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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Phosphorus sorbing materials : sorption dynamics and physicochemical characteristics 显示文摘 | Leader J W Dunne E J Reddy K R | 2008 | Journal of Environment Quality2008，37，1： | 1 |
| 3 | Particulate matter and carbon monoxide in highland Guatemala: indoor and outdoor levels from traditional and improved wood stoves and gas stoves显示文摘 | Naeher L P Leaderer B P Smith K R | 2000 | Indoor Air2000，10，： | 1 |
| 4 | Evaluation of vapor phase nicotine and respirable suspended particle mass as markers for environmental tobacco smoke显示文摘 | LEADERER B P HAMMOND S K | 1991 | Environmental Science & Technology1991，25，4： | 1 |
| 5 | Respiratory syncytial virus-coded pediatric hospitalizations, 1997 to 1999显示文摘 | Leader S Kohlhase K | 2002 | Pediatric Infect Dis J2002，21，7： | 1 |
| 6 | A Computational Geometry Approach to Automated Pulmonary Fissure Segmentation in CT Examinations显示文摘 | Pu J T Leader J K Zheng B | 2009 | IEEE Transactions on Medical Imaging2009，28，5： | 1 |
| 7 | Spotaneous obortcon and exposure to electric blankets and heated water beds显示文摘 | Belange K Leaderer B Hellenbrand K | 1998 | Epidemiology1998，9，： | 1 |
| 8 | Recent trends in severe respiratory syncytialvirus (RSV) among US infants,1997 to 2000显示文摘 | Leader S Kohlhase K | 2003 | J Pediatr2003，143，5： | 1 |
| 9 | Stroke in ovarian hyperstimulation syndrome in early pregnancy treated with intra-arterial rt-PA显示文摘 | Elford K Leader A Wee R | | 0，，： | 1 |
| 10 | The influence of radiographic phenotype and smoking status on peripheral blood biomarker patterns in chronic obstructive pulmonary disease显示文摘 | BON J M LEADER J K WEISSFELD | 2009 | PLOS One2009，4，8： | 1 |
| 11 | Carbon monoxide as a tracer for assessing exposures to particulate matter in wood and gas cookstove households of highland Guatemala显示文摘 | Naeher L P Smith K R Leaderer B P | | 0，，03： | 1 |
| 12 | Antibody re- sponses elicited against the Treponema pallidum repeat proteins differ during infection with different isolates of Treponema pal- lidum subsp, pallidum 显示文摘 | LEADER BT HEVNER K MOLIN1 B J | 2003 | Infect Immun2003，71，10： | 1 |
| 13 | Automated lung segmentation in X-ray computed tomography: development and evaluation of a heuristic threshold-based scheme 显示文摘 | Leader J K Zheng B Rogers R M | 2003 | AcadRadiol2003，10，12： | 1 |
| 14 | Phosphorus sorbing materials: sorption dynamics and physicochemical characteris- tics显示文摘 | LEADER J W DUNNE E J REDDY K R | 2008 | Journal of Environment Quality2008，37，1： | 1 |
| 15 | Automated lung segmentation in X-ray computed tomography:development and evaluation of a heuristic threshold-based scheme显示文摘 | Leader J K Zheng Bin | 2003 | Acad Radiol2003，10，： | 1 |
| 16 | Recent trends in severe respiratory syncycial virus(RSV)among US infants,1997 to 2000显示文摘 | Leader S Kohlhase K | 2003 | J Pediatr2003，143，5： | 1 |
| 17 | Inhibition of cholinesterases with cationic phosphonyl oximes highlights distinctive properties of the charged pyridine groups of quaternary oxime reactivators 显示文摘 | Ashani Y Bhattacharjee A K Leader H | 2003 | Biochem Pharmacol2003，66，： | 1 |
| 18 | An Ellipse-fitting Based Method for Efficient Registration of Breast Masses on Two Mammographic Views显示文摘 | Pu Jiantao Zheng Bin Leader J K | 2008 | Medical Physics2008，35，2： | 1 |
| 19 | Recent trends in sever respiratory syncytial virus amomg US infants,1997 to 2000显示文摘 | Leader S Kohlhase K | 2003 | J Pediatr2003，143，3： | 1 |
| 20 | A comprehensive vertebrate phylogeny using vector representations of protein se- quences from whole genomes 显示文摘 | STUART G W MOFFET K LEADER J J | 2002 | Mol Biol Evol2002，19，4： | 1 |
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