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| 1 | Stem cell therapy for chronic skin wounds in the era of personalized medicine:From bench to bedside显示文摘With the significant financial burden of chronic cutaneous wounds on the healthcare system,not to the personal burden mention on those individuals afflicted,it has become increasingly essential to improve our clinical treatments.This requires the translation of the most recent benchtop approaches to clinical wound repair as our current treatment modalities have proven insufficient.The most promising potential treatment options rely on stem cellbased therapies.Stem cell proliferation and signaling play crucial roles in every phase of the wound healing process and chronic wounds are often associated with impaired stem cell function.Clinical approaches involving stem cells could thus be utilized in some cases to improve a body’s inhibited healing capacity.We aim to present the laboratory research behind the mechanisms and effects of this technology as well as current clinical trials which showcase their therapeutic potential.Given the current problems and complications presented by chronic wounds,we hope to show that developing the clinical applications of stem cell therapies is the rational next step in improving wound care. | Elam Coalson Elliot Bishop Wei Liu Yixiao Feng Mia Spezia Bo Liu Yi Shen Di Wu Scott Du Alexander J.Li Zhenyu Ye Ling Zhao Daigui Cao Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Rex C.Haydon Lewis Shi Aravind Athiviraham Michael J.Lee Jennifer Moriatis Wolf Guillermo A.Ameer Tong-Chuan He Russell R.Reid | 2019 | Genes & Diseases2019，6，4： | 6 |
| 2 | Predictive biomarkers for immune checkpoint blockade and opportunities for combination therapies显示文摘Immune checkpoint blockade therapies(ICBs)are a prominent breakthrough in cancer immunotherapy in recent years(named the 2013“Breakthrough of the Year”by the Science magazine).Thus far,FDA-approved ICBs primarily target immune checkpoints CTLA-4,PD-1,and PD-L1.Notwithstanding their impressive long-term therapeutic benefits,their efficacy is limited to a small subset of cancer patients.In addition,ICBs induce inadvertent immune-related adverse events(irAEs)and can be costly for long-term use.To overcome these limitations,two strategies are actively being pursued:identification of predictive biomarkers for clinical response to ICBs and multi-pronged combination therapies.Biomarkers will allow clinicians to practice a precision medicine approach in ICBs(biomarker-based patient selection)such as treating triple-negative breast cancer patients that exhibit PD-L1 staining of tumor-infiltrating immune cells in1%of the tumor area with nanoparticle albumin-bound(nab)epaclitaxel plus anti-PD-L1 and treating patients of MSI-H or MMR deficient unresectable or metastatic solid tumors with pembrolizumab(anti-PD-1).Importantly,the insights gained from these biomarker studies can guide rational combinatorial strategies such as CDK4/6 inhibitor/fractionated radiotherapy/HDACi in conjunction with ICBs to maximize therapeutic benefits.Further,with the rapid technological advents(e.g.,ATCT-Seq),we predict more reliable biomarkers will be identified,which in turn will inspire more promising combination therapies. | Hongxing Shen Eddy Shih-Hsin Yang Marty Conry John Fiveash Carlo Contreras James A.Bonner Lewis Zhichang Shi | 2019 | Genes & Diseases2019，6，3： | 5 |
| 3 | Ultra-high-resolution detection of Pb2+ ions using a black phosphorus functionalized microfiber coil resonator显示文摘A black phosphorus(BP) functionalized optical fiber sensor based on a microfiber coil resonator(MCR) for Pb^2+ ion detection in an aquatic environment is presented and experimentally demonstrated. The MCR-BP sensor is manufactured by winding a tapered microfiber on a hollow rod composed of a low-refractive-index polycarbonate(PC) resin with the BP deposited on the internal wall of the rod. Based on the propagation properties of the MCR, the chemical interaction between the Pb^2+ ions and the BP alters the refractive index of the ambient environment and thus results in a detectable shift in the transmission spectrum. The resonance wavelength moves towards longer wavelengths with an increasing concentration of Pb^2+ ions, and the sensor has an ultra-high detection resolution of 0.0285 ppb(parts per billion). The temperature dependence is 106.95 pm/°C due to the strong thermo-optic and thermal-expansion effect of the low-refractive-index PC resin. In addition, the sensor shows good stability over a period of 15 days. The local pH also influences the sensor, with the resonance wavelength shift increasing as pH approaches a value of 7 but then decreasing as the pH value increases further due to the effect of the BP layer by H^+ and OH-ions. The sensor shows the potential for high-resolution detection of Pb^2+ ions in a liquid environment with the particular advantages of having a simple structure, ease of fabrication,low cost, low loss, and simple interrogation. | YU YIN SHI LI SHUNBIN WANG SHIJIE JIA JING REN GERALD FARRELL ELFED LEWIS PENGFEI WANG | 2019 | Photonics Research2019，7，6： | 2 |
| 4 | Development and mapping of microsatellite (SSR) markers in wheat显示文摘 | Q. J. Song J. R. Shi S. Singh E. W. Fickus J. M. Costa J. Lewis B. S. Gill R. Ward P. B. Cregan | 2005 | Theoretical and Applied Genetics2005，，3： | 2 |
| 5 | Bietti Crystalline Corneoretinal Dystrophy Is Caused by Mutations in the Novel Gene CYP4V2显示文摘 | Anren Li Xiaodong Jiao Francis L. Munier Daniel F. Schorderet Wenliang Yao Fumino Iwata Mutsuko Hayakawa Atsushi Kanai Muh Shy Chen Richard Alan Lewis John Heckenlively Richard G. Weleber Elias I. Traboulsi Qingjiong Zhang Xueshan Xiao Muriel Kaiser-Kupfe | 2004 | The American Journal of Human Genetics2004，，5： | 1 |
| 6 | Electrophysiological features of inherited demyelinating neuropathies:a reappraisal in the ear of moleculav diagnosis显示文摘 | Lewis RA Sumner AJ Shy ME | 2000 | Muscle Nerve2000，23，： | 1 |
| 7 | Development and mapping of microsatellite(SSR)markers in wheat显示文摘 | Song Q.J Shi J.R Singh S Fickus E.W. Costa J.M. Lewis J. Gill B.S. Ward R. Cregan P.B | | 0，，03： | 1 |
| 8 | A pipeline that integrates the discovery and verification of plasma protein biomarkers reveals candidate markers for cardiovascular disease显示文摘 | Addona T A Shi X Keshishian H Mani D R Burgess M Gillette M A Clauser K R Shen D Lewis G D Farrell L A Fifer M A Sabatine M S Gerszten R E Carr S A | | 0，，07： | 1 |
| 9 | Metabolic checkpoints in neurodegenerative T helper 17(TH17) and neuroregenerative regulatory T(Treg) cells as new therapeutic targets for multiple sclerosis显示文摘The central nervous system (CNS) is an immune-privileged site with tightly-regulated immune responses, a concept proposed by Nobel Laureate Sir Peter Medawar in 1960. Under physiological conditions, only a few T lymphocytes conducting immunosurveillance can infiltrate the CNS. | Hongxing Shen James A. Bonner Lewis Zhichang Shi | 2020 | Neural Regeneration Research2020，15，2： | 1 |
| 10 | Distribution of Body Fat and Its Influence on Esophageal Inflammation and Dysplasia in Patients With Barrett’s Esophagus显示文摘 | Eric M. Nelsen Yujiro Kirihara Naoki Takahashi Qian Shi Jason T. Lewis Vikneswaran Namasivayam Navtej S. Buttar Kelly T. Dunagan Ganapathy A. Prasad | 2012 | Clinical Gastroenterology and Hepatology2012，，7： | 1 |
| 11 | The Effects of Gene Polymorphisms in Interleukin-4 and Interleukin-6 on the Susceptibility of Rheumatoid Arthritis in a Chinese Population显示文摘 | Xiang Li Wei Chai Ming Ni Meng Xu Zijian Lian Lewis Shi Yang Bai Yan Wang Wei Chiao Chang | 2014 | BioMed Research International2014，，： | 1 |
| 12 | Distribution of Body Fat and Its Influence on Esophageal Inflammation and Dysplasia in Patients With Barrett’s Esophagus显示文摘 | Eric M. Nelsen Yujiro Kirihara Naoki Takahashi Qian Shi Jason T. Lewis Vikneswaran Namasivayam Navtej S. Buttar Kelly T. Dunagan Ganapathy A. Prasad | 2012 | Clinical Gastroenterology and Hepatology2012，，7： | 1 |
| 13 | Regulation of JNK and p38MAPK in the immune system:Signal integration,propagation and ter- mination显示文摘 | Gonghua Huang Lewis Zhichang Shi Hongbo Chi | 2009 | Cytokine2009，48，3： | 1 |
| 14 | 一个基于深度学习的眼病和肺炎两大类疾病的AI诊断系统显示文摘文章简介本研究开发了一个基于深度学习框架能诊断致盲性视网膜疾病的人工智能(AI)诊断工具。而且,该AI诊断工具还可用于诊断小儿肺炎。这是一项将AI应用于医疗领域的重磅研究成果,有望高精确诊断多种可治疗性疾病。在眼科治疗中,视网膜OCT(光学相干断层扫描)成像技术是最常用的诊断技术之一。 | Daniel S.Kermany Michael Goldbaum Wenjia Cai Carolina C.S.Valentim Huiying Liang Sally L.Baxter Alex McKeown Ge Yang Xiaokang Wu Fangbing Yan Justin Dong Made K.Prasadha Jacqueline Pei Magdalene Y.L.Ting Jie Zhu Christina Li Sierra Hewett Jason Dong Ian Ziyar Alexander Shi Runze Zhang Rui Hou William Shi Xin Fu Yaou Duan Viet A.N. Huu Cindy Wen Edward D. Zhang Charlotte L. Zhang Oulan Li Xiaobo Wang Michael A. Singer Xiaodong Sun Jie Xu Ali Tafreshi M. Anthony Lewis Huimin Xia 张康 | 2019 | 科学新闻2019，0，2： | 1 |
| 15 | Long noncoding RNA(lncRNA)H19:An essential developmental regulator with expanding roles in cancer,stem cell differentiation,and metabolic diseases显示文摘Recent advances in deep sequencing technologies have revealed that,while less than 2%of the human genome is transcribed into mRNA for protein synthesis,over 80%of the genome is transcribed,leading to the production of large amounts of noncoding RNAs(ncRNAs).It has been shown that ncRNAs,especially long non-coding RNAs(lncRNAs),may play crucial regulatory roles in gene expression.As one of the first isolated and reported lncRNAs,H19 has gained much attention due to its essential roles in regulating many physiological and/or pathological processes including embryogenesis,development,tumorigenesis,osteogen-esis,and metabolism.Mechanistically,H19 mediates diverse regulatory functions by serving as competing endogenous RNAs(CeRNAs),Igf2/H19 imprinted tandem gene,modular scaffold,cooperating with H19 antisense,and acting directly with other mRNAs or lncRNAs.Here,we summarized the current understanding of H19 in embryogenesis and development,cancer development and progression,mesenchymal stem cell lineage-specific differentiation,and metabolic diseases.We discussed the potential regulatory mechanisms underlying H19’s func-tions in those processes although more in-depth studies are warranted to delineate the exact molecular,cellular,epigenetic,and genomic regulatory mechanisms underlying the physiolog-ical and pathological roles of H19.Ultimately,these lines of investigation may lead to the development of novel therapeutics for human diseases by exploiting H19 functions. | Junyi Liao Bowen Chen Zhenglin Zhu Chengcheng Du Shengqiang Gao Guozhi Zhao Piao Zhao Yonghui Wang Annie Wang Zander Schwartz Lily Song Jeffrey Hong William Wagstaff Rex CHaydon Hue HLuu Jiaming Fan Russell RReid Tong-Chuan He Lewis Shi Ning Hu Wei Huang | 2023 | Genes & Diseases2023，10，4： | 1 |
| 16 | Hereditary neuropathy with liability to pressure palsy: the electrophysiology fits the name显示文摘 | Li J Krajewski K Shy M E Lewis R A | 2002 | Neurology2002，58，： | 1 |
| 17 | The tomato genome sequence provides insights into fleshy fruit evolution 显示文摘 | Sato S Tabata S Hirakawa H Asamizu E Shlrasawa K Isobe S Kaneko T Nakamura Y Shibata D Aoki K Egholm M Knight J Bogden R Li C Shuang Y Xu X Pan S Cheng S Liu X Ren Y Wang J Albiero A Dal Pero F Todesco S Van Eck J Buels R M Bombarely A Gosselin J R Huang M Leto J A Menda N Strickler S Mao L Gao S Tecle I Y York T Zheng Y Vrebalov JT Lee J Zhong S Mueller L A Stiekema W J Ribeca P Alioto T Yang W Huang S Du Y Zhang Z Gao J Guo Y Wang X Li Y He J Li C Cheng Z Zuo J Ren J Zhao J Yan L Jiang H Wang B Li H Li Z Fu F Chen B Feng Q Fan D Wang Y Ling H Xue Y Ware D McCombie W R Lippman Z B Chia J M Jiang K Pasternak S Gelley L Kramer M Anderson L K Chang S B Royer S M Shearer L A Stack S M Rose J K Xu Y Eannetta N Matas A J McQuinn R Tanksley S D Camara F Guiga R Rombauts S Fawcett J Van de Peer Y Zamir D Liang C Spannagl M Gundlach H Bruggmann R Mayer K Jia Z Zhang J Ye Z Bishop G J Butcher S Lopez-Cobollo R Buchan D Filippis I Abbott J Dixit R Singh M Singh A Pal J K Pandit A Singh P K Mahato A K Gaikwad V D Sharma R R Mohapatra T Singh N K Causse M Rothan C Schiex T Noirot C Bellec A Klopp C Delalande C Berges H Mariette J Frasse P Vautrin S Zouine M Latch6 A Rousseau C Regad F Pech J C Philippot M Bouzayen M Pericard P Osorio S Fernandez del Carmen A Monforte A Granell A Fernandez-Mufioz R Conte M Lichtenstein G Carrari F De Bellis G Fuligni F Peano C Grandillo S Termolino P Pietrella M Fantini E Falcone G Fiore A Giuliano G Lopez L Facella P Perotta G Daddiego L Bryan G Orozco M Pastor X Torrents D van Schriek M G Feron R M van Oeveren J de Heer P daPonte L Jacobs-Oomen S Cariaso M Prins M van Eijk M J Janssen A van Haaren M J Jungeun Kim S H Kwon S Y Kim S Koo D H Lee S Hur C G Clouser C Rico A Hallab A Gebhardt C Klee K Jocker A Warfsmann J Gobel U Kawamura S Yano K Sherman J D Fukuoka H Negoro S Bhutty S Chowdhury P Chattopadhyay D Datema E Smit S Schijlen E G van de Belt J van Haarst J C Peters S A van Staveren M A Henkens M H Mooyman P J Hesselink T van Ham R C Jiang G Droege M Choi D Kang B C Kim B D Park M Kim S Yeom SI Lee YH Choi Y D Li G Gao J Liu Y Huang S Fernandez-Pedrosa V Collado C Zufiiga S Wang G Cade R Dietrich R A Rogers J Knapp S Fei Z White R A Thannhauser T W Giovannoni J J Botella M A Gilbert L Gonzalez R Goieoechea J L Yu Y Kudrna D Collura K Wissotski M Wing R Meyers BC Gurazada AB Green P J Vyas S M Solanke A U Kumar R Gupta V Sharma A K Khurana P Khurana J P Tyagi A K Dalmay T Mohorianu 1 Waits B Chamala S Barbazuk W B Li J Guo H Lee T H Wang Y Zhang D Paterson A H Wang X Tang H Barone A Chiusano M L Ereolano M R D' Agostino N Di Filippo M Traini A Sanseverino W Frusciante L Seymour G B Elharam M Fu Y Hua A Kenton S Lewis J Lin S Najar F Lai H Qin B Qu C Shi R White D White J Xing Y Yang K Yi J Yao Z Zhou L Roe B A Vezzi A D' Angelo M Zimbello R Sehiavon R Caniato E Rigobello C Campagna D Vitulo N Valle G Nelson D R De Paoli E Szinay D de Jong H H Bai Y Visser R G Klein R Beasley H McLaren K Nicholson C Riddle C Gianese G | 2012 | Nature2012，485，7400： | 1 |
| 18 | Corrigendum to “Sox9 augments BMP2-induced chondrogenic differentiation by downregulating Smad7 in mesenchymal stem cells (MSCs)” [Genes & Diseases 4 (2017) 229–239]显示文摘The authors regret having image assembly errors in Figure 1A and Figure 3A.Specifically,in Figure 1A,the images for'C3H10T1/2',''BMP2'and'Sox9'were erroneously duplicated with the images from an irrelevant experiment that was conducted at the same time.In Figure 3A,the images for'Col2a1'and'β-actin'were erroneously duplicated with the images from an irrelevant experiment that was conducted at the same time. | Chen Zhao Wei Jiang Nian Zhou Junyi Liao Mingming Yang Ning Hu Xi Liang Wei Xu Hong Chen Wei Liu Lewis L. Shi Leonardo Oliveira Jennifer Moriatis Wolf Sherwin Ho Aravind Athiviraham H.M. Tsai Tong-Chuan He Wei Huang | 2023 | Genes & Diseases2023，10，2： | 0 |
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