miR-504-3p expression by targeting the p39/CDK5 axis and provide novel insights into AD treatment strategies. | Dongmei Chen Guihua Lan Ruomeng Li Yingxue Mei Xindong Shui Xi Gu Long Wang Tao Zhang Chen-Ling Gan Yongfang Xia Li Hu Yuan Tian Mi Zhang Tae Ho Lee | 2022 | Translational Neurodegeneration2022，11，1： | 0 |
| 6 | 人工智能白内障协同管理的通用平台显示文摘目的:建立和验证一个涉及多级临床场景的白内障协作通用的人工智能(artificial intelligence,AI)管理平台,探索基于AI的医疗转诊模式,以提高协作效率和资源覆盖率。方法:训练和验证的数据集来自中国AI医学联盟,涵盖多级医疗机构和采集模式。使用三步策略对数据集进行标记:1)识别采集模式;2)白内障诊断包括正常晶体眼、白内障眼或白内障术后眼;3)从病因和严重程度检测需转诊的白内障患者。此外,将白内障AI系统与真实世界中的居家自我监测、初级医疗保健机构和专科医院等多级转诊模式相结合。结果:通用AI平台和多级协作模式在三步任务中表现出可靠的诊断性能:1)识别采集模式的受试者操作特征(receiver operating characteristic curve,ROC)曲线下面积(area under the curve,AUC)为99.28%~99.71%);2)白内障诊断对正常晶体眼、白内障或术后眼,在散瞳-裂隙灯模式下的AUC分别为99.82%、99.96%和99.93%,其他采集模式的AUC均>99%;3)需转诊白内障的检测(在所有测试中AUC>91%)。在真实世界的三级转诊模式中,该系统建议30.3%的人转诊,与传统模式相比,眼科医生与人群服务比率大幅提高了10.2倍。结论:通用AI平台和多级协作模式显示了准确的白内障诊断性能和有效的白内障转诊服务。建议AI的医疗转诊模式扩展应用到其他常见疾病和资源密集型情景当中。 | WU Xiaohang HUANG Yelin LIU Zhenzhen LAI Weiyi LONG Erping ZHANG Kai JIANG Jiewei LIN Duoru CHEN Kexin YU Tongyong WU Dongxuan LI Cong CHEN Yanyi ZOU Minjie CHEN Chuan ZHU Yi GUO Chong ZHANG Xiayin WANG Ruixin YANG Yahan XIANG Yifan CHEN Lijian LIU Congxin XIONG Jianhao GE Zongyuan WANG Dingding XU Guihua DU Shaolin XIAO Chi WU Jianghao ZHU Ke NIE Danyao XU Fan LV Jian CHEN Weirong LIU Yizhi 林浩添 无 王厚硕(审校) 罗明杰(审校) | 2023 | 眼科学报2023，38，10： | 0 |
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