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| 1 | Double guidewire technique vs transpancreatic precut sphincterotomy in difficult biliary cannulation显示文摘AIM:To compare the outcomes between doubleguidewire technique(DGT) and transpancreatic precut sphincterotomy(TPS) in patients with difficult biliary cannulation.METHODS:This was a prospective,randomized study conducted in single tertiary referral hospital in Korea.Between January 2005 and September 2010.A total of 71 patients,who bile duct cannulation was not possible and selective pancreatic duct cannulation was achieved,were randomized into DGT(n = 34) and TPS(n = 37) groups.DGT or TPS was done for selective biliary cannulation.We measured the technical success rates of biliary cannulation,median cannulation time,and procedure related complications.RESULTS:The distribution of patients after randomization was balanced,and both groups were comparable in baseline characteristics,except the higher percentage of endoscopic nasobiliary drainage in the DGT group(55.9% vs 13.5%,P < 0.001).Successful cannulation rate and mean cannulation times in DGT and TPS groups were 91.2% vs 91.9% and 14.1 ± 13.2 min vs 15.4 ± 17.9 min,P = 0.732,respectively.There was no significant difference between the two groups.The overall incidence of post-endoscopic retrograde cholangiopancreatography(ERCP) pancreatitis was 38.2% vs 10.8%,P < 0.011 in the DGT group and the TPS group;post-procedure pancreatitis was significantly higher in the DGT group.But the overall incidence of post-ERCP hyperamylasemia was no significant difference between the two groups;DGT group vs TPS group:14.7% vs 16.2%,P < 1.0.CONCLUSION:When free bile duct cannulation was difficult and selective pancreatic duct cannulation was achieved,DGT and TPS facilitated biliary cannulation and showed similar success rates.However,post-procedure pancreatitis was significantly higher in the DGT group. | Young Wook Yoo Sang-Woo Cha Woong Cheul Lee Sae Hee Kim Anna Kim Young Deok Cho | 2013 | World Journal of Gastroenterology2013，19，1： | 25 |
| 2 | Colonoscopy-induced ischemic colitis in patients without risk factors显示文摘Ischemic colitis is the most common form of intestinal ischemia.It is a condition that is commonly seen in the elderly and among individuals with risk factors for ischemia.Common predisposing conditions for ischemic colitis are major vascular occlusion,small vessel disorder,shock,some medications,colonic obstructions and hematologic disorders.Ischemic colitis following colonoscopy is rare.Here,we report two cases of ischemic colitis after a routine screening colonoscopy in patients without risk factors for ischemia. | Sang Ok Lee Sae Hee Kim Sung Hee Jung Chan Woong Park Min Ji Lee Jin A Lee Hyun Cheol Koo Anna Kim Hyun-Young Han Dong-Wook Kang | 2014 | World Journal of Gastroenterology2014，20，13： | 9 |
| 3 | Comparison of selected inflammation-based prognostic markers in relapsed or refractory metastatic colorectal cancer patients显示文摘AIM: To investigate the impact of systemic inflammationbased prognostic markers on overall survival in relapsed/refractory metastatic colorectal cancer(m CRC) patients. METHODS: To investigate prognostic markers in m CRC patients,this study was performed with patients who have experienced relapsed/refractory m CRC with standard chemotherapy or were inapplicable to conventional treatment modality because of poor performance status,age,or comorbidity. We reviewed the medical records of 177 m CRC patients managed with Korean Medicine(KM) treatment modality using an anticancer agent of Rhus verniciflua Stokes extract from June 2006 to April 2013. The clinicopathologic characteristics,laboratory test,the systemic inflammation markers including the modified Glasgow prognostic score(m GPS),neutrophil lymphocyte ratio(NLR),platelet lymphocyte ratio(PLR),lymphocyte monocyte ratio(LMR),and prognostic nutritional index(PNI) were analyzed. The overall survival of patients was calculated with the Kaplan-Meier method and the statistical significance was compared using with the log-rank test. To compare the impact of systemic inflammation based markers,the hazard ratio(HR) of m GPS,NLR,PLR,LMR,and PNI for overall survival were evaluated with the Cox proportional hazards regression.RESULTS: The majority of m CRC patients had relapsed/refractory to standard chemotherapy; 128 patients(72.3%) had undergone more than second line chemotherapy,and the median time from diagnosis of m CRC to initiation of KM was 9.4 mo. The median overall survival of enrolled patients was 8.3 mo. On univariate analyses,the inflammation markers of higher m GPS(P < 0.001),NLR ≥ 5(P < 0.001),PLR > 300(P = 0.004),LMR ≤ 3.4(P < 0.001),and PNI ≤ 45.3(P = 0.001) were significantly associated with decreased survival time. On stepwise multivariate proportional hazards model,m GPS at 2 vs 0(HR = 3.212,95%CI: 1.437-7.716,P = 0.004),and LMR ≤ 3.4(HR = 1.658,95%CI: 1.092-2.518,P = 0.018) as independent predictors associated with poor overall survival along with carbohydrate antigen 19-9(HR = 1.482,95%CI: 1.007-2.182,P = 0.046),AST ≥ 40(HR = 2.377,95%CI: 1.359-4.155,P = 0.002),and the treatment duration for KM less than 2.9 mo(HR = 1.718,95%CI: 1.160-2.543,P = 0.007).CONCLUSION: These results indicate that the inflammatory markers,m GPS and LMR are independent prognostic factors for predicting overall survival in relapsed/refractory m CRC patients. | Anna Song Wankyu Eo Sookyung Lee | 2015 | World Journal of Gastroenterology2015，21，43： | 8 |
| 4 | 如何设计高质量针刺临床研究:基于证据的专家共识显示文摘本针刺随机对照试验(Randomised controlled trials, RCT)专家共识是基于目前针刺试验面临的最普遍、最关键问题,由临床医生、研究人员、从事针灸和外科的临床试验专家、统计专家、临床流行病学和方法学专家以及患者组成的国际临床研究小组联合制订。该共识将有助于临床试验资助者、注册者以及期刊编辑等评估针刺RCT方案及研究结果的相关性、重要性和质量。 | 张誉清 焦睿珉 Claudia M Witt 劳力行 刘建平 Lehana Thabane Karen J Sherman Mike Cummings Dawn P Richards Eun-Kyung Anna Kim Tae-Hun Kim Myeong Soo Lee Michael E Wechsler Benno Brinkhaus Jun J Mao Caroline A Smith 岗卫娟 刘保延 刘志顺 刘岩 郑晖 吴佳霓 AloBSO Carrasco-Labra Mohit Bhandari Philip J Devereaux 景向红 Gordon Guyatt | 2022 | 英国医学杂志中文版2022，25，6： | 7 |
| 5 | Cellular response to influenza virus infection: a potential role for autophagy in CXCL10 and interferon-alpha induction显示文摘Historically,influenza pandemics have arisen from avian influenza viruses.Avian influenza viruses H5N1 and H9N2 are potential pandemic candidates.Infection of humans with the highly pathogenic avian influenza H5N1 virus is associated with a mortality in excess of 60%,which has been attributed to dysregulation of the cytokine system.Human macrophages and epithelial cells infected with some genotypes of H5N1 and H9N2 viruses express markedly elevated cytokine and chemokine levels when compared with seasonal influenza A subtype H1N1 virus.The mechanisms underlying this cytokine and chemokine hyperinduction are not fully elucidated.In the present study,we demonstrate that autophagy,a tightly regulated homeostatic process for self-digestion of unwanted cellular subcomponents,plays a role in cytokine induction.Autophagy is induced to a greater extent by H9N2/G1,in association with cytokine hyperinduction,compared with H1N1 and the novel pandemic swine-origin influenza A/H1N1 viruses.Using 3-methyladenine to inhibit autophagy and small interfering RNA to silence the autophagy gene,Atg5,we further show that autophagic responses play a role in influenza virus-induced CXCL10 and interferon-a expression in primary human blood macrophages.Our results provide new insights into the pathogenic mechanisms of avian influenza viruses. | Anna Hing-Yee Law Davy Chun-Wai Lee Kwok-Yung Yuen Malik Peiris Allan Sik-Yin Lau | 2010 | Cellular & Molecular Immunology2010，7，4： | 7 |
| 6 | Maintenance Peginterferon Therapy and Other Factors Associated With Hepatocellular Carcinoma in Patients With Advanced Hepatitis C显示文摘 | Anna S. Lok James E. Everhart Elizabeth C. Wright Adrian M. Di Bisceglie Hae–Young Kim Richard K. Sterling Gregory T. Everson Karen L. Lindsay William M. Lee Herbert L. Bonkovsky Jules L. Dienstag Marc G. Ghany Chihiro Morishima Timothy R. Morgan | 2011 | Gastroenterology2011，，3： | 4 |
| 7 | Incidence of Hepatocellular Carcinoma and Associated Risk Factors in Hepatitis C-Related Advanced Liver Disease显示文摘 | Anna S. Lok Leonard B. Seeff Timothy R. Morgan Adrian M. di Bisceglie Richard K. Sterling Teresa M. Curto Gregory T. Everson Karen L. Lindsay William M. Lee Herbert L. Bonkovsky Jules L. Dienstag Marc G. Ghany Chihiro Morishima Zachary D. Goodman | 2009 | Gastroenterology2009，，1： | 3 |
| 8 | 《互动本能:语言的演化与习得》介绍显示文摘《互动本能:语言的演化与习得》(The Interactional Instinct:The Evolution and Acquisition of Language)是牛津大学出版社2009年出版的一部以复杂科学为理论基础,讨论语言演化及习得的著作。该书由加州大学的Namhee Lee,Lisa Mikesell,Anna L.Dinal Joaquin,Andrea W.Mates和John Schumann五位学者撰写。著者以《互动本能》为题名,似有意与Pinker(2000)的《语言本能》形成对照,凸显两种截然不同的语言观。本书否认生成语言学的基本观点,认为语言是一个典型的复杂适应系统,其演化及习得都与人的互动本能紧密相关:即人天生具有为建立社会亲和(social affiliation)和社会依附(social attachment)而与他人进行互动的本能。 | Namhee Lee Lisa Mikesell Anna L.Dinal Joaquin Andrea W.Mates John Schumann 高育松 薛小梅 | 2012 | 当代语言学2012，14，3： | 3 |
| 9 | Machine Learning-Based Presymptomatic Detection of Rice Sheath Blight Using Spectral Profiles显示文摘Early detection of plant diseases,prior to symptom development,can allow for targeted and more proactive disease management.The objective of this study was to evaluate the use of near-infrared(NIR)spectroscopy combined with machine learning for early detection of rice sheath blight(ShB),caused by the fungus Rhizoctonia solani.We collected NIR spectra from leaves of ShBsusceptible rice(Oryza sativa L.)cultivar,Lemont,growing in a growth chamber one day following inoculation with R.solani,and prior to the development of any disease symptoms.Support vector machine(SVM)and random forest,two machine learning algorithms,were used to build and evaluate the accuracy of supervised classification-based disease predictive models.Sparse partial least squares discriminant analysis was used to confirm the results.The most accurate model comparing mockinoculated and inoculated plants was SVM-based and had an overall testing accuracy of 86.1%(N=72),while when control,mock-inoculated,and inoculated plants were compared the most accurate SVM model had an overall testing accuracy of 73.3%(N=105).These results suggest that machine learning models could be developed into tools to diagnose infected but asymptomatic plants based on spectral profiles at the early stages of disease development.While testing and validation in field trials are still needed,this technique holds promise for application in the field for disease diagnosis and management. | Anna O.Conrad Wei Li Da-Young Lee Guo-Liang Wang Luis Rodriguez-Saona Pierluigi Bonello | 2020 | Plant Phenomics2020，2，1： | 3 |
| 10 | Identification of Molecular Subtypes of Gastric Cancer with Different Responses to PI3-Kinase Inhibitors and 5-Fluorouracil显示文摘 | Zhengdeng Lei Iain Beehuat Tan Kakoli Das Niantao Deng Hermioni Zouridis Sharon Pattison Clarinda Chua Zhu Feng Yeoh Khay Guan Chia Huey Ooi Tatiana Ivanova Shenli Zhang Minghui Lee Jeanie Wu Anna Ngo Sravanthy Manesh Elisabeth Tan Bin Tean Teh Jimmy Bok | 2013 | Gastroenterology2013，，： | 2 |
| 11 | 指导性集体锻炼对治疗中的早期乳腺癌妇女的益处:实用性随机对照试验显示文摘目的确定12周指导性集体锻炼对治疗中的早期乳腺癌患者在机体功能和心理上的获益,并随访6个月。设计实用性、前瞻性、随机对照、开放性试验。地点苏格兰3家国家医疗卫生服务体系肿瘤门诊和社区运动设施。参加者共203位妇女参加研究;其中177位完成6个月随访。干预与常规护理相对照,干预组予12周指导性集体锻炼加常规护理。主要结果评价癌症治疗功能评价(FACT)问卷、贝克抑郁问卷、正性和负性情绪量表、体重指数、7日体力活动回忆问卷、12分钟步行实验和肩关节活动度评估。结果对基线值、研究中心、基线治疗和参加干预试验时的年龄进行校正后,综合效应模型的评估结果(干预组减对照组)显示第12周时:12分钟步行距离为129米(95%可信区间83~176),1周的中等强度活动时间182分钟(75~289),肩关节活动度2.6(1.6~3.7),乳腺癌特定的生活质量量表2.5(1.0~3.9),正性情绪4.0(1.8~6.3)。初步结果未发现干预锻炼对生活质量综合量表(FACT-G)有影响。随访6个月后,大多数效果维持不变,并且在乳腺癌特定的生活质量上得到改善。尚未有不良反应的报道。结论在12周干预锻炼结束时以及6个月后,指导性集体锻炼均显示出机体功能和心理上的获益。因此临床医生应该鼓励患者活动,决策者们应该考虑把体育锻炼纳入到癌症康复服务中来。试验注册号当前对照试验 ISRCTN12587864[controlled-trial.com]。 | Nanette Mutrie Anna M Campbell Fiona Whyte Alex McConnachie Carol Emslie Laura Lee Nora Kearney Andrew Walker Diana Ritchie 方桦(译) 王燕(校) | 2007 | 英国医学杂志中文版2007，10，4： | 2 |
| 12 | Development of an Accurate Index for Predicting Outcomes of Patients With Acute Liver Failure显示文摘 | Anna Rutherford Lindsay Y. King Linda S. Hynan Chetan Vedvyas Wenyu Lin William M. Lee Raymond T. Chung | 2012 | Gastroenterology2012，，5： | 2 |
| 13 | Persistent elevation of high mobility group box-1 protein (HMGB1) in patients with severe sepsis and septic shock显示文摘 | Jonas Sundén-Cullberg Anna Norrby-Teglund Ari Rouhiainen Heikki Rauvala Gunilla Herman Kevin J. Tracey Martin L. Lee Jan Andersson Leif Tokics Carl Johan Treutiger | 2005 | Critical Care Medicine2005，，3： | 2 |
| 14 | Mitochondrial dysfunction promotes cell migration via reactive oxygen species-enhanced β5-integrin expression in human gastric cancer SC-M1 cells显示文摘 | Wen-Yi Hung Kuo-Hung Huang Chew-Wun Wu Chin-Wen Chi Hwa-Li Kao Anna Fen-Yau Li Pen-Hui Yin Hsin-Chen Lee | 2012 | BBA - General Subjects2012，，7： | 2 |
| 15 | Pancreatic pseudocyst filled with semisolid lipids mimicking solid mass on endoscopic ultrasound显示文摘Pancreatic pseudocysts,which account for 70%-90% of pancreatic cystic lesions,characteristically are non-epithelially lined cystic cavities that are contiguous with the pancreas. Pancreatic pseudocysts can be caused by acute,chronic or traumatic pancreatitis and should be differentiated from other pancreatic diseases with cystic appearances,especially cystic neoplasms. We report a unique case of a pancreatic pseudocyst filled with semisolid lipids,which appeared by endoscopic ultrasound as a solid mass,and was therefore resected. | Sang-Woo Cha Sae Hee Kim Hyang Ie Lee Yun Jung Lee Hyeon Woong Yang Sung Hee Jung Anna Kim Min Koo Lee Hyun Young Han Dong Wook Kang | 2010 | World Journal of Gastroenterology2010，16，8： | 2 |
| 16 | 烟酰胺腺嘌呤二核苷酸类CD38抑制剂的合成及生物活性评价显示文摘分别以1,3,5-三苯甲酰基-α-D-核糖、3,5-二苯甲酰基-2-脱氧-2,2-二氟戊呋喃糖-1-酮和D-木糖为原料,经由烟酰胺核苷及烟酰胺核苷酸中间体,合成了系列糖环经氟原子取代的烟酰胺腺嘌呤二核苷酸(NAD)类CD38抑制剂.基于对CD38的水解抑制能力的考察,评价了所合成氟代NAD类似物的活性.结果表明,糖环上氟原子取代的数目和位置对抑制剂活性的影响十分明显,烟酰胺核苷的端基构型对活性的影响较大.2个化合物均显示出非常好的CD38抑制活性,其中化合物2a的抑制活性高出阳性对照物阿糖型氟代烟酰胺腺嘌呤二核苷酸2个数量级. | 陈哲 KWONG Anna Ka-Yee 杨振军 张亮仁 LEE Hon Cheung 张礼和 | 2012 | 高等学校化学学报2012，33，6： | 2 |
| 17 | Des-γ-Carboxy Prothrombin and α-Fetoprotein as Biomarkers for the Early Detection of Hepatocellular Carcinoma显示文摘 | Anna S. Lok Richard K. Sterling James E. Everhart Elizabeth C. Wright John C. Hoefs Adrian M. Di Bisceglie Timothy R. Morgan Hae–Young Kim William M. Lee Herbert L. Bonkovsky Jules L. Dienstag | 2010 | Gastroenterology2010，，2： | 2 |
| 18 | Differentiation ofnestin-positive cells derived from bone marrow into pancreaticendocrine and ductal cells in vitro显示文摘 | Anna Milanesi Jang-Won Lee Qijin Xu | 2011 | Journal of Endocrinology2011，209，2： | 1 |
| 19 | Fibroblast Growth Factor 23, Bone Mineral Density, and Risk of Hip Fracture Among Older Adults: The Cardiovascular Health Study显示文摘 | Anna Jovanovich Petra Bù?ková Michel Chonchol John Robbins Howard A. Fink Ian H. de Boer Bryan Kestenbaum Ronit Katz Laura Carbone Jennifer Lee Gail A. Laughlin Kenneth J. Mukamal Linda F. Fried Michael G. Shlipak Joachim H. Ix | 2013 | The Journal of Clinical Endocrinology & Metabolism2013，，8： | 1 |
| 20 | Incidence of Hepatocellular Carcinoma and Associated Risk Factors in Hepatitis C-Related Advanced Liver Disease显示文摘 | Anna S. Lok Leonard B. Seeff Timothy R. Morgan Adrian M. di Bisceglie Richard K. Sterling Teresa M. Curto Gregory T. Everson Karen L. Lindsay William M. Lee Herbert L. Bonkovsky Jules L. Dienstag Marc G. Ghany Chihiro Morishima Zachary D. Goodman | 2009 | Gastroenterology2009，，1： | 1 |
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