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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Recurrent aneurysmal fibrous histiocytoma显示文摘 | Sheehan KM Leader MB Sexton S | 2004 | J Clin Pathol2004，57，3： | 1 |
| 3 | Systematic Spatial Analysis of Gene Expression during Wheat Caryopsis Development显示文摘 | DREA S LEADER D J ARNOLD B C | 2005 | The Plant Cell2005，17，8： | 1 |
| 4 | Optimal threshold in CT quantification of emphysema显示文摘 | Wang Z Gu S Leader JK | 2013 | Eur Radiol2013，23，4： | 1 |
| 5 | Evaluation of vapor phase nicotine and respirable suspended particle mass as markers for environmental tobacco smoke显示文摘 | LEADERER B P HAMMOND S K | 1991 | Environmental Science & Technology1991，25，4： | 1 |
| 6 | Technical report:fallopian tube recanalization:a simplified technique显示文摘 | MILLWARD S F CLAMAN P LEADER A | 1994 | Clin Radiol1994，49，7： | 1 |
| 7 | Respiratory syncytial virus-coded pediatric hospitalizations, 1997 to 1999显示文摘 | Leader S Kohlhase K | 2002 | Pediatric Infect Dis J2002，21，7： | 1 |
| 8 | Uniformly contractive fixed points in compact metric space显示文摘 | LEADER S | 1982 | Proc Amer Math Soc1982，，86： | 1 |
| 9 | Recent trends in severe respiratory syncytialvirus (RSV) among US infants,1997 to 2000显示文摘 | Leader S Kohlhase K | 2003 | J Pediatr2003，143，5： | 1 |
| 10 | A topological characterization of Banach contractions 显示文摘 | S LEADER | 1997 | ( 69 ) 2:461 - 4661997，，69： | 1 |
| 11 | Computerized estimation of the lung volume removed during lung volume reduction surgery 显示文摘 | Gilbert S Zheng B Leader JK | 2006 | Acad Radiol2006，13，11： | 1 |
| 12 | Recent trends in severe respiratory syncycial virus(RSV)among US infants,1997 to 2000显示文摘 | Leader S Kohlhase K | 2003 | J Pediatr2003，143，5： | 1 |
| 13 | Computerized estimation of the lung volume removed during lung volume reduction surgery显示文摘 | Gilbert S Zheng B Leader JK | | 0，，： | 1 |
| 14 | Recent trends in sever respiratory syncytial virus amomg US infants,1997 to 2000显示文摘 | Leader S Kohlhase K | 2003 | J Pediatr2003，143，3： | 1 |
| 15 | Cytochrorne P450 3A: ontogeny and drug disposition显示文摘 | De wddt S N Kearm G L Leader J S | 1999 | Clin Pharmaeokinet1999，37，6： | 1 |
| 16 | Recent trends in severe respiratory syncytial virus (RSV) among US infants, 1997 to 2000显示文摘 | Leader S Kohlhase K | 2003 | J Pediatr2003，143，5： | 1 |
| 17 | Recent trends in severe respiratory syncytial virus(RSV) among US infants, 1997 to 2000 显示文摘 | Leader S Kohlhase K | 2003 | Pediatr2003，143，5： | 1 |
| 18 | Computerized estimation of thelung volume removed duringlung volume reduction surgery显示文摘 | Gilbert S Zheng B Leader JK | 2006 | Acad Radiol2006，，13： | 1 |
| 19 | Sourceapportionment of indoor aerosols in Suffolk and Onondagacounties, New-York 显示文摘 | KOUTRAKIS P BRIGGS S LEADERER B P | 1992 | Environmental Science &Technology1992，26，3： | 1 |
| 20 | Observation and modeling of polarized light from scarab beetles显示文摘 | Lowrey S De Silva L Hodghinson I Leader J | | 0，，8： | 1 |
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