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| 1 | HPV16E7-HSP70 Hybrid DNA Vaccine Induces E7-Specific Cytotoxic T Cells and Antitumor Immunity显示文摘Using human papillomavirus type 16 (HPV16) E7 as an antigen and Heat Shock Protein 70 as adjuvant, we constructed a DNA vaccine by linking HSP70 gene to E7~ C91G gene. Mice, after being immunized with E7~ C91G -HSP70, E7~ C91G /HSP70, E7~ C91G , and wild E7 DNA vaccines respectively, produced E7 specific CD8^+ T-cell precursor frequencies of 280.33±2.52, 144.34±4.04, 164.34±5.13 and 82.33±3.51 respectively within every 1×10~5 mouse splenocytes. This proves that E7~ C91G -HSP70 fusion vaccine can significantly enhance the E7 specific cellular immunity within the mice body(p<0.01). After being immunized with E7~ C91G -HSP70 fusion vaccine, tumor-bearing mice of the group being treated have significantly longer latency and survival periods, comparing with other three categories of E7 vaccines. Experiment shows that this vaccine has a significant effect on enhancing E7 positive tumor-treatment within mice body. After being immunized with E7~ C91G -HSP70 vaccine, there were no pathological changes found in livers, kidneys and spleens of the mice, which proves that the vaccine is quite safe. After all, E7~ C91G -HSP70 fusion vaccine has a much stronger tumor- treatment effect than that of wild type E7 DNA vaccine. | ZHU Liqin LI Hui XIONG Jinhu WANG Tongxiang OU Xuan WEI Yun WU Xinxing | 2006 | Wuhan University Journal of Natural Sciences2006，11，3： | 2 |
| 2 | Folic Acid Functionalized PFBT Fluorescent Polymer Dots for Tumor Imaging显示文摘Folic 酸 functionalized PFBT-COOH 和 PFBT-NH 2 聚合物点用一个 nano 降水方法,和他们的应用被准备因为在 vitro 并且在 vivo 的肿瘤成像第一次被表明。综合 FA-PFBT-COOH 聚合物点是在有一个希腊语的第六个字母潜力的直径的 50-60 nm 比水里的 −30 mV 大,当综合 FA-PFBT-NH 2 聚合物点是在有一个希腊语的第六个字母潜力的直径的 90-105 nm 时比水里的 −20 mV 大。而且, FA-PFBT-COOH 聚合物点比 FA-PFBT-NH 2 聚合物点在水答案以及在房间生产了更强壮的荧光紧张,并且对在在静脉内的注射以后的生活鼠标的图象 H1299 肿瘤有能力。这研究作为荧光灯显示出 FA-PFBT-COOH 聚合物点的大潜力为生物医学的成像的 nanoprobes。 | Fengwen Cao Liqin Xiong | 2016 | Chinese Journal of Chemistry2016，34，6： | 1 |
| 3 | Dual‑Performance Optimized Silks from Ultra‑Low Dose Polymer Dots Feeding and Its Absorption, Distribution and Excretion in the Silkworms显示文摘Fluorescent polymer dots(Pdots)have the advantages of excellent optical properties,great biocompatibility and high photostability.Herein,we feed ultra-low doses Pdots to silkworms for the first time and aim to prepare dual-performance modified silks.After Pdots feeding,the fluorescence signal of cocoons and degummed silks increases significantly,which is more stable and more uniform than that of post-treatment silks.Moreover,Pdots hinder the conformation transformation of silk fibroin and improve the mechanical property of twisted silk strand.The highest elongation at break point is 20.75±0.03% and breaking strength is 271.7±3.8 MPa.With excellent fluorescence and mechanical properties,the optimized silks are successfully applied as a scaffold for cell culture and imaging.Furthermore,we investigate the metabolism of Pdots in the silkworms for understanding the behaviours of Pdots in the process of silks synthesis and secretion. | Jingru Li Yuqiao Li Shuting Lu Juxiang Zhang Chunfu Zhang Liqin Xiong | 2022 | Advanced Fiber Materials2022，4，4： | 1 |
| 4 | Multimodal-lumines- cence core-shell nanoeomposites for targeted imaging of tumor cells 显示文摘 | Hu He Xiong Liqin Zhou Jing | 2009 | Chem Eur J2009，15，4： | 1 |
| 5 | Regularization methods for a problem of analytic continuation显示文摘 | Xiangtuan Xiong Liqin Zhu Ming Li | 2011 | Mathematics and Computers in Simulation2011，，2： | 1 |
| 6 | Sustainable all-weather CO 2 utilization by mimicking natural photosynthesis in a single material显示文摘Solar-driven CO_(2)conversion into hydrocarbon fuels is a sustainable approach to synchronously alleviating the energy crisis and achieving net CO_(2)emissions.However,the dependence of the conversion process on solar illumination hinders its practical application due to the intermittent availability of sunlight at night and on cloudy or rainy days.Here,we report a model material of Pt-loaded hexagonal tungsten trioxide(Pt/h-WO3)for decoupling light and dark reaction processes,demonstrating the sustainable CO_(2)conversion under dark conditions for the first time.In such a material system,hydrogen atoms can be produced by photocatalytic water splitting under solar illumination,stored together with electrons in the h-WO_(3)through the transition of W^(6+)to W^(5+)and spontaneously released to trigger catalytic CO_(2)reduction under dark conditions.Furthermore,we demonstrate using natural light that CH4 production can persist at night and on rainy days,proving the accomplishment of all-weather CO_(2)conversion via a sustainable way. | Xianjin Shi Yu Huang Ran Long Zhenyu Wang Liqin Wang Junji Cao Gangqiang Zhu Yujie Xiong | 2024 | National Science Review2024，11，2： | 0 |
| 7 | Development of Space Environment Research and Service in China显示文摘During the past two years,space environment has achieved great development in space environment monitoring,model research,system developing and space environment service in China.In this paper,we mainly introduce space environment safety support for Shenzhou-7 manned spacecraft,two typical space environment operation platforms,and the advance of Re-locatable Atmospheric Observatory(RAO).At the last part of this paper,the Sub-committee on Space Environment(SSE) which was set up in 2009 under the Technical Committee on Space Technology and Operation of Standardization Administration of China is briefly introduced. | Gong Jiancun Liu Siqing Shi Liqin Hu Xiong Lin Kexin | 2010 | 空间科学学报2010，30，5： | 0 |
| 8 | Colorectal liver metastasis:molecular mechanism and interventional therapy显示文摘Colorectal cancer(CRC)is one of the most frequently occurring malignancy tumors with a high morbidity additionally,CRC patients may develop liver metastasis,which is the major cause of death.Despite significant advances in diagnostic and therapeutic techniques,the survival rate of colorectal liver metastasis(CRLM)patients remains very low.CRLM,as a complex cascade reaction process involving multiple factors and procedures,has complex and diverse molecular mechanisms.In this review,we summarize the mechanisms/pathophysiology,diagnosis,treatment of CRLM.We also focus on an overview of the recent advances in understanding the molecular basis of CRLM with a special emphasis on tumor microenvironment and promise of newer targeted therapies for CRLM,further improving the prognosis of CRLM patients. | Hui Zhou Zhongtao Liu Yongxiang Wang Xiaoyong Wen Eric HAmador Liqin Yuan Xin Ran Li Xiong Yuping Ran Wei Chen Yu Wen | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 0 |
| 9 | Advances in Research and Service of Space Environment in China显示文摘This paper presents the recent progress of space environment research and service in China.During the past two years,many models of space environment forecast and analysis methods of space environment effects have been developed for tailored space environment service for Chinese space mission.A new Re-locatable Atmospheric Observatory(RAO) for monitoring atmospheric wind,temperature,density and pressure of the near space from 20km up to 120km altitudes is being constructed.In space environment service space environment safety was provided to ensure the safety of CE-1 for its launch and operation in 2007. | SHI Liqin GONG Jiancun LIU Siqing HU Xiong LIU Jing HUANG Wengeng | 2008 | 空间科学学报2008，28，5： | 0 |
| 10 | Two antibodies show broad,synergistic neutralization against SARS-CoV-2 variants by inducing conformational change within the RBD显示文摘Continual evolution of the severe acute respiratory syndrome coronavirus(SARS-CoV-2)virus has allowed for its gradual evasion of neutralizing antibodies(nAbs)produced in response to natural infection or vaccination.The rapid nature of these changes has incited a need for the development of superior broad nAbs(bnAbs)and/or the rational design of an antibody cocktail that can protect against the mutated virus strain.Here,we report two angiotensin-converting enzyme 2 competing nAbs—8H12 and 3E2—with synergistic neutralization but evaded by some Omicron subvariants.Cryo-electron microscopy reveals the two nAbs synergistic neutralizing virus through a rigorous pairing permitted by rearrangement of the 472-489 loop in the receptor-binding domain to avoid steric clashing.Bispecific antibodies based on these two nAbs tremendously extend the neutralizing breadth and restore neutralization against recent variants including currently dominant XBB.1.5.Together,these findings expand our understanding of the potential strategies for the neutralization of SARS-CoV-2 variants toward the design of broad-acting antibody therapeutics and vaccines. | Hui Sun Tingting Deng Yali Zhang Yanling Lin Yanan Jiang Yichao Jiang Yang Huang Shuo Song Lingyan Cui Tingting Li Hualong Xiong Miaolin Lan Liqin Liu Yu Li Qianjiao Fang Kunyu Yu Wenling Jiang Lizhi Zhou Yuqiong Que Tianying Zhang Quan Yuan Tong Cheng Zheng Zhang Hai Yu Jun Zhang Wenxin Luo Shaowei Li Qingbing Zheng Ying Gu Ningshao Xia | 2024 | Protein & Cell2024，15，2： | 0 |
| 11 | CC@BCN@PANI core-shell nanoarrays as ultra-high cycle stability cathode for Zn-ion hybrid supercapacitors显示文摘Exploring cathode materials that combine excellent cycling stability and high energy density poses a challenge to aqueous Zn-ion hybrid supercapacitors(ZHSCs).Herein,polyaniline(PANI)coated boron-carbon-nitrogen(BCN)nanoarray on carbon cloth surface is prepared as advanced cathode materials via simple high-temperature calcination and electrochemical deposition methods.Because of the excellent specific capacity and conductivity of PANI,the CC@BCN@PANI core-shell nanoarrays cathode shows an excellent ion storage capability.Moreover,the 3D nanoarray structure can provide enough space for the volume expansion and contraction of PANI in the charging/discharging cycles,which effectively avoids the collapse of the microstructure and greatly improves the electrochemical stability of PANI.Therefore,the CC@BCN@PANI-based ZHSCs exhibit superior electrochemical performances showing a specific capacity of 145.8 mAh/g,a high energy density of 116.78 Wh/kg,an excellent power density of 12 kW/kg,and a capacity retention rate of 86.2%after 8000 charge/discharge cycles at a current density of 2 A/g.In addition,the flexible ZHSCs(FZHSCs)also show a capacity retention rate of 87.7%at the current density of 2 A/g after 450 cycles. | Shixian XIONG Hongcheng KE Lei CAO Yu WANG Qian ZHU Liqin ZHONG Lanlan FAN Feng GU | 2023 | Frontiers in Energy2023，17，4： | 0 |
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