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| 1 | Corrosion and biocompatibility improvement of magnesium-based alloys as bone implant materials:a review显示文摘Magnesium(Mg)or its alloys are widely tested as potential orthopedic implants,particularly as biodegradable alloys for fracture fixation due to their mechanical properties are close to those of bone.Currently,available Mg or its alloys are confronted with challenges in passing regulatory biosafety tests prior to clinical trials due to its fast degradation and associated degradation products.The degradation of Mg is accompanied by the release of Mg ions,the rise of pH and osmolality in surrounding environments.According to the standard of ISO 10993 Part 13,the pH value shall be appropriate to the site of intended use maintaining in an appropriate range.Approaches to overcome these challenges include the selection of adequate alloying elements,proper surface treatment techniques and control of the degradation rate of Mg or its alloys developed as orthopedic implants.To date,Mg or its alloy-based bone implants have not yet been widely used in clinical applications as medical implants.This review critically summarized published methods to improve the corrosion resistance of Mg and its alloys.The current progress on in vitro cytotoxicity and in vivo biocompatibility properties of these metals was also reviewed.This review aimed to provide a reference for further research and development(R&D)of biodegradable Mg and its alloys with regard to the evaluation of their corrosion process and biocompatibility and facilitation of their translation to clinical applications. | Long Li Ming Zhang Ye Li Jie Zhao Ling Qin Yuxiao Lai | 2017 | Regenerative Biomaterials2017，4，2： | 9 |
| 2 | Scalable volumetric imaging for ultrahigh-speed brain mapping at synaptic resolution显示文摘The speed of high-resolution optical imaging has been a rate-limiting factor for meso-scale mapping of brain structures and functional circuits,which is of fundamental importance for neuroscience research.Here,we describe a new microscopy method of Volumetric Imaging with Synchronized on-the-fly-scan and Readout(VISo R)for high-throughput,high-quality brain mapping.Combining synchronized scanning beam illumination and oblique imaging over cleared tissue sections in smooth motion,the VISo R system effectively eliminates motion blur to obtain undistorted images.By continuously imaging moving samples without stopping,the system achieves high-speed 3D image acquisition of an entire mouse brain within1.5 hours,at a resolution capable of visualizing synaptic spines.A pipeline is developed for sample preparation,imaging,3D image reconstruction and quantification.Our approach is compatible with immunofluorescence methods,enabling flexible cell-type specific brain mapping and is readily scalable for large biological samples such as primate brains.Using this system,we examined behaviorally relevant whole-brain neuronal activation in 16 c-Fos-sh EGFP mice under resting or forced swimming conditions.Our results indicate the involvement of multiple subcortical areas in stress response.Intriguingly,neuronal activation in these areas exhibits striking individual variability among different animals,suggesting the necessity of sufficient cohort size for such studies. | Hao Wang Qingyuan Zhu Lufeng Ding Yan Shen Chao-Yu Yang Fang Xu Chang Shu Yujie Guo Zhiwei Xiong Qinghong Shan Fan Jia Peng Su Qian-Ru Yang Bing Li Yuxiao Cheng Xiaobin He Xi Chen Feng Wu Jiang-Ning Zhou Fuqiang Xu Hua Han Pak-Ming Lau Guo-Qiang Bi | 2019 | National Science Review2019，6，5： | 7 |
| 3 | The RppC-AvrRppC NLR-effector interaction mediates the resistance to southern corn rust in maize显示文摘Southern corn rust(SCR),caused by the fungal pathogen Puccinia polysora,is a major threat to maize pro-duction worldwide.Efficient breeding and deployment of resistant hybrids are key to achieving durable control of SCR.Here,we report the molecular cloning and characterization of RppC,which encodes an NLR-type immune receptor and is responsible for a major SCR resistance quantitative trait locus.Further-more,we identified the corresponding avirulence effector,AvrRppC,which is secreted by P.polysora and triggers RppC-mediated resistance.Allelic variation of AvrRppC directly determines the effectiveness of RppC-mediated resistance,indicating that monitoring of AvrRppC variants in the field can guide the rational deployment of RppC-containing hybrids in maize production.Currently,RppC is the most frequently deployed SCR resistance gene in China,and a better understanding of its mode of action is crit-ical for extending its durability. | Ce Deng April Leonard James Cahill Meng Lv Yurong Li Shawn Thatcher Xueying Li Xiaodi Zhao Wenjie Du Zheng Li Huimin Li Victor Llaca Kevin Fengler Lisa Marshall Charlotte Harris Girma Tabor Zhimin Li Zhiqiang Tian Qinghua Yang Yanhui Chen Jihua Tang Xintao Wang Junjie Hao Jianbing Yan Zhibing Lai Xiaohong Fei Weibin Song Jinsheng Lai Xuecai Zhang Guoping Shu Yibo Wang Yuxiao Chang Weiling Zhu Wei Xiong Juan Sun Bailin Li Junqiang Ding | 2022 | Molecular Plant2022，15，5： | 6 |
| 4 | Network pharmacological prediction and molecular docking analysis of the combination of Atractylodes macrocephala Koidz.and Paeonia lactiflora Pall.in the treatment of functional constipation and its verification显示文摘Background:We aimed to reveal the mechanism of functional constipation in the treatment of Atractylodes macrocephala Koidz.(AMK)and Paeonia lactiflora Pall.(PLP).Methods:The main active ingredients of AMK and PLP were screened by the Traditional Chinese Medicine Systems Pharmacology(TCMSP)platform.A database of functional constipation targets was established by GeneCard and OMIM.An“ingredient-target”network map was constructed with Cytoscape software(version 3.7.1),and molecular docking analysis was performed on the components and genes with the highest scores.The rats in the normal group were given saline,and those in the other groups were given 10 mg/kg diphenoxylate once a day for 14 days.The serum and intestinal tissue levels of adenosine monophosphate(cAMP),protein kinase A(PKA),and adenylyl cyclase(AC)of the rats and aquaporin(AQP)1,AQP3,and AQP8 were measured.Results:AMK and PLP had a significant role in the regulation of targets in the treatment of functional constipation.After treatment with AMK,PLP,or mosapride,the serum and intestinal tissue levels of AC,cAMP,and PKA were significantly downregulated.Groups receiving AMK and PLP or mosapride exhibited a reduction in the level of AQP1,AQP3,and AQP8 to varying degrees.Conclusion:Molecular docking analysis revealed that AMK and PLP had a significant role in the regulation of targets in the treatment of functional constipation.Studies have confirmed that AMK and PLP can also affect AC,cAMP,and PKA.AC,cAMP,and PKA in model rats were significantly downregulated.AQP expression is closely related to AC,cAMP,and PKA.AMK and PLP can reduce the expression of AQP1,AQP3,and AQP9 in the colon of constipated rats. | Yuxiao Meng Xiaojun Li Xiaoting Wang Lu Zhang Jiaqi Guan | 2022 | Animal Models and Experimental Medicine2022，5，2： | 4 |
| 5 | The Development of a Two-finger Dexterous Bionic Hand with Three Grasping Patterns-NWAFU Hand显示文摘Bionic inspiration from human thumb and index finger was the drive to design a high-performance two-finger dexterous hand.The size of each phalanx and the motion range of each joint in the human thumb and index finger were summarized,and the features of three grasping patterns were described in detail.Subsequently,a two-finger dexterous bionic hand with 6 Degrees of Freedom(DoFs)was developed.Both the mechanical thumb and index finger were made up of three rigid phalanx links and three mechanical rotation joints.Some grasp-release tests validated that the bionic hand can perform three grasping patterns:power grasp,precision pinch and lateral pinch.The grasping success rates were high under the following cases:(1)when power grasping was used to grasp a ring with external diameter 20 mm-140 mm,a cylinder with mass<500 g,or objects with cylinder,sphere or ellipsoid shape;(2)when the precision pinch was used to grasp thin or small objects;(3)when the lateral pinch was used to grasp low length-to-width ratio of objects.The work provided a method for developing two-fimger bionic hand with three grasping patterns,and further revealed the linkage between the difference in fimger structure and size and the hand manipulation dexterity. | Zhiguo Li Zhongliang Hou Yuxiao Mao Yan Shang Lukasz Kuta | 2020 | Journal of Bionic Engineering2020，17，4： | 3 |
| 6 | A trilogy antimicrobial strategy for multiple infections of orthopedic implants throughout their life cycle显示文摘Bacteria-associated infection represents one of the major threats for orthopedic implants failure during their life cycles.However,ordinary antimicrobial treatments usually failed to combat multiple waves of infections during arthroplasty and prosthesis revisions etc.As these incidents could easily introduce new microbial pathogens in/onto the implants.Herein,we demonstrate that an antimicrobial trilogy strategy incorporating a sophisticated multilayered coating system leveraging multiple ion exchange mechanisms and fine nanotopography tuning,could effectively eradicate bacterial infection at various stages of implantation.Early stage bacteriostatic effect was realized via nano-topological structure of top mineral coating.Antibacterial effect at intermediate stage was mediated by sustained release of zinc ions from doped CaP coating.Strong antibacterial potency was validated at 4 weeks post implantation via an implanted model in vivo.Finally,the underlying zinc titanate fiber network enabled a long-term contact and release effect of residual zinc,which maintained a strong antibacterial ability against both Staphylococcus aureus and Escherichia coli even after the removal of top layer coating.Moreover,sustained release of Sr2+and Zn2+during CaP coating degradation substantially promoted implant osseointegration even under an infectious environment by showing more peri-implant new bone formation and substantially improved bone-implant bonding strength. | Yikai Wang Wangsiyuan Teng Zengjie Zhang Xingzhi Zhou Yuxiao Ye Peng Lin An Liu Yan Wu Binghao Li Chongda Zhang Xianyan Yang Weixu Li Xiaohua Yu Zhongru Gou Zhaoming Ye | 2021 | Bioactive Materials2021，6，7： | 3 |
| 7 | Antioxidative and hepatoprotective activities of a novel polysaccharide (LSAP) from Lepista sordida mycelia显示文摘A novel alkali-soluble polysaccharide from Lepista sordida(LSAP)mycelia with antioxidative and hepatoprotective activities was characterized.The weight-average molecular weight and number-average molecular weight of LSAP were 1.442×10^(3) and 6.05×10^(2) kDa,respectively.LSAP was consisted of glucose(57.9%),xylose(31.8%),and small amounts of rhamnose,arabinose,galactose,glucuronic acid,and galacturonic acid(1.2%–3.1%).The FT-IR and 2D NMR confi rmed that LSAP was composed of Xylp,Araf,4-O-Me-α-D-GlcpA,(1→4)-linkedβ-D-Glcp,and(1→4)-α-D-GalA,andβ-glycosidic linkages between these sugar units.LSAP displayed notable effects on 1,1-dephenyl-2-picryhydrazyl(DPPH)radical scavenging,hydrogen peroxide scavenging,lipid peroxidation inhibitory ability,reducing power and Fe^(2+)chelating property.These biological effects were further verifi ed by suppressing CCl_(4)-induced oxidative liver damage in mice at doses of 100 and 200 mg/kg.Administration of LSAP in mice prior to CCl_(4) signifi cantly prevented the CCl_(4)-induced elevation in serum alanine aminotransferase,aspartate aminotransferase,and hepatic malondialdehyde.Mice treated with LSAP demonstrated to increase activities in superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px)in the liver.We also found out that LSAP prevented CCl_(4)-induced oxidative liver histological alteration.LSAP may exert hepatoprotective effects against CCl_(4)-induced damage through antioxidant mechanisms in model mice. | Yingyin Xu Yuanhui Li Yuxiao Lu Xiaobin Feng Guoting Tian Qinghong Liu | 2021 | Food Science and Human Wellness2021，10，4： | 2 |
| 8 | Surface modification of magnesium alloys developed for bioabsorbable orthopedic implants: A general review显示文摘 | Jiali Wang Jian Tang Peng Zhang Yangde Li Jue Wang Yuxiao Lai Ling Qin | 2012 | J Biomed Mater Res2012，，6： | 2 |
| 9 | Microstructure and Oxidation Behavior of Modified Aluminide Coating on Ni3Al-based Single Crystal Superalloy显示文摘Al, Al-Si and Cr-Al-Si coatings are prepared onto IC20 alloy by powder pack cementation to improve the oxidation resistance of the alloy. The isothermal oxidation behaviors of the coatings and the uncoated IC20 alloy at 1 100 °C are comparatively investigated. For the coatings, less weight gains are obtained compared to the uncoated alloy after 100 h thermal exposure. The Al-Si coating exhibits the best oxidation resistance, while the addition of Cr accelerates the scale spallation. Phase transformation from β-NiAl to γ and γ′ occurs in the coating after oxidation for extended periods. The oxidation protection and degradation mechanisms for these coatings are discussed. | YANG Ruibo WU Yuxiao WU Qiong LI Shusuo MA Yue GONG Shengkai | 2012 | Chinese Journal of Aeronautics2012，25，5： | 2 |
| 10 | Performance-enhanced and cost-effective triboelectric nanogenerator based on stretchable electrode for wearable SpO2 monitoring显示文摘Recently,stretchable and wearable health monitoring equipment has greatly improved human’s daily life,which sets higher demands for portable power source in stretchability,sustainability,and biocompatibility.In this work,we proposed a stretchable triboelectric nanogenerator(TENG)based on stretchable poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate)(PEDOT:PSS)/porous carbon hybrid for oxyhemoglobin saturation(SpO2)monitoring.To combine advantages of carbon material for its high conductivity and organic electrode for its high stretchability,we spin-coated a solution of PEDOT:PSS/porous carbon onto a plasma-treated pre-stretched Ecoflex film to fabricate a stretchable electrode with rough surface.Due to its roughness and high potential difference with the dielectric material,the stretchable-electrode-based TENG exhibited better performance compared to the pristine TENG based on carbon or PEDOT:PSS material.The output voltage and current reached up to 51.5 V and 13.2μA as the carbon concentration increased.More importantly,the performance further increased under large strain(100%)which is suitable for wearable systems.Finally,the device demonstrated its application potential for powering a flexible blood oxygen monitor.This simple and cost-effective method can enhance the stretchability and stability of organic/inorganic electrode-based TENG,which paves the development of high-performance stretchable TENG. | Huamin Chen Wei Yang Cheng Zhang Mingqiang Wu Wenjie Li Yuxiao Zou Longfeng Lv Hualiang Yu Huizhen Ke Ruping Liu Yun Xu Jun Wang Zhou Li | 2022 | Nano Research2022，15，3： | 2 |
| 11 | A pillared-layer metal-organic framework for efficient separation of C_(3)H_(8)/C_(2)H_(6)/CH_(4) in natural gas显示文摘Metal-organic frameworks(MOFs)have great potentials as adsorbents for natural gas purification.However,the trade-off between selectivity and adsorption capacity remains a challenge.Herein,we report a pillared-layer metal-organic framework Ni(HBTC)(bipy)for efficiently separating the C_(3)H_(8)/C_(2)H_(6)/CH_(4) mixture.The experimental results show that the adsorption capacity of C_(3)H_(8) and C_(2)H_(6) on Ni(HBTC)(bipy)are as high as 6.18 and 5.85 mmol·g^(-1),while only 0.93 mmol·g^(-1) for CH_(4) at 298 K and 100 kPa.Especially,the adsorption capacity of C_(3)H_(8) at 5 kPa can reach an unprecedented 4.52 mmol·g^(-1) and for C_(2)H_(6) it is 1.48 mmol·g^(-1) at 10 kPa.The ideal adsorbed solution theory predicted C_(3)H_(8)/CH_(4) selectivity is as high as 1857.0,superior to most of the reported materials.Breakthrough experiment results indicated that material could completely separate the C_(3)H_(8)/C_(2)H_(6)/CH_(4) mixture.Therefore,Ni(HBTC)(bipy)is a promising material for separation of natural gas. | Pengtao Guo Miao Chang Tongan Yan Yuxiao Li Dahuan Liu | 2022 | Chinese Journal of Chemical Engineering2022，35，2： | 2 |
| 12 | Medical Additive Manufacturing: From a Frontier Technology to the Research and Development of Products显示文摘1.Research and development(R&D)and the challenges of raw materials for medical additive manufacturing Raw materials for medical additive manufacturing have a wide range of commonalities that are also seen in many other fields,making them an important basis in the field of three-dimensional(3D)printing.Problems and challenges related to material types,powder properties,formability,viscoelasticity,and so forth also share common features.For example,many metal materials are used in the field of aviation,while metals,polymers,and inorganic materials are used in the field of biomedicine.The most widely used materials in biomedicine are biocompatible.Various homogeneous and non-homogeneous composites are also available for 3D printing,and impose an additional challenge in additive manufacturing;the use of heterogeneous composites in 3D printing is particularly challenging. | Guixing Qiu Wenjiang Ding Wei Tian Ling Qin Yu Zhao Lianmeng Zhang Jian Lu Daijie Chen Guangyi Yuan Chengtie Wu Bingheng Lu Ruxu Du Jimin Chen Mo Elbestawi Zhongwei Gu Dichen Li Wei Sun Yuanjin Zhao Jie He Dadi Jin Bin Liu Kai Zhang Jianmo Li Kam WLeong Dewei Zhao Dingjun Hao Yingfang Ao Xuliang Deng Huilin Yang ShaoKeh Hsu Yingqi Chen Long Li Jianping Fan Guohui Nie Yun Chen Hui Zeng Wei Chen Yuxiao Lai | 2020 | Engineering2020，6，11： | 1 |
| 13 | 曲古菌素A对HeLa细胞增殖及其基因表达的影响研究(英文)显示文摘调查 p53 的表情的目的, RB1,船边交货, c-fos,地岬,在人的颈的癌症(HeLa ) 的 EGFR mRNA 响应 trichostatin A (TSA ) 的房间。我们与 TSA (0.2 μm/L ) 在不同孵化时间花了 HeLa 房间的计数的方法。当 HeLa 房间为 36 h 被孵化时,结果显示了房间显然改变了的那 HeLa。然后,我们用 SYBR 绿即时 PCR 为 36 h 调查了 HeLa 房间术后疗法的基因表示(mRNA 层次) 。我们表明了的结果那 trichostatin A (TSA ) 能使人的颈的癌症(HeLa ) 成为房间词法变化和 induce HeLa 房间 apoptosis。而且,数据为 36 h,和地岬建议 p53, RB1,船边交货,而是起来调整的 c-fos 基因表达式术后疗法的那条导致 TSA 的下面规定, EGFR 没显示出明显的反应到 TSA 治疗。结论 TSA 在基因表示上有不同效果。 | Guangyong Qin Huasheng Fang Yuxiao Li Fengqiu Zhang | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，5： | 1 |
| 14 | Local hyper- thermia treatment of extensive viral warts in Dafter disease: A case report and literature review 显示文摘 | Li Xiaodong Zhang Chao Hong Yuxiao | 2012 | International Journal of Hy- perthermia2012，28，5： | 1 |
| 15 | Synthesis and gas-sensing properties of ZnO particles from an ionic liquid preeurso显示文摘 | Li Rui Luan Yuxiao Zou Hua | 2012 | RSC Adv2012，2，： | 1 |
| 16 | Genetic determinants of high on-treatment platelet reactivity in clopidogrel treated Chinese patients显示文摘 | Lanning Zhang Yanming Chen Ying Jin Fei Qu Jiayue Li Cong Ma Jie Yang Bin Xu Hongjuan Wang Xiaoqi Li Yang Li Yuxiao Zhang Caiyi Lu Tong Yin | 2013 | Thrombosis Research2013，，： | 1 |
| 17 | The Indicator System Based on BP Neural Network Model for Net - mediated Public Opinion on Unexpected Emergency 显示文摘 | Zhang Yiwen Qi Jiayin Fang Binxing Li Yuxiao | 2011 | China Communications2011，，3： | 1 |
| 18 | Immune responses induced in HHD mice by multiepitope HIV vaccine based on cryptic epitope modhqcation显示文摘 | Yinghui Li Yuxiao Huang Jiao Liang | 2013 | Molecular Biology Reports2013，40，4： | 1 |
| 19 | AChinese liquor classification method based on liquidevaporation with one unmodulated metal oxide gas sensor显示文摘 | Zhou Qiong Zhang Shunping Li Yuxiao | 2011 | Sensors and Actuators B:Chemical2011，160，1： | 1 |
| 20 | The possible role of TRPC6 in atopic dermatitis显示文摘 | Xiao-Dong Sun Yang You Li Zhang Song Zheng Yuxiao Hong Jie Li Xing-Hua Gao | 2011 | Medical Hypotheses2011，，1： | 1 |
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