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| 1 | 1997年全国艾滋病哨点监测报告显示文摘1997年,全国HIV监测哨点共调整为60个,分布在27个省(自治区、直辖市)。性病门诊哨点和长卡哨点中只检出极少数HIV感染者。1997年,在3个暗娼哨点中的检出率约为1%~2%,而1996年同期仅为不到0.5%;在12个吸毒哨点中有7个哨点(包括2个新增哨点)报告了HIV感染者,而在1996年同期8个哨点中有3个哨点报告了感染者。新疆自治区报告了83例(20.8%)感染者,而在前几年同期同一哨点只有32例(8.0%)。在大部分吸毒监测哨点中的静注比例正不断增加或保持一个较高水平。暗娼人群中有60%从不使用避孕套。该监测结果表明,局部地区吸毒者中HIV感染率在不断上升,HIV波及的地区在不断地增多,HIV感染已开始向性乱人群扩散;可引起HIV流行的危险因素在不断增加。 | Department of Disease Control,Ministry of Health,People′s Republic of China 1 Center for AIDS Surveillance,Chinese Academy of Preventive Medicine 2 Group of National HIV Sentinel Surveillance Program (Written by Qu Shuquan 2,Sun Xinhua 1,Zheng X | 1998 | 中国性病艾滋病防治1998，4，4： | 15 |
| 2 | 1996年中国艾滋病哨点监测报告显示文摘我国自1995年开始在23个省(自治区、直辖市)的42个哨点中对性传播疾病(STDs)门诊就诊者、暗娼、吸毒者和长途卡车司机四类人群进行监测,当年监测结果显示,在监测哨点所在的城市中,被监测的STDs门诊就诊者、暗娼、吸毒者和长途卡车司机人群中HIV感染率均很低,但存在广泛传播的危险性。1996年第一轮共监测10085人,发现HIV感染者35例。其中在STDs门诊就诊者中发现HIV感染者1例,在吸毒者中发现HIV感染者34例(其中新疆32例);第二轮监测11909人,发现HIV感染者72例,其中在暗娼人群中发现1例,在吸毒人群中发现71例(其中新疆69例)。1996年监测结果表明,在哨点所在的城市中,尽管被监测的STDs门诊就诊者、暗娼和长途卡车司机人群中HIV感染率仍很低,但我国HIV流行形势已发生改变,HIV感染的流行已不仅仅局限于云南吸毒者中,在其它地区已开始在吸毒者中流行,个别地区该人群中HIV感染率上升很快。 | Department of Disease control.Ministry of Health,People′s Republic of China 1 Center for AIDS Surveillance,Chinese Academy of Preventive Medicine 2 Group of National HIV sentinel surveillance program (Written by Qu Shuquan 2,Sun Xinhua 1,Zheng Xiwen | 1997 | 中国性病艾滋病防治1997，3，5： | 12 |
| 3 | Biodegradable Zn-Sr alloy for bone regeneration in rat femoral condyle defect model: In vitro and in vivo studies显示文摘Bone defects are commonly caused by severe trauma,malignant tumors,or congenital diseases and remain among the toughest clinical problems faced by orthopedic surgeons,especially when of critical size.Biodegradable zinc-based metals have recently gained popularity for their desirable biocompatibility,suitable degradation rate,and favorable osteogenesis-promoting properties.The biphasic activity of Sr promotes osteogenesis and inhibits osteoclastogenesis,which imparts Zn-Sr alloys with the ideal theoretical osteogenic properties.Herein,a biodegradable Zn-Sr binary alloy system was fabricated.The cytocompatibility and osteogenesis of the Zn-Sr alloys were significantly better than those of pure Zn in MC3T3-E1 cells.RNA-sequencing illustrated that the Zn-0.8Sr alloy promoted osteogenesis by activating the wnt/β-catenin,PI3K/Akt,and MAPK/Erk signaling pathways.Furthermore,rat femoral condyle defects were repaired using Zn-0.8Sr alloy scaffolds,with pure Ti as a control.The scaffold-bone integration and bone ingrowth confirmed the favorable in vivo repair properties of the Zn-Sr alloy,which was verified to offer satisfactory biosafety based on the hematoxylin-eosin(H&E)staining and ion concentration testing of important organs.The Zn-0.8Sr alloy was identified as an ideal bone repair material candidate,especially for application in critical-sized defects on load-bearing sites due to its favorable biocompatibility and osteogenic properties in vitro and in vivo. | Bo Jia Hongtao Yang Zechuan Zhang Xinhua Qu Xiufeng Jia Qiang Wu Yu Han Yufeng Zheng Kerong Dai | 2021 | Bioactive Materials2021，6，6： | 9 |
| 4 | Serum zinc levels and multiple health outcomes: Implications for zinc-based biomaterials显示文摘Background:Zinc-based biomaterials,including biodegradable metal,nanoparticles,and coatings used in medical implants release zinc ions that may increase the whole-body and serum zinc concentrations.The impact of serum zinc concentrations on major health outcomes can provide insights for device design and clinical transformation of zinc-based biomaterials.Methods:This nationally representative cross-sectional study enrolled participants from the National Health and Nutrition Examination Survey(NHANES,2011-2014)including 3607 participants.Using unadjusted and multivariate-adjusted logistic regression analyses,two-piecewise linear regression model with a smoothing function and threshold level analysis,we evaluated the associations between elevated serum zinc levels and major health outcomes.Results:Elevated serum zinc levels were significantly associated with an increase in total spine and total femur bone mineral density(BMD).Every 10μg/dL increase was associated with a 1.12-fold increase in diabetes mellitus(DM)and 1.23-fold and 1.29-fold increase in cardiovascular diseases(CVD)and coronary heart disease(CHD),in participants with serum zinc levels≥100μg/dL.It had no significant linear or nonlinear associations with risk of fractures,congestive heart failure,heart attack,thyroid disease,arthritis,osteoarthritis,rheumatoid arthritis,dyslipidemia and cancer.Conclusion:Serum zinc levels are significantly associated with increased BMD in the total spine and total femur,and risk of DM,and CVD/CHD among participants with serum zinc levels≥100μg/dL. | Xinhua Qu Hongtao Yang Zhifeng Yu Bo Jia Han Qiao Yufeng Zheng Kerong Dai | 2020 | Bioactive Materials2020，5，2： | 7 |
| 5 | Zinc alloy-based bone internal fixation screw with antibacterial and anti-osteolytic properties显示文摘There is no targeted effective treatment for patients undergoing internal fixation surgery/two-stage total joint revision surgery with a high risk of postoperative infection and osteolysis,while the rate of reoperation due to infection and osteolysis remains high.In this study,we report a pioneering application of implants made of biodegradable Zn-Ag alloy with active antibacterial and anti-osteolytic properties in three classical animal models,illustrating antibacterial,anti-osteolysis,and internal fixation for fractures.The antibacterial activity of the Zn-2Ag alloy was verified in a rat femur osteomyelitis prevention model,while the anti-osteolytic properties were evaluated using a mouse cranial osteolysis model.Moreover,the Zn-2Ag based screws showed similar performance in bone fracture fixation compared to the Ti-6Al-4V counterpart.The fracture healed completely after 3 months in the rabbit femoral condyle fracture model.Furthermore,the underlying antibacterial mechanism may include inhibition of biofilm formation,autolysis-related pathways,and antibiotic resistance pathways.Osseointegration mechanisms may include inhibition of osteoclast-associated protein expression,no effect on osteogenic protein expression,and no activation of related inflammatory protein expression.The empirical findings here reveal the great potential of Zn-Ag-based alloys for degradable biomaterials in internal fixation surgery/two-stage total joint revision surgery for patients with a high risk of postoperative infection and osteolysis. | Xinhua Qu Hongtao Yang Bo Jia Minqi Wang Bing Yue Yufeng Zheng Kerong Dai | 2021 | Bioactive Materials2021，6，12： | 4 |
| 6 | Allelic Analyses of the Arabidopsis YUC1 Locus Reveal Residues and Domains Essential for the Functions of YUC Family of Flavin Monooxygenases显示文摘Flavin monooxygenases(FMOs) play critical roles in plant growth and development by synthesizing auxin and other signaling molecules.However,the structure and function relationship within plant FMOs is not understood.Here we defined the important residues and domains of the Arabidopsis YUC1 FMO,a key enzyme in auxin biosynthesis.We previously showed that simultaneous inactivation of YUC1 and its homologue YUC4 caused severe defects in vascular and floral development.We mutagenized the yuc4 mutant and screened for mutants with phenotypes similar to those of yuc1 yuc4 double mutants.Among the isolated mutants,five of them contained mutations in the YUC1 gene.Interestingly,the mutations identified in the new yuc1 alleles were concentrated in the two GXGXXG motifs that are highly conserved among the plant FMOs.One such motif presumably binds to flavin adenine dinucleotide(FAD) cofactor and the other binds to nicotinamide adenine dinucleotide phosphate(NADPH).We also identified the Ser139 to Phe conversion in yuc1,a mutation that is located between the two nucleotide-binding sites.By analyzing a series of yuc1 mutants,we identified key residues and motifs essential for the functions of YUC1 FMO. | Xianhui Hou Sainan Liu Florencia Pierri Xinhua Dai Li-Jia Qu Yunde Zhao | 2011 | Journal of Integrative Plant Biology2011，53，1： | 4 |
| 7 | Bone infection site targeting nanoparticle-antibiotics delivery vehicle to enhance treatment efficacy of orthopedic implant related infection显示文摘Orthopedic implants account for 99%of orthopedic surgeries,however,orthopedic implant-related infection is one of the most serious complications owing to the potential for limb-threatening sequelae and mortality.Current antibiotic treatments still lack the capacity to target bone infection sites,thereby resulting in unsatisfactory therapeutic effects.Here,the bone infection site targeting efficacy of D6 and UBI29-41 peptides was investigated,and bone-and-bacteria dual-targeted nanoparticles(NPs)with D6 and UBI29-41 peptides were first fabricated to target bone infection site and control the release of vancomycin in bone infection site.The results of this study demonstrated that the bone-and-bacteria dual-targeted mesoporous silica NPs exhibit excellent bone and bacteria targeting efficacy,excellent biocompatibility and effective antibacterial properties in vitro.Furthermore,in a rat model of orthopedic implant-related infection with methicillin-resistant Staphylococcus aureus,the growth of bacteria was evidently inhibited without cytotoxicity,thus realizing the early treatment of implant-related infection.Hence,the bone-and-bacteria dual-targeted molecule-modified NPs may target bacteria-infected bone sites and act as ideal candidates for the therapy of orthopedic implant-related infections. | Bin’en Nie Shicheng Huo Xinhua Qu Jingjing Guo Xi Liu Qimin Hong You Wang Jianping Yang Bing Yue | 2022 | Bioactive Materials2022，7，10： | 2 |
| 8 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 9 | Apple grading method based on neural network with ordered partitions and evidential ensemble learning显示文摘In order to improve the performance of the automatic apple grading and sorting system,in this paper,an ensemble model of ordinal classification based on neural network with ordered partitions and Dempster–Shafer theory is proposed.As a non-destructive grading method,apples are graded into three grades based on the Soluble Solids Content value,with features extracted from the preprocessed near-infrared spectrum of apple serving as model inputs.Considering the uncertainty in grading labels,mass generation approach and evidential encoding scheme for ordinal label are proposed,with uncertainty handled within the framework of Dempster–Shafer theory.Constructing neural network with ordered partitions as the base learner,the learning procedure of the Bagging-based ensemble model is detailed.Experiments on Yantai Red Fuji apples demonstrate the satisfactory grading performances of proposed evidential ensemble model for ordinal classification. | Liyao Ma Peng Wei Xinhua Qu Shuhui Bi Yuan Zhou Tao Shen | 2022 | CAAI Transactions on Intelligence Technology2022，7，4： | 1 |
| 10 | S-1 and Cisplatin With or Without Nimotuzumab for Patients With Untreated Unresectable or Metastatic Gastric Cancer: A Randomized, Open-Label Phase 2 Trial显示文摘 | Feng Du Zhaoxu Zheng SuSheng Shi Zhichao Jiang Tao Qu Xinhua Yuan Yongkun Sun Yan Song Lin Yang Jiuda Zhao Jinwan Wang Yihebali Chi | 2015 | Medicine2015，，23： | 1 |
| 11 | Free and forced vibration analysis of uniform and stepped circular cylindrical shells using a domain decomposition method显示文摘 | Qu Yegao Chen Yong Long Xinhua | | 0，，03： | 1 |
| 12 | Felodipine enhances aminoglycosides efficacy against implant infections caused by methicillin-resistant Staphylococcus aureus,persisters and biofilms显示文摘Methicillin-resistant Staphylococcus aureus(MRSA),biofilms,and persisters are three major factors leading to recurrent and recalcitrant implant infections.Although antibiotics are still the primary treatment for chronic implant infections in clinical,only few drugs are effective in clearing persisters and formed biofilms.Here,felodipine,a dihydropyridine calcium channel blocker,was reported for the first time to have antibacterial effects against MRSA,biofilm,and persisters.Even after continuous exposure to sub-lethal concentrations of felodipine,bacteria are less likely to develop resistance.Besides,low doses of felodipine enhances the antibacterial activity of gentamicin by inhibiting the expression of protein associated with aminoglycoside resistance(aacA-aphD).Next,biofilm eradication test and persisters killing assay suggested felodipine has an excellent bactericidal effect against formed biofilms and persisters.Furthermore,the result of protein profiling,and quantitative metabonomics analysis indicated felodipine reduce MRSA virulence(agrABC),biofilm formation and TCA cycle.Then,molecular docking showed felodipine inhibit the growth of persisters by binding to the H pocket of ClpP protease,which could lead to substantial protein degradation.Furthermore,murine infection models suggested felodipine in combination with gentamicin alleviate bacterial burden and inflammatory response.In conclusion,low dose of felodipine might be a promising agent for biomaterial delivery to enhance aminoglycosides efficacy against implant infections caused by MRSA,biofilm,and persisters. | Shutao Zhang Xinhua Qu Juyang Jiao Haozheng Tang Minqi Wang You Wang Hongtao Yang Weien Yuan Bing Yue | 2022 | Bioactive Materials2022，7，8： | 0 |
| 13 | Spatial Distribution of Mature Larvae of Obolodiplosis robiniae and Damage Regularity of Its First Generation Larvae on Leaves of Locust( Robinia pseudoacacia)显示文摘[Objective] The paper was to explore the population dynamics of Obolodiplosis robiniae( Haldemann).[Method] The spatial distribution of mature larvae of O.robiniae and the damage regularity of its first generation larvae on leaves of locust were studied in Fangshan District of Beijing City.[Result] The spatial distribution of mature larvae of O.robiniae in the forest was significantly higher than those in forest edge and periphery of forest edge.The attack of the first generation larvae was mainly concentrated in the lower part of tree crown.[Conclusion] The study provides theoretical basis for the effective control against O.robiniae. | Sun Jingshuang Cao Ning Tian Wendong Qu Haixue Xue Xinhua Tian Guihong | 2013 | Plant Diseases and Pests2013，4，4： | 0 |
| 14 | Titanium particles in peri-implantitis:distribution,pathogenesis and prospects显示文摘Peri-implantitis is one of the most important biological complications in the field of oral implantology.Identifying the causative factors of peri-implant inflammation and osteolysis is crucial for the disease’s prevention and treatment.The underlying risk factors and detailed pathogenesis of peri-implantitis remain to be elucidated.Titanium-based implants as the most widely used implant inevitably release titanium particles into the surrounding tissue.Notably,the concentration of titanium particles increases significantly at peri-implantitis sites,suggesting titanium particles as a potential risk factor for the condition.Previous studies have indicated that titanium particles can induce peripheral osteolysis and foster the development of aseptic osteoarthritis in orthopedic joint replacement.However,it remains unconfirmed whether this phenomenon also triggers inflammation and bone resorption in peri-implant tissues.This review summarizes the distribution of titanium particles around the implant,the potential roles in peri-implantitis and the prevalent prevention strategies,which expects to provide new directions for the study of the pathogenesis and treatment of peri-implantitis. | Long Chen Zian Tong Hongke Luo Yuan Qu Xinhua Gu Misi Si | 2023 | International Journal of Oral Science2023，15，4： | 0 |
| 15 | IQ67 DOMAIN protein 21 is critical for indentation formation in pavement cell morphogenesis显示文摘In plants, cortical microtubules anchor to the plasma membrane in arrays and play important roles in cell shape. However, the molecular mechanism of microtubule binding proteins, which connect the plasma membrane and cortical microtubules in cell morphology remains largely unknown. Here, we report that a plasma membrane and microtubule duallocalized IQ67 domain protein, IQD21, is critical for cotyledon pavement cell(PC) morphogenesis in Arabidopsis. iqd21 mutation caused increased indentation width, decreased lobe length, and similar lobe number of PCs, whereas IQD21 overexpression had a different effect on cotyledon PC shape. Weak overexpression led to increased lobe number, decreased indentation width, and similar lobe length, while moderate or great overexpression resulted in decreased lobe number, indentation width, and lobe length of PCs. Live-cell observations revealed that IQD21 accumulation at indentation regions correlates with lobe initiation and outgrowth during PC development. Cell biological and genetic approaches revealed that IQD21 promotes transfacial microtubules anchoring to the plasma membrane via its polybasic sites and bundling at the indentation regions in both periclinal and anticlinal walls. IQD21 controls cortical microtubule organization mainly through promoting Katanin 1-mediated microtubule severing during PC interdigitation. These findings provide the genetic evidence that transfacial microtubule arrays play a determinant role in lobe formation, and the insight into the molecular mechanism of IQD21 in transfacial microtubule organization at indentations and puzzle-shaped PC development. | Xinhua Feng Shujuan Pan Haifu Tu Junjie Huang Chuanlei Xiao Xin Shen Lei You Xinyan Zhao Yongqiang Chen Danyun Xu Xiaolu Qu Honghong Hu | 2023 | Journal of Integrative Plant Biology2023，65，3： | 0 |
| 16 | The Sterile 20-Like Kinase Tao Controls Tissue Homeostasis by Regulating the Hippo Pathway in Drosophila Adult Midgut显示文摘The proliferation and differentiation of adult stem cells must be tightly controlled in order to maintain resident tissue homeostasis.Dysfunction of stem cells is implicated in many human diseases, including cancer. However, the regulation of stem cell proliferation and differentiation is not fully understood. Here we show that the sterile-like 20 kinase, Tao, controls tissue homeostasis by regulating the Hippo pathway in the Drosophila adult midgut. Depletion of Tao in the progenitors leads to rapid intestinal stem cell(ISC) proliferation and midgut homeostasis loss. Meanwhile, we find that the Janus kinase(JAK)/signal transducer and activator of transcription(STAT)signaling activity and cytokine production are significantly increased, resulting in stimulated ISC proliferation. Furthermore, expression of the Hippo pathway downstream targets, Diap1 and bantam, is dramatically increased in Tao knockdown intestines. Consistently, we show that the Yorkie(Yki) acts downstream of Tao to regulate ISC proliferation. Together, our results provide insights into our understanding of the mechanisms of stem cell proliferation and tissue homeostasis control. | Xudong Huang Lai Shi Jun Cao Fangfei He Renling Li Yan Zhang Shuang Miao Longjin Jin Jia Qu Zhouhua Li Xinhua Lin | 2014 | Journal of Genetics and Genomics2014，41，8： | 0 |
| 17 | Enoxacin-loaded Poly(lactic-co-glycolic acid) Coating on Porous Magnesium Scaffold as a Drug Delivery System: Antibacterial Properties and Inhibition of Osteoclastic Bone Resorption显示文摘Implant-associated infection remains a difficult medical problem in orthopedic surgery. Therefore, the development of multifunctional bone implants for treating infection and regenerating lost bone tissue,which may be a result of infection, is important. In the present study, we report the fabrication of enoxacinloaded poly(lactic-co-glycolic acid)(PLGA) coating on porous magnesium scaffold(Enox-PLGA-Mg) which combine the favorable properties of magnesium, the antibacterial property and the effect of inhibition of osteoclastic bone resorption of enoxacin. The drug loaded PLGA coating of Mg scaffold enables higher drug loading efficiency(52%–56%) than non-coating enoxacin loaded Mg scaffold(Enox-Mg)(4%–5%). EnoxPLGA-Mg exhibits sustained drug release for more than 14 days, and this controlled release of enoxacin significantly inhibits bacterial adhesion and prevented biofilm formation by Staphylococcus epidermidis(ATCC35984) and Staphylococcus aureus(ATCC25923). Biocompatibility tests with Balb/c mouse embryo fibroblasts(Balb/c 3T3 cells) indicate that PLGA-Mg has better biocompatibility than Mg. Finally, we also demonstrate that Enox-PLGA-Mg extract potently inhibited osteoclast formation in vitro. Therefore, EnoxPLGA-Mg has the potential to be used as a multifunctional controlled drug delivery system bone scaffolds to prevent and/or treat orthopedic peri-implant infections. | Yang Li Xuqiang Liu Lili Tan Ling Ren Peng Wan Yongqiang Hao Xinhua Qu Ke Yang Kerong Dai | 2016 | Journal of Materials Science & Technology2016，32，9： | 0 |
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