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| 1 | MicroRNAs in idiopathic pulmonary fibrosis: involvement in pathogenesis and potential use in diagnosis and therapeutics显示文摘MicroRNAs(miRNAs) are a class of phylogenetically conserved, non-coding short RNAs,19–22 nt in length which suppress protein expression through base-pairing with the 30-untranslated region of target m RNAs. mi RNAs have been found to participate in cell proliferation, differentiation and apoptosis. Idiopathic pulmonary fibrosis(IPF) is a chronic, progressive, and high lethality fibrotic lung disease for which currently there is no effective treatment. Some mi RNAs have been reported to be involved in the pathogenesis of pulmonary fibrosis. In this review, we discuss the role of mi RNAs in the pathogenesis, diagnosis and treatment of IPF. | Huimin Li Xiaoguang Zhao Hongli Shan Haihai Liang | 2016 | Acta Pharmaceutica Sinica B2016，6，6： | 9 |
| 2 | Preliminary evidence for the presence of multiple forms of cell death in diabetes cardiomyopathy显示文摘Diabetic mellitus(DM) is a common degenerative chronic metabolic disease often accompanied by severe cardiovascular complications(DCCs) as major causes of death in diabetic patients with diabetic cardiomyopathy(DCM) as the most common DCC. The metabolic disturbance in DCM generates the conditions/substrates and inducers/triggers and activates the signaling molecules and death executioners leading to cardiomyocyte death which accelerates the development of DCM and the degeneration of DCM to heart failure.Various forms of programmed active cell death including apoptosis, pyroptosis, autophagic cell death, autosis,necroptosis, ferroptosis and entosis have been identified and characterized in many types of cardiac disease.Evidence has also been obtained for the presence of multiple forms of cell death in DCM. Most importantly,published animal experiments have demonstrated that suppression of cardiomyocyte death of any forms yields tremendous protective effects on DCM. Herein, we provide the most updated data on the subject of cell death in DCM, critical analysis of published results focusing on the pathophysiological roles of cell death, and pertinent perspectives of future studies. | Jinjing Wei Yongting Zhao Haihai Liang Weijie Du Lihong Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 8 |
| 3 | Acetyl salicylic acid attenuates cardiac hypertrophy through Wnt signaling显示文摘室的肥大是心血管的疾病的事件的一个强大、独立的预言者。低剂量的乙酰水杨酸酸(阿司匹林) 的脉管的性质通过血小板 cyclooxygenase 的不可逆的抑制提供心血管的好处 1;然而,可能的 anti-hypertrophic 性质和阿司匹林的潜在的机制没详细被调查。在这研究,健康野类型的雄的老鼠随机被划分成三个组并且使遭到了到横向的大动脉的收缩(TAC ) 或假冒的操作。操作 TAC 的老鼠与低剂量的阿司匹林的人的等价物被对待(10 mg 吗? | Samuel Chege Gitau Xuelian Li Dandan Zhao Zhenfeng Guo Haihai Liang Ming Qian Lifang Lv Tianshi Li Bozhi Xu Zhiguo Wang Yong Zhang Chaoqian Xu Yanjie Lu Zhiming Du Hongli Shan Baofeng Yang | 2015 | Frontiers of Medicine2015，9，4： | 6 |
| 4 | Coalbed methane enrichment model of low-rank coals in multi-coals superimposed regions: a case study in the middle section of southern Junggar Basin显示文摘The Middle Jurassic Xishanyao Formation in the central section of the southern Junggar Basin has substantial amounts of low-ranked coalbed methane(CBM)recourses and is typically characterized by multi superimposed coal seams.To establish the CBM enrichment model,a series of experimental and testing methods were adopted,including coal maceral observation,proximate analysis,low temperature nitrogen adsorption(LTNA),methane carbon isotope determination,porosity/permeability simulation caused by overburden,and gas content testing.The controlling effect of sedimentary environment,geological tectonic,and hydrogeological condition on gas content was analyzed in detail.The results demonstrate that the areas with higher gas content(an average of 8.57 m3/t)are mainly located in the Urumqi River-Santun River(eastern study area),whereas gas content(an average of 3.92 m3/t)in the Manasi River-Taxi River(western study area)is relatively low.Because of the combined effects of strata temperature and pressure,the gas content in coal seam first increases and then decreases with increasing buried depth,and the critical depth of the inflection point ranges from 600 m to 850 m.Affected by the changes in topography and water head height,the direction of groundwater migration is predicted from south to north and from west to east.Based on the gas content variation,the lower and middle parts of the Xishanyao Formation can be divided into three independent coalbearing gas systems.Within a single gas-bearing system,there is a positive correlation between gas content and strata pressure,and the key mudstone layers separating each gas-bearing system are usually developed at the end of each highstand system tract.The new CBM accumulation model of the multi-coals mixed genetic gas shows that both biological and thermal origins are found in a buried depth interval between 600 m and 850 m,suggesting that the coals with those depths are the CBM enrichment horizons and favorable exploration regions in the middle section of the southern Junggar Basin.An in-depth discussion of the low-rank CBM enrichment model with multi-coal seams in the study region can provide a basis for the optimization of CBM well locations and favorable exploration horizons. | Haihai HOU Guodong LIANG Longyi SHAO Yue TANG Guangyuan MU | 2021 | Frontiers of Earth Science2021，15，2： | 2 |
| 5 | A novel reciprocal loop between microRNA-21 and TGFβRIII is involved in cardiac fibrosis显示文摘 | Haihai Liang Chun Zhang Tao Ban Yu Liu Liu Mei Xianmei Piao Dan Zhao Yanjie Lu Wenfeng Chu Baofeng Yang | 2012 | International Journal of Biochemistry and Cell Biology2012，，12： | 1 |
| 6 | LncRNA DACH1 protects against pulmonary fibrosis by binding to SRSF1 to suppress CTNNB1 accumulation显示文摘Idiopathic pulmonary fibrosis(IPF)is a progressive disease with unknown etiology and limited therapeutic options.Activation of fibroblasts is a prominent feature of pulmonary fibrosis.Here we report that lncRNA DACH1(dachshund homolog 1)is downregulated in the lungs of IPF patients and in an experimental mouse model of lung fibrosis.LncDACH1 knockout mice develop spontaneous pulmonary fibrosis,whereas overexpression of LncDACH1 attenuated TGF-β1-induced aberrant activation,collagen deposition and differentiation of mouse lung fibroblasts.Similarly,forced expression of LncDACH1 not only prevented bleomycin(BLM)-induced lung fibrosis,but also reversed established lung fibrosis in a BLM model.Mechanistically,LncDACH1 binding to the serine/arginine-rich splicing factor 1(SRSF1)protein decreases its activity and inhibits the accumulation of Ctnnb1.Enhanced expression of SRSF1 blocked the anti-fibrotic effect of LncDACH1 in lung fibroblasts.Furthermore,loss of LncDACH1 promoted proliferation,differentiation,and extracellular matrix(ECM)deposition in mouse lung fibroblasts,whereas such effects were abolished by silencing of Ctnnb1.In addition,a conserved fragment of LncDACH1 alleviated hyperproliferation,ECM deposition and differentiation of MRC-5 cells driven by TGF-β1.Collectively,LncDACH1 inhibits lung fibrosis by interacting with SRSF1 to suppress CTNNB1 accumulation,suggesting that LncDACH1 might be a potential therapeutic target for pulmonary fibrosis. | Jian Sun Tongzhu Jin Zhihui Niu Jiayu Guo Yingying Guo Ruoxuan Yang Qianqian Wang Huiying Gao Yuhan Zhang Tianyu Li Wenxin He Zhixin Li Wenchao Ma Wei Su Liangliang Li Xingxing Fan Hongli Shan Haihai Liang | 2022 | Acta Pharmaceutica Sinica B2022，12，9： | 1 |
| 7 | microRNA‐124 Regulates Cardiomyocyte Differentiation of Bone Marrow‐Derived Mesenchymal Stem Cells Via Targeting STAT3 Signaling显示文摘 | Benzhi Cai Jianping Li Jinghao Wang Xiaobin Luo Jing Ai Yanju Liu Ning Wang Haihai Liang Mingyu Zhang Nan Chen Gang Wang Shu Xing Xin Zhou Baofeng Yang Xinyue Wang Yanjie Lu | 2012 | STEM CELLS2012，，8： | 1 |
| 8 | Prevention and control measures of the major cold-region diseases (hypertension) in China显示文摘Hypertension is the most common cardiovascular condition in clinical practice and a major risk factor for stroke and cardiovascular events.There are more than 270 million hypertension patients in China,and the prevalence of hypertension in the high-latitude cold areas is significantly higher than in the low-latitude warm areas.The unique epidemiological characteristics and risk factors of hypertension in the cold regions of China urge for establishment of the prevention and control system for targeted and more effective management of the condition. | Zhenwei Pan Yong Zhang Tengfei Pan Haihai Liang Baofeng Yang | 2021 | Frigid Zone Medicine2021，1，1： | 1 |
| 9 | Repeated Wildfires in the Middle Jurassic Xishanyao Formation(Aalenian and Bajocian Ages) in Northwestern China显示文摘The coal-bearing strata in the southern Junggar Basin in northwestern China have recently attracted the attention of coal geologists. Its abundance of coal resources is of great interest as there is a potential of unlocking details about the palaeoclimatic information. Coal deposits have the capacity to record wildfire events, even those with inefficient combustions. To characterize wildfire events and palaeoclimatic history of the Middle Jurassic Xishanyao Formation(Aalenian and Bajocian ages), 22 coal samples from borehole cores and coal mines in the southern Junggar Basin were collected and their macerals were analyzed. The results indicated that fusinite and semi-fusinite were the dominant components of inertinite with proportions of 35.27% and 54.67%, respectively. The presence of inertinite is an indicator that wildfires occurred at the time of peat land development, and the widespread occurrence suggests large scale wildfires during the Middle Jurassic. This study proposes a new parameter for the evaluation of wildfire features by combining burning frequency and burning temperature. The comprehensive evaluation index(CEI) was influenced by the lacustrine basin level and ancient plant types from a sequence framework. During the Middle Jurassic, most wildfires were surface fires with low level and ground fire with high level. High oxygen levels were estimated in the lower, middle, and upper members of the Xishanyao Formation with corresponding to 26.78%, 24.55%, and 23.55%, respectively. The high oxygen levels would be the primary cause of repeated wildfires in the Middle Jurassic. These results are helpful for understanding palaeoclimatic changes in the Middle Jurassic. | HOU Haihai SHAO Longyi LIANG Guodong TANG Yue ZHANG Huajie ZHANG Jiaqiang | 2022 | Acta Geologica Sinica(English Edition)2022，96，5： | 1 |
| 10 | Coal Seam Correlation in Terrestrial Basins by Sequence Stratigraphy and Its Implications for Paleoclimate and Paleoenvironment Evolution显示文摘Coal correlation cannot only guide coal and coalbed methane exploitation,but may also provide valuable information for the evolution of the paleoclimate and paleoenvironment during coalaccumulation periods.It is difficult to undertake coal correlation in a terrestrial basin due to multiple superimposed coal seams and a lack of effective marker beds.In this study,based on the analyses of coal-bearing sedimentary environments and the observations of field outcrops and drilling cores,three key sequence surfaces of the Middle Jurassic Xishanyao Formation were identified in the middle part of the southern Junggar Basin.Three third-order sequences(S.Ⅲ1,S.Ⅲ2 and S.Ⅲ3)and ten fourth-order sequences were divided within the Xishanyao Formation.Regional coal correlation was finally identified,combined with the layered vertical pattern coal and its interval thickness,coal maceral,and coal quality data.In terms of the coal correlation within a specific sequence set,the interval of the B2–B3 coals was approximately three times thicker than that of the B3–B5 coals,which was the main marker for regional coal correlation in the Lower Xishanyao Formation.Furthermore,the phenomena of steadily developed B4 coal seam(2–3 m in thickness)across the Liuhuanggou coal mining area(eastern study region)and the large-small-large variation for intervals between the B8 and B9,B9 and B10,and B10 and B11 coal seams in the Manasi coal mining(western study region)were also an effective means for local coal correlation.Increasing vitrinite and sulphur content and decreasing inertinite content in a third-order sequence were found,which were likely to be closely related to lake level fluctuations.Based on the variation of coal macerals,the wildfire frequency gradually decreased from the bottom to the top of the Xishanyao Formation.The predicted O2level of the S.Ⅲ1,S.Ⅲ2,and S.Ⅲ3 of the Xishanyao Formation was 26.36%,24.22%,and 22.51%,respectively.Except for global paleoclimate effects,the provenance direction changes caused by the Bogda Mountains uplifts would result in a regular variation of coal maceral and coal quality across the study region. | Haihai Hou Longyi Shao Yue Tang Yanan Li Guodong Liang Yilin Xin Jiaqiang Zhang | 2023 | Journal of Earth Science2023，34，2： | 0 |
| 11 | Antidiabetic agents:Do they hit the right targets?显示文摘Diabetes mellitus(DM)is a progressive metabolic disease characterized by chronic hyperglycemia and caused by different degree of pancreatic islet dysfunction and/or insulin resistance(IR).Long course DM can lead to a variety of macrovascular and microvascular complications which involve artery vessels,heart,kidney,retina,nervous system,etc.In recent years,DM has attracted more and more attention due to its high morbidity and mortality.In addition to achieve effective glycemic control,prevention of complications has also been considered a priority for type 2 diabetes mellitus(T2DM)management.Herein,we provide a comprehensive overview on the pharmacotherapeutics for T2DM and perspectives on the future directions of basic and translational research on anti-diabetic therapy and pharmatheutical development of new drugs. | Yongting Zhao Xiaofang Zhang Haihai Liang Lihong Wang | 2022 | Frigid Zone Medicine2022，2，4： | 0 |
| 12 | Notum protects against myocardial infarction-induced heart dysfunction by alleviating cardiac fibrosis显示文摘Background and Objective:Cardiac fibrosis is a pathological reparative process that follows myocardial infarctionand is associated with compromised cardiac systolic and reduced cardiac compliance.The Wnt signaling pathway is closely implicated in organ fibrosis,and Notum,a highly conserved secreted inhibitor,modulates Wnt signaling.The objective of this study was to explore the role and mechanism of Notum in cardiac fibrosis.Methods:A mouse model of cardiac remodeling was established through left coronary artery ligation surgery,with the addition of Notum injection following myocardial infarction surgery.The protective effect of Notum on myocardial infarction was assessed by evaluating cardiac function,including survival rate,echocardiographic assessment,and cardiac contraction analyses.Inflammatory cell necrosis and infiltration were confirmed through H&E and Masson staining.The expression of fibrosis-related genes andβ-catenin pathway markers was detected using Western blot quantificational RT-PCR(qRT-PCR).Additionally,EdU,wound healing,and immunofluorescence staining analyses were performed to detect the effect of Notum's in transforming growth factor beta-1(TGF-β1)induced myofibroblast transformation.Results:The administration of Notum treatment resulted in enhanced survival rates,improved cardiac function,and decreased necrosis and infiltration of inflammatory cells in mice subjected to left coronary artery ligation.Furthermore,Notum effectively impeded the senescence of cardiac fibroblasts and hindered their pathological transformation into cardiac fibroblasts.Additionally,it significantly reduced collagen production and attenuated the activation of the Wnt/β-catenin pathway.Our preliminary investigations successfully demonstrated the therapeutic potential of Notum in both fibroblasts in vitro and in a mouse model of myocardial infarction-induced cardiac fibrosis in vivo.Conclusion:Notum inhibition of the Wnt/β-catenin signaling pathway and cardiac fibroblast senescence ultimately hampers the onset of cardiac fibrosis.Our findings suggest that Notum could represent a new therapeutic strategy for the treatment of cardiac fibrosis. | Tongzhu Jin Zhen Ye Ruonan Fang Yue Li Wei Su Qianqian Wang Tianyu Li Hongli Shan Yanjie Lu Haihai Liang | 2024 | Frigid Zone Medicine2024，4，1： | 0 |
| 13 | YBX1 inhibits mitochondrial-mediated apoptosis in ischemic heart through the PI3K/AKT signaling pathway显示文摘Background:Myocardial infarction(MI)is associated with higher morbidity and mortality in the world,especially in cold weather.YBX1 is an RNA-binding protein that is required for pathological growth of cardiomyocyte by regulating cell growth and protein synthesis.But YBX1,as an individual RNA-binding protein,regulates cardiomyocytes through signaling cascades during myocardial infarction remain largely unexplored.Methods:In vivo,the mouse MI model was induced by ligating the left anterior descending coronary artery(LAD),and randomly divided into sham operation group,MI group,MI+YBX1 knockdown/overexpression group and MI+negative control(NC)group.The protective effect of YBX1 was verified by echocardiography and triphenyltetrazolium chloride staining.In vitro,mitochondrial-dependent apoptosis was investigated by using CCK8,TUNEL staining,reactive oxygen species(ROS)staining and JC-1 staining in hypoxic neonatal mouse cardiomyocytes(NMCMs).Results:YBX1 expression of cardiomyocytes was downregulated in a mouse model and a cellular model on the ischemic condition.Compared to mice induced by MI,YBX1 overexpression mediated by adeno-associated virus serotype 9(AAV9)vector reduced the infarcted size and improved cardiac function.Knockdown of endogenous YBX1 by shRNA partially aggravated ischemia-induced cardiac dysfunction.In hypoxic cardiomyocytes,YBX1 overexpression decreased lactic dehydrogenase(LDH)release,increased cell viability,and inhibited apoptosis by affecting the expression of apoptosis related proteins,while knockdown of endogenous YBX1 by siRNA had the opposite effect.Overexpression of YBX1 restored mitochondrial dysfunction in hypoxic NMCMs by increasing mitochondrial membrane potential and ATP content and decreasing ROS.In hypoxic NMCMs,YBX1 overexpression increased the expression of phosphorylated phosphatidylinositol 3 kinase(PI3K)/AKT,and the anti-apoptosis effect of YBX1 was eliminated t by LY294002,PI3K/AKT inhibitor.Conclusion:YBX1 protected the heart from ischemic damage by inhibiting the mitochondrial-dependent apoptosis through PI3K/AKT pathway.It is anticipated that YBX1 may serve as a novel therapeutic target for MI. | Fangfang Bi Miao Cao Yuquan Wang Qingming Pan Zehong Jing Danyang Bing Lifang Lyu Tong Yu Tianyu Li Xuelian Li Haihai Liang Hongli Shan Yuhong Zhou | 2024 | Frigid Zone Medicine2024，4，1： | 0 |
| 14 | Apelin aggravates the migration and invasion of non-small cell lung cancer cells via YAP1显示文摘Background:Apelin,an endogenous ligand of G-protein coupled receptor(GPCR),is a secreted peptide involved in the development of various tumors.However,the relationship between apelin and non-small cell lung cancer(NSCLC)is not quite clear.This study was designed to investigate the effect and mechanism of apelin on cell proliferation,migration and invasion of NSCLC cells.Methods:Twelve NSCLC specimens were collected for hematoxylin-eosin(HE)staining and immunohistochemistry analyses.Cell proliferation was examined by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)and cell migration and invasion were assessed using wound-healing and transwell assays.The subcellular location of yes associated protein 1(YAP1)in A549 cells was determined by immunofluorescence.The mRNA and protein levels in NSCLC tissues and cell lines were measured by qRT-PCR and western blot,respectively.Results:Apelin was upregulated in tumor tissues compared with the adjacent tissues.Apelin promoted proliferation,migration,and invasion of A549 and H460 cells,which was reversed by competitive apelin receptor(APJ)antagonist ML221.Additionally,apelin upregulated YAP1 expression,whereas silence of YAP1 by small interfering RNA(siRNA)attenuated apelin-induced cell proliferation,migration and invasion and suppressed epithelial-mesenchymal transition progression.Conclusion:Apelin promotes NSCLC cells proliferation,migration,and invasion by modulating YAP1 and might be a potential therapeutic target for NSCLC treatment. | Wenchao Ma Di Zhu Tong Yu Junwen Xue Xiang Sun Guofang Zhang Yumeng Hou Jinrui Li Yingzhun Chen Hongli Shan Haihai Liang | 2022 | Frigid Zone Medicine2022，2，1： | 0 |
| 15 | MicroRNAs Control Cardiac Fibrosis显示文摘 | Hongli Shan Haihai Liang Yanjie Lu Baofeng Yang | 2013 | 中国药理通讯2013，30，3： | 0 |
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