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    题名 作者 年代 出处 被引量
1Impact of concomitant use of proton pump inhibitors and clopidogrel or ticagrelor on clinical outcomes in patients with acute coronary syndrome显示文摘BackgroundThere 是在质子泵禁止者(PPI ) 和 clopidogrel 之间的可能的不利相互作用上的大争论。另外, PPI 的使用是否少些影响 ticagrelor 遗体的临床的功效,知道。在经皮的冠的干预(一种总线标准) .MethodsWe 回顾地从 “ 分析了数据以后,我们试图与急性冠的症候群(交流)在病人在临床的结果上决定 PPI 和 clopidogrel 或 ticagrelor 的伴随物管理的影响;真实 world” ;,国际,在 2003 和 2014 之间的多中心登记( n = 15,401 )并且在1年的合成主要端点上估计了 PPI 和 clopidogrel 或 ticagrelor 的伴随物管理的影响(所有原因死亡收到 PPI 的病人更老,更经常女性,并且是更可能的有 comorbidities。没有协会为收到 clopidogrel 的病人在 PPI 使用和主要端点之间被观察(调整 HR:1.036;95% CI:0.903-1.189 ) 或 ticagrelor (调整 HR:2.320;95% CI:0.875-6.151 )(P 相互作用 = 0.2004 ) 。同样, PPI 的使用没与所有原因死亡,重新梗塞,或与交流后面的一种总线标准的为与任何一个 clopidogrel 对待的病人或 ticagrelor.ConclusionsIn 病人的严重流血的减少的风险的增加的风险被联系, PPI 的伴随物使用没在收到 clopidogrel 或 ticagrelor 的病人与不利结果的增加的风险被联系。我们的调查结果显示与 clopidogrel 或 ticagrelor 在联合使用 PPI 是合理的,特别在有胃肠的流血的更高的风险的病人。Yan YAN Xiao WANG Jing-Yao FAN Shao-Ping NIE Sergio Raposeiras-Roubin Emad Abu-Assi Jose P Simao Henriques Fabrizio D'Ascenzo Jorge Saucedo Jose R Gonzfilez-Juanatey Stephen B Wilton Wouter J Kikkert Ivlin Nufiez-Gil Albert Ariza-Sole Xian-Tao SONG Dimitrios Alexopoulos Christoph Liebetrau Tetsuma Kawaji Claudio Moretti Zenon Huczek Toshiharu Fujii Luis C Correia Masa-aki Kawashiril Sasko Kedev 2016Journal of Geriatric Cardiology2016,13,3:12
2P2Y12受体抑制剂联合质子泵抑制剂对急性冠脉综合征患者缺血事件影响的临床分析显示文摘目的本研究旨在分析P2Y12受体抑制剂联合质子泵抑制剂(PPI)治疗对经皮冠状动脉介入(PCI)术后的急性冠脉综合征患者缺血事件的影响。方法基于国际多中心回顾性注册登记研究,纳入2003至2014年因急性冠脉综合征人院行PCI术的患者,分为PPI组及非PPI组并随访1年,主要临床终点为全因死亡/再发心肌梗死的复合终点。根据P2Y12受体抑制剂种类,将入组患者分为氯吡格雷组及替格瑞洛组,并比较不同药物与PPI联用发生临床终点事件的风险。结果研究入选9429例患者,PPI组占54.8%,具有更多高危因素。Cox回归结果提示PPI组较非PPI组全因死亡/再发心肌梗死复合事件的发生差异无统计学意义(HR1.00,95%CI 0.86—1.18)。根据P2Y12抑制剂种类不同分为氯吡格雷组和替格瑞洛组,不同P2Y12受体抑制剂联用PPI较未联用PPI患者的临床终点无差异,联用PPI的氯吡格雷组与替格瑞洛组的临床终点差异也无统计学意义。结论急性冠脉综合征患者PPI与P2Y12受体抑制剂联用不增加全因死亡和再发心肌梗死风险,尤其PPI联用氯吡格雷在患者的缺血事件上与替格瑞洛比较差异无统计学意义。冯斯婷 严妍 范婧尧 王晓 郑文 聂绍平 Sergio Raposeiras-Roubin Emad Abu-Assi Jose P Simao Henriques Fabrizio D' Ascenzo Jorge Saucedo Jose R Conzalez-Juanatey Stephen B Wilton Wouter J Kikkert Ivan Nunez-Gil Albert Ariza-Sole Dimitrios Alexopoulos Christoph Liebetrau Tetsuma Kawaji Claudio Moretti Zenon Huczek Toshiharu Fujii Luis C Correia Masa-aki Kawashiri Sasko Kedev 2016中华医学杂志2016,96,33:6
314-day triple, 5-day concomitant, and 10-day sequential therapies for Helicobacter pylori infection in seven Latin American sites: a randomised trial显示文摘E Robert Greenberg Garnet L Anderson Douglas R Morgan Javier Torres William D Chey Luis Eduardo Bravo Ricardo L Dominguez Catterina Ferreccio Rolando Herrero Eduardo C Lazcano-Ponce María Mercedes Meza-Montenegro Rodolfo Pe?a Edgar M Pe?a Eduardo Salazar- 2011The Lancet2011,,9790:2
4TGF-beta regates the blood testis barrier dynamics via the p38 mitogen activated protein (MAP) kinase pathway : an in vivo study显示文摘Lui W Y Wong C H Mruk D D 2003Endocrinology2003,14,41:1
5Numerical investigation of NOx emissions from a tangentially-fired utility boiler under conventional and overfire air operation显示文摘LUIS I D CRISTOBAL C JAVIER P 2007Fuel2007,87,7:1
6Sequential assembly and polymerization of the polyprenol-linked pentasacchariderepeating unit of the Xanthan polysaccharide in Xanthomonas campestris显示文摘Luis I Roberto O C Marcelo A D 1993Journal of Bacteriology1993,175,9:1
7Inhibition effects of nitrogen compounds on the hydrodesulfurization of dibenzothiophene显示文摘LAREDO S G C DE LOS REYES H J A LUIS CANO D J 2001Applied Catalysis2001,207,12:1
8Postoperative delirium in inten?sive care patients: risk factors and outcome显示文摘Veiga D Luis C Parente D 2012Rev Bras Aneste?siol2012,62,4:1
9Synthesis and properties of hydrophilic networks based on poly (ethylene glycol) and β-eyclodextrin 显示文摘Luis C Camilo A Ramirez D 2007Macromol Chem Phys2007,208,8:1
10Modelling of pulverized coal boilers: review and validation of on-line simulation techniques显示文摘Luis I D Cristobal C Antonio C 2005Applied Thermal Engineering2005,25,10:1
11Postoperative delirium in intensive care patients:risk factors and outcome显示文摘Veiga D Luis C Parente D 0,,04:1
12Understanding the paradoxical effects of power control on the capacity of wireless networks显示文摘WANG Y LUI J C S CHIU D 2009IEEE Trans on Wireless Communication2009,8,1:1
13On the limited memory BFGS method for large scale optimization 显示文摘LUI D C NOCEDAL J 1989Mathematical Programming1989,45,13:1
14DCAR: distributed coding-aware routing in wireless networks显示文摘LE J L LUI J C S CHIU D M 2008IEEE Transantion on Mobile Computing2008,9,4:1
15Profiling and identification of P2P traffic显示文摘HU Y CHIU D LUI J C S 0,,6:1
16Inhibition effects of nitrogen compounds on the hydrodesulfurization of dibenzothiophene 显示文摘Georgina L Antonio D L R Luis C 2001Applied Catalysis A: General2001,207,1:1
17Sequential assembly and polymerization of the polyprenol-linked pentasaccharide repeating unit of the Xanthan polysaccharide in Xanthomonas campestris显示文摘Luis I Roberto O C Marcelo A D 1993Journal of Bacteriology1993,175,9:1
18Utility of the aVL lead in the electrocardiographic diagnosis of atrioventricular node re-entrant tachycardia 显示文摘Di Toro D Hadid C Luis V 2009Europace2009,11,7:1
19Regulation of blood- testis barrier dynamics: an in vivo study 显示文摘Wong C Mruk D D Lui W 2004Journal of cell science2004,117,:1
20An integrated computeraid for generating and evaluating assembly sequences for mechanical products显示文摘Baldwin D F Abell T E Lui M C 1991IEEE Transactions on Robotics and Automation1991,7,1:1
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