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| 1 | Expenditure and financial burden for the diagnosis and treatment of colorectal cancer in China:a hospital.based,multicenter,cross-sectional survey显示文摘Background: The increasing prevalence of colorectal cancer(CRC) in China and the paucity of information about relevant expenditure highlight the necessity of better understanding the financial burden and effect of CRC diagnosis and treatment. We performed a survey to quantify the direct medical and non-medical expenditure as well as the resulting financial burden of CRC patients in China.Methods: We conducted a multicenter, cross-sectional survey in 37 tertiary hospitals in 13 provinces across China between 2012 and 2014. Each enrolled patient was interviewed using a structured questionnaire. All expenditure data were inflated to the 2014 Chinese Yuan(CNY; 1 CNY = 0.163 USD). We quantified the overall expenditure and financial burden and by subgroup(hospital type, age at diagnosis, sex, education, occupation, insurance type, household income, clinical stage, pathologic type, and therapeutic regimen). We then performed generalized linear modeling to determine the factors associated with overall expenditure.Results: A total of 2356 patients with a mean age of 57.4 years were included, 57.1 % of whom were men; 13.9% of patients had stage I cancer; and the average previous-year household income was 54,525 CNY.The overall average direct expenditure per patient was estimated to be 67,408 CNY, and the expenditures for stage Ⅰ, Ⅱ, Ⅲ, and Ⅳ disease were 56,099 CNY, 59,952 CNY, 67,292 CNY, and 82,729 CNY, respectively. Non-medical expenditure accounted for 8.3%of the overall expenditure. The 1-year out-of-pocket expenditure of a newly diagnosed patient was 32,649 CNY, which accounted for 59.9% of their previous-year household income and caused 75.0% of families to suffer an unmanageable financial burden. Univariate analysis showed that financial burden and overall expenditure differed in almost all subgroups(P < 0.05), except for sex. Multivariate analysis showed that patients who were treated in specialized hospitals and those who were diagnosed with adenocarcinoma or diagnosed at a later stage were likely to spend more,whereas those with a lower household income and those who underwent surgery spent less(all P < 0.05).Conclusions: For patients in China, direct expenditure for the diagnosis and treatment of CRC seemed catastrophic,and non-medical expenditure was non-ignorable. The financial burden varied among subgroups, especially among patients with different clinical stages of disease, which suggests that, in China, CRC screening might be cost-effective. | Hui-Yao Huang Ju-Fang Shi Lan-Wei Guo Ya-Na Bai Xian-Zhen Liao Guo-iangLiu A-Yan Mao Jian-Song Ren Xiao-Jie Sun Xin-Yu Zhu Le Wang Bing-Bing Song Ling-Bin Du Lin Zhu Ji-Yong Gong Qi Zhou Yu-Qin Liu Rong Cao Ling Mai Li Lan Xiao-Hua Sun Ying Ren Jin-Yi Zhou Yuan-Zheng Wang Xiao Qi Pei-An Lou Dian Shi Ni Li Kai Zhang Jie He Min Dai | 2017 | Chinese Journal of Cancer2017，36，8： | 25 |
| 2 | Dual-comb spectroscopy resolved three-degreeof-freedom sensing显示文摘Precise and fast determination of position and orientation, which is normally achieved by distance and angle measurements, has broad applications in academia and industry. We propose a dynamic three-degree-of-freedom measurement technique based on dual-comb interferometry and a self-designed grating-corner-cube(GCC) combined sensor. Benefiting from its unique combination of diffraction and reflection characteristics, the absolute distance, pitch, and yaw of the GCC sensor can be determined simultaneously by resolving the phase spectra of the corresponding diffracted beams. We experimentally demonstrate that the method exhibits a ranging precision(Allan deviation) of 13.7 nm and an angular precision of 0.088 arcsec, alongside a 1 ms reaction time. The proposed technique is capable of precise and fast measurement of distances and two-dimensional angles over long stand-off distances. A system with such an overall performance may be potentially applied to space missions,including in tight formation-flying satellites, for spacecraft rendezvous and docking, and for antenna measurement as well as the precise manufacture of components including lithography machines and aircraftmanufacturing devices. | SIYU ZHOU VUNAM LE SHILIN XIONG YUETANG YANG KAI NI QIAN ZHOU GUANHAO WU | 2021 | Photonics Research2021，9，2： | 8 |
| 3 | Ferroptosis as a novel form of regulated cell death:Implications in the pathogenesis,oncometabolism and treatment of human cancer显示文摘The treatment of cancer mainly involves surgical excision supplemented by radiotherapy and chemotherapy.Chemotherapy drugs act by interfering with tumor growth and inducing the death of cancer cells.Anti-tumor drugs were developed to induce apoptosis,but some patient’s show apoptosis escape and chemotherapy resistance.Therefore,other forms of cell death that can overcome the resistance of tumor cells are important in the context of cancer treatment.Ferroptosis is a newly discovered iron-dependent,non-apoptotic type of cell death that is highly negatively correlated with cancer development.Ferroptosis is mainly caused by the abnormal increase in iron-dependent lipid reactive oxygen species and the imbalance of redox homeostasis.This review summarizes the progression and regulatory mechanism of ferroptosis in cancer and discusses its possible clinical applications in cancer diagnosis and treatment. | Feifei Pu Fengxia Chen Zhicai Zhang Deyao Shi Binlong Zhong Xiao Lv Andrew Blake Tucker Jiaming Fan Alexander J.Li Kevin Qin Daniel Hu Connie Chen Hao Wang Fang He Na Ni Linjuan Huang Qing Liu William Wagstaff Hue H.Luu Rex C.Haydon Le Shen Tong-Chuan He Jianxiang Liu Zengwu Shao | 2022 | Genes & Diseases2022，9，2： | 6 |
| 4 | Synthesis and Photocatalytic Activity of One-Dimensional CdS@TiO_2 Core-Shell Hetero-structures显示文摘One-dimensional Cd S@TiO_2 core-shell heterostructures were fabricated via the hydrolysis of tetrabutyl titanate(TBT) on preformed Cd S nanowires. The as-prepared products were characterized by X-ray diffraction, transmission electron microscopy, selected area electron diffraction and diffuse reflectance spectroscopy techniques. Results demonstrated that the hydrolysis of TBT had a great influence on the morphology of the coated TiO_2 shell, resulting in the formation of TiO_2 nanoparticles and nanolayer-modified Cd S@TiO_2 heterostructures. Degradation of methylene blue using Cd S@TiO_2 core-shell heterostructures as photocatalysts under visible light irradiation was investigated. Comparative photocatalytic tests showed that the TiO_2 nanoparticles-modified heterostructure exhibited a superior activity due to the passivity of photogenerated charge carriers. | Hongwei Wei Le Wang Zhipeng Li Shouqing Ni Quanqin Zhao | 2011 | Nano-Micro Letters2011，3，1： | 5 |
| 5 | Inhibition of hepatic cytochrome P450 enzymes and sodium/bile acid cotransporter exacerbates leflunomide-induced hepatotoxicity显示文摘目的: Leflunomide 是作为修改疾病的治疗风湿药剂药出售的一个抑制免疫力的代理人。但是它引起严重副作用,包括的致命的肝炎和肝失败。在我们调查了的这研究,肝的新陈代谢的贡献和到 leflunomide 的 leflunomide 和它的主要代谢物 teriflunomide 的运输在 vitro 并且在 vivo.Methods 导致了 hepatotoxicity : leflunomide 和 teriflunomide 的新陈代谢和毒性在 vitro 在主要老鼠 hepatocytes 被评估。肝的细胞色素 P450 reductase 0 (HRN ) 老鼠被用来在 vivo 检验介绍的 PK 和 leflunomide 的 hepatotoxicity。钠 / 胆汁酸 cotransporter (NTCP ) 的表达式和函数在老鼠和人的 hepatocytes 和 NTCP-transfected HEK293 房间被估计。在男 Sprague-Dawley ( SD )老鼠以后是管理 teriflunomide ( 1,6 , 12 mg· ; kg −1·d−1, ig )为 4 个星期,他们的血样品是 analyzed.Results : A nonspecific CYP 禁止者 aminobenzotriazole ( ABT , 1 mmol/L )减少在从 409~216 μ 的老鼠 hepatocytes 的 leflunomide 的 IC 50价值; mol/L 另外一个 nonspecific CYP 禁止者 proadifen ( SKF , 30 μ ; mol/L )增加了 leflunomide 的细胞的累积到3.68褶层在口头的 dosing (15 mg/kg ) 以后,血浆暴露(leflunomide 的 AUC 0-t) 与野类型老鼠相比在 HRN 老鼠增加了到 3 褶层。leflunomide 的管理(25 mg·为 7 d 的 kg −1·d−1) 显著地在 HRN 老鼠增加了浆液中高音和著名计算机生产厂商层次;当剂量被增加到 50 mg· 时; kg −1·d−1, 所有 HRN 老鼠在 d 上死了 6。Teriflunomide 显著地减少了在人的 hepatocytes 的 NTCP 的表示,以及在老鼠 hepatocytes 和 NTCP-transfected HEK293 房间的 NTCP 的功能。teriflunomide 的四星期的管理显著地在雌老鼠,然而并非在男 rats.Conclusion 增加了浆液总数 bilirubin 和直接 bilirubin 层次: 而主要代谢物 teriflunomide 压制 NTCP 的表达式和函数,肝的 CYP 在 leflunomide 的 detoxification 过程起一个关键作用,导致潜在的 cholestasis。 | Lei-lei MA Zhi-tao WU Le WANG Xue-feng ZHANG Jing WANG Chen CHEN Xuan NI Yun-fei LIN Yi-yi CAO Yang LUAN Guo-yu PAN | 2016 | Acta Pharmacologica Sinica2016，37，3： | 3 |
| 6 | A Multicenter Application and Evaluation of the Oxford Classification of IgA Nephropathy in Adult Chinese Patients显示文摘 | Cai-Hong Zeng Weibo Le Zhaohui Ni Minfang Zhang Lining Miao Ping Luo Rong Wang Zhimei Lv Jianghua Chen Jiong Tian Nan Chen Xiaoxia Pan Ping Fu Zhangxue Hu Lining Wang Qiuling Fan Hongguang Zheng Dewei Zhang Yaping Wang Yanhong Huo Hongli Lin Shuni Chen Sh | 2012 | American Journal of Kidney Diseases2012，，5： | 2 |
| 7 | A muhicenter application and e- valuation of the Oxford classification of IgA nephropathy in adult Chinese patients 显示文摘 | Zeng CH Le W Ni Z | 2012 | Am J Kidney Dis2012，60，5： | 1 |
| 8 | A comprehensive process of reverse engineering from 3D meshes to CAD models显示文摘 | Roseline Bénière Gérard Subsol Gilles Gesquière Fran?ois Le Breton William Puech | 2013 | Computer-Aided Design2013，，11： | 1 |
| 9 | PKC-SWI6 signaling regulates asexual development,cell wall integrity,stress response,and lifestyle transition in the nematode-trapping fungus Arthrobotrys oligospora显示文摘Predatory fungi possess intricate signal transduction systems that regulate their development and support successful infection of the host.Herein,we characterized three components of the cell wall integrity-controlling pathway,namely protein kinase C(Ao PKC),SLT2-MAPK(Ao SLT2),and SWI6(Ao SWI6),in a representative nematode-trapping fungus Arthrobotrys oligospora,using gene disruption and multi-omics approaches.The phenotypic traits(such as mycelia development,conidiation,stress response,and trap morphogenesis) and metabolic profiles of ΔAopkc and ΔAoswi6 mutants were similar but differed from those of the ΔAoslt2 mutants.Transcriptomic analysis indicated that the genes differentially expressed in the absence of Aoswi6 were involved in DNA replication,repair,and recombination during trap formation.Moreover,the yeast two-hybrid assay showed that Ao PKC interacted with Ao SWI6,suggesting that in A.oligospora,PKC can directly regulate SWI6,bypassing the SLT2signaling cascade.Conclusively,our findings deepen our understanding of the regulatory mechanism of asexual development and lifestyle switching in nematode-trapping fungi. | Meihua Xie Ni Ma Na Bai Le Yang Xuewei Yang Ke-Qin Zhang Jinkui Yang | 2022 | Science China(Life Sciences)2022，65，12： | 1 |
| 10 | Characterization of copper-resistant bacteria and assessment of bacterial communities in rhizosphere soils of copper-tolerant plants显示文摘 | Lin Yan He Yan Feng Zhang Hai Yan Ma Le Ni Su Zhao Jin Chen Qing Ya Wang Meng Qian Xia Fang Sheng | 2009 | Applied Soil Ecology2009，，1： | 1 |
| 11 | Completeness of reporting of trials published in languages other than English: implications for conduct and reporting of systematic reviews显示文摘 | D. Moher P. Fortin A.R. Jadad P. Jüni T. Klassen J. Le Lorier A. Liberati A. Penna K. Linde | 1996 | The Lancet1996，，8998： | 1 |
| 12 | Acinar cell apoptosis and the origin of tubular complexes in caerulein-induced pancreatitis显示文摘 | Reid LE Walker NI | 1999 | Int J Exp Pathol1999，80，： | 1 |
| 13 | A muhicenter application and evaluation of the Oxford classification of IgA nephropathy in adult Chinese patients显示文摘 | Zeng C Le W Ni Z | 2012 | Am J Kidney Dis2012，60，5： | 1 |
| 14 | Simulation and optimization of a full-scale Carrousel oxidation ditch plant for municipal wastewater treatment显示文摘 | Wen-Ming Xie Rui Zhang Wen-Wei Li Bing-Jie Ni Fang Fang Guo-Ping Sheng Han-Qing Yu Jing Song De-Zhi Le Xue-Jun Bi Chang-Qing Liu Min Yang | 2011 | Biochemical Engineering Journal2011，，1： | 1 |
| 15 | Effect of Different Factors on the Quality of Life and Sequelae of COVID-19 Patients After Discharge显示文摘Background The continued spread of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)remains an international public health emergency,resulting in a significant global disease burden.The long-term effects of SARS-CoV-2 infection in humans and the long-term prognosis of patients with coronavirus disease 2019(COVID-19)after discharge remain unclear.We aimed to assess the quality of life(QoL)and sequelae in patients with COVID-19 after discharge from the hospital by conducting multiple follow-up visits to understand the long-term effects of SARS-CoV-2 on patients'health and its possible influencing factors.Methods COVID-19 patients discharged from Huoshenshan Hospital(Wuhan,China)between February 15 and April 5,2020,were followed up at 6,9,and 12 months after discharge.They completed questionnaires on postdischarge QoL and sequelae under the guidance of medical staff with professional training.The demographic and clinical characteristics of the COVID-19 patients were analyzed using descriptive statistics.A generalized estimating equation model was used to analyze the QoL-related factors.Theχ2 test(or Fisher exact test)and multivariate logistic regression analysis were used to analyze the sequelae and influencing factors.Results A total of 175 patients participated in at least 1 follow-up visit,and 120 completed all 3 follow-up visits.Patients diagnosed with severe and critically ill COVID-19 had worse mental conditions(χ2=7.653,P=0.022)than those with the nonsevere type(not severe or critical)and were more likely to feel fatigued(χ2=4.836,P=0.028).Female patients had a higher risk of sleep disturbance(χ2=10.026,P=0.002)and dyspnea(χ2=5.672,P=0.017)and had more difficulty returning to their original work and life(χ2=8.922,P=0.003)than male patients.Patients with diabetes had a worse appetite(χ2=4.669,P=0.031)and were more prone to sleep disturbance(χ2=4.417,P=0.036)after discharge.The proportion of patients with at least 1 sequela increased from 29.76%(50/168)at 6 months to 51.11%(69/135)at 9 months(χ2=14.305,P<0.001).Compared with the nonsevere type,patients diagnosed with severe and critically ill COVID-19 had an odds ratio(OR)of 4.325(95%confidence interval[CI],1.215–15.401)for memory decline.Female patients had an OR of 4.632(95%CI,1.716–12.501)for joint or muscle pain.Patients with hypertension had an OR of 3.014(95%CI,1.193–7.615)for joint or muscle pain.Conclusion One year after discharge,there were still some patients with varying degrees of decline in QoL and sequelae,which occurred in all follow-up visits.Moreover,QoL and sequelae after discharge were related to sex,clinical classification of COVID-19,and underlying diseases. | Nan Guo Ya-Ping Yao Le Song Guan-Zhen Wang Jun-Li He Ning Zheng Qiong Mo Wen-Xu Ni Bo Zhang Fu-Sheng Wang Lei Huang | 2023 | Infectious Diseases & Immunity2023，3，2： | 1 |
| 16 | A Multicenter Application and Evaluation of the Oxford Classification of IgA Nephropathy in Adult Chinese Patients显示文摘 | Zeng CH Le W Ni Z | | 0，，05： | 1 |
| 17 | Confocal com- parison of corneal reinnervation after small incision lenticule extraction (SMILE) and femtosecond laser in situ keratom- ileusis (FS-LASIK)显示文摘 | LJ M NIU L QIN B ZHOU Z NI K LE Q | 2013 | PLoS One2013，8，81： | 1 |
| 18 | Anti-bullous pemphi- gold 180 and 230 antibodies in a sample of unaffected subjects显示文摘 | Wieland CN Comfere NI Gibson LE | 2010 | Arch Dermatol2010，146，1： | 1 |
| 19 | A long/short-range interconnected carbon with well-defined mesopore for high-energy-density supercapacitors显示文摘Amorphous carbon derived from biomass unusually combines the merits of large specific surface area and abundant micropores,offering massive anchoring points for ion adsorption in electrolyte.Nevertheless,the short-range ordered structure in amorphous carbon hinders the fast electron transfer.Conversely,graphitic carbon with long-range ordered structure is beneficial for electron transfer.Thus,a low-cost strategy is required to marry hierarchical porous structure with long-range ordered structure,resulting in a long/short-range interconnected porous carbon and then leading to fast ion and electron transfer.Herein,we modified the solid-phase conversion process of biomass by employing the features of liquid-phase carbonization for petroleum asphalt.With the assistance of asphalt,the large specific surface area(>2,000 m^(2)·g^(-1)),high ratio of mesopores(ca.60%)together with long-range ordered structure are in-situ created in as-made porous carbon.Thanks to the well configured structure in small scale,the as-made co-converted carbon can be operated in high-viscosity EMIMBF4 electrolyte with a superior capacitance(315 F·g^(-1)@1 A·g^(-1)).Besides,the as-assembled symmetric supercapacitor can deliver a super-high specific energy of 174 Wh·kg^(-1)@2.0 kW·kg^(-1).This work provides a new version for designing highly porous biomass-derived carbon with long/short-range alternating structure at molecular level. | Yuanyang Xie Chang Yu Wei Guo Lin Ni Zhao Wang Jinhe Yu Le Yang Rong Fu Kunlun Liu Jieshan Qiu | 2022 | Nano Research2022，15，2： | 1 |
| 20 | Thermal sensitivity of endothelial cells显示文摘 | Fajardo LE Schreiber AB Kelly NI | 1985 | Radiat Res1985，103，： | 1 |
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