|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effect of rat serum containing Biejiajian oral liquid on proliferation of rat hepatic stellate cells显示文摘AIM: Liver fibrosis is a common pathological process of chronic liver diseases. Activation of hepatic stellate cells(HSCs) is the key issue in the occurrence of liver fibrosis. In this study, we observed the inhibitory action of rat serum containing Biejiajian oral liquid (BOL), a decoction of turtle shell, on proliferation of rat HSCs, and to explore the antihepatofibrotic mechanisms of BOL.METHODS: A rat model of hepatic fibrosis was induced by subcutaneous injection of CC14. Serum containing low,medium and high dosages of BOL was prepared respectively.Normal and fibrotic HSCs were isolated and cultured. The effect of sera containing BOL on proliferation of HSCs was determined by 3H-TdR incorporation.RESULTS: The inhibitory rate of normal rat HSC proliferation caused by 100 mL/mL sera containing medium and high dosages of BOL showed a remarkable difference as compared with that caused by colchicine (medium dosage group:34.56±4.21% vs29.12±2.85%, P<0.01; high dosage group:37.82±1.32% vs29.12±2.85%, P<0.01). The inhibitory rate of fibrotic rat HSC proliferation caused by 100 mL/L serum containing medium and high dosages of BOL showed a remarkable difference as compared with that caused by colchicine (medium dosage group: 51.31_+3.14% vs 38.32_+2.65%,P<0.01; high dosage group: 60.15_+5.36% vs38.32_+2.65%,P<0.01). The inhibitory rate of normal rat HSC proliferation caused by 100 mL/L and 200 mL/L sera containing a medium dosage of BOL showed a significant difference as compared with that caused by 50 mL/L (100 mL/L group: 69.02±9.96%vs 50.82±9.28%, P<0.05; 200 mL/L group: 81.78±8.92%vs50.82±9.28%, P<0.01). The inhibitory rate of fibrotic rat HSC proliferation caused by 100 mL/L and 200 mL/L sera containing a medium dosage of BOL showed a significant difference as compared with that caused by 50 mL/L (100 mL/L group:72.19±10.96% vs 61.38±7.16%, P<0.05; 200 mL/L group:87.16±8.54% vs 61.38±7.16%, P<0.01).CONCLUSION: Rat serum containing BOL can inhibit proliferation of rat HSCs, and the inhibition depends on the dosage and concentration of BOL. The inhibitory effect on HSC proliferation is one of the main anti-hepatofibroticmechanisms of BOL. | LiYao Zhen-MinYao HengWeng Ge-PingZhao Yue-JunZhou TaoYu | 2004 | World Journal of Gastroenterology2004，10，13： | 12 |
| 2 | Acetylglutamate kinase is required for both gametophyte function and embryo development in Arabidopsis thaliana显示文摘The specific functions of the genes encoding arginine biosynthesis enzymes in plants are not well characterized. We report the isolation and characterization of Arabidopsis thaliana N-acetylglutamate kinase(NAGK), which catalyzes the second step of arginine biosynthesis. NAGK is a plastid-localized protein and is expressed during most developmental processes in Arabidopsis. Heterologous expression of the Arabidopsis NAGK gene in a NAGK-deficient Escherichia coli strain fully restores bacterial growth on arginine-deficient medium. nagk mutant pollen tubes grow more slowly than wild type pollen tubes and the phenotype is restored by either specifically through complementation by NAGK in pollen, or exogenous supplementation of arginine. nagk female gametophytes are defective in micropylar pollen tube guidance due to the fact that female gametophyte cell fate specification was specifically affected. Expression of NAGK in synergid cells rescues the defect of nagk female gametophytes. Lossof-function of NAGK results in Arabidopsis embryos not developing beyond the four-celled embryo stage. The embryo-defective phenotype in nagk/NAGK plants cannot be rescued by watering nagk/NAGK plants with arginine or ornithine supplementation. In conclusion,our results reveal a novel role of NAGK and arginine in regulating gametophyte function and embryo development, and provide valuable insights into arginine transport during embryo development. | Jie Huang Dan Chen Hailong Yan Fei Xie Ying Yu Liyao Zhang Mengxiang Sun Xiongbo Peng | 2017 | Journal of Integrative Plant Biology2017，59，9： | 4 |
| 3 | Optimization of the thermoelectric properties of poly(nickel-ethylenetetrathiolate) synthesized via potentiostatic deposition显示文摘The coordination polymer poly(nickel-ethylenetetrathiolate)(poly(Ni-ett)), formed by nickel(II) and 1,1,2,2-ethenetetrathiolate(ett), is the most promising N-type organic thermoelectric material ever reported; it is synthesized via potentiostatic deposition,and the effect of different applied potentials on the optimal performance of the polymers is investigated. The optimal thermoelectric property of poly(Ni-ett) synthesized at 0.6 V is remarkably greater than that of the polymers synthesized at 1 and 1.6 V, exhibiting a maximum power factor of up to 131.6 μW/mK^2 at 360 K. Furthermore, the structure-property correlation of poly(Ni-ett) is also extensively investigated. X-ray diffraction(XRD) and X-ray photoelectron spectroscopy(XPS) analyses revealed that the larger size of crystalline domains and the higher oxidation state of poly(Ni-ett) synthesized at 0.6 V possibly results in the higher bulk mobility and carrier concentration in the polymer chains, respectively, accounting for the enhanced power factor. | Yuanhui Sun Jiajia Zhang Liyao Liu Yunke Qin Yimeng Sun Wei Xu Daoben Zhu | 2016 | Science China Chemistry2016，59，10： | 3 |
| 4 | cDNA microarray in isolation of novel differentially expressed genes related to human glioma and clone of a novel full- length gene显示文摘Background This investigation was undertaken to obtain differentially expressed genes related to human glioma using cDNA microarray and the characterization of one novel full-length gene. Methods Total RNA was extracted from human glioma tissues and normal brain tissues, and mRNA was used to make probes. After hybridization and washing, the results were scanned using a computer system. The gene named 681F05 clone was an expressed gene to human glioma through four-time hybridization and scanning. Subsequently northern blot analysis was performed by northern blot, 5’RACE and bioinformatics. Results Fifteen differentially expressed genes to human glioma were obtained through four-time hybridization and scanning. Northern blot analysis confirmed that 681F05 clone was low-expressed in human brain tissues and over-expressed in human glioma tissues. The analysis of BLASTn and BLASTx showed that 681F05 clone is two cDNA clones encoding two novel proteins that are highly identified to the cyclophilin isoform 10 of C. Elgans, respectively. Sequence analysis revealed the two cDNA clones are two different splicing variants of a novel cycophilin-like gene (PPIL3a and PPIL3b).Conclusions cDNA microarray technology can be successfully used to identify differentially expressed genes. The novel full-length gene of human PPIL3 may be correlated with the formation of human glioma. | QIZhen-yu HUIGuo-zhen LIYao ZHOUZong-xiang GUShao-hua YINGKang XIEYi | 2005 | Chinese Medical Journal2005，，10： | 3 |
| 5 | Identification of massive molecular markers in Echinochloa phyllopogon using a restriction-site associated DNA approach显示文摘Echinochloa phyllopogon proliferation seriously threatens rice production worldwide. We combined a restriction-site associated DNA(RAD) approach with Illumina DNA sequencing for rapid and mass discovery of simple sequence repeat(SSR) and single nucleotide polymorphism(SNP) markers for E. phyllopogon. RAD tags were generated from the genomic DNA of two E. phyllopogon plants, and sequenced to produce 5197.7 Mb and 5242.9 Mb high quality sequences, respectively. The GC content of E. phyllopogon was 45.8%, which is high for monocots. In total, 4710 putative SSRs were identified in 4132 contigs, which permitted the design of PCR primers for E. phyllopogon. Most repeat motifs among the SSRs identified were dinucleotide(>82%), and most of these SSRs were four motif-repeats(>75%). The most frequent motif was AT, accounting for 36.3%-37.2%, followed by AG and AC. In total, 78 putative polymorphic SSR loci were found. A total of 49,179 SNPs were discovered between the two samples of E. phyllopogon, 67.1% of which were transversions and 32.9% were transitions. We used eight SSRs to study the genetic diversity of four E. phyllopogon populations collected from rice fields in China and all eight loci tested were polymorphic. | Guoqi Chen Wei Zhang Jiapeng Fang Liyao Dong | 2017 | Plant Diversity2017，39，5： | 2 |
| 6 | A chromosome-level genome assembly of rugged rose (Rosa rugosa) provides insights into its evolution, ecology, and floral characteristics显示文摘Rosa rugosa,commonly known as rugged rose,is a perennial ornamental shrub.It produces beautiful flowers with a mild fragrance and colorful seed pods.Unlike many other cultivated roses,R.rugosa adapts to a wide range of habitat types and harsh environmental conditions such as salinity,alkaline,shade,drought,high humidity,and frigid temperatures.Here,we produced and analyzed a high-quality genome sequence for R.rugosa to understand its ecology,floral characteristics and evolution.PacBio HiFi reads were initially used to construct the draft genome of R.rugosa,and then Hi-C sequencing was applied to assemble the contigs into 7 chromosomes.We obtained a 382.6Mb genome encoding 39,704 protein-coding genes.The genome of R.rugosa appears to be conserved with no additional whole-genome duplication after the gamma whole-genome triplication(WGT),which occurred~100 million years ago in the ancestor of core eudicots.Based on a comparative analysis of the high-quality genome assembly of R.rugosa and other high-quality Rosaceae genomes,we found a unique large inverted segment in the Chinese rose R.chinensis and a retroposition in strawberry caused by post-WGT events.We also found that floral development-and stress response signaling-related gene modules were retained after the WGT.Two MADS-box genes involved in floral development and the stress-related transcription factors DREB2A-INTERACTING PROTEIN 2(DRIP2)and PEPTIDE TRANSPORTER 3(PTR3)were found to be positively selected in evolution,which may have contributed to the unique ability of this plant to adapt to harsh environments.In summary,the high-quality genome sequence of R.rugosa provides a map for genetic studies and molecular breeding of this plant and enables comparative genomic studies of Rosa in the near future. | Fei Chen Liyao Su Shuaiya Hu Jia-Yu Xue Hui Liu Guanhua Liu Yifan Jiang Jianke Du Yushan Qiao Yannan Fan Huan Liu Qi Yang Wenjie Lu Zhu-Qing Shao Jian Zhang Liangsheng Zhang Feng Chen Zong-Ming(Max)Cheng | 2021 | Horticulture Research2021，8，1： | 2 |
| 7 | New Methods of Fitting the Membership Function of Oceanic Water Masses显示文摘After reviewing the analytical theories of T S curve, some methods of T S relationship, and fuzzy sets for studying water masses, new methods of fitting the membership function of oceanic water masses are presented based on the characteristics of T S curve family of oceanic water masses. The membership functions of oceanic Subsurface Water Mass with high salinity and Intermediate Water Mass with low salinity are fitted and discussed using the new methods. The proposed methods are useful in analyzing the mixing and modifying processes of these water masses, especially in tracing their sources. The principles and formulae of the new methods and examples are given. | LIFengqi XIEJun LIYao | 2004 | Journal of Ocean University of China2004，3，1： | 2 |
| 8 | Advances in organic thermoelectric materials and devices for smart applications显示文摘Organic thermoelectric(OTE)materials have been considered to be promising candidates for large area and low‐cost wearable devices owing to their tailorable molecular structure,intrinsic flexibility,and prominent solution processability.More importantly,OTE materials offer direct energy conversion from the human body,solid‐state cooling at low electric consumption,and diversified functions.Herein,we summarize recent developments of OTE materials and devices for smart applications.We first review the fundamentals of OTE materials from the viewpoint of thermoelectric performance,mechanical properties and bionic functions.Second,we describe OTE devices in flexible generators,photothermoelectric detectors,self‐powered sensors,and ultra‐thin cooling elements.Finally,we present the challenges and perspectives on OTE materials as well as devices in wearable electronics and fascinating applications in the Internet of Things. | Yue Zhao Liyao Liu Fengjiao Zhang Chong‐an Di Daoben Zhu | 2021 | SmartMat2021，2，4： | 2 |
| 9 | Apple grading method based on neural network with ordered partitions and evidential ensemble learning显示文摘In order to improve the performance of the automatic apple grading and sorting system,in this paper,an ensemble model of ordinal classification based on neural network with ordered partitions and Dempster–Shafer theory is proposed.As a non-destructive grading method,apples are graded into three grades based on the Soluble Solids Content value,with features extracted from the preprocessed near-infrared spectrum of apple serving as model inputs.Considering the uncertainty in grading labels,mass generation approach and evidential encoding scheme for ordinal label are proposed,with uncertainty handled within the framework of Dempster–Shafer theory.Constructing neural network with ordered partitions as the base learner,the learning procedure of the Bagging-based ensemble model is detailed.Experiments on Yantai Red Fuji apples demonstrate the satisfactory grading performances of proposed evidential ensemble model for ordinal classification. | Liyao Ma Peng Wei Xinhua Qu Shuhui Bi Yuan Zhou Tao Shen | 2022 | CAAI Transactions on Intelligence Technology2022，7，4： | 1 |
| 10 | Lighting Up Neural Circuits by Viral Tracing显示文摘Neurons are highly interwoven to form intricate neural circuits that underlie the diverse functions of the brain.Dissecting the anatomical organization of neural circuits is key to deciphering how the brain processes information,produces thoughts,and instructs behaviors.Over the past decades,recombinant viral vectors have become the most commonly used tracing tools to define circuit architecture.In this review,we introduce the current categories of viral tools and their proper application in circuit tracing.We further discuss some advances in viral tracing strategy and prospective innovations of viral tools for future study. | Liyao Qiu Bin Zhang Zhihua Gao | 2022 | Neuroscience Bulletin2022，38，11： | 1 |
| 11 | To form AIE product with the target analyte:a new strategy for excellent fluorescent probes,and convenient detection of hydrazine in seconds with test strips显示文摘A new hydrazine probe was designed, which demonstrates ultrafast 'turn-on' response towards hydrazine both in solution and as gas, due to the excellent AIE(aggregation-induced emission) characteristic of the yielded products. Excitedly, the corresponding fabricated test strips can report the presence of trace hydrazine as low as 10 nmol/L in aqueous medium in seconds conveniently,with very high selectivity in the pH value ranging from 3.0 to 14.0. | Yuchen Song Luyi Zong Liyao Zhang Zhen Li | 2017 | Science China Chemistry2017，60，12： | 1 |
| 12 | Keeping quality of eggs packaged in acrylonitrile pouches显示文摘 | LI Liyao LAI C C GILBERT S G | 1985 | Journal of Food Processing and Preservation1985，9，3： | 1 |
| 13 | 显示文摘 | HouDongfang(侯东芳)DongXiaohua(董晓华) LiYao(李尧)etal | 2002 | 三峡大学学报2002，24，4： | 1 |
| 14 | Relative clause processing in Mandarin: Evidence from the maze task显示文摘 | Xiaomei Qiao Liyao Shen Kenneth Forster | 2012 | Language and Cognitive Processes2012，，4： | 1 |
| 15 | Molecular bases for resistance to acetyl-coenzyme A carboxylase inhibitor in Japa nese foxtail (Alopecurus japonicus) 显示文摘 | Tang Huaiwu Li Jun Dong Liyao | 2012 | Pest Management Science2012，68，9： | 1 |
| 16 | High gravity influence on boiling heat transfer in helical coils显示文摘 | XIE Liyao XIE Yaoqi WU Hongwei | 2014 | Inter- national Journal of Heat and Mass Transfer2014，73，： | 1 |
| 17 | Direct Electrochemistry of Glucose Oxidase at Carbon Nanotube‐gold Colloid Modified Electrode with Poly(diallyldimethylammonium chloride) Coating显示文摘 | Yan‐LiYao Kwok‐KeungShiu | 2008 | Electroanalysis2008，，14： | 1 |
| 18 | Using UAV to Detect Truth for Clean Data Collection in Sensor⁃Cloud Systems显示文摘Mobile edge users(MEUs)collect data from sensor devices and report to cloud systems,which can facilitate numerous applications in sensor‑cloud systems(SCS).However,because there is no effective way to access the ground truth to verify the quality of sensing devices’data or MEUs’reports,malicious sensing devices or MEUs may report false data and cause damage to the platform.It is critical for selecting sensing devices and MEUs to report truthful data.To tackle this challenge,a novel scheme that uses unmanned aerial vehicles(UAV)to detect the truth of sensing devices and MEUs(UAV‑DT)is proposed to construct a clean data collection platform for SCS.In the UAV‑DT scheme,the UAV delivers check codes to sensor devices and requires them to provide routes to the specified destination node.Then,the UAV flies along the path that enables maximal truth detection and collects the information of the sensing devices forwarding data packets to the cloud during this period.The information collected by the UAV will be checked in two aspects to verify the credibility of the sensor devices.The first is to check whether there is an abnormality in the received and sent data packets of the sensing devices and an evaluation of the degree of trust is given;the second is to compare the data packets submitted by the sensing devices to MEUs with the data packets submitted by the MEUs to the platform to verify the credibility of MEUs.Then,based on the verified trust value,an incentive mechanism is proposed to select credible MEUs for data collection,so as to create a clean data collection sensor‑cloud network.The simulation results show that the proposed UAV‑DT scheme can identify the trust of sensing devices and MEUs well.As a result,the proportion of clean data collected is greatly improved. | LI Xiuxian LI Zhetao OUYANG Yan DUAN Haohua XIANG Liyao | 2021 | ZTE Communications2021，19，3： | 1 |
| 19 | Review of ultraviolet ageing mechanisms and anti-ageing methods for asphalt binders显示文摘Asphalt binder is inevitably aged by ultraviolet(UV)light during its service period.UV ageing can significantly decrease the technical properties of asphalt binder.The sensitivity of asphalt to UV ageing and thermal-oxidative ageing differs,such that the UV ageing performance cannot be determined based on the thermal-oxidative ageing performance.Previous researches mainly focused on the chemical composite and technical performance changes of asphalt binder during UV ageing,and the UV light parameters effect on the ageing rate of asphalt binder.However,the theory for characterizing and explaining the development of UV ageing depth does not get too much attentions,and the UV ageing mechanism of asphalt binder is not very clear.Therefore,it cannot guide to develop or select the good methods or anti-UV ageing additives for asphalt binders.This paper focuses on the latest researches of the mechanisms and anti-ageing methods of asphalt binders.With the increase of UV ageing time,the UV ageing of asphalt binder develops gradually from the surface to inner part.There are various methods,such as low-penetration grade asphalt,less air void ratio,UV stabilizers and UV light absorbers,that can improve the UV ageing resistance of asphalt binders.A new theory of sensitive wavelengths of asphalt UV ageing is proposed,which can enrich the basic theory of asphalt UV ageing.Depending on this theory,different wavelengths of UV light have different ageing effects on asphalt binder.The composite anti-UV ageing additives with barrier and specific absorption effects on UV light is proposed,and may have better improvement effect on the anti-UV ageing performance of asphalt binder. | Yuanyuan Li Jianlin Feng Shaopeng Wu Anqi Chen Dongliang Kuang Tao Bai Yangming Gao Jizhe Zhang Linglin Li Liyao Wan Quantao Liu Zongwu Chen Dengjun Gu | 2022 | Journal of Road Engineering2022，2，2： | 1 |
| 20 | 显示文摘 | ZHANGHe-Xin(张贺新) HEXiao-Dong(赫晓东) LIYao(李垚) | | 稀有金属材料工程0，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员