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| 1 | Highly expressed BMP9/GDF2 in postnatal mouse liver and lungs may account for its pleiotropic effects on stem cell differentiation,angiogenesis,tumor growth and metabolism显示文摘Bone morphogenetic protein 9(BMP9)(or GDF2)was originally identified from fetal mouse liver cDNA libraries.Emerging evidence indicates BMP9 exerts diverse and pleiotropic functions during postnatal development and in maintaining tissue homeostasis.However,the expression landscape of BMP9 signaling during development and/or in adult tissues remains to be analyzed.Here,we conducted a comprehensive analysis of the expression landscape of BMP9 and its signaling mediators in postnatal mice.By analyzing mouse ENCODE transcriptome datasets we found Bmp9 was highly expressed in the liver and detectable in embryonic brain,adult lungs and adult placenta.We next conducted a comprehensive qPCR analysis of RNAs isolated from major mouse tissues/organs at various ages.We found that Bmp9 was highly expressed in the liver and lung tissues of young adult mice,but decreased in older mice.Interestingly,Bmp9 was only expressed at low to modest levels in developing bones.BMP9-associated TGFβ/BMPR type I receptor Alk1 was highly expressed in the adult lungs.Furthermore,the feedback inhibitor Smads Smad6 and Smad7 were widely expressed in mouse postnatal tissues.However,the BMP signaling antagonist noggin was highly expressed in fat and heart in the older age groups,as well as in kidney,liver and lungs in a biphasic fashion.Thus,our findings indicate that the circulating BMP9 produced in liver and lungs may account for its pleiotropic effects on postnatal tissues/organs although possible roles of BMP9 signaling in liver and lungs remain to be fully understood. | Wei Liu Zhongliang Deng Zongyue Zeng Jiaming Fan Yixiao Feng Xi Wang Daigui Cao Bo Zhang Lijuan Yang Bin Liu Mikhail Pakvasa William Wagstaff Xiaoxing Wu Huaxiu Luo Jing Zhang Meng Zhang Fang He Yukun Mao Huiming Ding Yongtao Zhang Changchun Niu Rex C.Haydon Hue H.Luu Jennifer Moriatis Wolf Michael J.Lee Wei Huang Tong-Chuan He Yulong Zou | 2020 | Genes & Diseases2020，7，2： | 9 |
| 2 | Reemergent Cases of COVID-19—Xinfadi Wholesales Market,Beijing Municipality,China,June 11,2020显示文摘No new local coronavirus disease 2019(COVID-19)cases were reported in Beijing for over 56 days before the reemergent COVID-19 cases that were reported on June 11,2020,and more than 200 confirmed cases have been reported as of June 20 in Beijing.All confirmed COVID-19 cases were associated with Xinfadi Wholesale Market.Here,we reported the phylogenetic characteristics of the COVID-19 viruses(also known as severe acute respiratory syndrome coronavirus 2,SARS-CoV-2,and human coronavirus 2019,HCoV-19)sequenced from the clinical specimens of 2 human cases and 1 environmental sample. | Wenjie Tan Peihua Niu Xiang Zhao Yang Pan Yong Zhang Lijuan Chen Li Zhao Yanhai Wang Dayan Wang Jun Han George FGao Chun Huang Wenbo Xu Guizhen Wu | 2020 | China CDC weekly2020，2，27： | 6 |
| 3 | Meteorological conditions of ice accretion based on real-time observation of high voltage transmission line显示文摘Meteorological conditions during ice accretion on the 500 kV high voltage transmission lines and test cables are presented, together with a calculation of liquid water content (LWC). The data include meteorological observations and real-time ice accretion on the transmission lines of the central China power grid, from 2008 to 2009 in Hubei Province. Also included are observations of ice thickness, microphysics of fog droplets, and other relevant data from a nearby automated weather station at Enshi radar station, from January to March 2009. Results show that temperature at Zhangen tower #307 was correlated with the temperature at Enshi radar station. The temperature on the surface of the high voltage transmission line was 2-4°C higher than ambient air temperature, although the temperatures were positively correlated. Ice formation temperature was about -2°C and ice shedding temperature was about -2 to -1°C on the high voltage transmission line, both of which were lower than the temperature threshold values on the test cable. Ice thickness was significantly affected by temperature variation when the ice was thin. The calculated LWC was correlated with observed LWC, although the calculated value was greater. | Yue Zhou ShengJie Niu JingJing Lü LiJuan Zhao | 2012 | Chinese Science Bulletin2012，57，7： | 6 |
| 4 | The Influences of Macro- and Microphysical Characteristics of Sea-Fog on Fog-Water Chemical Composition显示文摘During a sea-fog field observation campaign on Donghai Island in the spring of 2011, fog-water, visibility, meteorological elements, and fog droplet spectra were measured. The main cations and anions in 191 fog-water samples were Na+, NH+4,H+, NO-3, Cl-and SO2-4, and the average concentrations of cations and anions were 2630 and 2970 μeq L-1, respectively.The concentrations of Na+and Cl-originated from the ocean were high. The enhancement of anthropogenic pollution might have contributed to the high concentration of NH+4, H+, and NO-3. The average values of pH and electrical conductivity(EC)were 3.34 and 505 μS cm-1, respectively, with a negative correlation between them. Cold fronts associated with cyclonic circulations promoted the decline of ion loadings. Air masses from coastal areas had the highest ion loadings, contrary to those from the sea. The ranges of wind speed, wind direction and temperature corresponding to the maximum total ion concentration(TIC) were 3.5–4 m s-1, 79℃–90℃and 21℃C–22℃C, respectively. In view of the low correlation coefficients, a new parameter Lr was proposed as a predictive parameter for TIC and the correlation coefficient increased to 0.74. Based on aerosol concentrations during the sea-fog cases in 2010, we confirmed that fog-water chemical composition also depended on the species and sizes of aerosol particles. When a dust storm passed through Donghai Island, the number concentration of large aerosol particles(with diameter > 1 μm) increased. This caused the ratio of Ca2+/Na+in fog-water to increase significantly. | YUE Yanyu NIU Shengjie ZHAO Lijuan ZHANG Yu XU Feng | 2014 | Advances in Atmospheric Sciences2014，31，3： | 4 |
| 5 | Calculating standard captured γ spectra of formation elements显示文摘Multi-element gamma-ray spectrum logging requires standard spectra of individual elements for its interpretation.Since the standard element spectra are usually derived using Monte Carlo simulation of either a pure element or its oxide,we synthesized the standard neutron captured γ spectra(as would be observed using a NaI(Tl) detector) of elements H,Si,Ca and Fe from each element and its oxide.To compare the standard spectra from the elements and oxides,we operated three simulations of sandstone,limestone and mixed formation of sandstone and limestone each with ten different porosities,and used the two kinds of standard spectra to analyze the mixed spectra modeled from sandstone and limestone formations.The results show that the standard element spectra from oxides have more prominent energy peaks than the standard spectra from pure elements.The calculated formation element contents are close to the theoretical values when the standard element spectra from oxides are used to analyze the formation mixed spectra.Therefore,the formation element standard spectra should be calculated from oxide models in the analysis of neutron captured γ spectra by logging tools. | Wu Wensheng Xiao Lizhi Zhang Lijuan Niu Wei | 2012 | Petroleum Science2012，9，4： | 3 |
| 6 | Effect on electrochemical reduction of nitrogen to ammonia under ambient conditions: Challenges and opportunities for chemical fuels显示文摘The nitrogen cycle plays an important role in nature,but N-containing products cannot meet human needs.The electrochemical synthesis of ammonia under ambient conditions has attracted the interest of many researchers because it provides a clean and pollution-free synthesis method;however,it has certain difficulties,including a high activation energy,multiple electron transfer,and hydrogenation.Thermodynamic factors limit the selectivity and activity of ammonia synthesis techniques.This review summarizes progress in the electrochemical synthesis of ammonia from theory and experiment.Theoretically,the reduction of nitrogen molecules is analyzed using orbit theory and the thermodynamic reaction pathways.Experimentally,we first discuss the effect of the experimental setup on the nitrogen reduction reaction,and then the four critical of catalysts,including size,electronic,coordination,and orientation effects.These issues must be considered to produce highly-efficient catalysts for electrochemical nitrogen reduction(eNRR).This review provides an overview of the eNRR to enable future researchers to design rational catalysts. | Lijuan Niu Li An Xiayan Wang Zaicheng Sun | 2021 | Journal of Energy Chemistry2021，30，10： | 2 |
| 7 | Genetic tracing of HCoV-19 for the re-emerging outbreak of COVID-19 in Beijing, China显示文摘The ongoing pandemic of coronavirus disease 2019(COVID-19)caused by a novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2,also named as 2019-nCoV or HCoV-19)poses an unprecedented threat to public health(Zhu et al.,2020;Wang et al.,2020;Jiang et al.,2020).The novel HCoV-19 virus has rapidly spread into multiple countries across the world since it was first reported in December 2019.The World Health Organization(WHO)declared COVID-19 as a pandemic on 11th March 2020.As of 4th July,over 10 million confirmed COVID-19 cases have been reported in over 200 countries/regions with more than 0.5 million deaths,including 85,287 documented cases and 4,648 deaths in China(WHO,2020a). | Jing Yang Peihua Niu Lijuan Chen Liang Wang Li Zhao Baoying Huang Juncai Ma Songnian Hu Linhuan Wu Guizhen Wu Chun Huang Yuhai Bi Wenjie Tan | 2021 | Protein & Cell2021，12，1： | 2 |
| 8 | Surface hydrophobic modification enhanced catalytic performance of electrochemical nitrogen reduction reaction显示文摘Electrocatalytic nitrogen reduction reaction(NRR)is a sustainable approach for NH_(3)production with low energy consumption.However,competing hydrogen reduction reaction(HER)in aqueous solution results in low NH_(3)production and Faraday efficiency(FE).Here,MoS_(2)nanostructures with a hydrophobic surface are synthesized by alkyl thiols modification.Aerophilic and hydrophobic surface facilitates an efficient three-phase contact of N_(2),H_(2)O,and catalyst.Thus,localized concentrated N_(2)molecules can overcome the mass transfer limitation of N2 and depress the HER due to lowering the proton contacts.Although the active-sites decrease with the increase of the alkyl chain since the thiol may cover the active site,the optimized electrocatalyst achieves NH_(3)yield of 12.86×10^(-11)mol·cm^(-2)·s^(-1)at-0.25 V and 22.23%FE,which are 4.3 and 24 times higher than those of MoS2-CP electrocatalyst,respectively.The increased catalytic performance is attributed to the high N_(2)adsorption and depressed HER. | Lijuan Niu Ziwen Liu Guohua Liu Mengxuan Li Xupeng Zong Dandan Wang Li An Dan Qu Xiaoming Sun Xiayan Wang Zaicheng Sun | 2022 | Nano Research2022，15，5： | 2 |
| 9 | Physiology and Biochemistry Changes of Euphorbia pulcherrima During Leaf Color Transformation显示文摘Reasons for the color change of E.pulcherrima were studied with physiological and biochemical paraments such as: chlorophyll,carotenoids,anthocyanin,Phenylalanine ammonia-lyase (PAL),pH of cell sap in leaves and soluble sugar content etc.The results showed that during the period of the leaf color transmittion of E.pulcherrima,the contents of plastid pigment,soluble sugar and pH of cells sap in leaves showed a high-low-high dynamic change,while the contents of anthocyanin and PAL activity showed the low-high-low dynamic change.Anthocyanin stability had the close relationship with pH of cell sap in leaves,temperature and other conditions. | WANG Lijuan,SUN Meiqing,and NIU De College of Life Sciences,Northeast Agricultural University,Harbin 150030,China | 2010 | Journal of Northeast Agricultural University(English Edition)2010，17，2： | 2 |
| 10 | Genome-wide identification of droughtresponsive microRNAs in two sets of Malus from interspecific hybrid progenies显示文摘Drought stress can negatively impact apple fruit quality and yield.Apple microRNAs(miRNAs)participate in apple tree and fruit development,as well as in biotic stress tolerance;however,it is largely unknown whether these molecules are involved in the drought response.To identify drought-responsive miRNAs in Malus,we first examined the drought stress tolerance of ten F1 progenies of R3(M.×domestica)×M.sieversii.We performed Illumina sequencing on pooled total RNA from both drought-tolerant and drought-sensitive plants.The sequencing results identified a total of 206 known miRNAs and 253 candidate novel miRNAs from drought-tolerant plants and drought-sensitive plants under control or drought conditions.We identified 67 miRNAs that were differentially expressed in drought-tolerant plants compared with drought-sensitive plants under drought conditions.Under drought stress,61 and 35 miRNAs were differentially expressed in drought-tolerant and drought-sensitive plants,respectively.We determined the expression levels of seven out of eight miRNAs by stem-loop qPCR analysis.We also predicted the target genes of all differentially expressed miRNAs and identified the expression of some genes.Gene Ontology analyses indicated that the target genes were mainly involved in stimulus response and cellular and metabolic processes.Finally,we confirmed roles of two miRNAs in apple response to mannitol.Our results reveal candidate miRNAs and their associated mRNAs that could be targeted for improving drought tolerance in Malus species,thus providing a foundation for understanding the molecular networks involved in the response of apple trees to drought stress. | Chundong Niu Haiyan Li Lijuan Jiang Mingjia Yan Cuiying Li Dali Geng Yinpeng Xie Yan Yan Xiaoxia Shen Pengxiang Chen Jun Dong Fengwang Ma Qingmei Guan | 2019 | Horticulture Research2019，6，1： | 2 |
| 11 | Chemical composition of fog water in Nanjing area of China and its related fog microphysics显示文摘 | Chunsong Lu Shengjie Niu Lili Tang Jingjing Lv Lijuan Zhao Bin Zhu | 2010 | Atmospheric Research2010，，： | 1 |
| 12 | Recovery of Li_(2)CO_(3)and FePO_(4)from spent LiFePO_(4)by coupling technics of isomorphic substitution leaching and solvent extraction显示文摘Efficient and low-cost recycling of spent lithium iron phosphate(LiFePO_(4),LFP)batteries has become an inevitable trend.In this study,an integrated closed-loop recycling strategy including isomorphic substitution leaching and solvent extraction process for spent LFP was proposed.An inexpensive FeCl_(3)was used as leaching agent to directly substitute Fe^(2+)from LFP.99%of Li can be rapidly leached in just 30 min,accompanied by 98%of FePO_(4)precipitated in lixivium.The tri-n-butyl phosphate(TBP)-sulfonated kerosene(SK)system was applied to extract Li from lixivium through a twelve-stage countercurrent process containing synchronous extraction and stepwise stripping of Li^(+)and Fe^(3+).80.81%of Li can be selectively enriched in stripping liquor containing 3.059 mol·L^(-1)of Li^(+)under optimal conditions.And the Fe stripping liquor was recovered for LFP re-leaching,of which,Fe^(2+)was oxidized to Fe^(3+)by appropriate H_(2)O_(2).Raffinate and lixivium were concentrated and entered into extraction process to accomplished closeloop recycling process.Overall,the results suggest that more than 99%of Li was recovered.FeCl_(3)holding in solution was directly regenerated without any pollutant emission.The sustainable mothed would be an alternative candidate for total element recycling of spent LFP batteries with industrial potential. | Yong Niu Xiaowu Peng Jinfeng Li Yuze Zhang Fugen Song Dong Shi Lijuan Li | 2023 | Chinese Journal of Chemical Engineering2023，54，2： | 1 |
| 13 | Study on Polyphenol Oxidase Activity and Total Phenol Content of Docynia indica显示文摘[Objectives] To study the polyphenol oxidase (PPO) activity and total phenol content of Docynia indica .[Methods] The tender branches and petioles of the medicinal and edible plant D. indica were used as experimental materials, and the annual changes of total phenol content and polyphenol oxidase (PPO) activity were analyzed.[Results] pH 7.0 was the optimum value of polyphenol oxidase activity in D. indica plants;the best substrate was catechol with the concentration of 0.15 mol/L;the optimum temperature was 25 ℃.[Conclusions] The total phenol content of D. indica plants was the lowest in April, May and September of each year. The polyphenol oxidase activity of D. indica plants at flowering and fruiting stage was significantly higher than that at pre-flowering stage. | Xiaobo QIN Xinyi XU Bei NIU Xiaodong SHI Bingbing ZHANG Lijuan FAN Dongmei HU | 2019 | Medicinal Plant2019，10，4： | 1 |
| 14 | Chemical composition of fog water in Nanjing area of China and its related fog microphysics显示文摘 | Chunsong Lu Shengjie Niu Lili Tang Jingjing Lv Lijuan Zhao Bin Zhu | 2010 | Atmospheric Research2010，，1： | 1 |
| 15 | Identification of serum microRNAs for cardiovascular risk stratification in dyslipidemia subjects显示文摘 | Jia Wu Jiaxi Song Cheng Wang Dongmei Niu Hanqing Li Yuxiu Liu Lijuan Ma Ruijie Yu Xi Chen Ke Zen Qi Yang Chunni Zhang Chen-Yu Zhang Junjun Wang | 2014 | International Journal of Cardiology2014，，： | 1 |
| 16 | Fe_(2)Mo_(3)O_(8)/XC-72 electrocatalyst for enhanced electrocatalytic nitrogen reduction reaction under ambient conditions显示文摘To perform the electrochemical nitrogen reduction reaction(NRR)under milder conditions for sustainable ammonia production,electrocatalysts should exhibit high selectivity,activity,and durability.However,the key restrictions are the highly stable N≡N triple bond and the competitive hydrogen evolution reaction(HER),which make it difficult to adsorb and activate N2 on the surface of electrocatalysts,leading to a low ammonia yield and Faraday efficiency.Inspired by the enzymatic nitrogenase process and using the Fe-Mo as the active center,here we report supported Fe_(2)Mo_(3)O_(8)/XC-72 as an effective and durable electrocatalyst for the NRR.Fe_(2)Mo_(3)O_(8)/XC-72 exhibited NRR activity with an NH3 yield of 30.4μg·h^(−1)·mg^(−1)(−0.3 V)and a Faraday efficiency of 8.2%(−0.3 V).Theoretical calculations demonstrated that the electrocatalytic nitrogen fixation mechanism involved the Fe atom in the Fe_(2)Mo_(3)O_(8)/XC-72 electrocatalyst acting as the main active site in the enzymatic pathway(*NH2→*NH3),which activated nitrogen molecules and promoted the NRR performance. | Guohua Liu Lijuan Niu Zhixue Ma Li An Dan Qu Dandan Wang Xiayan Wang Zaicheng Sun | 2022 | Nano Research2022，15，7： | 0 |
| 17 | A Biomimetic Tooth Replicate That Is Hard,Damage-Tolerant,and Self-Healable显示文摘Hard materials typically lack the mechanism of energy dissipation and cannot self-heal.Nature addresses this challenge by creating multiscale interfaces between high-contrast materials,namely minerals and biopolymers.Inspired by the enamel-dentin junction in nature,an enamel-like crown consisting ofβFeOOH nanocolumns is interdigitated with a flexible self-healing layer.The iron oxide top layer has exceptionally high modulus and hardness,which is more resistant to cyclic deformation than the bottom layer.The latter however provides an additional pathway for viscous and plastic energy dissipation and enables self-healing by allowing upward polymer diffusion to seal the damage.Picture-frame crack patterns were observed under large loading conditions using microindentation,which localizes the damage at the indentation site.The bending properties can be optimized by varying the thickness of the bottom layer,and the crack induced by bending can be effectively captured at the interface without any delamination.The biomimetic tooth replicate is highly adhesive to a ceramic surface and shows an obvious inhibition effect against Streptococcus mutans,a significant contributor to tooth decay.Combined with ultralow thermal diffusivity,this has great potential as dental material.Learning from nature,our work thus provides a powerful pathway to broadening the scope of synthetic materials for dental replicates. | Ying Yan Kai Niu Wenbo Zhang Weiming Sun Yue Jiang Zhonghao Jiang Lijuan Zhao Ming Yang Baosheng Li Ying Hou Guangshe Li Ming Yang Shouhua Feng | 2023 | CCS Chemistry2023，5，1： | 0 |
| 18 | Synthesis and Biological Activity of Imidazo[4,5-c]quinoline Derivatives as PI3K/mTOR Inhibitors显示文摘 | LI Yanjie ZHANG Xingmin NIU Shengxiu ZHAO Yanping YANG Lijuan SHAO Xiaowei WANG Ensi | 2017 | Chemical Research in Chinese Universities2017，33，6： | 0 |
| 19 | Research Progress in Biological Control of Soft Rot of Amorphophallus konjac显示文摘In this paper,the main control methods of soft rot of Amorphophallus konjac are reviewed,with a focus on the current research status of using plant growth promoting rhizobacteria for biological control of soft rot of A.konjac,and future research directions are looked forward to. | Lisha NIU Tongshu DAI Zhenliang CAO Boxuan JIA Bo HUANG Lijuan DENG Shuanglin YANG Zhen REN Yu ZHONG | 2023 | Asian Agricultural Research2023，15，5： | 0 |
| 20 | A conserved unusual posttranscriptional processing mediated by short,direct repeated (SDR) sequences in plants显示文摘In several stress responsive gene loci of monocot cereal crops,we have previously identified an unusual posttranscriptional processing mediated by paired presence of short direct repeated (SDR) sequences at 5' and 3' splicing junctions that are distinct from conventional (U2/U12-type) splicing boundaries.By using the known SDR-containing sequences as probes,24 plant candidate genes involved in diverse functional pathways from both monocots and dicots that potentially possess SDR-mediated posttranscriptional processing were predicted in the GenBank database.The SDRs-mediated posttranscriptional processing events including cis-and trans-actions were experimentally detected in majority of the predicted candidates.Extensive sequence analysis demonstrates several types of SDR-associated splicing peculiarities including partial exon deletion,exon fragment repetition,exon fragment scrambling and trans-splicing that result in either loss of partial exon or unusual exonic sequence rearrangements within or between RNA molecules.In addition,we show that the paired presence of SDR is necessary but not sufficient in SDR-mediated splicing in transient expression and stable transformation systems.We also show prokaryote is incapable of SDR-mediated premRNA splicing. | Xiangli Niu Di Luo Shaopei Gao Guangjun Ren Lijuan Chang Yuke Zhou Xiaoli Luo Yuxiang Li Pei Hou Wei Tang Bao-Rong Lu Yongsheng Liu | 2010 | Journal of Genetics and Genomics2010，37，1： | 0 |
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