|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | MicroRNAs in idiopathic pulmonary fibrosis: involvement in pathogenesis and potential use in diagnosis and therapeutics显示文摘MicroRNAs(miRNAs) are a class of phylogenetically conserved, non-coding short RNAs,19–22 nt in length which suppress protein expression through base-pairing with the 30-untranslated region of target m RNAs. mi RNAs have been found to participate in cell proliferation, differentiation and apoptosis. Idiopathic pulmonary fibrosis(IPF) is a chronic, progressive, and high lethality fibrotic lung disease for which currently there is no effective treatment. Some mi RNAs have been reported to be involved in the pathogenesis of pulmonary fibrosis. In this review, we discuss the role of mi RNAs in the pathogenesis, diagnosis and treatment of IPF. | Huimin Li Xiaoguang Zhao Hongli Shan Haihai Liang | 2016 | Acta Pharmaceutica Sinica B2016，6，6： | 9 |
| 2 | Development of NIR-II fluorescence image-guided and pH-responsive nanocapsules for cocktail drug delivery显示文摘基于 Nanocapsule 的指向的交货和刺激应答的版本能增加药有效性,当减少这药的副作用时。然而,在按比例增加合成,快爆炸版本,和低 degradability 的困难,能从实验室妨碍药 nanocapsules 的翻译到诊所。这里,我们 controllably 有 functionalized 可被细菌破坏、广泛地可得到的 polysuccinimide,以便 poly 获得 amphiphilic (氨基酸) 。用这聚合物,我们设计了 nanocapsules (< 100 nm ) 为恐水病的药交货,能便于指向的肿瘤,氢基于契约的 pH 应答的版本,并且即时荧光在第二个在红外线附近的区域追踪。这个方法万用、 eco 友好、容易以低成本扩大规模。另外,这个系统能带药的鸡尾酒,由装载多重 anticancer 药到一样的车辆获得了。我们的 nanocapsules 被观察在血容器稳定(pH = 7.4 ) ,并且 pH 应答的版本(pH = 5.0 在 lysosome ) 被支撑。在肿瘤异种皮移植老鼠的化疗结果建议我们的 nanocapsule 安全、有效,并且可以是为药交货的一个有用工具。 | Sheng Huang Shan Peng Yuanbao Li Jiabin Cui Hongli Chen Leyu Wang | 2015 | Nano Research2015，8，6： | 7 |
| 3 | Acetyl salicylic acid attenuates cardiac hypertrophy through Wnt signaling显示文摘室的肥大是心血管的疾病的事件的一个强大、独立的预言者。低剂量的乙酰水杨酸酸(阿司匹林) 的脉管的性质通过血小板 cyclooxygenase 的不可逆的抑制提供心血管的好处 1;然而,可能的 anti-hypertrophic 性质和阿司匹林的潜在的机制没详细被调查。在这研究,健康野类型的雄的老鼠随机被划分成三个组并且使遭到了到横向的大动脉的收缩(TAC ) 或假冒的操作。操作 TAC 的老鼠与低剂量的阿司匹林的人的等价物被对待(10 mg 吗? | Samuel Chege Gitau Xuelian Li Dandan Zhao Zhenfeng Guo Haihai Liang Ming Qian Lifang Lv Tianshi Li Bozhi Xu Zhiguo Wang Yong Zhang Chaoqian Xu Yanjie Lu Zhiming Du Hongli Shan Baofeng Yang | 2015 | Frontiers of Medicine2015，9，4： | 6 |
| 4 | Genetic basis of high aroma and stress toleranee in the oolong tea cultivar genome显示文摘Tea plants(Camellia sinensis)are commercially cultivated in>60 countries,and their fresh leaves are processed into tea,which is the most widely consumed beverage in the world.Although several chromosome-level tea plant genomes have been published,they collapsed the two haplotypes and ignored a large number of allelic variations that may underlie important biological functions in this species.Here,we present a phased chromosome-scale assembly for an elite oolong tea cultivar,'Huangdan',that is well known for its high levels of aroma.Based on the two sets of haplotype genome data,we identi fi ed numerous genetic variations and a substantial proportion of allelic imbalance related to important traits,including aroma-and stress-related alleles.Comparative genomics revealed extensive structural variations as well as expansion of some gene families,such as terpene synthases(TPSs),that likely contribute to the high-aroma characteristics of the backbone parent,underlying the molecular basis for the biosynthesis of aroma-related chemicals in oolong tea.Our results uncovered the genetic basis of special features of this oolong tea cultivar,providing fundamental genomic resources to study evolution and domestication for the economically important tea crop. | Pengjie Wang Jiaxin Yu Shan Jin Shuai Chen Chuan Yue Wenling Wang Shuilian Gao Hongli Cao Yucheng Zheng Mengya Gu Xuejin Chen Yun Sun Yuqiong Guo Jiangfan Yang Xingtan Zhang Naixing Ye | 2021 | Horticulture Research2021，8，1： | 4 |
| 5 | Circulating microRNA-1 as a potential novel biomarker for acute myocardial infarction显示文摘 | Jing Ai Rong Zhang Yue Li Jielin Pu Yanjie Lu Jundong Jiao Kang Li Bo Yu Zhuqin Li Rongrong Wang Lihong Wang Qiang Li Ning Wang Hongli Shan Zhongyu Li Baofeng Yang | 2009 | Biochemical and Biophysical Research Communications2009，，： | 2 |
| 6 | MicroRNA-101 Inhibited Postinfarct Cardiac Fibrosis and Improved Left Ventricular Compliance via the FBJ Osteosarcoma Oncogene/Transforming Growth Factor-β1 Pathway显示文摘 | Zhenwei Pan Xuelin Sun Hongli Shan Ning Wang Jinghao Wang Jinshuai Ren Shuya Feng Liangjun Xie Chunying Lu Ye Yuan Yang Zhang Ying Wang Yanjie Lu Baofeng Yang | 2012 | Circulation2012，，7： | 2 |
| 7 | Geostatistical Analysis of Spatial Distribution and Dynamics of Dead Heart of Sugarcane Seedlings Caused by Borer显示文摘Dead heart of sugarcane is an important symptom caused by borer attack. In the present study, the spatial distribution and dynamics of dead heart of sugarcane in the field were investigated based on geostatistical analysis, and semivariograms were computed in four separate directions(0°, 45°, 90° and 135°) and fitted with various theoretical models to determine the best fitted one. The Ordinary Kriging was used to interpolate spatial data. The results revealed that the density of dead hearts of sugarcane increased in a single-peak pattern, and the degree of spatial aggregation and random variation both decreased with the increase in the density of dead heart. In addition, dead heart of sugarcane caused by borer exhibited spatial aggregation.With the increase in the density of dead heart, the degree of spatial aggregation decreased, while the correlation increased. Kriging interpolation indicated that the correlation between the spatial patches was weak in early seedling stage, and became strong in middle and late seedling stage. | Zhiming LUO Jiong YIN Wenfeng LI Rongyue ZHANG Hongli SHAN Xiaoyan WANG Yingkun HUANG | 2017 | Agricultural Science & Technology2017，18，4： | 2 |
| 8 | Cocoon Silk-Derived, Hierarchically Porous Carbon as Anode for Highly Robust Potassium-Ion Hybrid Capacitors显示文摘Potassium-ion hybrid capacitors(KIHCs) have attracted increasing research interest because of the virtues of potassium-ion batteries and supercapacitors.The development of KIHCs is subject to the investigation of applicable K+storage materials which are able to accommodate the relatively large size and high activity of potassium.Here,we report a cocoon silk chemistry strategy to synthesize a hierarchically porous nitrogen-doped carbon(SHPNC).The as-prepared SHPNC with high surface area and rich N-doping not only offers highly efficient channels for the fast transport of electrons and K ions during cycling,but also provides sufficient void space to relieve volume expansion of electrode and improves its stability.Therefore,KIHCs with SHPNC anode and activated carbon cathode afford high energy of 135 Wh kg-1(calculated based on the total mass of anode and cathode),long lifespan,and ultrafast charge/slow discharge performance.This study defines that the KIHCs show great application prospect in the field of high-performance energy storage devices. | Haiyan Luo Maoxin Chen Jinhui Cao Meng Zhang Shan Tan Lei Wang Jiang Zhong Hongli Deng Jian Zhu Bingan Lu | 2020 | Nano-Micro Letters2020，12，9： | 2 |
| 9 | Occurrence and Epidemic Dynamics and Accurate Prevention and Control of Important Sugarcane Pests and Diseases in the Sugarcane Areas of Yunnan显示文摘Based on investigation and research,according to the current actual production of sugarcane,the occurrence dynamics and outbreak causes of important pests and diseases that seriously affect sugarcane production were summarized,and accurate and efficient green prevention and control technology was put forward according to the occurrence and damage characteristics of important pests and diseases,such as strengthening sugarcane introduction and quarantine,breeding and selecting varieties resistant to diseases and pests,promoting the use of detoxified healthy seedlings vigorously,applying lamp trapping technology on a large scale,scientifically guiding and promoting biological prevention and control technology,practically promoting the precise and efficient application of slow-release longacting and low toxic pesticides,strengthening field management,spraying pesticides in time at the early stage of a disease,and doing a good job of monitoring and emergency prevention and control of sudden pests. | Wenfeng LI Rongyue ZHANG Hongli SHAN Xiaoyan WANG Jiong YIN Zhiming LUO Jie LI Xiaoyan CANG Yingkun HUANG | 2018 | Agricultural Biotechnology2018，7，5： | 2 |
| 10 | MicroRNA-1 down regulation by propranolol in a rat model of myocardial infarction:A new mechanism for ischaemic cardioprotection显示文摘 | Yanjie Lu Yong Zhang Hongli Shan | 2009 | Cardiovascular Research2009，84，： | 1 |
| 11 | Control Effect of Slow-release, Long-acting and Multi-functional New Pesticides on Sugarcane Borders and Woolly Aphids显示文摘In order to select the long-acting,low toxic,low-risk and multi-functional new pesticides for the control of sugarcane borders and woolly aphids and precise and efficient application technology,the control effect of 10% monosultap · thiamethoxam granular formulation and 1% Bt · clothianidin granular formulation on sugarcane borders and woolly aphids were studied.The results showed that 10% monosultap·thiamethoxam GR and 1% Bt·clothianidin GR had good control effects on sugarcane borders and woolly aphids.They were ideal slow-release,long-acting,low toxic and multi-functional new pesticides used to control sugarcane borders and woolly aphids.They could be used alternately with other pesticides to delay the emergence and development of pest resistance to pesticides.The best dosage of the two pesticides in the field was 45 kg/hm^2.They could be mixed with fertilizer( 1200-1800 kg/hm^2),scattered in sugarcane ditches or at the base of sugarcane plants,and covered with soil or film from January to July.The control effect on dead heart seedlings damaged by borers could be up to above 79.2%,and the control effect on sugarcane woolly aphids could reach more than 98.8%.In comparison with the control group,the actual yield and sugar content of sugarcane increased by above 41 555 kg/hm^2 and 6.5% respectively.The application of slow-release,long-acting,strong systemic and multi-functional new agents with fertilizer around roots is convenient,precise and efficient,labor-saving,time-saving and environmentally friendly,and is worthy of being widely applied in sugarcane areas. | Wenfeng LI Rongyue ZHANG Xiaoyan WANG Hongli SHAN Jiong YIN Yonglei MAO Chao FANG Zhiming LUO Yingkun HUANG | 2018 | Agricultural Biotechnology2018，7，6： | 1 |
| 12 | The muscle-specific microRNAs miR-1 and miR-133 produce opposing effects on apoptosis by targeting HSP60, HSP70 and caspase-9 in cardiomyocytes显示文摘 | Chaoqian Xu Yanjie Lu Zhenwei Pan Wenfeng Chu Xiaobin Luo Huixian Lin Jiening Xiao Hongli Shan Zhiguo Wang and Baofeng Yang | | Journal of Cell Science0，120，17： | 1 |
| 13 | Research Progress and Prospect of Sugarcane Smut显示文摘Sugarcane smut disease( Ustilago scitaminea Sydow) is an important fungal disease worldwide,which seriously affects yield and quality of sugarcane and threatens the stability and development of sugarcane industry. This paper reviewed disease occurrence,damage,pathogen,symptoms,genetic diversity and detection methods of sugarcane smut,response of sugarcane to sugarcane smut stress and control measures of sugarcane smut. The in-depth research of sugarcane smut was also prospected,aiming to provide theoretical reference and scientific basis for the effective control of sugarcane smut. | Changmi WANG Jie LI Rongyue ZHANG Xiaoyan WANG Hongli SHAN Xiaoyan CANG Jiong YIN Zhiming LUO Yingkun HUANG | 2020 | Agricultural Biotechnology2020，9，3： | 1 |
| 14 | LncRNA DACH1 protects against pulmonary fibrosis by binding to SRSF1 to suppress CTNNB1 accumulation显示文摘Idiopathic pulmonary fibrosis(IPF)is a progressive disease with unknown etiology and limited therapeutic options.Activation of fibroblasts is a prominent feature of pulmonary fibrosis.Here we report that lncRNA DACH1(dachshund homolog 1)is downregulated in the lungs of IPF patients and in an experimental mouse model of lung fibrosis.LncDACH1 knockout mice develop spontaneous pulmonary fibrosis,whereas overexpression of LncDACH1 attenuated TGF-β1-induced aberrant activation,collagen deposition and differentiation of mouse lung fibroblasts.Similarly,forced expression of LncDACH1 not only prevented bleomycin(BLM)-induced lung fibrosis,but also reversed established lung fibrosis in a BLM model.Mechanistically,LncDACH1 binding to the serine/arginine-rich splicing factor 1(SRSF1)protein decreases its activity and inhibits the accumulation of Ctnnb1.Enhanced expression of SRSF1 blocked the anti-fibrotic effect of LncDACH1 in lung fibroblasts.Furthermore,loss of LncDACH1 promoted proliferation,differentiation,and extracellular matrix(ECM)deposition in mouse lung fibroblasts,whereas such effects were abolished by silencing of Ctnnb1.In addition,a conserved fragment of LncDACH1 alleviated hyperproliferation,ECM deposition and differentiation of MRC-5 cells driven by TGF-β1.Collectively,LncDACH1 inhibits lung fibrosis by interacting with SRSF1 to suppress CTNNB1 accumulation,suggesting that LncDACH1 might be a potential therapeutic target for pulmonary fibrosis. | Jian Sun Tongzhu Jin Zhihui Niu Jiayu Guo Yingying Guo Ruoxuan Yang Qianqian Wang Huiying Gao Yuhan Zhang Tianyu Li Wenxin He Zhixin Li Wenchao Ma Wei Su Liangliang Li Xingxing Fan Hongli Shan Haihai Liang | 2022 | Acta Pharmaceutica Sinica B2022，12，9： | 1 |
| 15 | Evaluation of Control Effects against Sugarcane Pests:A New Sustained-release and Long-lasting Pesticide and Convenient and Efficient Pesticide Application Technology显示文摘[Objective]The paper was to screen a new ideal sustained-release,long-lasting and low-toxic pesticide and convenient and efficient pesticide application technology for controlling Ceratovacuna lanigera and Baliathrips serratus. [Method]2% Imidacloprid GR were selected and applied in the soil for field efficacy trial. [Result] The optimum dosage of 2% imidacloprid GR was 30 kg/hm^2( active ingredient 600 g),which can be mixed with fertilizer( 30 kg pesticide and 40-80 kg fertilizer per hm^2) once combined with sugarcane planting management or big ridging during February and June. The control effects against C. lanigera and B. serratus could be more than 98. 2% and 81. 1%,respectively. The actual yield and sugar content in various pesticide treatments were increased by 33 390 kg/hm^2 and 6. 6% respectively compared to blank control. [Conclusion]2% imidacloprid GR has good control effects on C. lanigera and B. serratus. It is a new pesticide with ideal sustained-release,long-lasting and low-toxin effects against C. lanigera and B. serratus. Therefore,it could be used alternatively with other pesticides,to delay production and development of drug resistance. | Li Wenfeng Pu Chunhua Zhang Rongyue Yin Jiong Luo Zhiming Shan Hongli Wang Xiaoyan Huang Yingkun | 2017 | Plant Diseases and Pests2017，8，5： | 1 |
| 16 | Unmanned Aerial Vehicle Control of Major Sugarcane Diseases and Pests in Low Latitude Plateau显示文摘This research was aimed at the defects in traditional artificial spraying control method and the problems such as the difficulty in pesticides applying,labor shortage and low operating efficiency in the middle and late stage of sugarcane high stalk crops.The aerial pesticide application technology for sugarcane main diseases and pests was systematically developed and demonstrated from the aspects of aircraft type choice,selection of special pesticides and auxiliaries,integration of pesticides and equipment,field operation,technical specifications,and large-scale application organization mode.The UAV model and flight technical parameters suitable for the sugarcane planting area in low-latitude plateau were analyzed,and the optimal agent formulation combination and application technology of the UAV flight control were screened out,and the UAV flight control was applied to the major sugarcane pests and diseases control in the low-latitude plateau in large scale(UAV flight control was popularized and applied to 15 527 hm 2 in 2018).The research results provided mature whole-process technical support for the normalization of the application of the UVA flight control of major sugarcane pests and diseases.The UAV control technology for major sugarcane pests and diseases had the advantages of ultra-low pesticides applying dosage and high operating efficiency,and could effectively solve the problems such as the difficulty in pesticides applying,labor shortage and low operating efficiency in the middle late growth stage of high stalk crops.This technology successfully opened up a simple,efficient and new way for the effective control of major sugarcane pests and diseases,and practically accelerated the process of integrated control and prevention of sugarcane pests and diseases.In addition,this technology had an extremely significant effect on reducing the loss of sugarcane farmers and enterprises caused by the epidemic and outbreak of sugarcane pests and diseases,increasing sugarcane yield and sugar content.At the same time,this technology played an important role in realizing the whole-process precise control of sugarcane pests and diseases,improving the quality and increasing the efficiency of sugarcane,and guaranteeing the national sugar safety. | Xiaoyan WANG Rongyue ZHANG Hongli SHAN Yuanhong FAN Hong XU Pizhong HUANG Zejuan LI Tingying DUAN Ning KANG Wenfeng LI Yingkun HUANG | 2019 | Agricultural Biotechnology2019，8，4： | 1 |
| 17 | Tanshinone H Aprotects against sudden cardiac death induced by lethal arrhyth-mias via repression of microRNA - 1 显示文摘 | Hongli Shan Xuelian Li Zhenwei Pan | 2009 | Br J Pharmacol2009，158，5： | 1 |
| 18 | Control Effect Evaluation of 70% Thiamethoxam ZF against Ceratovacuna lanigera Zehntner and Baliathrips serratus Kobus on Sugarcane显示文摘[Objective]The paper was to provide scientific basis for popularization and application of 70% Thiamethoxam ZF. [Method]70% Thiamethoxam ZF was selected and applied in the soil for controlling Ceratovacuna lanigera Zehntner and Baliathrips serratus Kobus. [Result]70% Thiamethoxam ZF had good control effect against C. lanigera and B. serratus. The optimum dosage of 70% Thiamethoxam ZF was 450 g/hm^2( effective ingredients 315 g). 70% Thiamethoxam ZF( dosage per hm^2) mixed with the regular fertilizer( dosage per hm^2) should be applied together in sugarcane planting and management from February to June. The control effects against C. lanigera and B. serratus were above 98. 4% and 82. 9% respectively. The actual yield and sugar content were increased by more than 34290 kg/hm^2 and 6. 8% respectively compared to blank control. [Conclusion]70% Thiamethoxam ZF was a new ideal pesticide with characteristics of sustainedrelease,long-lasting and low-toxic for controlling C. lanigera and B. serratus,and should be applied widely in the sugarcane planting area. | Li Wenfeng Zhang Rongyue Huang Yingkun Pu Chunhua Cang Xiaoyan Yin Jiong Luo Zhiming Wang Xiaoyan Shan Hongli | 2017 | Plant Diseases and Pests2017，8，4： | 0 |
| 19 | Prevention and Control Effects of New Biological Formulations Sprayed by Different Methods on Proceras venosatus (Walker) and Tryporyza intacta Snellen in Middle and Late Stages显示文摘To screen new biological formulations, accurate and efficient application technology, field test was conducted with 72% Bacillus thuringiensis(Bt)·monosultap WP, 8% lambda-cyhalothrin·emamectin benzoate SA and 3.6% lambda-cyhalothrin·Bt SA through manual spraying and unmanned aerial vehicle spraying. Test results and comprehensive evaluation analysis demonstrated that 72% Bt·monosultap WP and 8%lambda-cyhalothrin·emamectin benzoate SA by manual spraying and unmanned aerial vehicle spraying had good prevention and control effect on strains and internodes damaged by Tryporyza intacta Snellen in middle and late stage, which were ideal new biological formulations with high effi-ciency and low risk for prevention and control of T. intacta in middle and late stage, and could be popularized in sugarcane area. 72% Bt·monosultap WP at the dose of 3 000 g/hectare and 8% lambda-cyhalothrin·emamectin benzoate SA at the dose of 750 mL/hectare could be sprayed in mid September at the peak occurrence period of the forth and fifth generations of T. intacta and Proceras venosatus. Agents were diluted with 900 kg water per hectare, and manually sprayed with electric knapsack sprayer; or agents were diluted with 15 kg of Haoyang aerial control special addi-tives and water per hectare, and sprayed with unmanned aerial vehicle. The control effect against borer-damaged strain rate was above 81.3% and that against borer-damaged internode rate was above 88.6%. | Li Wenfeng Shan Hongli Wang Xiaoyan Zhang Rongyue Luo Zhiming Fang Chao Mao Yonglei Yin Jiong Huang Yingkun | 2018 | Plant Diseases and Pests2018，9，3： | 0 |
| 20 | Evaluation of the Effect of High-efficiency Compound Formulations on the Prevention and Control of Sugarcane Brown Stripe显示文摘[Objectives]This study was conducted to screen high-efficiency compound formulations and precise application technologies for the prevention and control of sugarcane brown stripe disease.[Methods]Carbendazim,benomyl,chlorothalonil,azoxystrobin,pyraclostrobine and difenoconazole·azoxystrobin were selected for field efficacy tests.[Results]Three formulations,(50%carbendazim WP 1500 g+75%chlorothalonil WP 1500 g+potassium dihydrogen phosphate 2400 g+agricultural synergist 300 ml)/hm^(2),(50%benomyl WP 1500 g+75%chlorothalonil WP 1500 g+potassium dihydrogen phosphate 2400 g+agricultural synergist 300 ml)/hm^(2) and(25%pyraclostrobin 600 ml+potassium dihydrogen phosphate 2400 g+agricultural synergist 300 ml)/hm^(2) had good control effects on sugarcane brown stripe disease,and showed disease index below 14.02 and control efficacy above 84.41%.The three formulations are ideal high-efficiency compound formulations for the prevention and control of sugarcane brown stripe disease.They can be sprayed manually and by unmanned aerial vehicles on the foliar surface from July to August,once every 7 to 10 d,continuously for 2 times.[Conclusions]This study provides new technical support for accurate and efficient prevention and control of sugarcane brown stripe disease. | Wenfeng LI Xiaoyan WANG Hongli SHAN Rongyue ZHANG Yinhu LI Jie LI Yingkun HUANG | 2022 | Agricultural Biotechnology2022，11，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员