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| 1 | The Relation between Age Structure of Population and Resident Consumption Based on Endogenous Growth Theory显示文摘Within the framework of endogenous growth theory,the dynamic relation between age structure of population and resident consumption was studied,and explicit relation between resident consumption and dependency coefficient was obtained through Hamiltonian function method. Then,an empirical study was carried out based on panel data of 31 provinces of China in 2000-2013. The study gave following results: there is negative correlation between child dependency coefficient and resident consumption and there is positive correlation between elderly dependency coefficient and resident consumption; urbanization level weakens the negative effect of child dependency coefficient on resident consumption but it increases the positive effect of elderly dependency coefficient on resident consumption; social expenditure weakens the negative effect of child dependency coefficient on resident consumption,but it intensifies positive effect of elderly dependency coefficient on resident consumption. These results indicate that current population structure of China is favorable for growth of resident consumption demand,but in such aging population structure,economic development may lose demographic dividends. | Huan ZHOU Jun HE Liangliang LIU | 2016 | Asian Agricultural Research2016，8，9： | 7 |
| 2 | Elevated preoperative plasma D-dimer dose not adversely affect survival of gastric cancer after gastrectomy with curative intent: A propensity score analysis显示文摘Objective: Elevated plasma D-dimer has been reported to be associated with advanced tumor stage and poor survival in several types of malignancies. The purpose of this study was to assess the potential impact of preoperative plasma D-dimer level(PDL) on overall survival(OS) of gastric cancer(GC) patients undergoing curative surgery by applying propensity score analysis.Methods: A total of 1,025 curatively resected GC patients in Tianjin Medical University Cancer Institute &Hospital were enrolled. Patients were categorized into two groups based on preoperative PDL: the elevated group(EG) and the normal group(NG). To overcome bias due to the different distribution of covariates for the two groups, a one-to-one match was applied using propensity score analysis, after matching, prognostic factors were analyzed.Results: In analysis for the whole study series, patients in the EG were more likely to have a larger proportion of tumor size ≥5 cm(67.5% vs. 55.8%, P=0.006), elder mean age(64.0±10.8 years vs. 60.5±11.6 years, P<0.001) and advanced tumor(T), node(N), and TNM stage. Patients with elevated PDL demonstrated a significantly lower 5-year OS than those with normal PDL(27.0% vs. 42.6%, P<0.001), however, the PDL was not an independent prognostic factor for OS in multivariate analysis [hazard ratio: 1.13, 95% confidence interval(95% CI): 0.92–1.39,P=0.236]. After matching, 163 patients in the EG and 163 patients in the NG had the same characteristics. The 5-year OS rate for patients in the EG was 27.0% compared with 25.8% for those in the NG(P=0.809, log-rank).Conclusions: The poor prognosis of GC patients with elevated preoperative PDL was due to the advanced tumor stage and elder age rather than the elevated D-dimer itself. | Yuexiang Liang Donglei He Liangliang Wu Xuewei Ding Xiaona Wang Baogui Wang Rupeng Zhang Han Liang | 2018 | Chinese Journal of Cancer Research2018，30，2： | 6 |
| 3 | Heterogeneously integrated,superconducting silicon-photonic platform for measurementdevice-independent quantum key distribution显示文摘Integrated photonics provides a route to both miniaturization of quantum key distribution(QKD)devices and enhancing their performance.A key element for achieving discrete-variable QKD is a singlephoton detector.It is highly desirable to integrate detectors onto a photonic chip to enable the realization of practical and scalable quantum networks.We realize a heterogeneously integrated,superconducting silicon-photonic chip.Harnessing the unique high-speed feature of our optical waveguide-integrated superconducting detector,we perform the first optimal Bell-state measurement(BSM)of time-bin encoded qubits generated from two independent lasers.The optimal BSM enables an increased key rate of measurement-device-independent QKD(MDI-QKD),which is immune to all attacks against the detection system and hence provides the basis for a QKD network with untrusted relays.Together with the timemultiplexed technique,we have enhanced the sifted key rate by almost one order of magnitude.With a 125-MHz clock rate,we obtain a secure key rate of 6.166 kbps over 24.0 dB loss,which is comparable to the state-of-the-art MDI-QKD experimental results with a GHz clock rate.Combined with integrated QKD transmitters,a scalable,chip-based,and cost-effective QKD network should become realizable in the near future. | Xiaodong Zheng Peiyu Zhang Renyou Ge Liangliang Lu Guanglong He Qi Chen Fangchao Qu Labao Zhang Xinlun Cai Yanqing Lu Shining Zhu Peiheng Wu Xiao-Song Ma | 2021 | Advanced Photonics2021，3，5： | 5 |
| 4 | In-situ optimizing the valence configuration of vanadium sites in NiV-LDH nanosheet arrays for enhanced hydrogen evolution reaction显示文摘Developing the highly active, cost-effective, environmental-friendly, and ultra-stable nonprecious electrocatalysts for hydrogen evolution reaction(HER) is distinctly indispensable for the large-scale practical applications of hydrolytic hydrogen production. Herein, we report the synthesis of well-integrated electrode, NiV layered double hydroxide nanosheet array grown in-situ on porous nickel foam(abbreviated as in-NiV-LDH/NF) via the facile one-step hydrothermal route. Interestingly, the valence configuration of vanadium(V) sites in such NiV-LDH are well dominated by the innovative use of NF as the reducing regulator, achieving the reassembled in-NiV-LDH/NF with a high proportion of trivalent V ions(V3+), and then an enhanced intrinsic electrocatalytic HER activity. The HER testing results show that the in-NiVLDH/NF drives the current densities of 10 and 100 mA cm-2 at extremely low overpotentials of 114 and 245 mV without iR-compensation respectively, even outperforms commercial 20 wt% Pt/C at the large current density of over 80 mA cm-2 in alkaline media, as well as gives robust catalytic durability of at least 100 h in both alkaline and neutral media. More importantly, this work provides a fresh perspective for designing bimetal(oxy) hydroxides electrocatalysts with efficient hydrogen generation. | Danyang He Liyun Cao Jianfeng Huang Koji Kajiyoshi Jianpeng Wu Changcong Wang Qianqian Liu Dan Yang Liangliang Feng | 2020 | Journal of Energy Chemistry2020，29，8： | 5 |
| 5 | Synthesis of large-scale atomic-layer SnS2 through chemical vapor deposition显示文摘因为他们的 ultrathin 厚度和潜在的应用,金属 dichalcogenides 的二维的层在电子学和光电子吸引了许多注意。有 ~ 的乐队差距的单层 SnS 2, 2.6 eV,有用硫的二原子层和锡的一原子层做的一个八面的格子。到日期为止,在那里被限制了作为一个半导体在大规模、高质量的 SnS 2 的生长上报导原子层和他们的性质的调查。这里,我们与一种大水晶尺寸和一致性报导原子层的 SnS 2 的化学蒸汽免职(CVD ) 生长。另外,层的数字能被改变生长时间从单层改变到很少层并且到体积。扫描传播电子显微镜学被用来分析原子结构并且表明叠不同的层的 poly 类型的 2H。结果的 SnS 2 晶体象 150% 一样高与外部量效率被用作一个光电探测器,建议为 optoelectronic 应用的诺言。 | Gonglan Ye Yongji Gong Sidong Lei Yongmin He Bo Li Xiang Zhang Zehua Jin Liangliang Dong Jun Lou Robert Vajtai Wu Zhou Pulickel M. Ajayan | 2017 | Nano Research2017，10，7： | 4 |
| 6 | Rapid room-temperature synthesis of a porphyrinic MOF for encapsulating metal nanoparticles显示文摘While metal nanoparticles(NPs)have shown great promising applications as heterogeneous catalysts,their agglomeration caused by thermodynamic instability is detrimental to the catalytic performance.To tackle this hurdle,we successfully prepared a functional and stable porphyrinic metal-organic framework(MOF),PCN-224-RT,as a host for encapsulating metal nanoparticles by direct stirring at room temperature.As a result,Pt@PCN-224-RT composites with well-dispersed Pt NPs can be constructed by introducing pre-synthesized Pt NPs into the precursor solution of PCN-224-RT.Of note,the rapid and simple stirring method in this work is more in line with the requirements of environmental friendly and industrialization compared with traditional solvothermal methods. | Huihui He Luyan Li Yang Liu Meruyert Kassymova Dandan Li Liangliang Zhang Hai-Long Jiang | 2021 | Nano Research2021，14，2： | 3 |
| 7 | Rabies Virus Pseudotyped with CVS-N2C Glycoprotein as a Powerful Tool for Retrograde Neuronal Network Tracing显示文摘Efficient viral vectors for mapping and manipulating long-projection neuronal circuits are crucial in structural and functional studies of the brain. The SAD strain rabies virus with the glycoprotein gene deleted pseudotyped with the N2 C glycoprotein(SAD-RV(DG)-N2 C(G)) shows strong neuro-tropism in cell culture, but its in vivo efficiency for retrograde gene transduction and neuro-tropism have not been systematically characterized.We compared these features in different mouse brain regions for SAD-RV-N2 C(G) and two other widely-used retrograde tracers, SAD-RV(DG)-B19(G) and r AAV2-retro. We found that SAD-RV(DG)-N2 C(G) enhanced the infection efficiency of long-projecting neurons by^10 times but with very similar neuro-tropism, compared with SAD-RV(DG)-B19(G). On the other hand, SAD-RV(DG)-N2 C(G) had an infection efficiency comparable with r AAV2-retro, but a more restricted diffusion range, and broader tropism to different types and regions of longprojecting neuronal populations. These results demonstrate that SAD-RV(DG)-N2 C(G) can serve as an effective retrograde vector for studying neuronal circuits. | Xutao Zhu Kunzhang Lin Qing Liu Xinpei Yue Huijie Mi Xiaoping Huang Xiaobin He Ruiqi Wu Danhao Zheng Dong Wei Liangliang Jia Weilin Wang Anne Manyande Jie Wang Zhijian Zhang Fuqiang Xu | 2020 | Neuroscience Bulletin2020，36，3： | 2 |
| 8 | Rce1 expression in renal cell carcinoma and its regulatory effect on 786-O cell apoptosis through endoplasmic reticulum stress显示文摘(Rce1 ) 地岬和 a-factor-converting 酶 1 位于 endoplasmic 蜂窝胃(嗯) 并且被认为为绝大多数 CAAX 蛋白质处理的 endoproteolytic 负责。Endoplasmic 蜂窝胃应力(ERS ) 在肾的房间癌(RCC ) 起一个重要作用;然而,在 RCC 的 Rce1 的表示和角色广泛地没被学习。我们试图在 RCC 786-O 房间在嗯导致 apoptosis 在 RCC 纸巾和它的分子的机制调查 Rce1 的表示。我们首先使用了检测在肾的癌纸巾和 paracancerous 纸巾的 Rce1 表示的西方的弄污,量的反向的 transcriptase 聚合酶链反应,和 immunohistochemistry。Rce1 表示是在 RCC 的 upregulated,这被发现纸巾,和它的积极表示水平强烈与 clinicopathologic 特征被联系。下次,我们在人的胚胎的肾房间线 HEK293 和人的肾的癌房间线 786-O 检测了 Rce1 的表示, ACHN,和 A498。Rce1 的更高的表示在人的肾的癌房间线被发现,特别在 786-O 房间。在 786-O 房间的 Rce1 击倒增加的 apoptosis | Jianjun Li Delin Wang Junnan Liu Yunlang Qin Liangliang Huang Qiangfeng Zeng Maolin Xiao Jie Hu Qixin Yang Jiang He Li Mai Ying Li Wujiang Liu | 2017 | Acta Biochimica et Biophysica Sinica2017，49，3： | 2 |
| 9 | Enzymatically-degradable hydrogel coatings on titanium for bacterial infection inhibition and enhanced soft tissue compatibility via a self-adaptive strategy显示文摘Ideal percutaneous titanium implants request both antibacterial ability and soft tissue compatibility.ZnO structure constructed on titanium has been widely proved to be helpful to combat pathogen contamination,but the biosafety of ZnO is always questioned.How to maintain the remarkable antibacterial ability of ZnO and efficiently reduce the corresponding toxicity is still challenging.Herein,a hybrid hydrogel coating was constructed on the fabricated ZnO structure of titanium,and the coating was proved to be enzymatically-degradable when bacteria exist.Then the antibacterial activity of ZnO was presented.When under the normal condition(no bacteria),the hydrogel coating was stable and tightly adhered to titanium.The toxicity of ZnO was reduced,and the viability of fibroblasts was largely improved.More importantly,the hydrogel coating provided a good buffer zone for cell ingrowth and soft tissue integration.The curbed Zn ion release was also proved to be useful to regulate fibroblast responses such as the expression of CTGF and COL-I.These results were also validated by in vivo studies.Therefore,this study proposed a valid self-adaptive strategy for ZnO improvement.Under different conditions,the sample could present different functions,and both the antibacterial ability and soft tissue compatibility were finely preserved. | Jin Leng Ye He Zhang Yuan Bailong Tao Ke Li Chuanchuan Lin Kun Xu Maowen Chen Liangliang Dai Xuemin Li Tony Jun Huang Kaiyong Cai | 2021 | Bioactive Materials2021，6，12： | 2 |
| 10 | Integrated multi-scheme digital modulations of spoof surface plasmon polaritons显示文摘The future wireless communications require different kinds of modulation functions to be integrated in a single intelligent device under different scenarios.Here,we propose a multi-scheme digital modulator to achieve this goal based on integrated spoof surface plasmon polaritons(SPP)in different frequency bands.By constructing switchable spoof SPP units,the propagating wave in the proposed spoof SPP waveguide can be manipulated in amplitude domain,frequency domain,and phase domain.As a proof of concept,the integrated multi-scheme digital modulator is experimentally verified to achieve at least three kinds of modulations,including amplitude shift keying,phase shift keying,and frequency shift keying,in a single digital spoof plasmonic waveguide.The simulated and measured results show that the modulator has excellent property of field confinement and is capable of frequency-domain modulation.Hence,the multi-scheme modulation property makes the proposed SPP digital modulator be an effective and reliable candidate for efficient manipulations of SPP waves and for advanced modulation technology. | Lepeng ZHANG Haochi ZHANG Min TANG Peihang HE Lingyun NIU Liangliang LIU Jiayuan LU Wenxuan TANG Junfa MAO Tiejun CUI | 2020 | Science China(Information Sciences)2020，63，10： | 2 |
| 11 | LncRNA DACH1 protects against pulmonary fibrosis by binding to SRSF1 to suppress CTNNB1 accumulation显示文摘Idiopathic pulmonary fibrosis(IPF)is a progressive disease with unknown etiology and limited therapeutic options.Activation of fibroblasts is a prominent feature of pulmonary fibrosis.Here we report that lncRNA DACH1(dachshund homolog 1)is downregulated in the lungs of IPF patients and in an experimental mouse model of lung fibrosis.LncDACH1 knockout mice develop spontaneous pulmonary fibrosis,whereas overexpression of LncDACH1 attenuated TGF-β1-induced aberrant activation,collagen deposition and differentiation of mouse lung fibroblasts.Similarly,forced expression of LncDACH1 not only prevented bleomycin(BLM)-induced lung fibrosis,but also reversed established lung fibrosis in a BLM model.Mechanistically,LncDACH1 binding to the serine/arginine-rich splicing factor 1(SRSF1)protein decreases its activity and inhibits the accumulation of Ctnnb1.Enhanced expression of SRSF1 blocked the anti-fibrotic effect of LncDACH1 in lung fibroblasts.Furthermore,loss of LncDACH1 promoted proliferation,differentiation,and extracellular matrix(ECM)deposition in mouse lung fibroblasts,whereas such effects were abolished by silencing of Ctnnb1.In addition,a conserved fragment of LncDACH1 alleviated hyperproliferation,ECM deposition and differentiation of MRC-5 cells driven by TGF-β1.Collectively,LncDACH1 inhibits lung fibrosis by interacting with SRSF1 to suppress CTNNB1 accumulation,suggesting that LncDACH1 might be a potential therapeutic target for pulmonary fibrosis. | Jian Sun Tongzhu Jin Zhihui Niu Jiayu Guo Yingying Guo Ruoxuan Yang Qianqian Wang Huiying Gao Yuhan Zhang Tianyu Li Wenxin He Zhixin Li Wenchao Ma Wei Su Liangliang Li Xingxing Fan Hongli Shan Haihai Liang | 2022 | Acta Pharmaceutica Sinica B2022，12，9： | 1 |
| 12 | The role of Re in improving the oxidation-resistance of a Re modified PtAl coating on Mo-rich single crystal superalloy显示文摘A novel Re modifiedβ-(Ni,Pt)Al coating was prepared on a Mo-rich Ni_3 Al-based single crystal(SC)superalloy by electro-deposition of Re/Pt dual films and low-activity aluminizing.The isothermal oxidation behavior of the Re modifiedβ-(Ni,Pt)Al coating and traditionalβ-(Ni,Pt)Al coating was comparatively studied at 1100℃.Apparent spallation of oxide scale was found on the surface of traditionalβ-(Ni,Pt)Al coating after 300 h isothermal exposure,which mainly resulted from the evaporation of Mo-containing oxides.It is further found that the outward diffusion of Mo from the SC substrate was effectively inhibited in the Re modifiedβ-(Ni,Pt)Al coating by forming theσ-MoRe phase both at the coating/superalloy interface and grain boundaries.It is also revealed that the addition of Re can stabilise Mo to form theσ-MoRe phase,allowing the improved oxidation resistance of the Re modifiedβ-(Ni,Pt)Al coating. | Jingchen Li Liangliang Wei Jian He Hao Chen Hongbo Guo | 2020 | Journal of Materials Science & Technology2020，58，23： | 1 |
| 13 | Discovery of potential anti-SARS-CoV-2 drugs based on large-scale screening in vitro and effect evaluation in vivo显示文摘The coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARSCoV-2)is a global crisis.Clinical candidates with high efficacy,ready availability,and that do not develop resistance are in urgent need.Despite that screening to repurpose clinically approved drugs has provided a variety of hits shown to be effective against SARS-CoV-2 infection in cell culture,there are few confirmed antiviral candidates in vivo.In this study,94 compounds showing high antiviral activity against SARS-CoV-2 in Vero E6 cells were identified from 2,580 FDA-approved small-molecule drugs.Among them,24 compounds with low cytotoxicity were selected,and of these,17 compounds also effectively suppressed SARS-CoV-2 infection in He La cells transduced with human ACE2.Six compounds disturb multiple processes of the SARSCoV-2 life cycle.Their prophylactic efficacies were determined in vivo using Syrian hamsters challenged with SARS-CoV-2infection.Seven compounds reduced weight loss and promoted weight regain of hamsters infected not only with the original strain but also the D614G variant.Except for cisatracurium,six compounds reduced hamster pulmonary viral load,and IL-6 and TNF-αm RNAwhen assayed at 4 d postinfection.In particular,sertraline,salinomycin,and gilteritinib showed similar protective effects as remdesivir in vivo and did not induce antiviral drug resistance after 10 serial passages of SARS-CoV-2 in vitro,suggesting promising application for COVID-19 treatment. | Haoran Peng Cuiling Ding Liangliang Jiang Wanda Tang Yan Liu Lanjuan Zhao Zhigang Yi Hao Ren Chong Li Yanhua He Xu Zheng Hailin Tang Zhihui Chen Zhongtian Qi Ping Zhao | 2022 | Science China(Life Sciences)2022，65，6： | 1 |
| 14 | Photocatalytic Activity of TiO_2 Sensitized by CdS Quantum Dots under Visible-Light Irradiation显示文摘In this paper, CdS quantum dots sensitized TiO2 composite powders (QD-CdS/TiO2) were synthesized by impregnating TiO2 powder into CdS sol with different concentrations. X-ray diffraction pattern (XRD) shows the crystal structures of CdS and TiO2 are cubic phase and anatase phase separately in QD- CdS/TiO2 powder samples; the crystal size of CdS in QD- CdS/TiO2 is about 3-7 nm, while TiO2 crystal size is about 20 nm. With increasing CdS content in QD-CdS/TiO2 composite, the UV-Vis absorption spectrum shifted to the longer wavelength lines, exhibiting obvious quantum size effect. The fluorescence intensity of QD-CdS/TiO2 irradiated by blue light is weaker than that of pure CdS. When the molar ratio of CdS and TiO2 is about 1∶2, the QD-CdS/TiO2 powder has the best catalytic properties under visible-light irradiation, and the degradation rate of rhodamine B (RhB) is up to 92.2% within 60 min. | MAO Liangliang JIANG Wuzhou HE Lijuan FANG Pengfei | 2011 | Wuhan University Journal of Natural Sciences2011，16，4： | 0 |
| 15 | Inhibition mechanisms of ammonia and sulfate in high-solids anaerobic digesters for food waste treatment: Microbial community and element distributions responses显示文摘The horizontal flow anaerobic digester indicated that high ammonia (2923 mg/L) and SO42-(3653 mg/L)would influence the performance of methane production with food waste as substrates.Therefore,bottle anaerobic digestion reactors were carried out to investigate the effect of ammonia/sulfate concentrations on the methane production.Experimental results manifested that the anaerobic digesters with an ammonia concentration of 3500 mg/L or sulfate of 1600 mg/L showed the best performance of methane production,with an average methane yield of 0.32 and 0.33 L (g VS)^(-1)d^(-1),respectively.Specifically,a higher ammonia (6500 mg/L) or sulfate (1600-3500 mg/L) level hindered the bioconversion of C from liquid to gas phase (2.68%or 1.73%CH_(4)-Gas,respectively),while insignificantly for the hydrolyzation of C and N from solid to liquid phase.Similar to sulfate,high ammonia nitrogen seriously inhibited the methanation process,leading to a significant carbon accumulation in the anaerobic reactor,especially for propionic acid.The predominant archaea Methanosarcina at genus level indicated that aceticlastic methanogenesis was the major methanogenic pathway.Meanwhile,high ammonia level suppressed the activity of Methanosarcina,while modest sulfate improved H_(2)-consuming methanogens activity.A large fraction of unclassified bacteria within the Firmicutes (43.78%-63.17%) and Bacteroidetes (24.20%-33.30%) phylum played an important role in substrates hydrolysis. | Likui Feng Weixin Zhao Yu Liu Yan Chen Shufei He Jing Ding Qingliang Zhao Liangliang Wei | 2023 | Chinese Chemical Letters2023，34，2： | 0 |
| 16 | 3-75 Radiosensitizing Effects of miR-185 on Melanoma Cells显示文摘Melanoma is an aggressive malignancy with high metastasis and low survival rate, of which the incidence rate keeps increasing year by year worldwide while the therapeutic options are still limited up to now[1;2]. Melanoma is considered to be a relatively radioresistant tumor, and radiotherapy has an important role in its treatment, especially in patients with central nervous system metastases[3], so enhancement of cellular radiosensitivity by radiosensitizer is an efficient strategy to improve the outcome of radiotherapy. | He Jinpeng Tian Ning Yang Yanli Jin Liangliang Feng Xiu Hua Junrui Lin Sulan Wang Bing Li He Wang Jufang | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
| 17 | Extracellular polymeric substances-antibiotics interaction in activated sludge:A review显示文摘Antibiotics,the most frequently prescribed drugs,have been widely applied to prevent or cure human and veterinary diseases and have undoubtedly led to massive releases into sewer networks and wastewater treatment systems,a hotspot where the occurrence and transformation of antibiotic resistance take place.Extracellular polymeric substances(EPS),biopolymers secreted via microbial activity,play an important role in cell adhesion,nutrient retention,and toxicity resistance.However,the potential roles of sludge EPS related to the resistance and removal of antibiotics are still unclear.This work summarizes the composition and physicochemical characteristics of state-of-the-art microbial EPS,highlights the critical role of EPS in antibiotics removal,evaluates their defense performances under different antibiotics exposures,and analyzes the typical factors that could affect the sorption and biotransformation behavior of antibiotics.Next,interactions between microbial EPS and antibiotic resistance genes are analyzed.Future perspectives,especially the engineering application of microbial EPS for antibiotics toxicity detection and defense,are also emphatically stressed. | Weixin Zhao Jia You Shilei Yin Haizhou Yang Shufei He Likui Feng Jianju Li Qingliang Zhao Liangliang Wei | 2023 | Environmental Science and Ecotechnology2023，，1： | 0 |
| 18 | SP2509, an inhibitor of LSD1, exerts potential antitumor effects by targeting the JAK/STAT3 signaling显示文摘Hyperactivation of Janus kinase(JAK)/signal transducer and activator of transcription(STAT)signaling promotes tumorigenesis and cancer progression.STAT3 participates in the essential processes of cell proliferation,survival,and differentiation in many types of tumors.In the present study,SP2509 was identified as a potent inhibitor of the JAK/STAT3 signaling pathway by high-throughput drug screening based on a STAT3-driven luciferase expression system.Our results indicated that SP2509 inhibits constitutive STAT3 activation and the expression of STAT3-driven downstream genes.Bcl-xL,c-Myc,and Cyclin D1 were downregulated after treatment with SP2509.In addition,SP2509 specifically inhibits JAK activity,which could cause cell cycle arrest,inhibit cell growth,and induce apoptosis of various cancer cells.These results confirmed that SP2509 inhibits tumor progression by suppressing the expression of JAK/STAT3 signaling and STAT3-related downstream genes.Moreover,we demonstrated that SP2509 inhibits tumor growth in vivo and induces cell death in vitro.SP2509-mediated inhibition of STAT3 phosphorylation is dependent on its original target lysine-specific demethylase 1 in cancer cells.In summary,our results indicate that SP2509 is a novel inhibitor of JAK/STAT3 signaling. | Huiyan Zhen Xinxin Zhang Lei Zhang Mingming Zhou Liangliang Lu Lihong Wu Na He Juan Wang Rui Li Yan Guo | 2021 | Acta Biochimica et Biophysica Sinica2021，53，8： | 0 |
| 19 | Preparation,Structure,and Properties of Flexible Polyurethane Foams Filled with Fumed Silica显示文摘Flexible polyurethane (PU) foams with different load-ing mass fraction (0%-2.0%) of fumed silica were synthesized by free-rising foaming method. The addition of 1.4% fumed silica makes the cells diffuse more uniform in the PU foam and the temperature of degradation occurring with a maximum weight loss rate is about 7℃ higher than that of pure PU foam. Most signifi-cantly,the sound absorption peaks of the filled PU foams shift to the low frequency region (from 997 Hz to 711 Hz) with increasing fumed silica content (0%-2.0%). The average sound absorption coefficients of filled PU foams increase except the content of 0.35% fumed silica. The experimental results show that flexible PU foams filled with fumed silica have excellent sound absorption characteristics in low-frequency regions. | LIU Ting MAO Liangliang LIU Fuwei JIANG Wuzhou HE Zhaobo FANG Pengfei | 2011 | Wuhan University Journal of Natural Sciences2011，16，1： | 0 |
| 20 | Two types of coumarins-specific enzymes complete the last missing steps in pyran- and furanocoumarins biosynthesis显示文摘Pyran-and furanocoumarins are key representatives of tetrahydropyrans and tetrahydrofurans,respectively,exhibiting diverse physiological and medical bioactivities.However,the biosynthetic mechanisms for their core structures remain poorly understood.Here we combined multiomics analyses of biosynthetic enzymes in Peucedanum praeruptorum and in vitro functional verification and identified two types of key enzymes critical for pyran and furan ring biosynthesis in plants.These included three distinct P.praeruptorum prenyltransferases(PpPT1e3)responsible for the prenylation of the simple coumarin skeleton 7 into linear or angular precursors,and two novel CYP450 cyclases(PpDC and PpOC)crucial for the cyclization of the linear/angular precursors into either tetrahydropyran or tetrahydrofuran scaffolds.Biochemical analyses of cyclases indicated that acid/base-assisted epoxide ring opening contributed to the enzyme-catalyzed tetrahydropyran and tetrahydrofuran ring refactoring.The possible acid/base-assisted catalytic mechanisms of the identified cyclases were theoretically investigated and assessed using site-specific mutagenesis.We identified two possible acidic amino acids Glu303 in PpDC and Asp301 in PpOC as vital in the catalytic process.This study provides new enzymatic tools in the epoxide formation/epoxide-opening mediated cascade reaction and exemplifies how plants become chemically diverse in terms of enzyme function and catalytic process. | Yucheng Zhao Yuedong He Liangliang Han Libo Zhang Yuanzheng Xia Fucheng Yin Xiaobing Wang Deqing Zhao Sheng Xu Fei Qiao Yibei Xiao Lingyi Kong | 2024 | Acta Pharmaceutica Sinica B2024，14，2： | 0 |
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