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| 1 | Transgenic rhesus monkeys carrying the human MCPH1 gene copies show human-like neoteny of brain development显示文摘Brain size and cognitive skills are the most dramatically changed traits in humans during evolution and yet the genetic mechanisms underlying these human-specific changes remain elusive.Here,we successfully generated 11 transgenic rhesus monkeys(8 first-generation and 3 second-generation)carrying human copies of MCPH1,an important gene for brain development and brain evolution.Brain-image and tissue-section analyses indicated an altered pattern of neural-cell differentiation,resulting in a delayed neuronal maturation and neural-fiber myelination of the transgenic monkeys,similar to the known evolutionary change of developmental delay(neoteny)in humans.Further brain-transcriptome and tissue-section analyses of major developmental stages showed a marked human-like expression delay of neuron differentiation and synaptic-signaling genes,providing a molecular explanation for the observed brain-developmental delay of the transgenic monkeys.More importantly,the transgenic monkeys exhibited better short-term memory and shorter reaction time compared with the wild-type controls in the delayed-matching-to-sample task.The presented data represent the first attempt to experimentally interrogate the genetic basis of human brain origin using a transgenic monkey model and it values the use of non-human primates in understanding unique human traits. | Lei Shi Xin Luo Jin Jiang Yongchang chen Cirong Liu Ting Hu Min Li Qiang Lin Yanjiao Li Jun Huang Hong Wang Yuyu Niu Yundi Shi Martin Styner Jianhong Wang Yi Lu Xuejin Sun Hualin Yu Weizhi Ji Bing Su | 2019 | National Science Review2019，6，3： | 12 |
| 2 | MTBAC: A Mutual Trust Based Access Control Model in Cloud Computing显示文摘As a new computing mode,cloud computing can provide users with virtualized and scalable web services,which faced with serious security challenges,however.Access control is one of the most important measures to ensure the security of cloud computing.But applying traditional access control model into the Cloud directly could not solve the uncertainty and vulnerability caused by the open conditions of cloud computing.In cloud computing environment,only when the security and reliability of both interaction parties are ensured,data security can be effectively guaranteed during interactions between users and the Cloud.Therefore,building a mutual trust relationship between users and cloud platform is the key to implement new kinds of access control method in cloud computing environment.Combining with Trust Management(TM),a mutual trust based access control(MTBAC) model is proposed in this paper.MTBAC model take both user's behavior trust and cloud services node's credibility into consideration.Trust relationships between users and cloud service nodes are established by mutual trust mechanism.Security problems of access control are solved by implementing MTBAC model into cloud computing environment.Simulation experiments show that MTBAC model can guarantee the interaction between users and cloud service nodes. | LIN Guoyuan WANG Danru BIE Yuyu LEI Min | 2014 | China Communications2014，11，4： | 12 |
| 3 | Doping bioactive elements into a collagen scaffold based on synchronous self-assembly/mineralization for bone tissue engineering显示文摘Pure collagen is biocompatible but lacks inherent osteoinductive,osteoimmunomodulatory and antibacterial activities.To obtain collagen with these characteristics,we developed a novel methodology of doping bioactive elements into collagen through the synchronous self-assembly/mineralization(SSM)of collagen.In the SSM model,amorphous mineral nanoparticles(AMN)(amorphous SrCO3,amorphous Ag3PO4,etc.)stabilized by the polyampholyte,carboxymethyl chitosan(CMC),and collagen molecules were the primary components under acidic conditions.As the pH gradually increased,intrafibrillar mineralization occurred via the self-adaptive interaction between the AMNs and the collagen microfibrils,which were self-assembling;the AMNs wrapped around the microfibrils became situated in the gap zones of collagen and finally transformed into crystals.Srdoped collagen scaffolds(Sr-CS)promoted in vitro cell proliferation and osteogenic differentiation of rat bone marrow mesenchymal stromal cells(rBMSCs)and synergistically improved osteogenesis of rBMSCs by altering the macrophage response.Ag-doped collagen scaffolds(Ag-CS)exhibited in vitro antibacterial effects on S.aureus,as well as cell/tissue compatibility.Moreover,Sr-CS implanted into the calvarial defect of a rat resulted in improved bone regeneration.Therefore,the SSM model is a de novo synthetic strategy for doping bioactive elements into collagen,and can be used to fabricate multifunctional collagen scaffolds to meet the clinical challenges of encouraging osteogenesis,boosting the immune response and fighting severe infection in bone defects. | Huanhuan Liu Mingli Lin Xue Liu Ye Zhang Yuyu Luo Yanyun Pang Haitao Chen Dongwang Zhu Xue Zhong Shiqing Ma Yanhong Zhao Qiang Yang Xu Zhang | 2020 | Bioactive Materials2020，5，4： | 6 |
| 4 | Incidence and clinical characteristics of inflammatory bowel disease in a developed region of G uangdong P rovince, C hina: A prospective population‐based study显示文摘 | Zhirong Zeng Zhenhua Zhu Yuyu Yang Weishan Ruan Xiabiao Peng Yuhuan Su Lin Peng Jinquan Chen Quan Yin Chao Zhao Haihua Zhou Shuai Yuan Yuantao Hao Jiaming Qian Siew Chien Ng Minhu Chen Pinjin Hu | 2013 | J Gastroenterol Hepatol2013，，7： | 5 |
| 5 | Visual analytics of taxi trajectory data via topical sub-trajectories显示文摘GPS-based taxi trajectories contain valuable knowledge about movement patterns for transportation and urban planning.Topic modeling is an effective tool to extract semantic information from taxi trajectory data.However,previous methods generally ignore trajectory directions that are important in the analysis of movement patterns.In this paper,we employ the bigram topic model rather than traditional topic models to analyze textualized trajectories and consider the direction information of trajectories.We further propose a modified Apriori algorithm to extract topical sub-trajectories and use them to represent each topic.Finally,we design a visual analytics system with several linked views to facilitate users to interactively explore movement patterns from topics and topical sub-trajectories.The case studies with Chengdu taxi trajectory data demonstrate the effectiveness of the proposed system. | Huan Liu Sichen Jin Yuyu Yan Yubo Tao Hai Lin | 2019 | Visual Informatics2019，3，3： | 3 |
| 6 | Raindrop energy-powered autonomous wireless hyetometer based on liquid-solid contact electrification显示文摘Triboelectric nanogenerators(TENGs)can directly harvest energy via solid-liquid interface contact electrification,making them very suitable for harvesting raindrop energy and as active rainfall sensors.This technology is promising for realizing a fully self-powered system for autonomous rainfall monitoring combined with energy harvesting/sensing.Here,we report a raindrop energy-powered autonomous rainfall monitoring and wireless transmission system(R-RMS),in which a raindrop-TENG(R-TENG)array simultaneously serves as a raindrop energy harvester and rainfall sensor.At a rainfall intensity of 71 mm/min,the R-TENG array can generate an average short-circuit current,open-circuit voltage,and maximum output power of 15 pA,1800 V,and 325 pW,respectively.The collected energy can be adjusted to act as a stable 2.5 V direct-current source for the whole system by a power management circuit.Meanwhile,the R-TENG array acts as a rainfall sensor,in which the output signal can be monitored and the measured data are wirelessly transmitted.Linder a rainfall intensity of 71 mm/min,the R-RMS can be continuously powered and autonomously transmit rainfall data once every 4 min.This work has paved the way for raindrop energy-powered wireless hyetometers,which have exhibited broad prospects in unattended weather monitoring,field surveys,and the Internet of Things. | Chaoqun Xu Xianpeng Fu Chengyu Li Guoxu Liu Yuyu Gao Youchao Qi Tianzhao Bu Yuanfen Chen Zhong Lin Wang Chi Zhang | 2022 | Microsystems & Nanoengineering2022，8，2： | 2 |
| 7 | Synthesis of an amino-terminated hyperbranched polymer and its application in reactive dyeing on cotton as a salt-free dyeing auxiliary显示文摘 | ZHANG Fens CHEN Yuyue LIN Hong | 2007 | Coloration Technology2007，，6： | 1 |
| 8 | Study on the preparation of steady-state chitosan nanoparticle as silkfabric finishing agent显示文摘 | WANG Cheng LIN Hong CHEN Yuyue | | 0，，175： | 1 |
| 9 | Synthesis of an amino-terminate Hyperbranched polymer and its ap- plication in reactive dyeing on cotton as a salt-free dyeing auxiliary显示文摘 | ZHANG Feng CHEN Yuyue LIN Hong | 2007 | Society of Dyes and Coloration Technology2007，123，6： | 1 |
| 10 | HBP-NH2 grafted cotton fiber: preparation and salt-free dyeing properties 显示文摘 | ZHANG Feng CHEN Yuyue LIN Hong | 2008 | Carbohydrate Polymers2008，74，： | 1 |
| 11 | Synthesis of an amino-terminated hyperbranched polymer and its application in reactive dyeing on cotton as a salt-free dyeing auxiliary显示文摘 | ZHANG Feng CHEN Yuyue LIN Hong | 2007 | Coloration Technology2007，123，： | 1 |
| 12 | Flameless combustion for hydrogen containing fuels显示文摘 | YuYu Gaofeng Wang Qizhao Lin | 2010 | International Journal of Hydrogen Energy2010，，35： | 1 |
| 13 | Synthesis of an ami-no-terminated hyperbranched polymer and its application in reactive dyeing on cotton as a salt-free dyeing auxiliary 显示文摘 | Feng Zhang Yuyue Chen Hong Lin | 2007 | Coloration Technology2007，123，： | 1 |
| 14 | Synthesis of an amino-terminated hyperbranched polymer and its application in reactive dyeing on cotton as a salt- free dyeing auxiliary 显示文摘 | ZHANG Feng CHEN Yuyue LIN Hong | 2007 | Coloration Technology2007，123，6： | 1 |
| 15 | HBP-NI-I2 grafted cotton fiber: Preparation and salt-free dyeing properties 显示文摘 | Feng Zhang Yuyue Chen Hong Lin | 2008 | Car- bohydrate Polymers2008，74，： | 1 |
| 16 | HBP- NH2 grafted cotton fiber: preparation and salt-free dyeing properties 显示文摘 | ZHANG Feng CHEN Yuyue LIN Hong | 2008 | Carbohydrate Polymers2008，74，2： | 1 |
| 17 | Deoxygenation of bio-oil during pyrolysis of biomass in the presence of CaO in a fluidized-bed reactor 显示文摘 | Lin Yuyu Zhang Chu Zhang Mingchuan | 2010 | Energy andFuels2010，24，： | 1 |
| 18 | Deoxygenation of bio-oil during pyrolysis of biomass in the presence of CaO in a fluidized-bed reactor 显示文摘 | Lin Yuyu Zhang Chu Zhang Mingchuan | 2010 | Energy and Fuels2010，24，： | 1 |
| 19 | The assessment of health- related quality of life and related factors in Chinese el- derly patients undergoing chemotherapy for advanced cancer: A cross-sectional study显示文摘 | Qiuping Li Yi Lin Yuyu Qiu | 2014 | European Journal of Cncology Nursing2014，18，4： | 1 |
| 20 | Aberrant nuclear localization of EBP50 promotes colorectal carcinogenesis in xenotransplanted mice by modulating TCF-1 and β-catenin interactions显示文摘 | LIN Yuyu HSU Y H HUANG H Y | 2012 | Journal of Clinical Investigation2012，122，5： | 1 |
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