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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Formin-2, polyploidy, hypofertility and positioning of the meiotic spindle in mouse oocytes 显示文摘 | Leader B Lim H Carabatsos M J Harrington A Ecsedy J Pellman D Maas R Leder P | 2002 | Nature Cell Biology2002，4，： | 1 |
| 3 | Maternal trait anxiety, depression and life event stress in pregnancy: relation- ships with infant temperament显示文摘 | Austin M P Hadzi-Pavlovic D Leader L | 2005 | Early Hum Dev2005，81，2： | 1 |
| 4 | Multiple snoRNA gene clusters from Arabidopsis 显示文摘 | Brown J W Clark G P Leader D J | 2001 | RNA2001，7，： | 1 |
| 5 | Multiple snoRNA gene clusters from Arabidopsis显示文摘 | BROWN J W CLARK G P LEADER D J | 2001 | RNA2001，7，： | 1 |
| 6 | Maternal trait anxiety, depression and life event stress in pregnancy: Relationships with infant temperament 显示文摘 | AUSTIN M P HADZI-PAVLOVIC D LEADER L | 2005 | Early Hum Dev2005，81，2： | 1 |
| 7 | Multiple snoRNA gene clusters from Arabidopsis显示文摘 | BROWN J W CLARK G P LEADER D J | 2001 | RNA2001，7，12： | 1 |
| 8 | The protein kinase encoded in the short unique region of pseudorabies virus: description of the gene and identification of its product in virions and in infected cells 显示文摘 | ZHAN G STEVENS R LEADER D P | 1990 | J Gen Virol1990，71，： | 1 |
| 9 | The organization of ribosomal RNA processing correlates with the distribution of nucleolar snRNAs 显示文摘 | Beven A F Lee R Razaz M Leader D J Brown J W Shaw P J | 1996 | J Cell Sci1996，109，6： | 1 |
| 10 | The phosphorylation of riboso- mal proteins L14 and $3 in Krebs II ascites cells显示文摘 | Leader D P Coia A A | 1978 | Bioehim Biophys Acta1978，519，1： | 1 |
| 11 | PC-SPES: herbal formuation for prostate cancer 显示文摘 | Marks L S DiPaola R S Nelson P Chen S Heber D Belldegrun A S Lowe F C Fan J Leaders F E Pantuck A J Tyler V E | 2002 | Urology2002，60，3： | 1 |
| 12 | A comparison of Dextran 70 with carbon dioxide as the distention medium for hysteroscopy in patients with infertility or requesting reversal of a prior tubal sterilization 显示文摘 | TAYLOR P J LEWINTHAL D LEADER A et ai | 1987 | Fertil Steril1987，47，5： | 1 |
| 13 | Maternal trait anxiety,depression and life event stress in pregnancy:Relationships with infant temperament显示文摘 | Austin M P Hadzi-Pavlovic D Leader L | 2005 | Early Hum Dev2005，81，2： | 1 |
| 14 | The prodition of ovulation:a com- parison of the basal body temperature graph, cervical mucus score, and real - time pelvic ultrasonography 显示文摘 | Leader A Wiseman D Taylor P J | 1985 | Fertil Steril1985，43，3： | 1 |
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